142 results about "Carbene" patented technology

The invention relates to a synthesis method of a diunsaturated ester compound catalyzed by N-heterocyclic carbene, and belongs to the field of organic synthesis. According to the preparation method, the synergistic effect of N-heterocyclic carbene and light is utilized, gamma-oxo unsaturated aldehyde and Katritzky salt are taken as starting raw materials, the Katritzky salt generates alpha-ester free radicals through a single electron transfer process under the illumination condition, the free radicals react with a nucleophilic trienol intermediate generated through catalysis of the N-heterocyclic carbene, and the alpha-ester free radicals react with the nucleophilic trienol intermediate to generate the gamma-oxo unsaturated aldehyde. Target products are obtained with good yield and high regioselectivity, so that a series of epsilon-alkylated diunsaturated ester compounds are efficiently synthesized. The method is simple and convenient to operate, green and efficient, has the advantages of no transition metal participation, wide substrate applicability and the like, provides a new way for synthesis of the diunsaturated ester compound, and has a wide application prospect.

The present application relates to a kind of ionic nitrogen heterocyclic carbene covalent organic framework and its preparation method and application, the ionic nitrogen heterocyclic carbene covalent organic framework with amine monomer, aldehyde monomer and vinyl ionic liquid as raw material, by one-pot method, it is prepared by povalorov reaction.The ionic nitrogen heterocyclic carbene covalent organic framework prepared in the present application can be used for the deuterium reaction of a variety of aromatic aldehyde, heterocyclic aldehyde and multi-site substituted aldehyde substrate as catalyst, with high catalytic activity and recyclable performance.

Tetradentate platinum complexes including an imidazole / benzimidazole carbene having a structure of Formula Iis disclosed. In Formula I, M is Pd or Pt. These platinum carbenes with the specific substituents disclosed herein are novel and provides phosphorescent emissive compounds that exhibit physical properties that can be tuned, such as sublimation temperature, emission color, and device stability.

This invention discloses a magnetically supported thioether-chelated nitrogen heterocyclic carbene palladium complex MNPs-NHC-Pd, its preparation method, and its applications. Using an amino alcohol as a starting material, an imidazole derivative containing a hydroxyl group on the N-substituent is obtained through a condensation and ring-closing reaction. This derivative is then subjected to substitution reactions with thionyl chloride and cyclohexanethiol sequentially to obtain an imidazole derivative containing a thioether on the N-substituent. This derivative is then reacted with 1,3-dibromopropane to obtain an N-bromopropyl-N'-cyclohexane thioether-substituted imidazole bromium salt. This salt is then reacted with Pd(OAc)₂ or PdCl₂ via a direct metallization reaction to obtain the N-bromopropyl-substituted thioether-chelated nitrogen heterocyclic carbene palladium complex NHC-Pd. The NHC-Pd complex is then reacted with amino-functionalized magnetic nanoparticles (MNPs-NH₂) to prepare the magnetically supported thioether-chelated nitrogen heterocyclic carbene palladium complex MNPs-NHC-Pd. It not only possesses the activity of homogeneous nitrogen heterocyclic carbene palladium catalysts, but also has a simple synthesis method, high yield, and is easy to separate and reuse in catalytic C-C bonding reactions, showing good application prospects in the field of catalysis.

Provided herein are methods composition for treating lung cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an imidazolate gold compound according to Formula I, or a pharmaceutically acceptable salt, racemate, or enantiomer thereof, wherein Formula I is a gold complex having a structure Au(L)(L′)n, wherein: n is an integer from 1 to 3; L is an imidazolyl-based N-heterocyclic carbene (NHC) ligand; and each L′ is independently selected from an imidazolyl-based NHC ligand, a triaryl phosphine, or a halide.

A method for selectively depositing material on a dielectric surface relative to a metal surface is disclosed. The metal surface is protected with a self-assembled monolayer comprising N-heterocyclic carbides before depositing a liner or barrier layer on an adjacent dielectric surface.

The present invention relates to a composition comprising at least one amine selected from the group consisting of N,N,N',N'-tetramethylethylenediamine, N,N,N',N'- tetramethylpropylenediamine, 1,8-diazabicyclo[5.4.0]undec-7-ene, N,N- dimethylethylenediamine, 4-methylmorpholine, dimethyl-(2-azidoethyl)amine and mixtures thereof; at least one organic solvent selected from the group consisting of acetonitrile, dimethyl isosorbide, acetone, dimethylsulfoxide, and mixtures thereof; and at least one carboxylic, nitrate, or sulfate salt of a transition metal; wherein the transition metal is completely dissolved in the composition. The invention also relates to hypergolic compositions and uses thereof.

The invention provides a production method and system of tetracyclododecene. The production method comprises the following steps: feeding a norbornene solution of dicyclopentadiene and gasified norbornene into a spray reactor, and reacting in the spray reactor to obtain a reaction product; the molar ratio of the norbornene to the dicyclopentadiene is (5-9): 1; buffering and depressurizing the reaction product to obtain reaction product liquid; and rectifying the reaction product liquid to respectively obtain norbornene and tetracyclododecene. The invention also provides a production system of tetracyclododecene. According to the production method, the spray reactor is used for reaction, so that the rate of converting the DCPD into the TCD can be remarkably improved, and the conversion rate of the DCPD and the selectivity of the TCD are improved.

This invention provides a neutral-electron-reversed carbene, its preparation method, and its applications, belonging to the fields of organic chemistry and organic catalysis. The neutral-electron-reversed carbene described in this invention has the structure shown in formula (I). This invention synthesizes the neutral-electron-reversed carbene in one step by reacting a diazo compound as a precursor with a rhodium complex, followed by nitrogen removal and COD (1,5-cyclooctadiene) removal processes. The reaction conditions of this invention are simple, and the yield is good. Stable separation of neutral-electron-reversed carbene is achieved for the first time.

The invention relates to organic electroluminescent materials and devices. The present disclosure provides carbene emitters of formula (I) wherein the ligand LigA has one or more electron withdrawing substituents; an organic light emitting device (OLED) comprising an anode, a cathode, and an organic layer disposed between the anode and the cathode, the organic layer comprising a compound of formula (I); and a consumer product comprising an OLED comprising a compound of formula (I): Formula (I).

The present invention provides a (6Z)-6-tridecenyl metal compound (1) wherein M1 represents Li or MgZ1, and Z1 represents a halogen atom or a (6Z)-6-tridecenyl group; also provided is a method for preparing a compound (1) comprising the steps of: preparing a (3Z)-3-decenyl metal compound (3) from a 1-halo-(3Z)-3-decenyl compound (2), where X1 represents a halogen atom, where M2 represents Li or MgZ2, and Z2 represents a halogen atom or a (3Z)-3-decenyl group; a coupling reaction of the compound (3) with a 1, 3-dihalopropane compound (4), where X2 and X3 independently of each other represent a halogen atom, to form a 1-halo-(6Z)-6-tridecene compound (5), where X4 represents a halogen atom; and preparing a (6Z)-6-tridecenyl metal compound (1) from the compound (5).

The application discloses a 2-aryl-3-trifluoroethyl indole compound with a structure as shown in formula A and a preparation method and application thereof. 3 The target object A is obtained through the reaction of the aromatic aldehyde, the azacyclic carbene (NHC) and the o-amino styrene, 3,3-dimethyl-1-(trifluoromethyl)-1,3-dihydro-1 lambda The 2-aryl-3-trifluoroethyl indole compound disclosed by the application has excellent antibacterial activity, is a novel material with a novel structure, raw materials are easy to obtain, reaction conditions are mild, green and environment-friendly, and operation is simple.

The invention discloses a high-efficiency catalyst composition for preparing optical-grade PC (polycarbonate), the catalyst composition comprises a non-metal catalyst and a rare earth oxide, and the mass ratio of the non-metal catalyst to the rare earth oxide is 1: (0.1-1); the non-metal catalyst is prepared from at least one of N-heterocyclic carbene borate, 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene, N, N '-di-tert-butyltetramethylguanidine or 1, 3-di (2, 6-diisopropyl phenyl) imidazole-2-subunit, and the non-metal catalyst is prepared from at least one of N-heterocyclic carbene borate, 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene, N, N'-di-tert-butyltetramethylguanidine and 1, 3-di (2, 6 In the efficient catalyst for preparing the optical grade PC, the nonmetal catalyst has a high steric hindrance effect and can inhibit Fries side reaction, meanwhile, the rare earth oxide is introduced to serve as a cocatalyst, carbonyl is activated through Lewis acid, and the catalytic activity and catalytic efficiency are greatly improved.

The invention relates to the technical field of daily chemical products, and particularly discloses selenium disulfide dispersion slurry, a preparation method thereof and application of the selenium disulfide dispersion slurry in anti-dandruff shampoo. The invention discloses selenium disulfide dispersion slurry, which is prepared from the following ingredients in percentage by weight: 15 to 45 percent of selenium disulfide, 0.1 to 10 percent of PVP (Polyvinyl Pyrrolidone) / hexadecene copolymers, 0.05 to 5 percent of carbomer, 0.05 to 2 percent of emulsifying agents, 1 to 70 percent of wetting agents, 0.01 to 0.1 percent of preservatives, 0.01 to 2 percent of neutralizing agents and the balance of water. The pH (Potential of Hydrogen) of the selenium disulfide dispersion slurry is 5.5 to 6.5. According to the technical scheme, sufficient dispersion of selenium disulfide particles and precise fixation of a rigid gel network can be achieved, the technical bottleneck that high-concentration and high-density selenium disulfide particles are difficult to suspend stably for a long time is broken through, and a stable system which is extremely low in sedimentation rate and can be reversibly recovered by shaking is prepared.

The present invention relates to a process for the preparation of (4Z)-11,11-dialkoxy-4-undecenyl triaryl phosphonium halides of general formula (3-Z), wherein Y represents a halogen atom, Ar represents independently of each other an aryl group, R 1 and R 2 represent independently of each other a monovalent hydrocarbon group having 1 to 15 carbon atoms, or R 1 and R 2 may together form a divalent hydrocarbon group R 1 -R 2 having 2 to 10 carbon atoms, which process comprises: subjecting a (7Z)-11-halo-1,1-dialkoxy-7-undecene compound of general formula (1-Z), wherein X 1 represents a halogen atom, R 1 and R 2 are as defined above, to a phosphonium salt forming reaction with a phosphine compound of general formula (2), wherein Ar is as defined above, to form said compound (3-Z); and also relates to a compound of general formula (A) L(CH2)3CH=CH(CH2)5CH(OR 1 )(OR 2 )(A), wherein R 1 and R 2 are as defined above.

The invention relates to a novel N-heterocyclic carbene catalyst and a synthesis process thereof, and belongs to the field of organic synthesis. The invention provides a novel N-heterocyclic carbene catalyst, the structural formula of which is as shown in formula I. A synthesis process of the novel N-heterocyclic carbene catalyst comprises the following steps: taking (S)-5-(hydroxymethyl) pyrrolidine-2-ketone as a raw material, and sequentially preparing (S)-5-(bromomethyl) pyrrolidine-2-ketone, (S)-5-((9H-carbazole-9-yl) methyl) pyrrolidine-2-ketone and an N-heterocyclic carbene catalyst with a carbazole structure. According to the invention, bromomethyl is introduced to a pyrrolidine-2-ketone structure, and the pyrrolidine-2-ketone structure reacts with carbazole compounds, so that a series of N-heterocyclic carbene catalysts with carbazole structures are synthesized. Besides, by introducing carbazole and other electron-rich structures, the catalyst can be used in an asymmetric reaction, the catalytic efficiency of the reaction is improved, and the catalyst has a good application prospect.

Disclosed is a process for preparing asymmetrically substituted bicyclic compound of formula (III) or (IV) from a compound of formula (I) by pairing a compound of formula (II) with a carbene ligated transition-metal catalyst or a precursor in the presence of a hydride source, wherein the structure of the compound of formula (II) is used as one of the key factors that can alter the selectivity of (III) and (IV) under a given condition.

The invention provides indole C3-O functionalized derivatives as well as a preparation method and insecticidal and antibacterial application thereof, and relates to the technical field of pesticide development. The indole C3-O functionalized derivative provided by the invention has a structure of a general formula (1), is prepared through a free radical cyclization reaction catalyzed by N-heterocyclic carbene (NHC), does not need a transition metal catalyst, and efficiently constructs a C3-site oxygen functional group by taking o-nitroalkyne or cis-o-nitrostyrene and aldehyde as raw materials through multi-step series conversion in an inert atmosphere. The method has the advantages of being high in atom economy, good in functional group compatibility, easy and convenient to operate, environmentally friendly and the like. The obtained derivative shows remarkable activity in prevention and treatment of various agricultural diseases and insect pests such as rice sheath blight disease, aflatoxin and brown planthopper, can be prepared into various pesticide preparations, has the characteristics of broad spectrum, high efficiency and low toxicity, and is suitable for development of green pesticides.

This application relates to the field of display technology, specifically to an ink, a composite material, a light-emitting device, a method for preparing the same, and a light-emitting apparatus. It addresses the problem that solution-based light-emitting devices in related technologies are only suitable for inverted light-emitting devices, and that these devices suffer from poor stability and performance. An ink comprises: transition metal oxide nanoparticles, an N-heterocyclic carbene precursor, and a solvent; the N-heterocyclic carbene precursor comprises one or more compounds represented by the following structural formulas (i), (ii), and (iii): in formulas (i), (ii), and (iii), R1 and R2 are each independently selected from hydrogen, deuterium, unsubstituted or substituted C1-C... 20 Alkyl, unsubstituted or substituted C6-C 20 aryl and unsubstituted or substituted C1-C 20 Any of the heteroaryl groups, wherein the heteroaryl group includes at least one heteroatom selected from at least one of N, P, O, and S, and the substituent is selected from halogen, cyano, C1-C20 alkyl, C1-C20 alkoxy, and C1-C20 alkylthio.

The present invention relates to cationic molybdenum and tungsten complexes containing heterocyclic nitrogen carbene (NHC) and preferably halogen-containing aryloxy ligands. Such catalysts are active in olefin metathesis reactions and can provide E-selectivity.

Disclosed herein is a compound according to Formula Ia:. Also disclosed herein are pharmaceutical compositions comprising the above compounds, uses of the above compounds, a method of treating one or both of bacterial and fungal infections comprising the step of administering a pharmaceutically effective amount of the above compounds or the above pharmaceutical compositions, and an antibacterial and / or antifungal detergent composition comprising the above compound and a surfactant.

This invention discloses a method for the selective synthesis of 4-amino-N-(hetero)arylsulfonamide compounds. Using bipyridine as a ligand and nickel as a catalyst, and inexpensive and readily available low-activity (hetero)aryl chlorides and 4-aminobenzenesulfonamides as substrates, 1,8-diazabicycloundec-7-ene and other organic bases are used, along with sodium iodide and other additives. The synthesis of various 4-amino-N-(hetero)arylsulfonamide compounds is achieved through a photo-driven nickel-catalyzed selective C-N coupling reaction of (hetero)aryl chlorides and 4-aminobenzenesulfonamides under an argon atmosphere. This invention features a simple reaction system, convenient operation, mild reaction conditions, and simple post-processing. It exhibits good selectivity for target compounds and high yields, avoiding the problems of complex catalytic systems and poor functional group compatibility caused by the use of traditional expensive metal catalysts and inorganic bases. Therefore, it has significant application value and market prospects.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of terminal alkyne. The method comprises the following steps: mixing a 2-methylpyridine compound as shown in a formula 1 and N, N-dimethylformamide as shown in a formula 2 with an organic solvent (cyclopentyl methyl ether or tetrahydrofuran) in the presence of lithium bis (trimethylsilyl) amide, cesium fluoride, perfluorobutyl sulfonyl fluoride and 1, 8-diazabicyclo [5.4. 0] undec-7-ene, and reacting to synthesize the terminal alkyne as shown in a formula 3. The raw materials adopted by the invention are common chemicals in the market. The method is wide in application range, common terminal alkyne compounds can be synthesized, reaction substrates can be adjusted according to needs, and a series of terminal alkyne derivatives can be synthesized. Certain support is provided for research in the fields of medicine, material science and the like. The invention provides biological activity of an iso-terminal alkyne compound on oomycetes plant pathogens and a determination method of the iso-terminal alkyne compound.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for catalytically synthesizing N-substituted-3-methyl indole compounds by using aza carbene oxazoline ring palladium compound. The application aims to provide a new synthesis method for N-substituted-3-methyl indole compounds, specifically, a high-catalytic-activity aza carbene oxazoline ring palladium compound is used as a catalyst to catalyze a direct coupling cyclization reaction of o-dichlorobenzene or o-bromochlorobenzene compounds and allyl arylamine, so as to obtain N-substituted-3-methyl indole compounds. The catalyst used in the application has high catalytic activity, the reaction has good product and functional group compatibility, in addition, the catalyst itself is easy to synthesize, and aryl chlorides used in the synthesis route are cheap and easy to obtain. Therefore, the synthesis route provided in the application has great competitive advantages and industrial production utilization value.

The invention belongs to the technical field of medicinal chemistry, and discloses a synthesis method of a flutomil compound, which comprises the following steps: (1) taking 4-fluoromethylbenzylamine and dihydroxy acetone as raw materials, and reacting with potassium thiocyanate in an acidic acetonitrile solution to synthesize an intermediate A; (2) carrying out oxidative desulfurization on the intermediate A and 2-6eq of peroxidant sodium nitrite in an acidic solvent to prepare an intermediate B; (3) further oxidizing the intermediate B into an intermediate C; and (4) reacting the intermediate C in the reaction mixed solution with n-heterocyclic carbene under a DBU alkaline condition to generate an active intermediate, and then degrading the active intermediate into the flutomi ester compound. The synthesis route is high in atom utilization rate, simple in post-treatment, free of high temperature and high heat in the reaction process, less in reaction waste liquid and low in environmental protection pressure, and compared with original literature patents, the reaction steps are few, reagents are cheap, and the process route is easy to implement, economical and efficient.

A metal carbene complex for organic light emitting diodes (OLEDs) includes a ligand L having Formula (I). The metal carbene complex can be used in organic emitting diodes.

The application discloses a carbene currency metal complex and preparation and application thereof, and belongs to the technical field of electroluminescent materials.The complex structure features of the application are that a monovalent currency metal is taken as a core, and a cyclic alkyl amino carbene ligand and a carbazole ligand with a five-membered ring side wing group are connected respectively.The carbene ligand with the five-membered ring side wing group in the complex has the characteristics of simple and efficient synthesis and cheap and easily available raw materials, and can solve the current design problem of the carbene ligand.In addition, the carbene currency metal complex has the characteristics of thermal activation delayed fluorescence, and has the advantages of high photo-induced quantum yield, short exciton lifetime and high efficient device performance, and provides a new scheme for constructing an organic electroluminescent device with high efficiency and low cost.

The application belongs to the technical field of hydrogen sulfide and peroxynitrite ion detection, and specifically discloses a near-infrared fluorescent probe DCI-TSO based on an ICT mechanism, a preparation method and application, and comprises the following steps: S1, synthesizing compound 1; S2, synthesizing compound 2; S3, synthesizing compound 3: dissolving compound 1 obtained in S1 and compound 2 obtained in S2, and adding dropwise 1,8-diazabicyclo[5.4.0]-7-undecene reaction; S4, synthesizing compound 4; S5, synthesizing probe DCI-TSO: dissolving compound 3 obtained in S3 and compound 4 obtained in S4, and adding dropwise sodium methoxide under stirring reaction at room temperature in a protective atmosphere. The application adopts the above-mentioned near-infrared fluorescent probe DCI-TSO based on an ICT mechanism, a preparation method and application, and can detect H2S and ONOO ‑ with good optical properties and biocompatibility, and has great commercial value.

This invention discloses a method for side-stream extraction of refined tetracyclododecene, comprising: using dicyclopentadiene, ethylene, and norbornene as raw materials, and toluene as solvent, conducting a Diels-Alder reaction in a batch reactor to obtain crude tetracyclododecene product; removing ethylene, norbornene, and toluene from the crude product by atmospheric distillation, and then sending it to a vacuum distillation column; in the vacuum distillation column, dicyclopentadiene and tetracyclododecene products are obtained at the top of the column, high-purity tetracyclododecene product is obtained by side-stream extraction, and heavy components are removed from the bottom of the column.