The invention discloses an
epoxiconazole intermediate synthesis method and application, and the
epoxiconazole intermediate synthesis method comprises the following steps: adding 55-65 g of 1-chloro-3-(2-chlorphenyl)-2-(4-fluorophenyl)-2-
propanol, 130-140 g of
toluene and 5 g of
ethylene glycol into a reaction flask, uniformly mixing, then dropwise adding concentrated
sulfuric acid at 20-30 DEG C, then dropwise adding
acetic anhydride, reacting for 1-2 hours, then adding a catalyst, and reacting for 1-2 hours at the temperature of 20-30 DEG C to obtain the
epoxiconazole intermediate. The preparation method comprises the following steps: adding
toluene into a reaction kettle, carrying out a
thermal insulation reaction at 20-30 DEG C, dropwise adding water after the reaction is completed, stirring for layering, adding water into a
toluene layer, washing to be neutral, carrying out reduced pressure concentration on the toluene layer until the toluene layer is dry to obtain an
intermediate product, adding the
intermediate product into
methanol, dissolving, cooling, crystallizing, filtering and
drying. According to the method, 1-chloro-3-(2-chlorphenyl)-2-(4-fluorophenyl)-2-
propanol is adopted as a
raw material, a small amount of ethidene
diamine and concentrated
sulfuric acid are adopted as catalysts,
acetic anhydride is adopted as a dehydrating agent, water in molecules can be well removed under the low-temperature condition, 80% or above of target Z-configuration target products can be obtained, and the method is suitable for industrial production.