158 results about "Streptomyces" patented technology

The invention discloses preparation of a trichoderma composite flora and application of the trichoderma composite flora in prevention and control of crop fusarium wilt and improvement of soil, and relates to the field of agricultural production, and the composite flora is prepared by mixing trichoderma asperellum (5 * 10 < 7 > CFU / L), streptomyces (108 CFU / L), Chinese monospora (108 CFU / L), ensifer adhesion (108 CFU / L), pseudomonas nitroreducens (108 CFU / L) and paenibacillus alvei (108 CFU / L) according to the volume ratio of 6: 1: 1: 1: 1: 1: 1: 1 (V: V). According to the composite flora in the scheme, the composite flora is used for promoting growth of cucumber plants, and compared with a clear water control group (Foc), the fresh weight of cucumbers is increased by 55.51%, the stem diameter is increased by 12.76%, and the plant height is increased by 34.25%. The composite flora can also effectively prevent and treat fusarium wilt of cucumbers, and the prevention and treatment effect reaches 71.43%. Compared with the Trichoderma asperellum FJ035 treated group, the Trichoderma asperellum FJ035 has the advantages that the Trichoderma asperellum FJ035 is better than the Trichoderma asperellum FJ035 which is independently applied in the aspects of promoting the growth of cucumber plants and preventing and treating cucumber fusarium wilt, and compared with the Trichoderma asperellum FJ035 treated group, the control effect is improved by 56.25%. Meanwhile, the composite flora can be used for improving soil and preventing and treating multi-crop fusarium wilt.

The invention discloses talaromyces purpurogenum as well as a fermented supernatant and application thereof. The preservation number of the talaromyces purpureogenus F-4 is CCTCC NO: M 20252023, and the talaromyces purpureogenus F-4 has the growth promoting effects of dissolving phosphorus, fixing nitrogen and generating siderophores, also has the disease preventing and treating effects of preventing and treating garlic root rot, potato scab and wheat stem rot, and also can resist salt stress, alkali stress, salt-alkali composite stress, heavy metal stress and osmotic pressure stress. The fermentation supernatant of the talaromyces purpureus F-4 can be used for inhibiting the growth of fusarium solani spores, streptomyces botrytis spores and fusarium pseudograminearum and the germination of the spores of the fusarium solani, the streptomyces botrytis and the fusarium pseudograminearum. The talaromyces purpurogenus and the fermented supernatant thereof can effectively control the growth and reproduction of plant pathogens, reduce the risk of disease occurrence, reduce the dependence on chemical pesticides, and reduce the risk of environmental pollution and agricultural product residues, and have important significance for promoting the sustainable development of agriculture.

The invention discloses streptomyces griseorubens and an application of the streptomyces griseorubens in phthalate pollution remediation. The bacterial strain is Streptomyces griseorubens FZ202, the preservation number of the bacterial strain is GDMCC No: 61372, the bacterial strain has good environmental adaptability and efficient degradation capacity, DEHP can be effectively degraded within 100-800 mg / L, the highest degradation efficiency can reach 94.1%, and complete degradation can be achieved. The strain is inoculated into PAEs contaminated soil and interacts with rice, DEHP residues in the soil and crop bodies can be effectively reduced, various PAEs can be synergistically degraded, and the strain has the broad-spectrum degradation characteristic. Meanwhile, through multiple mechanisms of degrading pollutants, promoting plant growth, improving the soil environment and regulating and controlling microbial communities, the strain remarkably improves the growth performance of rice and the self-cleaning capacity of soil, and has a wide agricultural application prospect.

The invention discloses a growth-promoting rhizosphere bacterium streptomyces cerevisiae QS9-7 and application thereof, and belongs to the technical field of microorganisms. According to the invention, a strain of Streptomyces setonii QS9-7 is obtained through separation, and the preservation number of the Streptomyces setonii QS9-7 is CGMCC (China General Microbiological Culture Collection Center) No.32329. Experiments show that the strain QS9-7 has a relatively strong inhibition effect on various plant pathogens, and shows excellent biocontrol bacterium potential. The strain can effectively improve radicle length, germ length, lateral root number and germination rate of plant seeds and plant height and stem diameter of plant seedlings, obviously promotes plant growth, and has high application value in green prevention and control of plant diseases.

The invention discloses a special microbial fertilizer for cotton and a preparation method thereof, and belongs to the technical field of microbial fertilizers. The fertilizer is prepared from the following raw materials in parts by weight: 40-60 parts of a microbial agent, 80-100 parts of a microbial agent carrier, 40-60 parts of a nitrogen fertilizer, 30-50 parts of a phosphate fertilizer, 20-30 parts of a potassium fertilizer and 10-20 parts of a stabilizer, the microbial agent is prepared from nitrogen-fixing paenibacillus mucilaginosus MSSW01, bacillus nissi and streptomyces widermomole, and the microbial agent is prepared from bacillus mucilaginosus MSSW01 and streptomyces widermomole. The stabilizer is prepared from roxburgh rose extract, soybean protein isolate and gamma-aminobutyric acid according to the mass ratio of 2: 1: (0.2-0.5). By screening and optimizing three beneficial microbial strains and combining the synergistic effect of raw material components in a specific ratio, the yield and quality improvement of cotton can be remarkably promoted, and meanwhile, the occurrence rate of common diseases of cotton is effectively reduced.

The invention provides a plasmid, an alpha-ketoglutaric acid engineering strain and a construction method and application of the alpha-ketoglutaric acid engineering strain, the strain is obtained by adopting a directional transformation method, transcriptional levels of katE, katG, sodB and grxA genes are up-regulated, a catR gene and a katA gene are heterologously expressed, a high-copy plasmid pETKG is carried, and the plasmid simultaneously expresses L-glutamate oxidase LGOX genes from Streptomyces sp and Chain A; the strain self-synthesized catalase eliminates H2O2 generated in the process of producing alpha-ketoglutaric acid through enzyme catalysis, engineering bacteria of L-glutamate oxidase LGOX expressed by pETKG plasmids are used for performing whole-cell catalysis on L-sodium glutamate to synthesize alpha-ketoglutaric acid, and the engineering strain is a high-level engineering strain capable of industrially and stably producing alpha-ketoglutaric acid.

The invention relates to the technical field of agricultural biology, and discloses a microbial agent for preventing and treating fructus aurantii scab and a preparation method of the microbial agent. The microbial agent comprises the following raw materials in percentage by weight: 10-13% of paenibacillus mucilaginosus; 15%-20% of trichoderma sp. 7%-10% of paecilomyces lilacinus; 5%-8% of bacillus pumilus; 7%-9% of mycorrhizal fungi; 5%-8% of streptomyces; 5%-9% of a coptis chinensis extract; 4%-7% of a sophora flavescens extract; 2%-4% of realgar; 1%-3% of a rheum officinale extract; 10%-13% of soybean meal; 5%-8% of a water-soluble fertilizer; 7%-9% of potassium fulvate; 1%-3% of chitosan; 0.5%-1% of trace elements; 3%-8% of humic acid; the raw materials are subjected to microbial flora amplification culture, plant antibacterial component light-shielding mixing and low-temperature mixing to effectively protect the microbial activity of the microbial agent, and step-by-step operation can avoid damage of high temperature and mechanical shearing to microorganisms, so that the microbial activity of the microbial agent is effectively protected. And the loss of microbial active ingredients is reduced by vacuum drying and low-temperature granulation processes.

The present invention relates to a composition comprising components (A) and (B) as active ingredients, wherein component (A) comprises a Streptomyces and component (B) is a compound selected from the group consisting of sulphur, phosphonate, copper hydroxide, copper oxychloride, bicarbonate, Bacillus sp, Trichoderma sp, aureobasidin A, jawsamycin, kasugamycin, natamycin, a polysaccharide elicitor, a plant biostimulant (PBS) comprising an algal extract, a plant extract and / or vinasse, orange oil, and / or tea tree oil. The invention further relates to a method of controlling or preventing phytopathogenic diseases, preferably phytopathogenic fungi, on a plant or on plant propagation material and / or on harvested food crops, which comprises applying to the plant, on plant propagation material, the locus thereof, and / or on harvested food crops the composition according to the present invention.

The invention provides a dynamic control system for coordinating streptomyces secondary metabolite production and application of the dynamic control system. Firstly, a general artificial promoter PQS (trigger) responding to a quorum sensing system of various streptomycetes is designed, then a stabilizer is constructed based on a bistable gene circuit, instantaneous signal output is converted into stable signal output, dependence of an inducer is successfully eliminated, finally, an orthogonal amplifier is developed based on a streptomycete rare extracellular function sigma factor, and finally, the specific function of the quorum sensing system of various streptomycetes is achieved. And different promoter element libraries containing amplifiers with response from weak to strong and with strength span of about 535 times are constructed. An amplifier and a CRISPRi system are combined to construct a turner, and gene expression inhibition with the strength span of about 200 times is achieved. The combination of the amplifier, the promoter library and the turner is called a multi-effect device, and abundant elements are provided for fine target gene expression. The combination of the trigger, the stabilizer and the multiple-effect device is called as a streptomycete multipath manual control system (SMARTS), and control tools of streptomycete are enriched.

The invention discloses a microbial agent for increasing manure compost temperature and application thereof in high-temperature compost, and belongs to the field of agricultural solid waste treatment. The microbial agent for increasing the manure composting temperature comprises phanerochaete chrysosporium, bacillus stearothermophilus, penicillium oxalicum, streptomyces, common thermoactinomycetes and bacillus subtilis. The livestock padding manure high-temperature clean composting technology is established through adjustment and optimization, the purposes that the temperature of the padding manure is increased fast, the high-temperature period is long, the composting period is shortened, base materials are fully degraded are achieved, reference can be provided for resource utilization of livestock and poultry breeding solid waste, and important application value is achieved.

The invention discloses a polyketone compound derived from actinomycetes as well as a preparation method and application thereof, and relates to the technical field of microbial natural product mining and biological medicine, and the key point of the technical scheme is that the invention discloses a novel polyketone compound Strepactone derived from actinomycetes Streptomyces sp. DP0001, and the molecular formula of the novel polyketone compound Strepactone is C25H38O5. The compound is obtained through strain fermentation, ethyl acetate extraction and multi-step chromatographic purification, and the structure is identified through ESI-MS, 1H NMR and 13C NMR. Experiments show that Strepactone has an inhibition effect on staphylococcus aureus and methicillin-resistant staphylococcus aureus and has remarkable inhibition activity on human non-small cell lung cancer A549 cells, the half inhibitory concentration IC50 of the Strepactone is 5.36 mu M, and the Strepactone has no obvious cytotoxic activity on human embryo kidney cells 293T cells at the concentration of 30 mu M. The compound provided by the invention can be used for preparing anti-drug-resistant bacteria drugs and anti-human non-small cell lung cancer drugs, and also provides a structural basis for the development of novel antibacterial and anti-tumor leading drugs.

The invention discloses a strain of streptomyces angustifolius and application of the streptomyces angustifolius. The streptomyces angusticus disclosed by the invention is separated from banana rhizosphere soil, is named as a strain GD7-29, is preserved in the Guangdong Microbial Culture Collection Center on June 26, 2024, and has the preservation number of GDMCC No: 64803. The streptomyces angusticus disclosed by the invention has the advantages that the streptomyces angusticus is named as a strain GD7-29, and the preservation number is GDMCC No: 64803. The streptomyces narrow-mycin strain GD7-29 can effectively inhibit various plant pathogenic fungi including fusarium oxysporum, can promote plant growth, can be used for preventing and treating plant pathogenic fungus diseases, and particularly can be applied to preventing and treating banana fusarium wilt and promoting banana growth. The streptomyces narrow-mycin strain GD7-29 disclosed by the invention has a good application prospect in the aspects of preventing and treating plant fungal diseases and promoting plant growth.

The invention relates to the technical field of compound microbial additives, and particularly discloses a compound microbial additive suitable for alpine regions and a preparation method, the additive comprises microbial thalli, a protective agent and a carrier; the microorganisms are low-temperature-resistant nitrogen-fixing bacteria, cold-resistant phosphate-solubilizing bacteria, cold-resistant potassium-solubilizing bacteria, low-temperature-resistant plant growth-promoting rhizobacteria and cold-resistant streptomyces; the selected microbial strains are all derived from extreme environments of the alpine regions, are naturally selected and artificially domesticated for a long time, and have extremely strong adaptability to severe conditions such as low temperature and oxygen deficit of the alpine regions. Compared with the existing microbial additive in the market, the growth rate and metabolic activity of the microbial strain in the additive are kept at a relatively high level in a low-temperature environment of 0-15 DEG C.

The invention relates to the technical field of agricultural microorganisms, and provides a microbial agent for promoting growth of fruits and vegetables, the microbial agent is mainly prepared from a compound bacteria liquid, the total viable count of the compound bacteria liquid is greater than or equal to 1 * 10 < 10 > CFU / g, and the compound bacteria liquid comprises the following components in percentage by viable bacteria: 35-40% of aspergillus terreus, 10-20% of aspergillus niger, 5-10% of aspergillus niger, 5-10% of aspergillus niger, and the balance of water. 10 to 20% of bacillus subtilis; 15 to 20% of streptomyces sp. 10-12% of saccharomyces cerevisiae; and 18 to 25% of pseudomonas chlororaphis. The invention overcomes the defects of the prior art, is reasonable in design and relatively comprehensive in function, and also solves the technical problems that the function of the existing single microbial agent is limited and the activity of the complex microbial agent is relatively low under a high-temperature condition.

The present invention discloses a compound microbial agent for alleviating continuous cropping obstacles of traditional Chinese medicine crops and its application. The compound microbial agent of the present invention contains Bacillus amyloliquefaciens Y34, Serratia marcescens Y35, Bacillus amyloliquefaciens Y40 and Streptomyces SD; it can be applied to improve soil, eliminate diseases of Polygonatum odoratum, Pogostemon cablin and Cynanchum stauntonii, and promote crop growth. The compound microbial agent of the present invention can reduce soil-borne diseases during the planting process of traditional Chinese medicine, alleviate continuous cropping obstacles of traditional Chinese medicine, improve the yield and quality of traditional Chinese medicine, and has important application value especially in the cultivation and production of traditional Chinese medicine crops such as Polygonatum odoratum and Pogostemon cablin.

The invention belongs to the technical field of microbial pharmacy, and discloses a polyketone macrolide compound generated by genetically engineered streptomyces as well as a preparation method and application thereof. The polyketone macrolide compound disclosed by the invention is a cinnamyl streptomycin derivative, has cell proliferation inhibition activity better than that of a natural product Cinnamomycin A-D, can exert anti-tumor activity by inhibiting activity of human exonucleotide pyrophosphatase / phosphodiesterase 1 (ENPP1) and activating an inherent immune pathway, can be prepared into a medicine or a medicinal composition, and can be used for preparing medicines or medicinal compositions. The compound is used for treating tumors and related diseases.

The invention discloses a biosynthesis method and application of cannabinoid compounds. The specific method comprises the following steps: constructing a non-reductive polyketide synthase (NRPKS) AtnG from a fungus Arthrinum sp.NF2194, an isopentenyl transferase NphBV49W / Y288P from an actinomycetes Streptomyces sp.CL190, a cyclase Svz9 from an actinomycetes Streptoviensis NA431, a GPP synthase AgGPPS from a plant Abis grandis and a terpene synthesis enhancement path MEV into a heterologous expression vector, and sequentially introducing the heterologous expression vector into escherichia coli, so as to successfully realize the production of the cannabinoid compounds OA, CBGA and CBCA. The cannabinoid compound disclosed by the invention has important medical and industrial values.

The invention discloses a preparation method and application of a novel heterocyclic isomer sourced from streptomyces. The heterocyclic isomer is separated from a fermentation culture of streptomyces and has a remarkable antibacterial effect.

The invention discloses a naphthocycline type pentacyclic aromatic polyketone compound. The structural formula of the naphthocycline type pentacyclic aromatic polyketone compound is as shown in a formula (I): # imgabs0 #. According to the invention, six naphthocycline type pentacyclic aromatic polyketone compounds are separated from a rice fermentation product of actinomycetes Streptomyces sp.NAK5495 for the first time, and the six naphthocycline type pentacyclic aromatic polyketone compounds are separated from rice fermentation products of actinomycetes Streptomyces sp.NAK5495; according to the present invention, with the medium-pressure liquid chromatography (MPLC) system and the semi-preparative HPLC separation and purification technology, the efficient separation and purification of the naphthocycline pentacyclic aromatic polyketones are achieved, and the recovery rate and the purity of the target compound are improved.

This invention discloses a strain of Streptomyces gravidarum and its application, belonging to the field of biotechnology. The preservation number of the Streptomyces gravidarum is: CCTCC NO: M 20251912. The Streptomyces gravidarum can be used to control rice sheath blight.

The application discloses a kind of for preventing and treating cruciferous crops root rot complex microbial inoculant, comprising: the rose chain-forming Streptomyces agent numbered B98035, the Trichoderma citrinoviride agent numbered BMZ102895 and the Bacillus sonorensis agent numbered BMZ065932;The volume ratio of the rose chain-forming Streptomyces agent, Trichoderma citrinoviride agent and Bacillus sonorensis agent is 1:2-4:2, wherein the effective viable count in the rose chain-forming Streptomyces agent, Trichoderma citrinoviride agent is not less than 1×10 8 CFU / ml, and the effective viable count in Bacillus sonorensis agent is not less than 1×10 9 CFU / ml.The complex microbial inoculant of the application can effectively prevent and treat cruciferous crops root rot caused by Plamodiophora brassicae.

The invention belongs to the technical field of soil improvement, particularly relates to a compound microorganism saline-alkali soil conditioner as well as a preparation method and application thereof, and aims at solving the problems that the existing soil conditioner mostly adopts a single strain or a simple combination, is difficult to colonize in a harsh saline-alkali environment, has a single function, cannot systematically improve the physical and chemical properties of soil, is slow in organic material decomposition and is difficult to promote. In order to solve the problems that in the prior art, the soil conditioner is not durable in effect due to the fact that the soil conditioner is prone to failure due to saline-alkali stress, the following scheme is provided: the soil conditioner comprises the following raw materials in parts by weight: 5-10 parts of bacillus; by using bacillus, streptomyces, saccharomycetes, actinomycetes, nitrogen-fixing bacteria, phosphate bacteria, potassium bacteria, pyroligneous liquor, seaweed extract, amino acid chelate, potassium fulvate, citric acid and monopotassium phosphate, the content of organic matters in soil can be effectively increased, the aggregate structure of the soil is improved, a more lasting soil improvement effect is achieved, and the soil conditioner has a good application prospect. And the use frequency and cost of the modifier are reduced.

The invention discloses streptomyces-sourced acidic cellulase S4-Cel2 and application thereof, and belongs to the technical field of genetic engineering, the amino acid sequence of the acidic cellulase S4-Cel2 is as shown in SEQ ID NO.2, and the nucleotide sequence of a gene for coding the acidic cellulase S4-Cel2 is as shown in SEQ ID NO.1. The invention further discloses a preparation method of the acidic cellulase S4-Cel2. The optimal reaction pH of the acidic cellulase S4-Cel2 is 4.5, the optimal reaction temperature is 50 DEG C, the acidic cellulase S4-Cel2 keeps the relative enzyme activity of 62% or above in a buffer system at the temperature of 40-60 DEG C, and still keeps the relative activity of 20% or above after being treated at the temperature of 60-80 DEG C for 1 h, and the acidic cellulase S4-Cel2 can be applied to the fields of food, feed, textile, environmental protection, energy and industry to achieve efficient enzymolysis of cellulose.

The application discloses application of eugenol in preparation of a bacteriostatic agent for enhancing symbiotic nitrogen fixation efficiency of legume-rhizobium, and relates to the field of agricultural microorganisms. ‑1 The application is safe and non-inhibiting to seed germination of Medicago polymorpha and target rhizobium LL2 in a concentration range of 500-1000 muL / L ‑1 of eugenol, can significantly reshape rhizosphere microbial community structure by selectively inhibiting competitive microorganisms such as bacillus and streptomyces in soil, and is environment-friendly and free of antibiotic residue risk, thereby providing a green and efficient new approach for improving symbiotic nitrogen fixation efficiency of legume-rhizobium.

The present application relates to the technical field of biological medicine, in particular to streptomyces AH1901-2 and application thereof, preparation method and application of naphthymycin compounds, and belongs to the field of biological medicine. The streptomyces AH1901-2 is isolated from rhizosphere soil of Ligularia sibirica in Tianshan region (5.8°E, 28.0°N) in Xinjiang, and naphthymycin compounds are isolated and purified from liquid fermentation liquor of the streptomyces AH1901-2, and subsequent studies show that the naphthymycin compounds have obvious inhibitory effect on NO production of mouse mononuclear macrophages, and can be used for preparing anti-inflammatory drugs and treating inflammation.

The invention belongs to the technical field of microorganisms, and discloses an amorphophallus bulbifer southern blight infection influence analysis method based on metabonomics and microbiomics. Conjoint analysis shows that core florae (such as Streptomyces, Penicillium and Bauldia) are in significant positive correlation with phenylpropanoids and glutathione (succinic acid, coniferyl alcohol and glutamic acid), succinic acid is in positive correlation with Kribbella and Terrimonas, 2 ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', 2' ', the 3, 3 '-cycle CMP is negatively correlated with pathogen-related bacteria, which indicates that the metabolite regulates and controls the abundance of specific bacteria through positive / negative feedback so as to drive the microecological balance of rhizosphere, and a collaborative defense strategy that plants recruit beneficial microorganisms and inhibit pathogenic bacteria through metabolism reprogramming is disclosed.

The invention provides non-sugar-tolerant beta-glucosidase, an expression vector and application of the non-sugar-tolerant beta-glucosidase in improvement of cellulose degradation capacity, and belongs to the technical field of genetic engineering. According to the invention, the non-sugar tolerance type beta-glucosidase BGLC27 is obtained from streptomyces decomposer C27, and the amino acid sequence of the BGLC27 is as shown in SEQ ID No. 1. According to the invention, the BGLC27 is used as an exogenous enzyme and is added into a degradation system of cellulose degradation bacteria, and research finds that after the BLGC27 is exogenously added into the compound bacteria system, the cellulose degradation capability can be obviously improved.

The invention belongs to the technical field of organic substrates, and particularly relates to an organic substrate preparation process based on complex microbial inoculant synergistic fermentation, which comprises the following steps: selecting agricultural wastes, livestock and poultry manure and food industry byproducts, and carrying out staged fermentation by adopting complex microorganisms such as bacillus, streptomyces, clostridium and bacteroides; the decomposition efficiency of degradation-resistant substances such as cellulose and lignin is obviously improved. By combining precise temperature control and oxygen concentration adjustment strategies, the stability of the fermentation process is enhanced, nitrogen volatilization is reduced, and the total nitrogen content is stabilized at 1.2-1.5%. Nitrogen-fixing bacteria and phosphate solubilizing bacteria are introduced in the after-ripening stage, the biological activity of the matrix is improved, the screening process ensures that the finished product is uniform in particle size and few in impurities, the content of organic matter reaches 45% or above, the pH value is stabilized at 6.5-7.5, excellent agricultural performance is achieved, and efficient resource utilization of organic waste is achieved; the problems that in the prior art, organic matter degradation is not thorough, the controllability of the fermentation process is poor, nutrient loss is serious, and the quality of a finished product is unstable are effectively solved.

The invention belongs to the technical field of biology, and particularly relates to a construction method and application of an exogenous gene cluster chromosome integration system in streptomyces. The invention reports a new way of integrating an exogenous gene cluster onto a streptomyces chromosome, namely RMCE. The RMCE reduces the influence of other DNA sequences on the stable existence of the gene cluster as much as possible; secondly, the RMCE landing site still has functions after recombination and can be reused; in addition, lox71 and lox66 sites are added on a Dre, Vika and PhiBT1 mediated integration vector for knockout of the resistance gene of the apolamycin, so that the resistance gene can be conveniently used for multiple times. In addition, the recombinase Cre, the recombinase Dre and the recombinase Vika are used for integrating gene clusters in the streptomycete for the first time, the function of the tyrosine recombinase in the streptomycete is expanded, and therefore the tyrosine recombinase has good practical application value.

The invention belongs to the field of biological pharmacy, and particularly relates to a chalcanthicidin compound and application thereof. The invention discloses a chalcanthicidin compound which is separated from a secondary metabolite of marine actinomycetes Streptomyces sp. KCB-132 (marine actinomycetes sp. KCB-132). Pharmacological activity experiments show that the compound has a moderate inhibition effect on ESKAPE pathogenic bacteria with multiple drug resistance, such as enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii and escherichia coli. Therefore, the compound has the potential of being developed into a novel antibacterial agent.