The invention discloses a soil conditioning, fertility-increasing and salt-reducing agent for sulfate-type saline soil. The soil conditioning, fertility-increasing and salt-reducing agent comprises the following ingredients by mass: 42-50 parts of phosphogypsum, 15-18 parts of fulvic acid, 6-10 parts of straw, 4-11 parts of medical stone, 7-9 parts of bagasse, 10-20 parts of coal ash, 6-9 parts of aluminium sulfate, 3-8 parts of bean cake, 2-3 parts of hawthorn fruit powder, 0.5-0.8 part of a water-retaining agent, 0.6-0.9 part of lauryl ethoxy ammonium sulfate, 10-16 parts of starch-acrylonitrile, 15-18 parts of hollyhock powder, 10-13 parts of fennel powder and 0.01-0.05 part of halomonas halophiles. The invention further discloses application of the soil conditioning, fertility-increasing and salt-reducing agent to sculellaria barbata planting. The soil conditioning, fertility-increasing and salt-reducing agent and the application thereof to sculellaria barbata planting have the benefits that 12 months after sculellaria barbata planting, sulfate in 100 g of soil has the milliequivalent of 0.09-0.13, the available phosphorus content and the organic matter content of soil are both increased, and the soil moisture permeability and the soil water-retaining capacity are improved.