8 results about "Olefin metathesis" patented technology

A method for deconstruction of an olefinic thermoset is provided in which the olefinic thermoset, an organic solvent, and a ruthenium metathesis catalyst are contacted under conditions effective to provide a deconstructed olefinic polymer composition. Methods for the manufacture of a recycled thermoset are also disclosed in which a virgin cyclic olefin monomer and a deconstructed olefinic polymer composition are polymerized in the presence of an olefin metathesis catalyst to provide the recycled thermoset.

This invention provides a method for the precise deuterium labeling of long-chain fatty acids in the mid-chain, its preparation, and its applications. The method uses commercially available and inexpensive deuterated ethylene glycol-D4 as a starting material, and involves eight core steps: protection, activation, nucleophilic substitution, deprotection, secondary activation, substitution reaction, olefin metathesis, and hydrogenation reduction. This method offers mild preparation conditions and controllable reactions, enabling precise deuterium labeling at the mid-chain sites of various long-chain and very long-chain fatty acids, with a deuteration rate of no less than 98%. Furthermore, this invention can react the obtained long-chain fatty acids with phospholipid intermediates to prepare deuterium-labeled lecithin products targeting the mid-chain, addressing the drawbacks of traditional deuterium-labeled phospholipids, such as easy metabolic shedding of the labeling site and significant interference with detection signals. It also boasts advantages such as high purity, metabolic stability, and good biocompatibility, and can be widely applied in fields such as lipidomics quantification, biochemical metabolic tracing, food adulteration identification, and pharmaceutical research, providing a precise and efficient technical tool for related studies.

This invention relates to nano-carbonized polymer dots with excellent photothermal properties, their preparation method, and their application in the field of photothermal catalysis, belonging to the fields of nanomaterials and photothermal catalysis. The method involves dissolving citric acid and reduced glutathione in formamide solvent, placing the mixture in a reaction vessel, and dehydrating and condensing the precursor under high-temperature solvothermal conditions. The precursor is then purified by dialysis, filtered, concentrated, and dried to obtain the nano-carbonized polymer dots with excellent photothermal properties. When used in photothermal catalysis of olefin metathesis reactions, under mild white LED or xenon lamp irradiation, ring-closure metathesis, cross-metathesis, and ring-opening metathesis polymerization can be achieved, achieving extremely high conversion rates. Further, through surface acrylylation modification, the nano-carbonized polymer dots are covalently crosslinked to a polydicyclopentadiene network to prepare a nanocomposite photothermal plastic with intrinsic photothermal response. This invention is low-cost, simple to prepare, and the obtained material has broad application prospects in the fields of photothermal catalysis and functional composite materials.

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: wherein: M is a Group 6 metal atom; X is an oxygen atom, =N-R5, =N-N(R5)(R5') or =N-0-R5, R5 and R5' independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.

This invention belongs to the field of composite ruthenium compound synthesis technology, specifically relating to an acyclic aminooxycarbene composite ruthenium catalyst with the following structure: M is a ruthenium atom, Z1 and Z2 each independently represent an anionic ligand, X1 is an oxygen atom, and L1 represents an inert ligand selected from one of the acyclic aminocarbene ligands shown in [examples omitted]. This catalyst simultaneously achieves high catalytic efficiency and excellent selectivity in olefin metathesis reactions, and the inert ligand can be conveniently synthesized in a one-pot, multi-gram scale reaction, thereby reducing catalyst production costs.

This invention discloses a stapled peptide, its preparation method, and its applications. The method involves using an amino resin as a solid-phase support, synthesizing a peptide chain in a condensation system according to the linear peptide template LNWGAILKHIIK-NH2 via Fmoc solid-phase synthesis. While retaining key amino acid residues, S5 is used to replace the original amino acid at positions i and i+4, where i = 1-7, resulting in a linear peptide linked to the resin. This linear peptide undergoes an olefin metathesis reaction under the catalysis of Grubbs I reagent, followed by cyclization and cleavage from the resin to obtain the target stapled peptide. This method is simple and easy to implement, yielding a stapled peptide with a purity greater than 95% and a high yield. The synthesized stapled peptide significantly improves protein hydrolysis stability and cell membrane permeability, and can significantly inhibit the growth and proliferation of human breast cancer cells and human liver cancer cells, showing potential application value in the treatment of tumor diseases.

This invention provides a method for synthesizing aliphatic olefin metathesis products with high Z-isomer purity from olefin starting materials with low Z-isomer purity. [Solution] This method includes contacting an internal olefin with an olefin metathesis reaction partner, such as an acylated alkenol or alkenal acetal, in the presence of a Z-selective metathesis catalyst to form an aliphatic olefin metathesis product. In various embodiments, the aliphatic olefin metathesis product is an insect pheromone. Pheromone compositions and methods of use thereof are also described.