65 results about "Imidazolidines" patented technology

The present invention is concerned with a crystalline pharmaceutically acceptable salt of the glutaminyl cyclase inhibitor Varoglutamstat. Varoglutamstat is chemically designated as (S)-1- (1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one and is also known under the code PQ912. The invention further relates to a polymorphic form of the hydrochloride salt of (S)- 1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, to processes for preparing said hydrochloride salt and its polymorphic form, pharmaceutical compositions containing the same, therapeutic uses thereof and methods of treatment employing them.

The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema.

The invention discloses an antibacterial sanitary towel surface layer material and a sanitary towel, and relates to the technical field of daily necessities. When the antibacterial sanitary towel surface layer material is prepared, bamboo pulp fibers and a salicylaldehyde Schiff base calcium complex react to prepare modified bamboo pulp fibers; the preparation method comprises the following steps: enabling 3-imidazole-1-propionic acid and 1-chlorohexane to react to prepare propionyl imidazolium salt; the preparation method comprises the following steps: carrying out reaction on China hemp fibers and propionyl imidazolium salt to prepare modified China hemp fibers; the preparation method comprises the following steps: polymerizing vinyl perfluoro caprylate and 5-allylimidazolidine-2, 4-diketone, and chloridizing with sodium hypochlorite to obtain an antibacterial water-repellent finishing agent; the modified bamboo pulp fibers and the modified China hemp fibers are subjected to opening, carding, lapping and overlapping respectively and then subjected to spunlace reinforcement, a composite surface layer is prepared, the composite surface layer is coated with an antibacterial water-repellent finishing agent and dried, and the antibacterial sanitary towel surface layer material is prepared. The antibacterial sanitary towel surface layer material prepared by the invention has excellent antibacterial property and anti-back-permeation property.

The present invention belongs to the technical field of medicines. The present invention relates to an imidazolidinedione HDAC inhibitor, and a preparation method therefor and the use thereof. Provided in the present invention is an imidazolidinedione HDAC inhibitor, which inhibitor is a substituted imidazolidinedione compound as represented by general formula V, or a stereoisomer, a hydrate or a pharmaceutically acceptable salt thereof. The inhibitor has efficient and good HDAC enzyme inhibitory activity, and also has good in-vitro anti-tumor activity. The inhibitor provides a new way for the application of an HDAC inhibitor in tumors / or the treatment of diseases related to uncontrolled histone deacetylase activity.

Disclosed herein include crystalline (S)-2-amino-N-((3R,5R)-8-hydroxy-6-oxo-7-oxa-1-aza-8-boraspiro[4.7]dodecan-3-yl)-3-methylbutyramide of Form D and Form E: Formula (I); (3R,5R)-8-hydroxy-3-((S)-4-isopropyl-2,2-dimethyl-5-oxoimidazolidin-1-yl)-7-oxa-1-aza-8-boraspiro[4.7]dodecan-6-one or a pharmaceutically acceptable salt thereof or Crystal Form 1 thereof: Formula (II); and pharmaceutical compositions and methods of using the same. #imgabs0#

The present invention belongs to the field of functional porous materials, and particularly relates to imidazolidinone compounds, porous organic polymer gels, and their preparation methods and applications. The present invention uses amino acid amide monomers and pyridine aldehyde monomers as raw materials to prepare a positively charged porous organic polymer gel in one step. The porous organic polymer gel has good processing performance and high conductivity.

The invention provides a one-pot synthesis method of 1, 3-dimethyl-2-imidazolidinone, which comprises the following steps: mixing a basic catalyst, an ionic liquid and methanol, adding ethylenediamine to synthesize 2-imidazolidinone under a low-temperature condition, and raising the temperature to enable the 2-imidazolidinone and dimethyl carbonate to have an N-methylation reaction. According to the synthesis method, the ionic liquid is adopted as the catalyst, on one hand, the ionic liquid serves as a phase transfer catalyst, and the acid binding effect of the acid binding agent is enhanced; on the other hand, as a carbene catalyst, dimethyl carbonate is activated, so that the acylation and methylation reaction efficiency is improved.

A raw material proportioning device for imidazolidine production belongs to the technical field of imidazolidine production proportioning and is characterized by comprising a reaction tank body and a feeding through hole formed in the upper portion of the side surface of the reaction tank body, and a sealing device is movably inserted in the circle center of the inner side end of the feeding through hole. A feeding pipeline is connected to the peripheral edge of the outer side surface of the feeding through hole, a protective outer cover is inserted in the circle center of the outer side surface of the feeding pipeline, a material collecting device is inserted in the circle center of the outer side surface of the protective outer cover, and a sealing upper cover is inserted in the circle center of the outer side surface of the material collecting device; a worker can fill the proportioned raw materials into the reaction kettle without opening a feed port of the reaction kettle, so that the filler can react more sufficiently when the temperature in the reaction kettle is constant.

The present invention provides a polymeric chain made of acrylate-containing imidazolidinyl urea monomers and having antimicrobial properties, a UV polymerizable resin comprising said polymeric chain, and a product such as a medical device, obtained by 3D printing of said UV polymerizable resin.

Embodiments relate to an imidazolidine derivative or a pharmaceutically acceptable salt thereof and its use for preventing, ameliorating, or treating arthritis. The compound of one embodiment can be effectively utilized for preventing, ameliorating, or treating arthritis by inhibiting degeneration or damage to cartilage tissue through inhibition of the activity of ADAMTS4 or ADAMTS5.

The application belongs to the technical field of organic synthesis, and particularly relates to a benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative, a preparation method and application thereof. The benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative provided by the application has a structure shown in formula 1 or formula 2. The application combines an anemarrhena saponin aglycone skeleton and a benzimidazole skeleton, and the obtained benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative with the structure shown in formula 1 or formula 2 has significant antitumor activity. The antitumor growth inhibition activity of the benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative provided by the application is better than that of cisplatin (DDP), an anticancer drug.

The present invention relates to a polymer solid electrolyte comprising: an ion-conductive polymer; organic ionic plastic crystals containing imidazolium; and a lithium salt. The polymer solid electrolyte according to an aspect can simultaneously achieve excellent ion conductivity and electrochemical stability.

The utility model discloses drying and screening integrated equipment for 2-imidazolidinone production, and relates to the technical field of drying and screening equipment, the drying and screening integrated equipment comprises a supporting frame, a drying box and a box cover, a rotatable placing plate is installed in the drying box, a first motor is fixedly installed on the outer wall of the drying box, and a second motor is fixedly installed on the outer wall of the drying box. The first motor is in transmission connection with the containing plate, the lower portion of the drying box is fixedly connected to a material guiding groove which is in a funnel shape on the whole, a guiding cylinder is fixedly connected to the bottom of the material guiding groove, screening holes are formed in the bottom of the inner wall of the guiding cylinder, and a rotatable supporting frame is installed on the inner wall of the guiding cylinder. According to the device, the drying box is arranged above the guide cylinder, the screening holes are formed in the outer wall of the guide cylinder, and the rotatable feeding auger is installed in the guide cylinder, so that the device can quickly transfer materials into the guide cylinder to be screened after completing drying of the materials, manual interference of transferring is not needed, and the drying efficiency is improved. And the materials are prevented from being polluted in the transferring process.

The present application provides a kind of big granule glue for diaphragm, diaphragm coating slurry, diaphragm and battery, the big granule glue is copolymer, the copolymer includes: aromatic ethylene structural unit;Acrylate structural unit;Crosslinking structural unit, the side chain of the crosslinking structural unit contains reactive functional group, the reactive functional group includes one or more of epoxy group, isocyanate group, siloxane group, hydroxyl group, amino group, carboxyl group and unsaturated hydrocarbon group;And acrylamide structural unit, the acrylamide structural unit contains imidazolidinone group, to overcome the problem that existing ceramic diaphragm exists high battery impedance and insufficient rate performance.

The present invention relates to use of a compound represented by formula (I) or an ester thereof or a pharmaceutically acceptable salt thereof in the treatment of a disease accompanied by fibrosis.

The invention discloses a high-efficiency and environment-friendly electrochemical method which is used for synthesizing a 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivative. The invention further discloses a preparation method of the 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivative. Aiming at the problems of tedious steps, harsh conditions, serious pollution and the like of the traditional synthesis method, the method disclosed by the invention takes an alkenyl urea compound which is easy to obtain as a raw material, and realizes efficient synthesis of a target product through a one-step electrochemical iodine cyclization reaction under a mild condition. According to the method, the active iodine species are generated in situ by utilizing an electrochemical means, expensive or toxic reagents are not needed, and the environmental pollution and the synthesis cost are remarkably reduced. The reaction is carried out at normal temperature and normal pressure, the operation is simple and easy to control, and the method has wide substrate applicability. By optimizing reaction conditions, efficient selective synthesis of a target product can be realized. The method has the remarkable advantages of no need of high temperature and high pressure, green and environment-friendly reagents, simple reaction steps and clear product structure. Experimental results show that the method can efficiently synthesize various 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivatives, has a good application prospect, and provides a new way for development of related drugs and functional materials. In conclusion, the invention provides a novel strategy with great potential for green synthesis of the imidazolidine-2-ketone compound.

The utility model discloses a quantitative control imidazolidine batching and feeding device which comprises a machine body, a stirring chamber is arranged at the bottom end in the machine body, batching tanks are fixedly connected to two sides of the top end of the machine body, two groups of mounting sleeves are movably connected to the top end in the stirring chamber, stirring shafts are mounted at the bottom ends of the mounting sleeves, and the stirring shafts are fixedly connected to the stirring chamber. And the outer part of the stirring shaft is fixedly connected with a stirring rod. According to the quantitative control imidazolidine ingredient feeding device, the feeding mode is selected according to the ingredient requirement, when ingredients can directly enter the stirring cavity to be mixed, the electromagnetic valve of the first connecting pipe is opened, the electromagnetic valve achieves quantitative feeding according to the regulations of time and flow, when multiple ingredients need to be mixed and then enter, the electromagnetic valve of the second connecting pipe can be opened, and the multiple ingredients can be mixed. The ingredients enter the mixing box, the driving motor drives the mixing shaft to fully mix the ingredients, and then the ingredients enter the stirring chamber, so that the problems of inconvenience in quantification and flexible feeding are solved.

The present invention relates to the use of a compound represented by formula (I) or an ester or a pharmaceutically acceptable salt thereof in the treatment of diseases accompanied by fibrosis. # imgabs0 #

The invention provides large-particle glue for a diaphragm, diaphragm coating slurry, the diaphragm and a battery, the large-particle glue is a copolymer, and the copolymer comprises an aromatic ethylene structural unit; an acrylate structural unit; the side chain of the crosslinking structure unit contains a reactive functional group, and the reactive functional group comprises one or more of an epoxy group, an isocyanate group, a siloxane group, a hydroxyl group, an amino group, a carboxyl group and an unsaturated alkyl group; the acrylamide structural unit contains an imidazolidinone group, so that the problems of high battery impedance and insufficient rate capability of an existing ceramic diaphragm are solved.

The invention discloses a stable lactic dehydrogenase and uric acid combined detection kit with strong anti-interference capability, and belongs to the technical field of detection. The joint detection kit comprises a reagent R1 and a reagent R2, wherein the reagent R1 contains a buffer solution, a composite anti-interference agent, a composite stabilizer, L-lithium lactate, a compound surfactant, 4-aminoantipyrine, peroxidase and a preservative diazolidinyl urea; the reagent R2 contains a buffer solution, a coenzyme (NAD < + >), N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt uricase, a compound stabilizer, a compound surfactant and a preservative epsilon-polylysine hydrochloride. According to the present invention, the lactic dehydrogenase detection and the uric acid detection can be simultaneously achieved by one reagent, such that the use convenience is substantially improved, and the stability and the anti-interference ability of the reagent are further improved. The reagent disclosed by the invention is simple, convenient and rapid to operate, is suitable for automatic analysis, and is a lactic dehydrogenase and uric acid combined detection reagent which is more stable and strong in anti-interference capability.

The present invention is concerned with a crystalline pharmaceutically acceptable salt of the glutaminyl cyclase inhibitor Varoglutamstat. Varoglutamstat is chemically designated as(S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl) imidazolidin-2-one and is also known under the code PQ912. The invention further relates to a polymorphic form of the hydrochloride salt of(S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl) imidazolidin-2-one, to processes for preparing said hydrochloride salt and its polymorphic form, pharmaceutical compositions containing the same, therapeutic uses thereof and methods of treatment employing them.

This invention relates to a method for preparing imidazoline derivatives using heterogeneous catalysis. The invention addresses the technical problem that existing methods for synthesizing imidazoline derivatives require transition metal catalysis and involve cumbersome reaction processes. The method comprises: 1. Preparing a photocatalyst using melamine and glyoxal; 2. Preparing the imidazoline derivative under blue LED light. This invention provides a simple one-step method for synthesizing imidazolines and their derivatives, using heterogeneous materials as photocatalysts. This method eliminates cumbersome synthesis steps, achieves high yields, and is environmentally friendly. The reaction can be carried out at room temperature and pressure under mild conditions, requires no transition metal catalysis, and achieves a yield of over 40%. It has advantages such as simple operation, safety, environmental friendliness, and low cost. This invention is used for the preparation of imidazoline derivatives.

The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and an additional compound chosen from a monovalent or divalent metal salt of pyrithione, piroctone olamine, diazolidinylurea, a hexamidine compound, and imidazolidinylurea,and also to a cosmetic composition containing such a mixture.Application to caring for, making up and cleansing keratin materials.

The present invention belongs to the field of biomedical detection technology, and specifically relates to an inactivation preservation solution and a detection test tube that keep virus particles intact. An inactivation preservation solution that keeps virus particles intact, the preservation solution includes the following components by mass percentage: a buffer 20-100mM, a protein denaturant 1.00wt%-3.00wt%, a stabilizer 0.20wt%-2.00wt%, a free radical scavenger 0.50wt%-2.00wt%, a calcium and magnesium ion chelator 0.10wt%-0.50wt%; the protein denaturant is selected from one or more mixtures of ethyl p-hydroxybenzoate, diazolidinyl urea, and imidazolidinyl urea. This preservation solution can protect the integrity of virus particles at room temperature, avoid RNA release, degradation and contamination, and improve the accuracy of subsequent detection.

The utility model relates to the technical field of conveying and transferring, in particular to an anti-blocking imidazolidine conveying and transferring device which comprises a conveying device and an anti-blocking device. One side of a first shell in the conveying device is connected with a cover through bolts, a first clamping block is movably connected into the first shell, the front end of a first connecting block is welded to the rear end of the first clamping block, the protruding position of the front end of the first clamping block is connected with the rear end of a second clamping block in an inserted mode, and the rear end of the second clamping block is welded to the front end of a second connecting block. According to the material conveying device, air flow can be input into the first shell through the air pump, so that the material conveying device has certain air pressure when conveying materials, the materials can be conveyed more quickly, and the conveying efficiency is improved. And blockage of the material conveying device in the conveying process is reduced due to the pressure of air pressure, and the heating structure can enable air blown out of the air pump to be hot air so that the materials can be further blow-dried in the conveying process.

The invention discloses a low-density high-resilience polyurethane foam packaging material and a preparation method thereof, and relates to a light-weight high-resilience packaging material and a preparation method thereof. The low-density high-resilience polyurethane foam packaging material is suitable for packaging instruments, equipment and the like. The foaming material is formed by foaming a prepolymer C and a composite material, the prepolymer C is prepared from isophorone diisocyanate, a modifier B, imidazolidinyl urea, isobornyl acrylate and hydroxyethyl acrylate through a reaction; the modifier B is prepared from xylene, terephthalaldehyde and ethanolamine through a reaction; the combined material D is prepared by mixing polyether polyol E and F, polyester polyol, polyethylene glycol adipate, a foam stabilizer, water, cyclopentane, triethylene diamine (33% aqueous solution), stannous octoate and a modifier A; the modifier A is prepared by mixing and reacting a water phase consisting of water, nano silicon dioxide, polyvinylpyrrolidone and sodium chloride with an oil phase consisting of a polymeric monomer, low-boiling-point saturated hydrocarbon and azodiisobutyronitrile. The high-elasticity and impact-resistant rubber material is good in buffering and impact-resistant performance and rebound resilience, low in density, light in weight and environment-friendly.

The present invention is concerned with a crystalline pharmaceutically acceptable salt of the glutaminyl cyclase inhibitor Varoglutamstat. Varoglutamstat is chemically designated as (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one and is also known under the code PQ912. The invention further relates to a polymorphic form of the hydrochloride salt of (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, to processes for preparing said hydrochloride salt and its polymorphic form, pharmaceutical compositions containing the same, therapeutic uses thereof and methods of treatment employing them.

A cosmetic product, containing a composition A including one or more alkalizing agents, an aqueous composition B having a pH in a range of 1 to 6 and containing one or more oxidizing agents, and a composition C containing one or more compounds selected from the following groups:1)where R1, R2, and R3 are independently selected from H and CH3,2) one or more orthodiphenols and salts thereof, and3) one or more imidazolidin-2,4-diones and salts thereof.

A grafted modified membrane, a preparation method thereof, and a water treatment method and system using the same. The preparation method of the grafted modified membrane comprises: sealing the mesh of a membrane for filtration with vaseline, keeping the surface clean and hydrophilic; immersing the membrane surface in an aqueous solution of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride for 10-20 min; adding N-hydroxysuccinimide to the aqueous solution; adding an aqueous solution of a polymer containing primary amino groups to the aqueous solution, standing in the dark for 8-24 h; and cleaning the membrane surface to obtain the grafted modified membrane. The grafted modification method of the application can form a temporary protective film, and at the same time strengthen the strength of the protective film and reserve a gap for destroying the protective film, so that the service life of the membrane can be prolonged through multiple grafting and destruction operations, and the antibacterial property of the membrane surface can be enhanced and bacterial growth can be reduced due to the grafted imidazole alkyl urea.

The application provides a preparation method, special equipment and application of 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione, wherein the preparation method comprises the following steps: S1, continuously inputting dry inorganic acidic gas into a reactor; S2, mixing raw material N-[[(3,5-dichlorophenyl)amino] carbonyl] amino acetic acid and an auxiliary agent and then inputting the mixture into the reactor; S3, under the catalysis of the acidic gas, the raw material and the auxiliary agent perform cyclization reaction to obtain a mixture of 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione, water and the auxiliary agent; and S4, cooling and separating the mixture obtained in the step S3 to obtain 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione solid and an aqueous auxiliary agent solution respectively. The preparation method of 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione has the advantages of continuous production, high efficiency, simplicity, near-zero emission and mild reaction conditions, can effectively shorten the reaction time, improve the production efficiency, reduce the safety risk, and the yield of the product can reach more than 93%, and the purity can reach more than 99%.