33 results about "Imidazolidines" patented technology

The present invention belongs to the technical field of medicines. The present invention relates to an imidazolidinedione HDAC inhibitor, and a preparation method therefor and the use thereof. Provided in the present invention is an imidazolidinedione HDAC inhibitor, which inhibitor is a substituted imidazolidinedione compound as represented by general formula V, or a stereoisomer, a hydrate or a pharmaceutically acceptable salt thereof. The inhibitor has efficient and good HDAC enzyme inhibitory activity, and also has good in-vitro anti-tumor activity. The inhibitor provides a new way for the application of an HDAC inhibitor in tumors / or the treatment of diseases related to uncontrolled histone deacetylase activity.

The invention provides a one-pot synthesis method of 1, 3-dimethyl-2-imidazolidinone, which comprises the following steps: mixing a basic catalyst, an ionic liquid and methanol, adding ethylenediamine to synthesize 2-imidazolidinone under a low-temperature condition, and raising the temperature to enable the 2-imidazolidinone and dimethyl carbonate to have an N-methylation reaction. According to the synthesis method, the ionic liquid is adopted as the catalyst, on one hand, the ionic liquid serves as a phase transfer catalyst, and the acid binding effect of the acid binding agent is enhanced; on the other hand, as a carbene catalyst, dimethyl carbonate is activated, so that the acylation and methylation reaction efficiency is improved.

The present invention provides a polymeric chain made of acrylate-containing imidazolidinyl urea monomers and having antimicrobial properties, a UV polymerizable resin comprising said polymeric chain, and a product such as a medical device, obtained by 3D printing of said UV polymerizable resin.

Embodiments relate to an imidazolidine derivative or a pharmaceutically acceptable salt thereof and its use for preventing, ameliorating, or treating arthritis. The compound of one embodiment can be effectively utilized for preventing, ameliorating, or treating arthritis by inhibiting degeneration or damage to cartilage tissue through inhibition of the activity of ADAMTS4 or ADAMTS5.

The application belongs to the technical field of organic synthesis, and particularly relates to a benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative, a preparation method and application thereof. The benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative provided by the application has a structure shown in formula 1 or formula 2. The application combines an anemarrhena saponin aglycone skeleton and a benzimidazole skeleton, and the obtained benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative with the structure shown in formula 1 or formula 2 has significant antitumor activity. The antitumor growth inhibition activity of the benzimidazole alkyl bromide salt-anemarrhena saponin aglycone derivative provided by the application is better than that of cisplatin (DDP), an anticancer drug.

The utility model discloses drying and screening integrated equipment for 2-imidazolidinone production, and relates to the technical field of drying and screening equipment, the drying and screening integrated equipment comprises a supporting frame, a drying box and a box cover, a rotatable placing plate is installed in the drying box, a first motor is fixedly installed on the outer wall of the drying box, and a second motor is fixedly installed on the outer wall of the drying box. The first motor is in transmission connection with the containing plate, the lower portion of the drying box is fixedly connected to a material guiding groove which is in a funnel shape on the whole, a guiding cylinder is fixedly connected to the bottom of the material guiding groove, screening holes are formed in the bottom of the inner wall of the guiding cylinder, and a rotatable supporting frame is installed on the inner wall of the guiding cylinder. According to the device, the drying box is arranged above the guide cylinder, the screening holes are formed in the outer wall of the guide cylinder, and the rotatable feeding auger is installed in the guide cylinder, so that the device can quickly transfer materials into the guide cylinder to be screened after completing drying of the materials, manual interference of transferring is not needed, and the drying efficiency is improved. And the materials are prevented from being polluted in the transferring process.

The present application provides a kind of big granule glue for diaphragm, diaphragm coating slurry, diaphragm and battery, the big granule glue is copolymer, the copolymer includes: aromatic ethylene structural unit;Acrylate structural unit;Crosslinking structural unit, the side chain of the crosslinking structural unit contains reactive functional group, the reactive functional group includes one or more of epoxy group, isocyanate group, siloxane group, hydroxyl group, amino group, carboxyl group and unsaturated hydrocarbon group;And acrylamide structural unit, the acrylamide structural unit contains imidazolidinone group, to overcome the problem that existing ceramic diaphragm exists high battery impedance and insufficient rate performance.

The present invention relates to use of a compound represented by formula (I) or an ester thereof or a pharmaceutically acceptable salt thereof in the treatment of a disease accompanied by fibrosis.

The invention discloses a high-efficiency and environment-friendly electrochemical method which is used for synthesizing a 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivative. The invention further discloses a preparation method of the 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivative. Aiming at the problems of tedious steps, harsh conditions, serious pollution and the like of the traditional synthesis method, the method disclosed by the invention takes an alkenyl urea compound which is easy to obtain as a raw material, and realizes efficient synthesis of a target product through a one-step electrochemical iodine cyclization reaction under a mild condition. According to the method, the active iodine species are generated in situ by utilizing an electrochemical means, expensive or toxic reagents are not needed, and the environmental pollution and the synthesis cost are remarkably reduced. The reaction is carried out at normal temperature and normal pressure, the operation is simple and easy to control, and the method has wide substrate applicability. By optimizing reaction conditions, efficient selective synthesis of a target product can be realized. The method has the remarkable advantages of no need of high temperature and high pressure, green and environment-friendly reagents, simple reaction steps and clear product structure. Experimental results show that the method can efficiently synthesize various 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivatives, has a good application prospect, and provides a new way for development of related drugs and functional materials. In conclusion, the invention provides a novel strategy with great potential for green synthesis of the imidazolidine-2-ketone compound.

The invention provides large-particle glue for a diaphragm, diaphragm coating slurry, the diaphragm and a battery, the large-particle glue is a copolymer, and the copolymer comprises an aromatic ethylene structural unit; an acrylate structural unit; the side chain of the crosslinking structure unit contains a reactive functional group, and the reactive functional group comprises one or more of an epoxy group, an isocyanate group, a siloxane group, a hydroxyl group, an amino group, a carboxyl group and an unsaturated alkyl group; the acrylamide structural unit contains an imidazolidinone group, so that the problems of high battery impedance and insufficient rate capability of an existing ceramic diaphragm are solved.

The invention discloses a stable lactic dehydrogenase and uric acid combined detection kit with strong anti-interference capability, and belongs to the technical field of detection. The joint detection kit comprises a reagent R1 and a reagent R2, wherein the reagent R1 contains a buffer solution, a composite anti-interference agent, a composite stabilizer, L-lithium lactate, a compound surfactant, 4-aminoantipyrine, peroxidase and a preservative diazolidinyl urea; the reagent R2 contains a buffer solution, a coenzyme (NAD < + >), N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt uricase, a compound stabilizer, a compound surfactant and a preservative epsilon-polylysine hydrochloride. According to the present invention, the lactic dehydrogenase detection and the uric acid detection can be simultaneously achieved by one reagent, such that the use convenience is substantially improved, and the stability and the anti-interference ability of the reagent are further improved. The reagent disclosed by the invention is simple, convenient and rapid to operate, is suitable for automatic analysis, and is a lactic dehydrogenase and uric acid combined detection reagent which is more stable and strong in anti-interference capability.

This invention relates to a method for preparing imidazoline derivatives using heterogeneous catalysis. The invention addresses the technical problem that existing methods for synthesizing imidazoline derivatives require transition metal catalysis and involve cumbersome reaction processes. The method comprises: 1. Preparing a photocatalyst using melamine and glyoxal; 2. Preparing the imidazoline derivative under blue LED light. This invention provides a simple one-step method for synthesizing imidazolines and their derivatives, using heterogeneous materials as photocatalysts. This method eliminates cumbersome synthesis steps, achieves high yields, and is environmentally friendly. The reaction can be carried out at room temperature and pressure under mild conditions, requires no transition metal catalysis, and achieves a yield of over 40%. It has advantages such as simple operation, safety, environmental friendliness, and low cost. This invention is used for the preparation of imidazoline derivatives.

The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and an additional compound chosen from a monovalent or divalent metal salt of pyrithione, piroctone olamine, diazolidinylurea, a hexamidine compound, and imidazolidinylurea,and also to a cosmetic composition containing such a mixture.Application to caring for, making up and cleansing keratin materials.

The invention discloses a low-density high-resilience polyurethane foam packaging material and a preparation method thereof, and relates to a light-weight high-resilience packaging material and a preparation method thereof. The low-density high-resilience polyurethane foam packaging material is suitable for packaging instruments, equipment and the like. The foaming material is formed by foaming a prepolymer C and a composite material, the prepolymer C is prepared from isophorone diisocyanate, a modifier B, imidazolidinyl urea, isobornyl acrylate and hydroxyethyl acrylate through a reaction; the modifier B is prepared from xylene, terephthalaldehyde and ethanolamine through a reaction; the combined material D is prepared by mixing polyether polyol E and F, polyester polyol, polyethylene glycol adipate, a foam stabilizer, water, cyclopentane, triethylene diamine (33% aqueous solution), stannous octoate and a modifier A; the modifier A is prepared by mixing and reacting a water phase consisting of water, nano silicon dioxide, polyvinylpyrrolidone and sodium chloride with an oil phase consisting of a polymeric monomer, low-boiling-point saturated hydrocarbon and azodiisobutyronitrile. The high-elasticity and impact-resistant rubber material is good in buffering and impact-resistant performance and rebound resilience, low in density, light in weight and environment-friendly.

A grafted modified membrane, a preparation method thereof, and a water treatment method and system using the same. The preparation method of the grafted modified membrane comprises: sealing the mesh of a membrane for filtration with vaseline, keeping the surface clean and hydrophilic; immersing the membrane surface in an aqueous solution of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride for 10-20 min; adding N-hydroxysuccinimide to the aqueous solution; adding an aqueous solution of a polymer containing primary amino groups to the aqueous solution, standing in the dark for 8-24 h; and cleaning the membrane surface to obtain the grafted modified membrane. The grafted modification method of the application can form a temporary protective film, and at the same time strengthen the strength of the protective film and reserve a gap for destroying the protective film, so that the service life of the membrane can be prolonged through multiple grafting and destruction operations, and the antibacterial property of the membrane surface can be enhanced and bacterial growth can be reduced due to the grafted imidazole alkyl urea.

The application provides a preparation method, special equipment and application of 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione, wherein the preparation method comprises the following steps: S1, continuously inputting dry inorganic acidic gas into a reactor; S2, mixing raw material N-[[(3,5-dichlorophenyl)amino] carbonyl] amino acetic acid and an auxiliary agent and then inputting the mixture into the reactor; S3, under the catalysis of the acidic gas, the raw material and the auxiliary agent perform cyclization reaction to obtain a mixture of 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione, water and the auxiliary agent; and S4, cooling and separating the mixture obtained in the step S3 to obtain 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione solid and an aqueous auxiliary agent solution respectively. The preparation method of 3-(3,5-dichlorophenyl)-2,4-imidazolidinedione has the advantages of continuous production, high efficiency, simplicity, near-zero emission and mild reaction conditions, can effectively shorten the reaction time, improve the production efficiency, reduce the safety risk, and the yield of the product can reach more than 93%, and the purity can reach more than 99%.

The application discloses a phosphorescent carbon dot material, a preparation method and application in preparation of a phosphorescent high polymer material, relates to the technical field of chemiluminescent materials, and comprises the following steps: taking 2-imidazolidone and diaphosphorus pentoxide as raw materials, and synthesizing intermediate phosphorescent carbon dot material one through a heating carbonization method; coating the surface of the intermediate phosphorescent carbon dot material one with silicon dioxide through tetraethyl orthosilicate to obtain intermediate phosphorescent carbon dot material two with a core-shell structure; and using a silane coupling agent to modify the surface to obtain phosphorescent carbon dot material containing hydrophobic groups on the surface; mixing the phosphorescent carbon dot material with ultraviolet light polymerizable monomers and a photoinitiator, and obtaining the phosphorescent high polymer material through ultraviolet light curing; the application has the advantages of simple process, easy operation and control, mild preparation conditions, easy availability of raw materials, and easiness in large-scale batch production; the prepared phosphorescent carbon dot material has long phosphorescent lifetime and stable luminescent properties, can be uniformly fixed in a polymer matrix through covalent crosslinking, and solves the problem of phase separation of doped phosphors in polymers.

The present invention discloses an antibacterial sanitary napkin surface material and a sanitary napkin, and relates to the technical field of daily necessities. When preparing the antibacterial sanitary napkin surface material, the present invention comprises the following steps: reacting bamboo pulp fiber and salicylaldehyde Schiff base calcium complex to obtain modified bamboo pulp fiber; reacting 3-imidazole-1-propionic acid and 1-chlorohexane to obtain propionic imidazole salt; reacting hemp fiber and propionic imidazole salt to obtain modified hemp fiber; polymerizing vinyl perfluorooctanoate and 5-allylimidazolidine-2,4-dione, and then chlorinating with sodium hypochlorite to obtain an antibacterial water-repellent finishing agent; opening, carding, and laying the modified bamboo pulp fiber and the modified hemp fiber, respectively, superimposing and reinforcing the composite surface layer, applying the antibacterial water-repellent finishing agent, and drying to obtain the antibacterial sanitary napkin surface material. The antibacterial sanitary napkin surface material prepared by the present invention has excellent antibacterial and anti-rewetting properties.

The present invention relates to a method for manufacturing a polyurethane urea elastic yarn, characterized by using an imidazolidinone-based organic solvent as an organic solvent for polyurethane urea elastic yarn synthesis, and to a polyurethane urea elastic yarn manufactured thereby. According to the present invention, by using the imidazolidinone-based organic solvent, the reaction can be controlled, thereby obtaining a high-molecular-weight polyurethane urea polymer, and the obtained polyurethane urea solution exhibits excellent transparency, has good storage stability due to the absence of cloudiness even after long-term storage, is not subject to environmental regulations, and can secure stability even under high-temperature process conditions due to a high flash point thereof.

A compound of formula (I) is:wherein: X2 represents a —CO—NRk— group, a —NR′k—CO— group, a —O— group, a —CO— group, a —SO2-group, a —CS—NH— group, a —CH2—NH—, agroup, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and / or N; Y2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C1-C4)alkyl group or a trifluoromethyl group, a bridged morpholinyl group, a (C5-C11)bicycloalkyl group, an adamantyl group, a piperidinyl group, a (C1-C4)alkenyl group, a —PO(ORa)(ORb) group, a 5-membered heteroaromatic ring or a —CR1R2R3 group, or any of its pharmaceutically acceptable salt.

The application discloses an N-substituted 2-(2,5-dioxoimidazolidin-4-yl) acetamide compound and a synthesis method and application thereof, and belongs to the technical field of tumor immunotherapy drug development.The N-substituted 2-(2,5-dioxoimidazolidin-4-yl) acetamide compound disclosed by the application is a small-molecule ITIM motif inhibitor, the action mechanism of which is to combine with the ITIM motif of tyrosine phosphorylation in the tumor cell membrane, thereby blocking the combination of the ITIM of tyrosine phosphorylation and SH2, making SHP2 always in an inhibition state, simultaneously blocking multiple inhibitory receptor pathways including PECAM-1, PD-1, BTLA, KIR, CD3 and SIRP alpha, and finally improving the anti-tumor activity of immune cells.The experimental data show that the N-substituted 2-(2,5-dioxoimidazolidin-4-yl) acetamide compound can effectively enhance the killing of tumor cells by immune cells, inhibit the growth of tumors, and fully support the application of the compound in tumor immunotherapy.

The invention discloses a flame-retardant high-resilience polyurethane foam packaging material and a preparation method thereof, and belongs to the technical field of new materials, the flame-retardant high-resilience polyurethane foam packaging material can be used for packaging precise instruments, precious equipment and the like, and the flame-retardant high-resilience polyurethane foam packaging material is prepared by foaming a flame-retardant black material A and a flame-retardant white material B to obtain a body material and then soaking the body material in halloysite branched polyethyleneimine and polyacrylic acid suspension in sequence; the A is prepared by mixing a flame retardant, imidazolidinyl urea, isobornyl acrylate and hydroxyethyl acrylate, wherein the flame retardant is prepared by mixing isophorone diisocyanate, benzoguanamine, phosphonitrilic chloride trimer and triethylamine; the component B is prepared by mixing polyester polyol, two polyether polyols, silicone oil, glycerol, water, pentamethyldiethylenetriamine, stannous octoate and a flame retardant F; the F is formed by mixing a ZIF solution G and a flame-retardant solution H; g is formed by mixing 2-methylimidazole and an ethanol solution of cobalt nitrate hexahydrate; h is prepared by mixing and reacting a diethylenetriamine ethanol solution with a mixed solution of ethanol, diphenyl chlorophosphate and triethylamine. The environment-friendly flame-retardant rubber has good flame retardance and resilience and is environment-friendly.

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: wherein: M is a Group 6 metal atom; X is an oxygen atom, =N-R5, =N-N(R5)(R5') or =N-0-R5, R5 and R5' independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.

The novel compounds of structural formula (I) and their pharmaceutically acceptable salts are Na v 1.8 channel activity and can be used in the treatment, prevention, management, amelioration, control and inhibition of diseases mediated by Na v 1.8 channel activity. The compounds of the present invention can be used in the treatment, prevention or management of pain conditions, cough conditions, acute itch conditions and chronic itch conditions.

The invention discloses a graft modified membrane and a preparation method thereof, and a water treatment method and system adopting the graft modified membrane. The preparation method of the graft modified membrane comprises the following steps: sealing meshes of the membrane for filtration by adopting vaseline, wherein the surface is clean and keeps hydrophilic; the surface of the diaphragm is immersed in an aqueous solution of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride for 10 min to 20 min; adding N-hydroxysuccinimide into the aqueous solution; adding an aqueous solution of a polymer containing a primary amino group into the aqueous solution, standing and reacting in a dark place for 8-24 hours; the surface of the membrane is clean, and the graft modified membrane is prepared. According to the grafting modification method, a temporary protective film can be formed, a notch for destroying the protective film is reserved while the strength of the protective film is reinforced, so that the service life of the protective film can be prolonged through multiple grafting and destroying operations, and due to the fact that imidazolidinyl urea is grafted, the antibacterial property of the surface of the film can be enhanced, and bacterium breeding can be reduced.

The invention provides a bacteriostatic deodorant absorbent pad and a preparation method thereof, the upper layer of the bacteriostatic deodorant absorbent pad is a hydrophobic fiber layer containing inorganic porous minerals, and the lower layer of the bacteriostatic deodorant absorbent pad is a fluff pulp hydrophilic fiber layer containing super absorbent resin subjected to bacteriostatic deodorant treatment and moisture-absorbing inorganic salt; various substances and a multi-layer structure form an obvious water absorption trend, so that moisture generated by fresh food can be actively and quickly absorbed, and the fresh food is prevented from being rotten; the super absorbent resin treated by the chlorinated imidazolidinone endows the water absorption pad with the functions of inhibiting bacteria and removing odor, and the produced odor is removed while the growth and reproduction of bacteria are inhibited, so that the fresh products are prevented from going bad and decaying. The prepared water absorption pad is applied to packaging of fresh products, the freshness of the fresh products can be guaranteed, the shelf life of the fresh products can be prolonged, and the quality of the fresh products and the satisfaction degree of consumers can be improved.

The invention relates to peptide cyclization, a peptide compound having a cyclic portion, and the development of peptide-based drugs. Provided is a method for providing a cyclic peptide, or a peptide compound having a cyclic portion, comprising reacting a linear peptide comprising an amino acid sequence of the formula NH2-Xaa1-Gly-(Xaa)n-Cys, wherein NH2 indicates the N-terminus of the peptide; Xaa is any natural or non-natural amino acid residue and n is 2 to 15; with a bifunctional synthetic scaffold comprising a first functionality HC(O)–(CH2)x – and a second functionality – (CH2)y-LG, wherein x is 1 to 5, y is 1 to 5, preferably 1 to 3; LG is an electrophilic leaving group or a cysteine-reactive electrophile, preferably a halogen atom, more preferably Br, under conditions allowing for the formation of an imidazolidinone-fused macrocyclic peptide (MP).

The present invention relates to a pharmaceutically acceptable salt of the crystal of the glutamine acyl cyclase inhibitor valroglustat. The present invention relates to valroglustat, which is chemically named as (S)-1-(1H-benzo [d] imidazol-5-yl)-5-(4-propoxyphenyl) imidazolidin-2-one, and is also known in code PQ912. The present invention also relates to a polymorphic form of (S)-1-(1H-benzo [d] imidazol-5-yl)-5-(4-propoxyphenyl) imidazolidin-2-one hydrochloride, a process for preparing said hydrochloride and polymorphic forms thereof, pharmaceutical compositions containing the same, their therapeutic use and methods of treatment using the same.

The aluminum foil comprises an aluminum foil base layer and the anti-corrosion coating arranged on at least one surface of the aluminum foil base layer, and paint of the anti-corrosion coating comprises water-based acrylic resin emulsion, water-based antibacterial polyurethane, a curing agent, a catalyst, a flatting agent and first deionized water; the water-based acrylic resin emulsion is obtained from a soft monomer, a hard monomer, a cross-linking monomer and a functional monomer under the action of an emulsifier and an initiator, and the functional monomer comprises hexafluorobutyl acrylate and vinyltriethoxysilane; the waterborne antibacterial polyurethane is obtained by reacting a polyurethane prepolymer with an antibacterial chain extender, a cross-linking chain extender and a hydrophilic chain extender, the antibacterial chain extender is dihydroxy quaternary ammonium salt, and the cross-linking chain extender is imidazolidinyl urea. The anti-corrosion coating for the aluminum foil is modified through the water-based acrylic resin emulsion, antibacterial and multi-crosslinking-point water-based antibacterial polyurethane is compounded, and the antibacterial continuity and corrosion resistance of the coating are improved.