257 results about "Ethyl oleate" patented technology

A pharmaceutical composition contains cyclosporine as the active ingredient. More specifically, the composition is an orally administered pharmaceutical formulation in the form of a spontaneous emulsion comprising cyclosporine, ethanol ethyl oleate and polyoxyethylene glycerol trioleate. A method for preparing an orally administered pharmaceutical composition involves first dissolving cyclosporine in ethanol. Polyoxyethylene glycerol trioleate and an oil component are then added, mixed and diluted in an aqueous media to form a spontaneous emulsion.

The present Invention relates to a preservative composition comprising:

a mixture of two to ten of well characterized fragrance raw materials with a cosmetic function, of which at least two are selected from: allyl caproate, benzyl acetate, benzaldehyde, dihydrolsojasmonate, ethyl phenethylacetal, ethyl cinnamate, ethyl methyl phenyl glycidate, ethyl vanillin, 2-heptylcyclopentanone, geranyl acetate, heliotropine, cis-hex-3-en-1-ol, ethylene brassylate, nonalactone gamma, camphylcyclohexanol, undecalactone gamma, 2-t-butylcyclohexylacetate, pentyl salicylate, 2-phenylethanol and 2-phenylethyl acetate; and are contained in at least 20% by weight of said mixture;

at least one preservative; and a sequestrant.

The present invention relates to an injectable, pharmaceutical composition comprising a C_1-6 alkyl ester of a C_10-20 fatty acid. In an embodiment, the fatty acid is ethyl oleate, isopropyl oleate, ethyl myristate, or isopropyl myristate. These compositions are useful for the delivery of anti-psychotic drugs.

The invention discloses a tanshinone II A microemulsion preparation which has targeting and comparatively high entrapment efficiency and drug-loading rate, is not haemolytic and mainly applied to the treatment of tumor and a preparation method thereof. The invention comprises the following raw materials by weight percentage: 0.6-0.8 percent of tanshinone II A, 0.6-1.8 percent of phosphotide for injection, 2.5-3 percent of glycerin for injection, 1.5-3 percent of F68 for injection, 11-15 percent of ethyl oleate and water for injection. The preparation method of the invention is that first the tanshinone II A is dissolved in the ethyl oleate to prepare the oil phase mixture solution; next the phosphotide for injection, the glycerin for injection and the F68 for injection are dissolved in the water for injection which accounts for 60-70percent of the total water for injection to prepare the water phase solution; then the oil phase solution and the water phase solution are respectively preheated to 60-70DEG C and the oil phase solution is slowly dropped to the water phase solution when the water phase solution is blended; the mixed solution is then sheared for 1-2minutes in a high shearing dispersing emulsification machine and filtrated with a 0.8Mum filtration membrane when the solution is still hot and the rest water for injection is added to the filtrate; the liquid obtained from step d is homogenized by a high pressure emulsification machine and next filtrated with the 0.8 Mum filtration membrane; finally the filtrate obtained from step e is packaged, filled with nitrogen, sealed and disinfected.

The invention relates to an icariin microemulsion which takes icariin as active ingredient; the icariin is dissolved in oil and then added with emulsifying agent, assistant emulsifier and water to prepare microemulsion with the micro emulsion grain diameter of 10-100nm, wherein, the oil can be one or more in oleic acid, ethyl oleate, isopropyl myristate or castor oil; the icariin microemulsion has the components with the mass percent: 0.66-6.02% of saturated solution of oil of icariin, 10-50% of emulsifying agent, 10-38% of assistant emulsifier and the balance water, Hank's balanced salt solution (HBSS), PBS buffer solution or normal saline. The icariin microemulsion can be kept clear, transparent, stable and uniform when being placed at room temperature for a year, thus good stability is verified evidently. The experiments of cells and animals prove that the icariin microemulsion can strengthen the icariin to penetrate cell layers, promote the medicine to be ingested and absorbed and enhance the healing effect of the medicine. The invention also discloses a preparation method of the icariin microemulsion.

The present invention relates to preparation process of iodized vegetable oil ethyl ester. Iodized vegetable oil is first produced with vegetable oil and hydrogen iodide gas through addition reaction, and iodized vegetable oil and ethanol then produce ester exchange reaction under the action of alkali catalyst to produce iodized vegetable oil ethyl ester, with the hydrogen iodide gas being produced through reaction of iodine, red phosphorus and water. The present invention has facile cheap materials and high conversion rate of ester exchange reaction, and the product has low viscosity.

The invention relates to the technical field of pharmaceutical preparations and particularly relates to an abiraterone oral spray. The abiraterone oral spray comprises the following components in percent by weight: abiraterone acetate, an oil phase, a surfactant, a co-surfactant and the balance of water, wherein the oil phase is used as a carrier for prompting system micro-emulsification, and the oil phase is medium chain triglyceride, ethyl oleate or oleic acid; the surfactant is used for improving the performance of the abiraterone oral spray, expanding the range of application and realizing solubilization, and the surfactant is polyoxyethylene 40 hydrogenated castor oil or polyoxyethylene 35 castor oil; and the co-surfactant is used for reducing the surface tension of liquid and enhancing the emulsifying, moistening and blistering effects, and the co-surfactant is ethanol, n-butyl alcohol or propylene glycol. The spray has the advantages that the taking dose is reduced, so that the manufacturing cost is lowered; the formation of invalid metabolites is reduced, so that adverse reactions are effectively reduced; and the drug effect of the spray is longer than that of an oral drug.

The invention relates to matrine microemulsion and a preparation method thereof, which overcomes the defects of low solubility and low bioavailability of matrine and improves the stability of matrine microemulsion. The invention adopts microemulsion as a pharmaceutical carrier to prepare matrine O/W type microemulsion with liquid drop of 1 to 100nm particle size so as to improve the dispersity of enveloped medicaments, promote the percutaneous absorption of plant surface cuticle and strengthen the effect of eliminiting insect injury, thereby providing scientific basis for theory and application study. The invention also relates to a method of forming stable O/W emulsion by doping matrine into oil. The compound comprises matrine, oil phase, water and surfactant. In a preferred embodiment, the oil is tween 80, an emulgator is ethyl oleate, and an emulgator assistant is absolute ethyl alcohol. The medicament content of soluble water aqua of matrine type alkaloid microemulsion is improved,the medicament effect is strengthened, the cost is saved and the medicament is more effectively to be absorbed by crops by forming matrine type alkaloid O/W microemulsion.

Methods are provided for purification of epothilone D and epothilone D analogs from epothilone producing cells such as, for example, Sorangium cellulosum and Myxococcus xanthus (recombinant). Epothilone can be purified from fermentation broth, for example by using resins, chromatography, and crystallization. Epothilone D can be crystallized from a binary solvent system in which water is the forcing solvent.

The invention discloses a method for epoxidating methyl oleate, which comprises the following steps of: adding the methyl oleate into a reactor, adding a catalyst and an organic solvent, heating the mixture to the required reaction temperature of 50 to 70 DEG C, keeping constant the temperature, adding dropwise hydrogen peroxide with the concentration of 30 weight percent according to the mass ratio of the hydrogen peroxide to the methyl oleate of 1-2:1 in a way of ensuring that the dropwise addition of the hydrogen peroxide is finished within 2 to 2.5 hours, and continuing to preserve the heat for 2 to 6 hours after the dropwise addition is finished, wherein the mass ratio of the organic solvent to the methyl oleate is 2.0-5.0:1, and the mass ratio of the catalyst to the methyl oleate is 5-25:1,000; standing the reacted mixed solution in an environment of 5 to 10 DEG C for 3 to 5 hours to slowly separate the catalyst out and filtering the mixed solution to remove the catalyst; and standing and demixing filtrate, and distilling an organic layer under reduced pressure to remove the organic solvent to obtain the product epoxy methyl oleate. The method has the advantages of easy post-treatment, no environmental pollution, and high percent conversion and selectivity.

The invention discloses a rubber material for a wind power generation cable sheath. The rubber material is prepared from the following raw materials in parts by weight: 50-70 parts of chloroprene rubber, 10-18 parts of butadiene rubber, 20-32 parts of natural rubber, 15-20 parts of organic modified montmorillonite, 1-1.5 parts of magnesium oxide, 0.8-1.3 parts of zinc oxide, 1.5-2.8 parts of dicumyl peroxide, 0.3-0.8 part of triallyl polyisocyanurate, 1-3 parts of diisobutyl adipate, 0.8-2.2 parts of ethyl oleate, 5-8 parts of hazelnut oil, 1.2-1.6 parts of stearic acid, 20-35 parts of carbon black, 10-15 parts of carbon black purple, 1.0-1.5 parts of N-cyclohexyl-2-benzothiazole sulfonamide, 0.5-1.6 parts of tetramethyl thiuram disulfide, 1.8-2.2 parts of N-isopropyl-N'-phenyl p-phenylenediamine and 0.4-0.8 part of N-phenyl-2-naphthylamine. The organic modified montmorillonite is prepared by the following steps: adding sodium-based montmorillonite into water, stirring and standing and taking supernate; and after heating the supernate, adding octadecyl trimethyl ammonium chloride, carrying out ultrasonic treatment for 60-80 minutes, and after stirring, filtering and washing. The rubber material for the wind power generation cable sheath, which is disclosed by the invention, has low-temperature resistance and high elasticity and the flame retardance is further improved.

The invention relates to a dairy product, in particular to a manufacture method of 1, 3-bi-oleic acid-2-palmitic acid triglyceride. The manufacture method mainly solves the technical problems that if normal hexane is used as a solvent in manufacture in the prior art, product quality is affect, the normal hexane is not suitable for infant products, and production capacity is reduced; and if monoglyceride is used alone to be in reaction with oleic acid so as to generate OPO, production procedures are increased, production cost is high and the like. According to the manufacture method of the 1, 3-bi-oleic acid-2-palmitic acid triglyceride, solid super acid is used as a catalyst, and glycerol and palmitic acid undergo esterification reaction so as to generate tri-palmitic acid glyceride. Immobilization positioning lipase is used as a catalyst, the manufactured tri-palmitic acid glyceride undergoes ester exchange with one of oleic acid, methyl oleate, and ethyl oleate, and the 1, 3-bi-oleic acid-2-palmitic acid triglyceride is manufactured.

The invention discloses a high epoxide number environment-friendly plasticizer production process. The production process comprises the following steps of: adding cottonseed oil, methanol and sodium methoxide into an ester exchange reactor for reaction to obtain mixed fatty acid methyl ester; adding into a rectifying tower for separation, and performing epoxidation, neutralization, washing and dehydration on methyl oleate obtained from the tower bottom to obtain a high epoxide number environment-friendly plasticizer; and performing sulfonation reaction on palmitic acid methyl ester obtained from the tower top and sulfur trioxide, and ageing, esterifying, neutralizing and drying to obtain an environment-friendly surfactant MES. By the production process, the raw materials are readily available, the process is advanced, equipment is simple, the high epoxide number plasticizer can be prepared, and the byproduct, namely the palmitic acid methyl ester can be used for producing the environment-friendly surfactant.

The invention relates to a gas chromatography method for qualitatively and quantitatively detecting soya fatty acid components. The gas chromatography method is characterized in that fatty acids in soya seeds are extracted by adopting methods of heating and methylating and detected by adopting a gas chromatography, and the actual content of the fatty acid components in the soya seeds can be accurately detected according to a standard curve and a regression equation of standard samples of five fatty acid methyl esters (methyl palmitate, methyl stearate, methyl oleate, methyl linoleate and methyl linolenate). The method is applicable to qualitative and quantitative analysis of the fatty acid components of the soya seeds, is simple and convenient to operate, easy to control and easy to popularize, can be used for detecting relative percentage content of the five fatty acid components and accurately calculating the absolute content of each fatty acid component in the soya seeds, and has an important meaning in soya fatty acid detecting and breeding.

The invention discloses a method for synthesizing methyl oleate. The method is characterized by comprising the following steps: carrying out an esterification reaction between oleic acid and methanol in the presence of an H2SO4/SiO2 immobilized catalyst, filtering the reaction solution, and purifying the filtrate through column chromatography to obtain colorless transparent oily liquid methyl oleate, wherein the molar ratio of oleic acid to methanol is 1: (1.5-5); and the molar ratio of the catalyst to oleic acid is 1: (10-50). Compared with the prior art, the method has the advantages that the method is simple in process, convenient to operate, low in production cost, high in yield and mild in reaction conditions, the consumption of raw materials is further reduced, the yield can be improved to be over 90 percent, and the production cost is obviously reduced; and moreover, the catalyst is simple in after-treatment and slight in pollution and can be recycled, and the method is a methyl oleate synthesizing method which is environment-friendly, economic and high-efficiency and has a good application prospect.

The invention provides a weed killer containing moxa leaf extract and application thereof in saline-alkali soil sugarbeet planting. The weed killer comprises the following raw material components in parts by weight: 5-9 parts of clopyralid, 6.4-7.8 parts of moxa leaf extract, 2.3-5.5 parts of phosethyl-al, 1.2-2.6 parts of sophocarpidine, 1-2 parts of ethyl oleate, 3-4 parts of camphor, 8-10 parts of adhesive and 19-22 parts of solid carrier; the adhesive is triphenylmethyl ethylphenol polyoxyethylene ether; and the solid carrier is tapioca flour. In the application of the weed killer in saline-alkali soil sugarbeet planting, the control effect of green bristlegrass is 99.5% to 100%, the control effect of Chenopodium glaucum is 98.8% to 99.6%, the control effect of Siberian cocklebur is 99.5% to 100%, the control effect of nightshade is 98.5% to 99.2%, and the control effect of wormwood is 97.4% to 98.6%.

The invention discloses an Artesunate nanoemulsion drug that is an O/W (oil-in-water type) nanoemulsion system consisting of ethyl oleate, Tween-80, normal butanol, ultrapure water and Artesunate. The nanoemulsion drug effectively overcomes the first-pass effect of traditional tablets in liver, causes no sense of pain in injection and greatly improves the insecticidal and helminthic effect of original Artesunate. Meanwhile, the nanoemulsion system has high drug-loading rate, is stable when stored, has certain slow release function compared with merchant Artesunate injection, and further is convenient for administration, thus greatly improving the bioavailability. Besides, shown by acute toxicity tests and clinical drug effect tests on mice, the nanoemulsion has no obvious toxic or side effect and is a safe, reliable and high-efficiency nano level antiparasitic drug.

The invention discloses a C18 series fatty acid and C20-C22 series fatty acid fine separation method. The method includes: pretreating the raw material animal and vegetable oil by a ionic liquid to obtain high-yield and low-acid value biodiesel, i.e. a mixture of a variety of fatty acid methyl esters, with the process being simple, green and environment-friendly; then placing the obtained biodiesel in a pressured reduced rectification tower kettle, taking the ionic liquid as an extraction agent to conduct extraction pressured reduced rectification, and collecting methyl stearate, methyl oleate and methyl linoleate or eicosapentaenoic acid methyl ester and docosahexaenoic acid methyl ester with mass percentage purity of over 98% at the tower top. The method provided by the invention makes up the blank of the prior art, has a convenient operation process, provides the operation process for separation of long-chain fatty-acid methyl esters with a same carbon number, different double-bond numbers and poor heat sensitivity, and lays the foundation for fine separation of fatty acid methyl ester.

A stable carbon deposit-removing gasoline additive is prepared from the following raw materials in parts by weight: 8-14 parts of polyoxyethylene sorbitan monooleate, 3-9 parts of ethyl oleate, 5-10 parts of isopropanol, 4-9 parts of fatty alcohol polyoxyethylene ether, 4-10 parts of cyclohexane acid glycerol ester, 1-5 parts of oleic acid, 3-9 parts of vegetable oil, 1-6 parts of isobutanol, 2-6 parts of naphtha, 1-6 parts of Tween 80, 3-10 parts of trichloroethane, 6-10 parts of m-methyl benzoic acid, 1-5 parts of trichloroacetic acid, 3-5 parts of ethanol, 6-11 parts of a camphor extracting solution and 5-10 parts of glycerol monostearate. The stable carbon deposit-removing gasoline additive has the benefits as follows: the stable carbon deposit-removing gasoline additive can reduce emission and reduce environment pollution, has a very good cleaning and carbon-removing effect, and can protect an engine well.

The invention discloses a method for preparing a Sarah rhzomorph nano emulsion medicine composition and a formula. The preparation is an O/W (oil-in-water type) nano emulsion system which consists of ethylis oleas, Tween-80, n-butyl alcohol, ultrapure water and Sarah rhzomorph; the nano emulsion system has high medicine loading quantity (more than 11 percent); the medicine can be diluted by injection water or normal saline according to any rate in accordance with the clinical practical requirements; and the medicine is stably placed, so that the bioavailability of the medicine is greatly improved, the high dosage of the traditional transdermal medicine is effectively overcome; the insecticidal insect repellent function on the Sarah rhzomorph is greatly improved; and the clinical dosage of the Sarah rhzomorph is reduced to an extreme limit. The content of 1 percent of the preparation auxiliary materials (ethylis oleas, Tween-80, n-butyl alcohol and the like) is reduced to 4.1 percent on year-on-year basis; the content of 1 millesimal of the preparation auxiliary materials is reduced to 4.1 millesimal; the external properties are the same as those of true solution; compared with the transdermal preparation, the clinical dosage of the Sarah rhzomorph is reduced from 6mg/kg to 0.2mg/kg, and the curative effect is same; and therefore, at the present of deficiency of raw material medicines, the Sarah rhzomorph nano emulsion medicine is successfully researched, so that the dosage quantity is reduced, the dosage cost of a livestock master is reduced, the damage of the medicines to environment and public hygiene is greatly reduced; and in addition, according to an acute toxicity test and clinical pharmacodynamic test on mice, the nano emulsion medicine is free of toxic and side effects, so that the nano-level anti-parasitic medicine is safe, reliable and effective.

The invention provides a bonding agent for starch-based corrugated paper and a preparation method thereof. The preparation method comprises the following steps: (1) preparing 8 to 12 percent sodium hydroxide and a 20 to 30 percent hydrogen peroxide solution, and performing ultrasonic oscillation to mix uniformly; (2) placing potato starch into a clean and dry reaction vessel, adding water, and stirring for 10 to 15 minutes at a speed of 80 to 160 revolution/minute until uniform mixing; (3) adding ferrous sulfate and the hydrogen peroxide solution, stirring for reacting for 10 to 20 minutes, adding the sodium hydroxide solution while stirring, and stirring and pasting until the shape of the solution does not change any more; (4) adding sodium borate and tributyl phosphate, and stirring continually for 20 to 30 minutes; (5) adding modified urea resin, ethylis oleas, ammonium oxide, modified konjac glucomannan, modified carrageenan and a preservative, and uniformly mixing to obtain the bonding agent. The bonding agent for the starch-based corrugated paper has very high viscosity and water resistance.

The invention discloses nanometer emulsion capable of promoting hair growth and a preparation method of the nanometer emulsion capable of promoting hair growth. The nanometer emulsion capable of promoting hair growth comprises a hair growth promoting compound consisting of a pyrrolidinyl diaminopyrimidine oxide and baicalin, and a nanometer compound which consists of polyoxyethylene castor oil, lecithin, ethyl oleate, glutathione and ethanol and of which the particle diameter is 10-133m, wherein the mass ratio of the pyrrolidinyl diaminopyrimidine oxide to the baicalin is 5 to 2. The nanometercompound capable of promoting hair growth provided by the invention is an effective hair growth promoting substance consisting of the pyrrolidinyl diaminopyrimidine oxide and the baicalin, and can effectively promote hair growth; after the nanometer compound capable of promoting hair growth is prepared into the nanometer emulsion, the nanometer emulsion is low in irritants, good in stability andbetter in effects. The preparation technology is simple, and under low temperature and ordinary pressure, the nanometer compound having the effect of promoting hair growth can be prepared, is free from any toxic reagents, is green, efficient, short in cycle, high in yield and easy for popularization and mass production.