159 results about "Imidazolidines" patented technology

This invention provides a catalyst system useful in many coupling reactions, such as Suzuki, Kumada, Heck, and amination reactions. The catalyst system of the present invention makes use of N-heterocyclic carbenes or their protonated salts. The composition of the catalyst system comprises at least one transition metal compound and at least one N-heterocyclic carbene or its protonated salt. This invention further provides novel N-heterocyclic carbenes and their protonated salts. One type of N-heterocyclic carbene used in this invention is an imidazolinc-2-ylidene wherein the 1 and 3 positions are each, independently, substituted by an aromatic group in which each ortho position is, independently, substituted by a secondary or tertiary group which has at least three atoms.

The present invention provides a process for producing methionine which is advantageous from the viewpoints of cost and wastewater disposal, and which comprises the following steps (1) to (5): (1) a reaction step comprising hydrolysis of 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) a first crystallization step comprising introduction of carbon dioxide into the reaction solution obtained in step (1) to precipitate methionine, and separation of the resultant slurry into a precipitate and a mother liquor; (3) a second crystallization step comprising concentration of the mother liquor obtained in step (2), mixing with a lower alcohol, introduction of carbon dioxide into the mixture to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor; (4) a heating step comprising concentration of the mother liquor obtained in step (3) followed by a heating treatment at 150 to 200 DEG C; and (5) a third crystallization step comprising introduction of carbon dioxide into the heated mother liquor obtained in step (4) to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor.

The present invention provides a process for producing methionine, which comprises the steps of: hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound in a non-stirred continuous first reaction tank, and heat-treating the reaction solution after hydrolysis in a second reaction tank. According to the process of the present invention, a methionine crystal with a higher bulk density can be produced.

The invention relates to 1-(1,2-epoxypropyl)-N-nitroimidazoline-2-amine which has a structural formula as shown in the picture. A preparation method of the compound comprises the steps of adding ethylenediamine to a reaction container, dropwise adding epoxy chloropropane in the reaction container while stirring, reacting for 2-3h, cooling, and vaporizing out acetonitrile to obtain epoxypropyl ethylenediamine; taking and dissolving nitroguanidine and the epoxypropyl ethylenediamine into water, dropwise adding hydrochloric acid solution while stirring, reacting for 2-3h, cooling, extracting, desolventizing to obtain crude product, and recrystallizating to obtain the product; or adding N-nitroimidazoline, potassium carbonate and organic solvent to the reaction container, heating to 75-81.6 DEG C, dropwise adding epoxy chloropropane in the reaction container after dissolving the N-nitroimidazoline, continuously heating until completing the reaction after dropwise adding, cooling reaction products, filtering, vaporizing filtrate to dry, adding water to residues, extracting by using methylene dichloride, desolventizing to obtain phase product, and recrystallizating by using butanone to obtain the product.

The invention discloses a sterilizing and algae-removing agent and an application thereof. The sterilizing and algae-removing agent consists of the following components in parts by weight: 100 parts of dodecyl dimethyl benzyl ammonium chloride, 4-6 parts of sulfamic acid, 60-80 parts of isothiazolinone, 10-20 parts of crylic acid-acrylic ester-sulfonate terpolymer, 60-80 parts of attapulgite clay, 0.2-0.4 parts of 4,4' dichloro-2-hydroxy diphenyl oxide, 4-6 parts of dodecyl ethoxy imidazolidine, 10-18 parts of sodium dichloro isocyanurate, 10-18 parts of methane dithiocyanate and 1-2 parts of epoxiconazole. The sterilizing and algae-removing agent has the advantages of efficient sterilizing and algae-removing performance, small using amount, safety, nontoxicity and environmental friendliness. The sterilizing and algae-removing agent is applied to sterilizing treatment of a circular water system.

This invention provides a process for conducting Stille coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Stille couplings of aryl halides. A Stille coupling can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than stannyl groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one organotin compound wherein the tin atom is quaternary, wherein one group bound to the tin atom is unsaturated at the alpha or beta position, and wherein each of the remaining groups bound to the tin atom is a saturated group; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formulawherein R1 and R2 are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R3 and R4 are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group.

The invention discloses a cream for chap removal, which is composed of a water phase, an oil phase and a functional phase, wherein in parts by weigh, the water phase is composed of 45-85 parts of water, 0.1-0.5 part of allantoin and 0.05-0.2 part of diazolidinyl urea, the oil phase is composed of 0.5-1.5 parts of cetostearyl alcohol, 1-3 parts of glyceryl stearate, 0.5-1.5 parts of PEG-100 stearate, 2.5-5 parts of glycerin, 1-5 parts of polydimethylsiloxane, 2.5-5 parts of propylene glycol, 1-3 parts of isopropyl palmitate, 1-3 parts of petrolatum, 0.5-1.5 parts of polysorbate-60, 5-15 parts of mineral oil, 0.1-0.3 part of methylparaben, and 0.05-0.15 part of propyl hydroxybenzoate; and the functional phase is composed of 1-4 parts of one or more of ammonium polyacrylate, C13-16 isoparaffin, and laureths-25, 0.15-0.45 part of essence and 0.25-0.75 part of vitamin E. Experiments show that the cream both has the functions of water locking and moisturizing and has the effects of chap prevention and chap removal, therefore, the cream has a good market prospect.

Pressure-sensitive adhesive compositions that resist water-whitening are provided. The compositions comprise emulsion copolymers formed from a plurality of monomers that includes a plurality of (meth)acrylic monomers, at least one trifluoroalkyl(meth)acrylate monomer, and at least one alkylimidazolidone (meth)acrylate monomer. Preferably, the (meth)acrylic monomers comprise a plurality of soft monomers, at least one hard monomer and at least one acid monomer. The plurality of monomers may further include at least one aliphatic urethane di(meth)acrylate, an oligomer. The pressure-sensitive adhesive composition also comprises a surfactant system including at least one surfactant.

The invention discloses an amino acid cleansing cream and a preparation method thereof. The amino acid cleansing cream comprises the following components in percent by weight: 3-8 percent of glycerol, 0.05-0.2 percent of hydroxyethylcellulose, 5-13 percent of propylene glycol, 25-30 percent of sodium lauroyl glutamate, 5-8 percent of sodium cocoyl glutamate, 0.5-1.5 percent of ethal-octadeca-composite fatty alcohol, 0-2 percent of ethylene glycol distearate, 0.2-0.6 percent of cetearyl alcohol ether (20), 0.5-1.5 percent of cocoaminopropyl dimethyl betaine, 0.5-1.5 percent of cetearyl alcoholether-60 myristyl glycol, 1-3 percent of acrylate / polyoxyethylene-20 stearin alcohol ether methacrylate copolymer, 0.4-0.8 percent of citric acid, 0.1-0.2 percent of diazolidiny urea, 0.10-0.15 percent of methyl phydroxybenzoate and the balance of deionized water. the amino acid cleansing cream has better stability and solid content of sodium lauroyl glutamate of more than or equal to 25 percent,and can create a comfortable and clear microenvironment for healthy growth and metabolism for skin cells on the face.

This invention provides a process for conducting Kumada coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Kumada couplings of aryl halides. A Kumada coupling can be carried out by mixing, in a liquid medium, at least one aryl halide, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one Grignard reagent; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formulawherein R1 and R2 are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R3 and R4 are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group. Homocoupling of aryl pseudohalides is also feasible using the processes of this invention.

This invention provides a process for conducting amination reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in aminations of aryl halides and aryl pseudohalides. An amination can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than amino groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one primary amine and / or at least one secondary amine; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formulawherein R1 and R2 are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R3 and R4 are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group.

According to the present invention, a compound represented by formula (I):wherein Q is:A is a hydrogen atom, a halogen atom, —ORa or a C1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a C1-6 alkyl group; m is selected from integers from 0 to 3; R2 and R3 are independently selected from a C1-6 alkyl group; X1 and X2 are independently selected from O and S; Y is selected from an arylene group and a divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group, wherein the arylene group and the heterocyclic group may be substituted by 1 to 3 substituents independently selected from E1; E1 is independently selected from a hydroxyl group, a halogen atom, a C1-4 alkyl group, a cyano group, a C1-4 alkoky group, a carbamoyl group, a C1-4 alkylcarbamoyl group, a di(C1-4 alkyl)carbamoyl group, an amino group, a C1-4 alkylamino group, a di(C1-4 alkylamino group, a sulfamoyl group, a C1-4 alkylsulfamoyl group and a di(C1-4 alkyl)sulfamoyl group; Z is —CON(—Ra)—, —CO—, —COO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO2—, —SO2N(—Ra)—, —SO2NR1—, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR1)CO—, —N(—Ra)SO2—, —N(SO2R1)SO2—, —N(—Ra)— or —N(—Ra)SO2N(—Rb)—; R1 is independently a hydrogen atom, a hydroxyl group, a C1-6 alkyl group which may be substituted by one or more substituents, a heterocyclic group which may be substituted by one or more substituents, an aryl group which may be substituted by one or more substituents, a C3-8 cycloalkyl group which may be substituted by one or more substituents or a C3-8 cycloalkenyl group which may be substituted by one or more substituents, or a salt, prodrug or solvate thereof is provided. Furthermore, a pharmaceutical composition containing the compound, and the like are also provided.

The invention discloses a flame-retardant steel surface coating material and a preparation method thereof. The flame-retardant steel surface coating material is prepared from the following components in parts by weight: 35-48 parts of polyacrylamide, 5-9 parts of zinc oxide, 0.05-0.2 part of ammonium polyphosphate, 0.05-0.1 part of dibutyltin maleate, 0.03-0.1 part of diazolidinyl urea, 0.02-0.04 part of silane coupling agents, 0.01-0.2 part of antioxidants and 15-20 parts of 1,2-pentanediol. The invention also provides the preparation method of the flame-retardant steel surface coating material. The flame-retardant steel surface coating material prepared through the method disclosed by the invention not only has good flame-retardant property, but also has good scraping resistant property and antibacterial property. The flame-retardant steel surface coating material prepared through the method disclosed by the invention can be widely applied to the surfaces of a household appliance, an instrument, a meter, air purifying equipment and water purifying equipment.

The invention provides a synthetic method of imidacloprid, which comprises the synthetic steps of (1) sequentially adding an amine substance, 2-chlorine-5-chlorine picoline and a solvent into a reactor, conducting heating reflux for 2h, cooling, obtaining a catalyst solution, (2) sequentially adding a solvent, 2-nitryl imidogen imidazolidine and 1 / 5 alkali metal hydroxide into the catalyst solution, stirring, heating to 45 DEG C for heat preservation; (3) dropwise adding a solvent solution of 2-chlorine-5-chlorine picoline into reaction liquid for 30min each time and for four times totally after the heat preservation is over, adding 1 / 5 alkali metal hydroxide into the reaction liquid after dropwise adding the solvent solution each time, conducting heat preservation reaction for 1-2h after finishing the adding, and (4) conducting water washing for three times after the reaction is over, distilling the solvent out, crystallizing at 5 DEG C below zero, conducting suction filtration, drying, and obtaining a crude product of imidacloprid. According to the synthetic method, the reaction time is short; by-products are few; the purity of the crude product of imidacloprid reaches 98%; and a yield reaches 95.3%.

The invention relates to preservative systems which are particularly suitable in cosmetic and dermatological preparations. The preservative system which comprises a cationic surfactant, derived from the condensation of fatty acids and esterified dibasic amino acids, having the formula (I) where: X− is Br−, Cl−, or HSO4 R1: is a straight alkyl chain from an acid or saturated fatty hydroxy acid from 8 to 14 atoms of carbon bonded to the α-amino acid group through amidic bond. R2: is a straight or branched alkyl chain from 1 to 18 carbon atoms or aromatic. R3: is: (II) where n can be from 0 to 4, is combined with at least one other ionic or non-ionic preservative agent, whereby the combination displays a synergetic activity. A preservative system, wherein the cationic surfactant preservative derived from the condensation of fatty acids and esterified dibasic amino acid is LAE is particularly preferred. The other ionic or non ionic preservative agent is preferably at least one component selected from the group consisting of 2-bromo-2-nitro-1,3-propanediol (bronopol), parbens, imidazolidinyl urea, phenoxyethanol, DMDM hydantoin, 2-methyl-5-chloro-3,4-isothiazolinone / 2-methyl-3,4-isothiazolinone and quaternium-15.

A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided. The present invention relates to a process for producing methionine, comprising the following steps (1), (2), (3) and (4): (1) a reaction step of hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) a first crystallization step of introducing carbon dioxide into the reaction solution obtained in the step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) a second crystallization step of concentrating the mother liquor obtained in the step (2), mixing the resulting concentrate with a lower alcohol, introducing carbon dioxide into the resulting mixture to thereby precipitate methionine and potassium hydrogencarbonate, and separating the resulting slurry into a precipitate and a mother liquor; and (4) a heating step of concentrating the mother liquor obtained in the step (3), treating the resulting concentrate by heating at a temperature of from 150 to 200 DEG C, and recycling the treated solution for use in the step (3).

The present invention provides a process for producing methionine which is advantageous from the viewpoints of cost and wastewater disposal, and which comprises the following steps (1) to (5):(1) a reaction step comprising hydrolysis of 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound;(2) a first crystallization step comprising introduction of carbon dioxide into the reaction solution obtained in the step (1) to precipitate methionine, and separation of the resultant slurry into a precipitate and a mother liquor;(3) a second crystallization step comprising concentration of the mother liquor obtained in the step (2), mixing with a lower alcohol, introduction of carbon dioxide into the mixture to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor;(4) a heating step comprising concentration of the mother liquor obtained in the step (3) followed by a heating treatment at 150 to 200° C.; and(5) a third crystallization step comprising introduction of carbon dioxide into the heated mother liquor obtained in the step (4) to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor.

The invention provides a high-temperature-resistant desulfurizer for the oil-gas field and a preparation method of the desulfurizer. 30%-60% of a triazine compound, 5%-20% of organic phosphonic acid, 5%-20% of heterocyclic organic amine, 5%-20% of water-soluble imidazolidine and the balance of water are weighed firstly, wherein the sum of mass percentages of all the components is 100%; the triazine compound is added to water and stirred uniformly, and a mixture B is obtained; heterocyclic organic amine, water-soluble imidazolidine and organic phosphonic acid are added to the mixture B sequentially, the mixture is stirred uniformly, and the high-temperature-resistant desulfurizer for the oil-gas field is obtained. The prepared desulfurizer has high desulfurization efficiency under the high-temperature condition of 90 DEG C; the product has certain scale and corrosion inhibition and sterilization performance; the prepared desulfurizer has the pH value being 7-8, and the scaling trend of carbonate and sulfate in the highly mineralized water environment can be delayed; the whole synthesis process adopts simple conditions and is easy to operate, low in cost, non-toxic, environment-friendly and suitable for industrial production.

The invention relates to nitroimidazoline derivatives. The nitroimidazoline derivatives have a structural formula shown in a formula I, wherein R is substituted benzene, naphthalene, benzoxazole or benzimidazole. The preparation method comprises that different substituted chloromethylene compounds, N-nitroimidazoline, potassium carbonate and solvent are reacted to form the nitroimidazoline derivatives. The nitroimidazoline derivatives have the advantages that: 1) the synthetic method for the nitroimidazoline derivative compounds is simple; and 2) the nitroimidazoline derivative compounds have a structure different from that of imidacloprid and have high insecticidal activity, the structure of the compounds does not comprise pyridine rings, and the compounds have wide development prospect.

The invention provides a method of making a ruthenium or osmium carbene catalyst having an imidazolidine in the presence of an olefin with the application of energy. The resulting metal compound has two carbene ligands, one from the original carbene, the other from the imidazolidine. The imidazolidine has bulky protecting groups in the two positions adjacent to the carbene carbon. The method of making the imidazoline from the salt in the presence of a base and chloroform is also disclosed.

The invention discloses a coating and a preparation method thereof. The coating is prepared from raw materials in parts by mass as follows: 20-30 parts of waterborne resin, 10-15 parts of a polyurethane emulsion, 10-15 parts of diatomaceous earth, 8-15 parts of rare earth, 3-8 parts of polyacrylamide, 2-4 parts of imidazolidine, 0.5-1 part of hydroxymethyl cellulose, 1-3 parts of a nano-assistant, 5-10 parts of an adsorption auxiliary, 1-3 parts of a bactericide, 0.5-1 part of a film forming agent, 0.3-1 part of an antifoaming agent, 0.5-1 parts of a leveling agent, 0.2-0.5 parts of a wetting agent, 0.5-1 part of a dispersion agent, 0.4-1 part of a thickening agent, 2-4 parts of titanium dioxide and 20-30 parts of deionized water. The invention further discloses a preparation method. The coating and the preparation method have the benefits as follows: the prepared coating can prevent dust and keep clean after being applied to a wall, the inconvenience caused by dust accumulation is avoided, long-time cleanness is realized, and the toxic substances in air are purified.

Provided are imidazolidinedione compounds of formula (I), processes for preparation, uses and pharmaceutically compositions thereof. Said imidazolidinedione compounds posses androgen receptor antagonist activity and can be used for preventing and treating diseases and disorders related to androgen receptor, such as prostate cancer, alopecia, hair regeneration, acne and adolescent acne.

The invention relates to an air purifying liquid and a preparation method thereof. The air purifying liquid comprises the raw materials in parts by weight: 1 to 50 parts by weight of glycerol, 1 to 15 parts by weight of polyethylene glycol, 0.5 to 5 parts by weight of dendrimers, 0.1 to 5 parts by weight of an imidazole cation liquid, 0.5 to 10 parts by weight of imidazolizone, 0.1 to 5 parts by weight of a pH regulator, and the balance deionized water. The preparation method comprises the steps: adding glycerol and polyethylene glycol into deionized water, and stirring until the solution is uniform and transparent; adding the dendrimers in the formed uniform and transparent solution, and stirring until the solution is uniform and transparent; adding the pH regulator to adjust the solution pH to 6.5-8.5, and stirring uniformly; and adding the imidazole cation liquid component and imidazolizone, and stirring uniformly, to obtain the purifying liquid finished product. The air purifying liquid is convenient to use: the air purifying liquid is injected into a spray bottle for operating, and is simple and convenient; the air purifying liquid is safe and reliable: the air purifying liquid is safe to human bodies and has no damage to objects; and the air purifying liquid has high purification efficiency: the air purifying liquid has the purification ability on formaldehyde and TVOCs more than or equal to 90%.

The invention discloses a full-biodegradable plastic composite modified material suitable for a film bag. The full-biodegradable plastic composite modified material is mainly prepared from the following raw materials in percentage by mass: 25-30% of poly (butylene adipate-co-terephthalate); 25-30% of poly (butylene succinate); 10-15% of polylactic acid; 25-30% of calcium carbonate; and 4-6% of an auxiliary agent. The auxiliary agent is maleic anhydride, 2-imidazolidone and a copolymer of styrene and glycidyl acrylate. The composite modified material has excellent mechanical properties, high tensile strength and elongation at break, and good transparency, stiffness and printability. The invention further discloses a preparation method of the composite modified material. The method can prevent the degradable resin from being coked in the processing process, and the quality of the full-biodegradable plastic composite modified material is improved.

The present invention relates to the use of specific metal complexes of dithiolenes with aryl or heteroarylsubstituted imidazolidine-2-chalcogenone-4,5-dithione ligands as colourless IR absorbers.

The invention provides a synthetic method for semi-cucurbituril [6] with 2-imidazolidone and derivatives therefor as a unit. Semi-cucurbituril is a six-membered polymerization ring with a structure similar to half structure of unit glycoluril for synthesis of cucurbituril as a unit, namely, with 2- imidazolidone as a unit, also named after semi-cucurbituril [6], and is an organic heterocyclic compound. The synthetic method employs 2-imidazolidone, derivatives therefor, and formaldehyde as raw materials. The raw materials are subjected to heating reflux for 4-24 h in an acidic aqueous solution system at the temperature of 40- 80 DEG C, and then subjected to condensation, filtration, isolation and purification to obtain semi-cucurbituril [6]. The material molar ratio of 2-imidazolidone and derivatives therefor to formaldehyde is 1:1-1.2. The catalytic acidic system can be inorganic acids or organic acids, with a concentration range from pH=2 to 5 mol / L. Semi-cucurbituril [6] can be synthetised with inorganic salts and ionic liquids as template agents. Semi-cucurbituril [6] with single component can be synthetised through control of conditions such as concentration of the reactants, acidity and temperature of the reaction system and the like.