323 results about "Carbene" patented technology

The invention relates to a nitrogen-containing heterocyclic compound as well as a preparation method and application thereof, belongs to the technical field of heterocyclic compound synthesis, and solves the problems of low reaction efficiency and high energy consumption caused by the fact that an existing method for synthesizing an indole maleimide derivative needs to be carried out step by step. The preparation method comprises the following steps: step 1, adding indoleacetamide and a nucleophilic reagent into a mixed solution, and reacting; 2, performing post-treatment to obtain a nitrogen-containing heterocyclic compound; the mixed solution comprises alkali, an additive and an organic solvent; the alkali comprises one of triethylamine (Et3N), N, N-diisopropylethylamine, pyridine and 1, 8-diazabicyclo [5.4. 0] undec-7-ene, and the alkali comprises one of 1, 8-diazabicyclo [5.4. 0] undec-7-ene.

The invention relates to a synthesis method of a diunsaturated ester compound catalyzed by N-heterocyclic carbene, and belongs to the field of organic synthesis. According to the preparation method, the synergistic effect of N-heterocyclic carbene and light is utilized, gamma-oxo unsaturated aldehyde and Katritzky salt are taken as starting raw materials, the Katritzky salt generates alpha-ester free radicals through a single electron transfer process under the illumination condition, the free radicals react with a nucleophilic trienol intermediate generated through catalysis of the N-heterocyclic carbene, and the alpha-ester free radicals react with the nucleophilic trienol intermediate to generate the gamma-oxo unsaturated aldehyde. Target products are obtained with good yield and high regioselectivity, so that a series of epsilon-alkylated diunsaturated ester compounds are efficiently synthesized. The method is simple and convenient to operate, green and efficient, has the advantages of no transition metal participation, wide substrate applicability and the like, provides a new way for synthesis of the diunsaturated ester compound, and has a wide application prospect.

The invention discloses a tetracyclododecene preparation method, which comprises: mixing an N-methyl pyrrolidone (NMP) solvent, norbornene and toluene, heating to a reaction temperature in a reaction kettle, dropwise adding cyclopentadiene, and carrying out a Diels-Alder reaction in the reaction kettle to prepare tetracyclododecene, the high-purity tetracyclododecene with the mass content of 99% or above can be obtained through subsequent rectification. According to the process, cyclopentadiene is dropwise added, so that the reaction time is shortened, side reactions are reduced, the reaction is carried out in a liquid phase by taking NMP (N-Methyl Pyrrolidone) with a higher boiling point as a solvent, the reaction temperature can be reduced, the reaction process can be carried out at normal pressure, the production safety is improved, and the production operation cost is reduced.

The invention discloses a synthesis method of 3 ', 4', 5 '-trifluoro-o-aminobiphenyl, and belongs to the technical field of synthesis of pesticide bactericides, aryl o-amino halide and 3', 4 ', 5'-trifluorophenylboronic acid are used as raw materials, imidazole type N-heterocyclic carbene is used as a ligand, Suzuki coupling reaction is performed in a solvent under the protection atmosphere and the catalytic action of PdCl2 through a one-pot method, and the 3 ', 4', 5 '-trifluoro-o-aminobiphenyl is obtained. According to the method, aryl o-amino halide and 3 ', 4', 5 '-trifluorophenylboronic acid are coupled to obtain 3', 4 ', 5'-trifluoro-o-aminobiphenyl, and 3 ', 4', 5 '-trifluoro-o-aminobiphenyl is obtained. The method provided by the invention has the advantages of low catalyst dosage, low cost and cheap and easily available raw materials, successfully solves the problem of industrial synthesis of 3 ', 4', 5 '-trifluoro-o-aminobiphenyl, and has the advantages of simplicity in operation and easiness in large-scale production.

The present invention discloses a photocatalyst for the regeneration of coenzyme NADH and a preparation method thereof, wherein the photocatalyst is a donor-π-acceptor type conjugated organic polymer, with a triazine-based ligand as an acceptor unit and a heterocyclic ligand as a donor unit, wherein the molar ratio of the triazine-based ligand to the heterocyclic ligand is 1:(1-2), the triazine-based ligand raw material selects 2,4,6-trimethyl-1,3,5-triazine, and the heterocyclic ligand raw material selects a heterocyclic diformaldehyde containing a furan or thiophene structure. The photocatalyst is prepared by a solvothermal method through a Knoevenagel aldol condensation reaction, the reaction solvent selects a mixed solvent of n-butanol and o-dichlorobenzene or a mixed solvent of mesitylene and 1,4-dioxane, and the catalyst used in the reaction selects at least one of trifluoroacetic acid, potassium hydroxide, 1,8-diazabicycloundecane-7-ene, sodium hydroxide, and cesium carbonate. The developed photocatalyst has a donor-π-acceptor type conjugated structure, and has high catalytic activity, high selectivity, good stability, and easy separation and recovery for the regeneration of coenzyme NADH.

Methods of selectively depositing a passivation layer on a metal surface of a semiconductor substrate are described. Exemplary methods may include exposing the semiconductor substrate having a metal surface and a non-metal surface to a first precursor to form a first portion of the passivation layer on the metal surface, the first precursor including an isonitrile. The exemplary methods may further include exposing the semiconductor substrate comprising a metal surface and a non-metal surface to a second precursor to form the passivation layer on the metal surface. The second precursor may include an amine, an alcohol, or a thiol.

The present invention provides a material comprising (i) a crown ether of formula (I), (ii) a crown ether of formula (II), and / or (iii) a crown ether of formula (III), or a salt thereof, wherein each m is independently an integer from 1 to 8, p is an integer from 1 to 1000, each "(F)" represents an optional bond and / or structure, each X is an optional substituent, and each * independently represent -H, =O, or a bond to the remainder of the substance, provided that at least one * is the bond to the remainder of the material, and the remainder of the material is attached via an sp3-sp3 carbon-carbon bond, methods of making the material, and methods of using the material are provided. [Formula 1] JPEG2025535965000092.jpg69149

The present invention relates to cationic molybdenum and tungsten complexes containing a heterocyclic nitrogen carbene (NHC) and preferably a halogen-containing aryloxy ligand. The catalysts are active in olefin metathesis reactions and provide for E-selectivity.

The present application relates to a kind of ionic nitrogen heterocyclic carbene covalent organic framework and its preparation method and application, the ionic nitrogen heterocyclic carbene covalent organic framework with amine monomer, aldehyde monomer and vinyl ionic liquid as raw material, by one-pot method, it is prepared by povalorov reaction.The ionic nitrogen heterocyclic carbene covalent organic framework prepared in the present application can be used for the deuterium reaction of a variety of aromatic aldehyde, heterocyclic aldehyde and multi-site substituted aldehyde substrate as catalyst, with high catalytic activity and recyclable performance.

To provide means to produce glycolaldehyde dialkyl acetal in high yield.SOLUTION: A production method includes a glycolaldehyde formation step of converting paraformaldehyde to glycolaldehyde in an ether type solvent in the presence of an N-heterocyclic carbene catalyst, and an acetalization step of treating the glycolaldehyde with an alcohol solution of hydrogen chloride to obtain glycolaldehyde dialkyl acetal. The glycolaldehyde formation step and the acetalization step are performed in a single container.SELECTED DRAWING: None

The invention relates to the technical field of organic synthetic chemistry, and discloses a preparation method of alkenyl gem-diborate. According to the preparation method of the alkenyl gem-diborate, a cobalt catalyst serves as a core, a high-activity cobalt complex is formed under the combined action of a specific ionic N-heterocyclic carbene ligand and alkali, the complex can be reduced into a catalytic activity intermediate by a boron test, regeneration of the cobalt catalyst is achieved, and the next round of reaction continues to be catalyzed. The adopted cobalt catalyst is rich in reserves, low in price, easy to obtain and environment-friendly; reaction conditions are mild, and high efficiency and high selectivity are achieved; the reaction substrate functional group tolerance is high, the substrate source is wide, the method is suitable for aromatic alkyne, and aliphatic alkyne and alkyne with large steric hindrance can also be adopted; the reaction can be amplified to a gram scale for preparation; the yield, the selectivity and the purity of the product are improved; the invention provides a new synthesis route and method for alkenyl gem-diborates, and can provide alkenyl gem-diborates with various structures for synthesis of polysubstituted olefins, natural products or pharmaceutical molecules.

Tetradentate platinum complexes including an imidazole / benzimidazole carbene having a structure of Formula Iis disclosed. In Formula I, M is Pd or Pt. These platinum carbenes with the specific substituents disclosed herein are novel and provides phosphorescent emissive compounds that exhibit physical properties that can be tuned, such as sublimation temperature, emission color, and device stability.

This invention discloses a magnetically supported thioether-chelated nitrogen heterocyclic carbene palladium complex MNPs-NHC-Pd, its preparation method, and its applications. Using an amino alcohol as a starting material, an imidazole derivative containing a hydroxyl group on the N-substituent is obtained through a condensation and ring-closing reaction. This derivative is then subjected to substitution reactions with thionyl chloride and cyclohexanethiol sequentially to obtain an imidazole derivative containing a thioether on the N-substituent. This derivative is then reacted with 1,3-dibromopropane to obtain an N-bromopropyl-N'-cyclohexane thioether-substituted imidazole bromium salt. This salt is then reacted with Pd(OAc)₂ or PdCl₂ via a direct metallization reaction to obtain the N-bromopropyl-substituted thioether-chelated nitrogen heterocyclic carbene palladium complex NHC-Pd. The NHC-Pd complex is then reacted with amino-functionalized magnetic nanoparticles (MNPs-NH₂) to prepare the magnetically supported thioether-chelated nitrogen heterocyclic carbene palladium complex MNPs-NHC-Pd. It not only possesses the activity of homogeneous nitrogen heterocyclic carbene palladium catalysts, but also has a simple synthesis method, high yield, and is easy to separate and reuse in catalytic C-C bonding reactions, showing good application prospects in the field of catalysis.

The invention discloses a method for efficiently preparing benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures by catalyzing aromatic benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide and NHC catalytic oxidation cross dehydrogenation coupling of amine, alcohol, phenol, thiol and thiophenol through carbene, and is characterized in that benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide, a nucleophilic reagent, a carbene catalyst and alkali are used as raw materials for preparing the benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures. The preparation method comprises the following steps: putting benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide as a raw material, an oxidant and a solvent in an air atmosphere, reacting at room temperature or under a heating condition, removing the solvent in vacuum to obtain a coarse material, and performing silica gel column chromatography purification on the coarse material to obtain the target compound benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivative. The reaction is carried out under extremely mild conditions, the substrate range is wide, and the tolerance of functional groups is good. In addition, the biological activity research of the target compound shows that the compound has the potential of being developed into an effective antifungal agent for crop protection. The compound can be used as a potential candidate drug for inhibiting phytopathogen fungi, and has good research and development value.

Provided is a catalyst composition containing: an N-heterocyclic carbene ligand-containing ruthenium carbene complex (A) represented by general formula (1) or general formula (2); and a ruthenium-containing compound (B) other than the N-heterocyclic carbene ligand-containing ruthenium carbene complex (A). The content ratio of the N-heterocyclic carbene ligand-containing ruthenium carbene complex (A) and the ruthenium-containing compound (B) is such that, in terms of mass ratio, N-heterocyclic carbene ligand-containing ruthenium carbene complex (A) : ruthenium-containing compound (B) is 50:50 to 90:10.

Provided herein are methods composition for treating lung cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an imidazolate gold compound according to Formula I, or a pharmaceutically acceptable salt, racemate, or enantiomer thereof, wherein Formula I is a gold complex having a structure Au(L)(L′)n, wherein: n is an integer from 1 to 3; L is an imidazolyl-based N-heterocyclic carbene (NHC) ligand; and each L′ is independently selected from an imidazolyl-based NHC ligand, a triaryl phosphine, or a halide.

A method for selectively depositing material on a dielectric surface relative to a metal surface is disclosed. The metal surface is protected with a self-assembled monolayer comprising N-heterocyclic carbides before depositing a liner or barrier layer on an adjacent dielectric surface.

The present invention relates to a composition comprising at least one amine selected from the group consisting of N,N,N',N'-tetramethylethylenediamine, N,N,N',N'- tetramethylpropylenediamine, 1,8-diazabicyclo[5.4.0]undec-7-ene, N,N- dimethylethylenediamine, 4-methylmorpholine, dimethyl-(2-azidoethyl)amine and mixtures thereof; at least one organic solvent selected from the group consisting of acetonitrile, dimethyl isosorbide, acetone, dimethylsulfoxide, and mixtures thereof; and at least one carboxylic, nitrate, or sulfate salt of a transition metal; wherein the transition metal is completely dissolved in the composition. The invention also relates to hypergolic compositions and uses thereof.

The invention provides a production method and system of tetracyclododecene. The production method comprises the following steps: feeding a norbornene solution of dicyclopentadiene and gasified norbornene into a spray reactor, and reacting in the spray reactor to obtain a reaction product; the molar ratio of the norbornene to the dicyclopentadiene is (5-9): 1; buffering and depressurizing the reaction product to obtain reaction product liquid; and rectifying the reaction product liquid to respectively obtain norbornene and tetracyclododecene. The invention also provides a production system of tetracyclododecene. According to the production method, the spray reactor is used for reaction, so that the rate of converting the DCPD into the TCD can be remarkably improved, and the conversion rate of the DCPD and the selectivity of the TCD are improved.

The application discloses a kind of high-stable carbene-alkynyl probe molecule self-assembly interface and preparation method thereof, and systematically proposes the stability change of highly ordered monomolecular self-assembly interface under different experimental environments.The construction method includes: design and synthesis have with carbene-alkynyl as bonding assembly group probe molecule (CB-C≡C);Second, CB-C≡C molecule is self-assembled on gold nano surface by gold-carbene bond, gold-alkynyl bond, forms gold-carbene-alkynyl trident assembly sensing interface.And by electrode surface in situ combination ferrocene (Fc) electrochemical response group, generate gold-carbene-alkynyl-Fc molecular self-assembly interface, and systematically evaluate in different determination environments containing high concentration glutathione (5-10mMGSH), 25-50 DEG C, pH2-10 Interface high stability.The application utilizes this new CB-C≡C self-assembly molecular probe can realize high-stable determination under different determination environments for up to 90 days.

The present invention belongs to the technical field of synthesis of metal organic complexes, and specifically relates to a nitrogen heterocyclic carbene-Schiff base type C sp2 ^N sp2 Bidentate cyclic palladium complexes and their synthesis methods and applications. This type of complex is formed by in situ oxidation and chelation of benzylamine or substituted benzylamine in the presence of palladium acetate in air, and then coordinated by nitrogen heterocyclic carbene. This type of Schiff base type C sp2 ^N sp2 The bidentate ligand has a strong electron-donating ability, which increases the electron cloud density of the metal center and more effectively catalyzes the Suzuki-Miruaya coupling reaction.

This invention provides a neutral-electron-reversed carbene, its preparation method, and its applications, belonging to the fields of organic chemistry and organic catalysis. The neutral-electron-reversed carbene described in this invention has the structure shown in formula (I). This invention synthesizes the neutral-electron-reversed carbene in one step by reacting a diazo compound as a precursor with a rhodium complex, followed by nitrogen removal and COD (1,5-cyclooctadiene) removal processes. The reaction conditions of this invention are simple, and the yield is good. Stable separation of neutral-electron-reversed carbene is achieved for the first time.

The application discloses a preparation method and application of a bimodal linear polyethylene chromium carbene catalyst, and belongs to the technical field of chemical synthesis. The preparation method comprises the following steps: 1-nitro-2-aromatic sulfide benzene is prepared by taking 1-fluoro-2-nitrobenzene, aromatic mercaptan and potassium tert-butanolate as raw materials; 1-amino-2-aromatic sulfide benzene is prepared by taking 1-nitro-2-aromatic sulfide benzene and hydrazine hydrate as raw materials; 8-hydroxyimidazol[1,5-alpha] quinolinium salt is prepared by taking 1-amino-2-aromatic sulfide benzene, 8-hydroxyquinoline-2-methyl formaldehyde, formaldehyde solution and hydrogen chloride-1,4-dioxane solution as raw materials; and finally, the reaction is carried out by taking 8-hydroxyimidazol[1,5-alpha] quinolinium salt, silver trifluoromethanesulfonate, sodium bis(trimethylsilyl) amide and chromium trichloride as raw materials to obtain the bimodal linear polyethylene chromium carbene catalyst. According to the preparation method, the catalyst is effectively prevented from being poisoned, the catalytic activity of the catalyst is improved, and the catalyst has good thermal stability.

The disclosure is in the field of organic electroluminescence and particularly relates to [2,2]paracyclophane-based metal (II) complexes, electronic devices, apparatus, and use thereof. The disclosure provides a metal platinum (II) complexes introducing a planar-chiral [2,2]paracyclophane on an azacyclic carbene, which enhances the photochemical stability of the tetradentate platinum (II) complex and prevents undesirable host and guest interactions, helping to extend device lifetime and achieve higher color purity. The materials according to the disclosure all have good chemical stability and thermal stability, and are easy to prepare an evaporation-type OLED device. The organic electroluminescent device fabricated using the compound of the disclosure as a light-emitting layer shows a significant improvement in current efficiency and lifetime and a significant reduction in light-emitting voltage. In particular, the combination with the fluorescent doping material balances hole and electron transport, allowing for more efficient energy transfer between host and guest.

The present invention relates to a nitrogen-containing heterocyclic compound, its preparation method, and application, belonging to the technical field of heterocyclic compound synthesis. This method solves the problem that existing methods for synthesizing indolemaleimide derivatives require a step-by-step process, resulting in low reaction efficiency and high energy consumption. The preparation method comprises the following steps: Step 1: adding indoleacetamide and a nucleophilic reagent to a mixed solution for reaction; Step 2: post-processing to obtain a nitrogen-containing heterocyclic compound; the mixed solution comprises a base, an additive, and an organic solvent; the base comprises one of triethylamine (Et3N), N,N-diisopropylethylamine, pyridine, and 1,8-diazabicyclo[5.4.0]undec-7-ene.

The invention relates to organic electroluminescent materials and devices. The present disclosure provides carbene emitters of formula (I) wherein the ligand LigA has one or more electron withdrawing substituents; an organic light emitting device (OLED) comprising an anode, a cathode, and an organic layer disposed between the anode and the cathode, the organic layer comprising a compound of formula (I); and a consumer product comprising an OLED comprising a compound of formula (I): Formula (I).

In one embodiment is provided an energy-efficient post-combustion CO2 capturing process utilizing protic ionic liquids made of an organic superbase and a weak acid in the presence of moisture. The concept is demonstrated in one embodiment with the ionic liquid, 1,8-diazabiclclo(5.4.0)undec-7-enium imidazolate, [DBUH][Im].

The present invention provides a (6Z)-6-tridecenyl metal compound (1) wherein M1 represents Li or MgZ1, and Z1 represents a halogen atom or a (6Z)-6-tridecenyl group; also provided is a method for preparing a compound (1) comprising the steps of: preparing a (3Z)-3-decenyl metal compound (3) from a 1-halo-(3Z)-3-decenyl compound (2), where X1 represents a halogen atom, where M2 represents Li or MgZ2, and Z2 represents a halogen atom or a (3Z)-3-decenyl group; a coupling reaction of the compound (3) with a 1, 3-dihalopropane compound (4), where X2 and X3 independently of each other represent a halogen atom, to form a 1-halo-(6Z)-6-tridecene compound (5), where X4 represents a halogen atom; and preparing a (6Z)-6-tridecenyl metal compound (1) from the compound (5).

The application discloses a 2-aryl-3-trifluoroethyl indole compound with a structure as shown in formula A and a preparation method and application thereof. 3 The target object A is obtained through the reaction of the aromatic aldehyde, the azacyclic carbene (NHC) and the o-amino styrene, 3,3-dimethyl-1-(trifluoromethyl)-1,3-dihydro-1 lambda The 2-aryl-3-trifluoroethyl indole compound disclosed by the application has excellent antibacterial activity, is a novel material with a novel structure, raw materials are easy to obtain, reaction conditions are mild, green and environment-friendly, and operation is simple.

The invention discloses a high-efficiency catalyst composition for preparing optical-grade PC (polycarbonate), the catalyst composition comprises a non-metal catalyst and a rare earth oxide, and the mass ratio of the non-metal catalyst to the rare earth oxide is 1: (0.1-1); the non-metal catalyst is prepared from at least one of N-heterocyclic carbene borate, 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene, N, N '-di-tert-butyltetramethylguanidine or 1, 3-di (2, 6-diisopropyl phenyl) imidazole-2-subunit, and the non-metal catalyst is prepared from at least one of N-heterocyclic carbene borate, 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene, N, N'-di-tert-butyltetramethylguanidine and 1, 3-di (2, 6 In the efficient catalyst for preparing the optical grade PC, the nonmetal catalyst has a high steric hindrance effect and can inhibit Fries side reaction, meanwhile, the rare earth oxide is introduced to serve as a cocatalyst, carbonyl is activated through Lewis acid, and the catalytic activity and catalytic efficiency are greatly improved.