228 results about "Ethyl hexanoate" patented technology

The invention discloses a method for synthesizing ethyl caproate under the catalysis of yeast display lipase. The method comprises two steps, namely the production of full cellular zymin and the synthesis of ethyl caproate. The method comprises the following: a step of cloning the lipase gene into the Pichia yeast surface display vector pKFS to construct the Pichia yeast surface display expression vector pKFS-lipase which is transformed into the host bacteria of Pichia yeast through linearization, a yeast genetic engineering bacteria capable of displaying active pheron on the surface of the Pichia yeast being obtained through screening, and the engineering bacteria being fermented in a rocking bottle to obtain a thallus which is used to make the full cellular zymin after 24 hours of vacuum freeze drying; and then a step of adopting caproic acid and alcohol as raw material which is esterified at the action of the biocatalyst of yeast full cellular zymin with the lipase displayed on the surface to obtain the ethyl caproate product. The method is capable of collecting thalli centrifugally for reuse after the reaction with short reaction time, high yield and good operational stability, thereby greatly reducing production costs.

Low melting point organic liquid compounds with high boiling points are prepared by a preferred process having the J^+xQ_y(R—COO⁻)_x-y where x is 1 to 8, preferably 1-3, y is 0 to x−1, where R—COO⁻ is an anion selected from the group consisting of 2-ethyl hexanoate, pivalate, neodecanoate, and mixtures thereof, Q is another anion or mixture of other anions, and J^+x is a cation selected from cations of Groups IA, IIA, IB, IIB, IIIB, IVB, VB, VIB, VIIB, VIII and lanthanide metals, cations selected from cations of B, Si, Ge, As, Sb, Te and Po metalloids, an ammonium cation derived from ammonia or an organic amine, an organic phosphonium cation, and mixtures thereof the organic liquid compounds being substantially free of volatile organic compounds. These compounds, as liquids, are useful as low volatile organic solvents, e.g., solvents in which a variety of chemical reactions may be carried out.

The invention provides herbaceous plant nutritive water based on an emulsified microcapsule and a preparation method of the herbaceous plant nutritive water. The preparation method comprises the following specific steps: mixing hydrogenated vegetable oil, low erucic acid rapeseed oil , siloxane, microcrystalline wax and diglycerol, heating and uniformly stirring, and performing heat reservation and sterilization to obtain an oil phase; adding ethylene glycol, propylene glycol, glycine betaine, urea, poly-sodium glutamate, triethanolamine, caprylhydroxamic acid and hexylene glycol into deionized water, heating and uniformly stirring, performing heat preservation and sterilization to obtain a water phase; adding the oil phase into the water phase, performing heating, homogenization and low-speed stirring, adding cetyl ethyl hexanoate and stearic acid, then slowly adding PEG-40 hydrogenated castor oil and a microcapsule wall material, cooling, adding tremella, centella asiatica, polygonum cuspidatum, scutellaria baicalensis, tea leaves, glycyrrhiza glabra, female chrysanthemum, rosemary leaves, beer saccharomycete and grape fruit cell extract active components, and adding chondrus crispus extracts, bio-saccharide gum-1, diglycerol, palmitoyl tripeptide-1 and essence for mixing to obtain the herbaceous plant nutritive water based on the emulsified microcapsule.

A Feng-Luzhou-flavor composite liquor production process using the fermentation method adopts the production method of 'high-temperature starter-making, poly-grain brewing, and fermentation'. By adopting the new processes such as making starter from poly-grain at high temperature, cooling, adding the starter while stirring, reconstructing the conventional fermentation pit to prolong the fermentation cycle, poly-grain brewing and changing the storage method, the invention can make a Feng-Luzhou-flavor composite liquor, which is different from conventional Feng-type liquor and Luzhou-flavor liquor in sensory characteristics and is endowed with a mainly composite flavor of ethyl acetate and ethyl hexanoate. The liquor is aromatic, fragrant, dense, and harmonious in flavor, and is mellow, soft, sweet and unique in taste, thus radically solving the problem of product's homogenization.

The invention provides essence cream realizing repairing at night. The essence cream realizing repairing at night comprises allantoin, EDTA-2NA, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, hyaluronic acid, hydrogenated polyisobutene, cetyl ethyl hexanoate, glyceryl stearate/PEG-100 stearate, polydimethylsiloxane, C14-22 alcohol/C12-20 alkyl glucoside, shea butter oil, tocopherol acetate, polydimethylsiloxane/dimethiconol, methyl silanol mannuronic acid ester/sodium methyl hydroxybenzoate/sorbic acid/ propyl hydroxybenzoate, water/butanediol/1,2-hexanediol/beta-glucan/phenoxyethanol, water/phenoxyethanol/algae extract, nicotinamide, water/propylene glycol/flos buddlejae extract, and dipotassium glycyrrhizinate. The essence cream belongs to emulsified ointment essencewith the efficacies of repairing skin injuries and realizing the moisturizing effect. The essence cream system realizing repairing at night is stable, realizes permeation and absorption easily, is refreshing but not greasy, can effectively repair injuries caused to the skin by sunlight, can balance the skin color, can resist skin ageing, realizes effective moisturizing, and realizes regenerating and nursing at night.

An alcohol free or low alcohol fermented malt based beverage is disclosed. The malt based beverage has an alcohol content of not more than 1.0 vol. % preferably not more than 0.7 vol. % having an aroma profile close to the one of alcoholic lager beers. The beverage has 7.00-30.00 ppm ethyl acetate and 0.01-0.20 ppm ethyl butyrate. The beverage preferably has the esters 0.05-2.00 ppm isoamyl acetate; 0.01-0.10 ppm ethyl butyrate; and 0.01-0.05 ppm ethyl hexanoate. The beverage preferably has the higher alcohol 5.00-30.00 ppm (iso-)amyl alcohol. The (iso)amyl alcohol is defined as the sum of 3-methyl butanol and 2-methyl butanol.

The invention relates to a reaction and steam osmotic dehydration coupled ethyl hexanoate synthesizing process and device and belongs to the technical field of pervaporation membrane separation application and organic compound synthesis. Hexanoic acid and ethyl ester inside a reaction still are heated to a certain reaction temperature, and then are subjected to reaction under the catalytic action of a catalyst to mainly generate ethyl hexanoate and water. Steam generated in the reaction still in the reaction process passes through a rectifying column and then is subjected to heat transfer and mass transfer with returned flow, ethyl alcohol and water are distilled off from the tower top of the rectifying column after transfer, the distillate serves as the dehydration raw material for the steam osmosis membrane, steam osmotic dehydration is conducted, and the dehydrated ethyl alcohol solution high in purity is cooled and returned to the reaction still. Under the condition of not introducing other water-carrying agents bad for the environment, water in the esterification reaction is continuously removed in the ethyl alcohol water carrying and dehydration process, the reaction is promoted to move toward the production of ester, the reaction conversion rate is increased, aftertreatment of water-carrying agents and environmental pollution are avoided, and the production cost is reduced.

The invention discloses a formula of moisturizing milk. The formula comprises following ingredients: glycerin, 1,3-butanediol, cetyl ethyl hexanoate, caprylic/capric triglyceride, one or combination of cetearyl olivate and sorbitan olivate, polydimethyl siloxane, one or more combination of cetyl palmitate, sorbitan olivate and sorbitan palmitate, polyvinyl pyrrolidone, preservative, polyquaternium-10, carbomer, triethanolamine, xanthan gum, hyaluronic acid, EDTA-2Na and the balance being water. The moisturizing milk provided by the invention is good in thickness and sticky feeling; and by using the moisturizing milk, a breathable membrane can be formed on the skin surface, a moisturizing effect is obvious, and the moisture retention is still as before after 8 hours.

The invention belongs to the field of chemical industry for daily use and particularly relates to a factory formula and technology of a pineapple essence. The formula is composed of following raw materials with mass ratios: methyl caprylate 1-5, ethylene glycol 0.5-1, ethyl acetate 10-25, ethyl butyrate 10-30, ethyl hexanoate 4-9, furanone (pineapple ketone) 5-12, maltol 1-6, ethanol 60-85 and water 35. The raw materials after being dissolved in ethanol, reacted and solidified are cleaned to produce the pineapple essence. The pineapple essence produced by using the formula has the advantages of good natural taste, low cost, safety and hygiene.

The invention provides blueberry essence for cigarette paper. The blueberry essence is prepared from, by weight, 1-2 parts of blueberry essence and 8-9 parts of blueberry extract, the blueberry essence is prepared by mixing, by mass, 1%-2% of beta-ionone, 1%-2% of alpha-ionone, 5%-10% of hexadecanal, 10%-15% of heliotropin, 3%-5% of ethyl cinnamate, 8%-10% of ethyl butyrate, 8%-10% of benzyl acetate, 3%-5% of sweet orange oil, 1%-3% of amyl acetate, 1%-2% of ethyl hexanoate, 1%-2% of ethyl oenanthate, 1%-3% of citric acid, 3%-5% of ethyl vanillin and 26%-54% of 95% ethyl alcohol. The blueberry extract is extracted through a supercritical extraction process and has aroma components and natural anthocyanin of blueberries. The blueberry essence is added into the cigarette paper, so that cigarettes have obvious blueberry fragrance and meanwhile have the distinctive blue of the blueberries.

The invention discloses an aspergillus niger strain of a complex enzyme for liquor making, and belongs to the technical field of fermentation. The aspergillus niger strain is collected in China general microbiological culture collection center in July 9, 2015, and the collection number is CGMCC No.11064. Through culture medium optimization, a crude enzyme fluid obtained after 48 hours of solid fermentation contains various enzymes, wherein esterifying enzyme activity is 615.8mg.100mL<-1>, saccharifying enzyme activity is 7828.9U.g<-1>, and cellulase activity is 106.68U.g<-1>. Distilled liquid of esterified liquid obtained through enzymatic synthesis of esterifying enzymes generated from the strain has a typically rich and pure aroma of Luzhou-flavor liquor, and the content of ethyl hexanoate reaches 82.04% of the total flavor component. By the enzymes of the complex enzyme, utilization rate of starch-type substances in liquor-making raw materials, liquor yield and the content of esters in liquor bodies can be increased, liquor body flavors can be improved, high-quality liquor rate can be increased, and development of the liquor making industry can be promoted.

The invention relates to a rocking thickening double-layer cleansing lotion and a preparation method thereof, and is characterized in that the cleansing lotion is composed of an aqueous phase liquid and an oil phase liquid with the mass ratio of (1-15):3, the aqueous phase liquid includes purified water and a water-soluble moisturizer, and the oil phase liquid is composed of a surfactant composition and grease according to the mass ratio of 1:(1-5); the surfactant composition is composed of polyglyceryl-3-diisostearate, polyglyceryl-3-caprate and polyglyceryl-10-diisostearate with the mass ratio of 1 to 3 to 4 or is composed of PEG-40 hydrogenated castor oil and oleth-10 with the mass ratio of 1 to 3; the grease is one of butylene glycol dicaprylate/dicaprate, cetyl ethyl hexanoate, triethylhexanoin, coco-caprylate/caprate or a mixture thereof. The cleansing lotion has the advantages of high viscosity in a homogeneous state and has no dropping liquid phenomenon when in use.

The invention discloses essence of pickled Chinese cabbage and a preparation method and an application thereof. The method comprises the following steps: first, adding 60wt% of edible vegetable oil or glycerol triacetate as a solvent, heating to 60 DEG C, adding 4-hydroxyl-2, 5-dimethyl-3(2H) furanone, acetyl pyrazine, stirring till the components are completely dissolved, and cooling to below 30 DEG C; then, sequentially adding ethyl acetate, ethyl hexanoate, ethyl lactate, butyl caproate, 2-methyl butyric acid hexylester, phenethyl acetate, trans-2-heptenal, phenethyl alcohol, p-ethyl phenol, dimethyl disulfide, acetic acid, propionic acid, butyric acid, 2-methyl butyric acid, garlic oil or galic essential oil, fennel oil or fennel oil resin, ginger oil or ginger essential oil or distilled ginger oil and a pepper extract or pepper essential oil or pepper oil resin; and adding 40wt% of residual edible vegetable oil or glycerol triacetate, uniformly stirring and filling to obtain the essence. The essence of of pickled Chinese cabbage produced by the invention is vivid in frangrance compared with that of common fermented flavor essence, stable in quality, good in temperature resistance and unique in flavor.

An improved process for the preparation of ceftriaxone sodium comprising the steps of:

i) reacting the 3-cephem derivative of formula (II)

 with halo acid derivative of formula (III)

 wherein X represents halogen and Y represent halogen in the presence of silylating agent and methylene chloride at −25 to 10° C., to produce (IV),

ii) quenching the reaction by pouring the reaction mixture into water or in a aqueous solution of sodium carbonate, iii) preparing sodium salt solution of (IV) by adding sodium carbonate and separating the organic layer, iv) cyclizing the sodium salt of (IV) in the aqueous solution with thiourea at a temperature in the range of 0 to 30° C., v) adjusting the pH to 1.5 to 2.5 to precipitate the ceftriaxone free acid, vi) converting the ceftriaxone free acid to sodium salt using sodium-2-ethyl hexanoate in water and vii) precipitating and isolating the ceftriaxone sodium.

The invention relates to the technical field of makeup-removing products, and discloses a nano micro-emulsified makeup-removing lotion and a preparation method thereof. The micro-emulsified makeup-removing lotion comprises the following raw material components in percentage by weight: 5.0% to 10.0% of triglyceride; 3.0%-5.0% of olive fruit oil; 4.0%-8.0% of cetyl alcohol ethyl hexanoate; 15.0%-20.0% of a micro-emulsifier; 15.0%-23.0% of glycerol; 10.0% to 15.0% of butanediol; 3.0%-6.0% of a skin cleaning agent; 0.05%-0.15% of tocopheryl acetate; 0.01%-0.05% of sodium hyaluronate, 0.3%-0.45% ofa preservative, 0.10%-0.20% of ethylhexylglycerin, 0.20%-0.5% of caprylyl glycol, 0.01%-0.05% of citric acid, 0.02%-0.1% of sodium citrate, 0.05%-0.10% of essence and the balance deionized water. According to the makeup-removing lotion, oil dirt and pigment including waterproof cosmetics are dissolved through the grease with the nanometer micro-particle size, the dissolved oil dirt is removed through carefully choosing mild cleaning components, the makeup-removing lotion is thorough in cleansing effect, free of residues, low in irritation and free of facial cleanser recleaning, meanwhile, themakeup-removing lotion has the effects of moisturizing and nourishing the skin, the preparation method is easy to implement, and large-scale mass preparation can be achieved.

The invention discloses a production method of soft sesame-flavor white wine with high ester yield, relating to the technical field of wine making. The production method comprises the following steps:raw material proportioning, raw material treatment, raw material cooking, distiller's yeast stirring, accumulation, cultivation saccharification, fermented grain saccharification and distillation, fermented grain fermentation, pit discharging, wine cooking and storage, blending and storage of finished wine and the like. By soaking grains with hot water and steaming the raw materials in clear soup, the water absorption and gelatinization of red grain starch can be promoted, and the grains can be easily and thoroughly cooked when being cooked, so that the generation of mellow sweet substances is promoted, meanwhile, the raw material flavor and foreign flavor produced in a mixed steaming process can be effectively eliminated, the wine can be relatively clean, and the purity and cleanness ofthe wine can be improved; and compared with sesame-flavor white wine produced by virtue of prior art, the gentleness, softness and comfort are remarkably improved. Compared with the prior art, production method has the advantages that the high-quality wine rate is increased by 25%, the content of ethyl hexanoate is increased by 2-5 times, the richness and mellowness of the sesame-flavor white wineare increased, and a wine body is fine and plump and has obvious perception characters and special individuality.

The invention belongs to the field of asymmetrically preparing chiral medicine intermediates in a biocatalysis method, and particularly relates to a method for preparing 3R, 5S-dyhydroxy-6-benzyloxy-ethyl hexanoate with single optical purity via reduction by taking 3, 5- dicarbonyl-6-benzyloxy-ethyl hexanoate as a substrate and taking double carbonyl reductase as a biocatalyst. The method comprises the following steps: (1) adding the substrate, the double carbonyl reductase and a coenzyme cyclic regeneration system mediated by formate dehydrogenase in a reaction liquid, and oscillating for reaction for at least 1 hour, wherein the reaction liquid is the mixed solution of an organic solvent and a buffer solution; and (2) separating and purifying the product obtained in step (1) to obtain a single optical isomer 3R, 5S- dihydroxyl compound. The invention adopts the double carbonyl reductase and is simultaneously combined with the nonaqueous phase solvent system and the coenzyme regeneration system to synthesize the 3R, 5S-dyhydroxy-6-benzyloxy-ethyl hexanoate via catalysis, the optical purity ee and de values are both larger than 99.5%, the concentration of the substrate reaches 150g/L, and the method has wide practical value.

The invention discloses essence with natural pear extraction components. The essence mainly comprises the components such as propylene glycol, alcohol, ethyl acetate, butanol, ethyl propionate, butyl acetate, 2-methyl ethyl butyrate, leaf alcohol, hexyl alcohol, isoamyl acetate, ethyl hexanoate, hexyl acetate, anti-2-hexene aldehyde and natural pear extracted liquid, wherein the natural pear extracted liquid is taken as the main component. Compared with other pear essence, the essence with natural pear extraction components is more tender in mouthfeel, is more vivid and natural in fragrance and aroma, and has no unpleasant chemical smell of other essences, has fresh flavor of natural pear, is used for enhancing flavor of final products of food, beverages and the like as a food additive, and endows the mouthfeel of natural and fresh pears on these products.

The invention provides a formula of Baijiu composite blending and flavoring liquid and relates to the technical field of production of Baijiu. The formula comprises the following components in parts by weight: 26 to 30 parts of ethyl hexanoate, 14 to 18 parts of ethyl lactate, 0.6 to 1 part of ethyl formate, 12 to 16 parts of ethyl acetate, 0.1 to 0.3 part of ethyl propionate, 2.5 to 2.9 parts ofethyl butyrate, 0.6 to 0.8 part of ethyl valerate, 3 to 4 parts of hexanoic acid, 5 to 6 parts of lactic acid, 0.2 to 0.4 part of formic acid, 10 to 11 parts of acetic acid, 0.05 to 0.15 part of propionic acid, 1 to 3 parts of butyric acid, 0.1 to 0.3 part of pentanoic acid, 0.5 to 1.5 parts of normal propyl alcohol, 0.2 to 0.4 part of normal butanol, 0.5 to 0.7 part of isobutanol, 0.15 to 0.2 part of sec-butyl alcohol, 2.5 to 3.5 parts of isoamylol, 0.1 to 0.15 part of hexyl alcohol, 4 to 6 parts of acetaldehyde, 4 to 6 parts of acetal, 0.1 to 0.3 part of 2,3-butanedione and 0.05 to 0.15 partof 3-hydroxy-2-butanone. The Baijiu with various flavors such as strong flavor, faint scent, soy sauce flavor and all flavors can be prepared by the flavoring liquid and is suitable for different groups of users.

The invention discloses a pigment dispersing agent prepared by the amphiphilic precipitated silica and relates to the technical field of precipitated silica. The pigment dispersing agent is prepared from the following raw materials in parts by weight: 15-20 parts of amphiphilic precipitated silica, 10-15 parts of isopropyl alcohol, 6-11 parts of cetyl ethyl hexanoate, 5-9 parts of terpene resin, 5-9 parts of polyvinylpyrrolidone, 4-7 parts of hydrogenated castor oil, 3-6 parts of microcrystalline wax, 3-6 parts of polyethylene glycol 400, 2-4 parts of sodium cocoanutylglutamate, 2-4 parts of sodium polyacrylate, 2-4 parts of turpentine oil, 1-2 parts of isooctyl oleate, 1-2 parts of coupling agent of organic titanate, 0.5-1 part of nano gelatine powders, 0.5-1 part of urea, and 0.5-1 part of sulfurized lard oil. According to the invention, by means of the pigment dispersing agent, the pigment is uniformly dispersed in a binder, so that the particles of the pigment are uniformly suspended in the binder for a long time. Therefore, during the storage process of a colored paint, the pigment flocculation phenomenon is avoided. Moreover, the fluidity and the thermal stability of the colored paint are improved, so that the storage quality and the painting effect of the colored paint can be ensured.

The invention relates to strawberry essence for oil-based ink. The strawberry essence consists of strawberry essence, maltodextrin and starch sodium octenylsuccinate, wherein the strawberry essence consists of ethyl acetate, isoamyl acetate, ethyl caproate, ethyl butyrate, allyl hexanoate, leaf alcohol, cis-3-hexenyl acetate, decalactone, peach aldehyde, ethyl benzoate, geranyl acetate, citronellyl acetate, dihydrojasmonic acid methyl ester, hexyl salicylate, linalool oxide, trans-2-hexenol, eugenol, cinnamyl alcohol, cinnamyl acetate, beta-Ionone, vanillin, methyl cyclopentenolone, furanone, raspberry ketone, ethyl methylphenylglycidate, ethyl palmitate, benzyl benzoate and glycerol triacetate. The invention also provides a preparation method of the strawberry essence for the oil-based ink. The strawberry essence, the maltodextrin, the starch sodium octenylsuccinate and water are mixed; homogenizing and emulsification are performed; then, spray drying is carried out; particular strawberry essence is formed, so that the aroma retaining effect and the oil solubility of the essence are improved; the strawberry essence is applicable to perfuming of the oil-based ink.

The invention provides moisturizer suitable for being used on oily skin. The moisturizer comprises, by weight, 10-35% of emollient, 3-10% of emulsion stabilizer, 1-3% of moisture preserving agent, 0.1-2% of thickening agent, 0.5-5% of natural lignocellulose powder with mesh number ranging from 115 to 1340 and the balance deionized water; the emollient comprises one or more constituents from isooctyl palmitate, caprylic/capric triglycerides, isopropyl stearate, isopropyl isostearate, dodecanoic acid ethylhexyl ester, cetearyl ethyl hexanoate, isononyl isononyl ester, squalane, polydimethylsiloxane, phenyl trimethicone or cyclopentasiloxane; the emulsion stabilizer comprises one or more constituents from fatty alcohol-polyoxyethylene ether, methyl glucoside sesqui-stearate, stearate polyoxyethylene ester, glycerin monostearate, polysorbate, cetearyl alcohol or cetyl alcohol. By means of the moisturizer, the oily skin can be moistened deeply, and the fresh, cool, lubrication and skin-friendly feeling can be brought to a user. The invention further provides a preparation method of the moisturizer.

The invention provides a saccharomyces cerevisiae engineering bacterium for highly yielding medium-chain fatty acid ethyl ester. The saccharomyces cerevisiae engineering bacterium is realized by selecting a strong promoter PGK1 (Phosphoglycerate kinase 1) for overexpression coding of an EHT1 (Ethanol Hexanoyl Transferase 1) gene of alcohol acyltransferase and knocking out a gene FFA1 (Free Fatty Acid Receptor 1) of an exogenous fatty acid activating enzyme. The preservation number is CGMCC (China General Microbiological Culture Collection Center) No.7937. Under the condition that other fermenting properties are not affected, compared with a parent bacterial strain, the content of ethyl hexanoate can be improved to 2.23mg/L after simulating fermentation of corn raw material liquid white spirit for 15 days, wherein the content is 2.75 times the original bacteria. The contents of ethyl caprylate and ethyl caprate are respectively improved by 52% and 62%. After fermentation for 30 days, the contents of ethyl hexanoate, ethyl caprylate and ethyl caprate are respectively improved by 120%, 16.2% and 16.7%. After simulating fermentation of corn raw material liquid white spirit for 15 days, the content of ethyl hexanoate can be improved to 2.83mg/L which is 2.8 times the original bacteria, and the contents of ethyl caprylate and ethyl caprate are respectively improved by 43.3% and 40.9%.

The invention discloses a long-acting makeup-maintaining moistening repair emulsified lipstick and a preparation method thereof. The lipstick comprises the following components: polyglycerol-2-diisopstearate, cetyl ethyl hexanoate, ethylhexyl palmitate, hydrogenated castor oil dimer linoleate, a hippophae rhamnoides extract, a hibiscus mutabilis extract, a centella extract, a polygonum cuspidatumroot extract, a scutellaria baicalensis root extract, a glycyrrhiza glabra root extract, a chamomilla recutita flower extract, a rosmarinus officinalis leaf extract and the like. A used formula systemis different from a conventional method. A conventional lipstick is prepared by mixing oil, grease, wax, toner and the like, and a water system is not contained, so many low-water-activity matters cannot be added to a product. The conventional method is broken by using a combination technology related to raw materials of the oil, the grease, the wax, the toner, an emulgator, a water activity matter and the like. The makeup-lasting, waterproof, oil-proof and difficult makeup-removing effects are realized, and multiple functions of moistening, moisturizing, and repairing and the like are integrated. The preparation method thereof is capable of realizing large-scale production.