35 results about "Syringic acid" patented technology

The invention discloses Chinese angelica traditional Chinese medicine decoction pieces and a processing method thereof, and belongs to the technical field of traditional Chinese medicine processing. According to the invention, a bio-based eutectic solvent system is adopted, L-proline and syringic acid form a stable complexing structure through pi-pi accumulation and hydrogen-bond interaction, and the dissolution rate of active ingredients is improved by cooperating with the conjugation effect of hydrophobic groups and benzene rings of gamma-nonanolactone; nano cellulose crystals pretreated by sulfuric acid are introduced, surface hydroxyl groups of the nano cellulose crystals and DES components form a hydrogen bond network, a three-dimensional thermal stable structure is constructed, active components are effectively wrapped, and high-temperature degradation is prevented; the low surface tension of the gamma-nonanolactone is utilized to quickly permeate into the cell walls of the medicinal materials, and the magnetic eddy shear force is combined to destroy the fiber structure and accelerate the component release; trehalose is adopted as a freeze-drying protective agent, oil phase agglomeration is inhibited by forming an amorphous glassy state, and the structural integrity of thermosensitive components is protected by hydroxyl hydrogen bonds. No organic solvent is left, medicine residues are subjected to DES secondary extraction and then cooperatively processed with fresh angelica sinensis, and efficient recycling of resources is achieved.

The invention belongs to the field of biological pharmacy, and particularly relates to a phenolic acid composition and application thereof in promoting digestion. According to the invention, monophenolic acid for improving dyspepsia is found through a single-component phenolic acid experiment, and then a phenolic acid compound with a synergistic effect is searched in a compounding manner, so that unexpectedly, the combination of two phenolic acids with the best digestion promoting effect cannot realize the effect optimization; on the contrary, syringic acid with the worst digestion promoting effect is compounded with other phenolic acids, so that the synergistic digestion promoting effect is achieved, the effect of a positive medicine can be achieved, and a potential optional medicine is provided for improving dyspepsia.

The present invention belongs to the technical field of biological medicine, and discloses a ceramide compound shown in Chemical Formula I: #imgabs0# wherein, R 1 is selected from the residues after condensation of sialic acid, chelidamic acid monohydrate, 2,5-furandicarboxylic acid, quinic acid, chlorogenic acid, ectoine, nicotinic acid, shikimic acid, glucuronic acid, salicylic acid, carnosic acid, dihydrooat acylanthranilic acid, abietic acid, ursolic acid, tranexamic acid, syringic acid, gentisic acid, vanillic acid, 5-hydroxyisovanillic acid, orotic acid, 5-aminoorotic acid, 3,5-dihydroxy-4-methylbenzoic acid, glycyrrhizic acid or gallic acid, R 2 is selected from one of the following structures: -C 15 H 29 、-C 15 H 31 、-C 15 H 27 、-CHOHC 14 H 27 、-CHOHC 14 H 29 . The present invention also discloses a preparation method and application of the ceramide compound. The present invention introduces a molecular fragment with physiological activity of a functional carboxylic acid into ceramide, which will enhance the original efficacy of this type of molecule and also improve the physicochemical properties of the ceramide compound.

The present application belongs to the field of biopharmacy, and particularly relates to a phenolic acid composition and application thereof in promoting digestion. The present application firstly finds a single phenolic acid for improving dyspepsia through single-component phenolic acid experiments, then attempts to find a phenolic acid compound with a synergistic effect through compounding, and surprisingly, the combination of two phenolic acids with the best effect on promoting digestion cannot achieve the best effect optimization, but eugenol with the worst effect on promoting digestion achieves a synergistic effect on promoting digestion through compounding with other phenolic acids, and can achieve the effect of a positive drug, which provides a potential alternative drug for improving dyspepsia.

The present application relates to a kind of Huahong composition effective part extract and its preparation method, the Huahong composition effective part extract includes the following components: syringic acid, new chlorogenic acid, deacetyl carlina acid methyl ester, geniposidic acid, N-acetyl-L-tyrosine, fraxidin, 4-pyridoxinic acid, 7,8-dihydroxy-4-methyl coumarin, chlorogenic acid, ferulic acid;The total content of above components is 80%-95% of effective part extract.The Huahong composition effective part extract of the present application is from the effective part of Huahong composition.

The application discloses a kind of hydrazine compounds with eugenol as lead and its preparation method and application, and the biological activity test result shows that all compounds are excellent, broad-spectrum antibacterial activity to the plant pathogenic fungi tested.The inhibition effect of most target compounds on plant pathogenic fungi is better than that of positive control rynaxapyr, and the antibacterial effect of compound 11 on rhizoctonia solani, fusarium graminearum, alternaria solani, phoma exigua var. horii and phoma sorghicola is the best, and the EC 50 Values are 0.258 μg / mL, 0.679 μg / mL, 0.424 μg / mL, 0.384 μg / mL and 0.975 μg / mL respectively; for the gossypium gossypium, the antibacterial effect of compound 12 is the best, and the EC 50 Value is 0.989 μg / mL; followed by compound 11, and the EC 50 Value is 1.248 μg / mL.The hydrazine compounds prepared with eugenol as lead have excellent, broad-spectrum and high-efficiency anti-plant pathogenic microorganism activity, and can be used for preventing and treating plant diseases caused by plant pathogenic microorganisms.

The invention discloses an upatinib eutectic crystal form as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The invention provides an eutectic crystal form I formed by upatinib and vanillic acid and an eutectic crystal form G formed by upatinib and syringic acid, which have definite and reproducible characteristic X-ray powder diffraction pattern and melting point, have excellent solubility in an aqueous medium, do not generate crystal form transformation after being stored for 1 month under the condition of relative humidity of 40 DEG C / 75%, and can be used for preparing a crystal form of upatinib. And the stability is good. The preparation process route is short, the operation condition is mild, the used solvent is conventional, the target eutectic can be efficiently and repeatedly obtained, the defects that some existing eutectic preparation processes are complex, long in period or harsh in condition are overcome, and the method has good process amplification and industrialization prospects.

The application discloses a night work activating composition containing multiple plant extract, which comprises the following components in mass: 3-5 parts of extract A, 10-15 parts of extract B, 2-4 parts of extract C, 1.5-3 parts of curcumin nano-liposome, 2-5 parts of lactobacillus fermentation filtrate, 1-3 parts of lock water magnetite, 0.1-0.3 parts of xanthan gum / acrylate compound thickening agent and 0.5-1 part of preservative composition. The night work activating composition containing multiple plant extract of the application is compounded by extract A with methyl jasmonate as a target component, extract B with rhodioside and syringic acid as target components and curcumin nano-liposome, compared with the same kind of products on the market, the antioxidant and anti-glycation capacity of the night work activating composition can be targetedly strengthened, the transdermal efficiency is improved, and the DNA repair effect and anti-inflammatory effect are improved.

The invention relates to a method for the selective electro-oxidative fragmentation of lignin using an electrochemical system, comprising the following steps: (i) synthesis of a nickel-cobalt electrocatalyst; (ii) obtaining an anode coated with the electrocatalyst; and (iii) selective fragmentation and oxidation of solubilised lignin in an electrochemical reactor comprising said anode, in which vanillic acid and syringic acid are obtained as preferred products.

The invention provides a honey variety identification method based on amino acid and polyphenol compounds and application of the honey variety identification method, and relates to the technical field of honey variety detection. According to the invention, amino acids and polyphenol compounds in 14 honey varieties are analyzed by adopting a PLS-DA analysis method, and characteristic difference indexes with VIP values greater than 1 are screened out, specifically trans-cinnamic acid, protocatechuic acid, Pro, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 14 According to the method, 2, 4-dimethylcinnamic acid, rosmarinic acid, apigenin, Tyr, vanillic acid, cumaric acid, isoferulic acid, Cys, caffeic acid phenethyl ester, Met, Asp, gallic acid, naringenin, p-cumaric acid, ferulic acid, rhinoceroic acid, chrysin and syringic acid are screened, and then screened characteristic difference index data is used for establishing a linear discrimination model and a random forest prediction model. Through verification, the linear discrimination model and the random forest prediction model constructed by the method can be accurately and efficiently used for discriminating honey varieties.

The application discloses a preparation method of a eugenol-based aromatic dibasic acid and application thereof. The preparation method comprises the following steps: heating and refluxing reaction of chloroacetic acid and eugenol in an alkaline solution, acidification to obtain a crude product after the reaction is completed, and obtaining the eugenol-based aromatic dibasic acid after post-treatment of the crude product. The eugenol-based aromatic dibasic acid synthesized by using the widely-sourced eugenol as a raw material is green and environment-friendly, can be used for synthesizing a bio-based polyamide, and has excellent mechanical properties and good dissolving and processing capacity, and the bio-based polyamide has high economy. The whole preparation process is simple in operation and easy to popularize.

The invention belongs to the technical field of medicines, and particularly relates to application of hibiscus (the hibiscus is a plant hibiscus flower and an extract and an active monomer thereof) in preparation of medicines for treating stomach diseases (atrophic gastritis, gastric mucosal lesion and gastric cancer). The invention discloses application of hibiscus syriacus in treatment of gastric diseases. The application comprises at least one of chronic atrophic gastritis treatment, gastric mucosa protection and gastric cancer prevention. In-vitro experiments show that the shrub althea flower extract, shrub althea flower polyphenol, syringic acid (I), protocatechuic acid (II), kaempferol (III) and kaempferol-7-O-beta-D-glucoside (IV) have obvious antioxidant activity and gastric mucosa protection activity, can obviously reduce the ROS content in ethanol-induced GES-1 cells and the expression of apoptosis marker protein Caspase-3 / Bax, and have a wide application prospect.

The application provides a construction method of UPLC characteristic spectrum of Qinglongyi medicinal material, standard decoction and formula granules, comprising the following steps: dissolving and extracting raw materials of the test sample by using a solvent to obtain a test solution; determining the test solution by using high performance liquid chromatography to obtain the UPLC characteristic spectrum of Qinglongyi medicinal material, standard decoction and formula granules; and the high performance liquid chromatography conditions are as follows: a C 18 column is used as the chromatographic column; acetonitrile solution is used as mobile phase A, and 0.1% formic acid aqueous solution is used as mobile phase B, and gradient elution is adopted. The application adopts the high performance liquid chromatography, selects acetonitrile-0.1% formic acid solution as the mobile phase for gradient elution, takes protocatechuic acid, vanillic acid, syringic acid, ellagic acid, rutin and quercitrin as the reference substances, establishes the UPLC characteristic spectrum method of Qinglongyi medicinal material, standard decoction and formula granules, and provides more scientific technical means for controlling the medicinal quality of Qinglongyi medicinal material, standard decoction and formula granules.

The invention discloses a syringic acid-based acute graft-versus-host disease prediction and use method, and belongs to the technical field of biological medicine.The syringic acid-based acute graft-versus-host disease prediction and use method comprises the steps that the occurrence and prognosis of aGVHD after transplantation are predicted by detecting the syringic acid level in an allo-HSCT patient, and reduction of the syringic acid level in the patient indicates increase of the aGVHD occurrence risk and poor prognosis; comprising the steps of giving an effective dose of syringic acid, inhibiting T cell activation and inflammatory factor secretion, relieving aGVHD symptoms, prolonging the survival time of an aGVHD model animal and improving target organ injury, and the diagnosis and prediction value of syringic acid in aGVHD occurrence and clinical prognosis is evaluated through a clinical sample. The application of syringic acid in prevention and treatment of aGVHD by inhibiting T cell function and inflammatory factor secretion is explored through in-vitro and animal experiment research, and the technical effects of helping clinicians to timely discover high-risk patients, formulate intervention measures in advance, improve prognosis of the patients and improve the treatment effect are achieved.

The invention discloses a method for rapidly determining various phenolic acid substances in a fermentation product, and belongs to the technical field of detection. The determination method comprises the following steps: 1. Taking a to-be-detected substance, and extracting phenolic acid substances in the to-be-detected substance through an alcohol precipitation-SAX solid-phase extraction combined technology to obtain a to-be-detected sample; analyzing the to-be-detected sample by adopting ultra-high performance liquid chromatography tandem triple quadrupole mass spectrometry to obtain the content of the target substance in the to-be-detected substance; the target substance is a non-volatile phenolic acid substance. Accurate quantification of trace and trace caffeic acid, dihydrocaffeic acid, ferulic acid, chlorogenic acid, gallic acid, vanillic acid, syringic acid, p-coumaric acid, salicylic acid and (+ / -)-catechin in fermentation products within 8-15 min is achieved by combining impurity removal and concentration pretreatment with ultra-high performance liquid chromatography tandem triple quadrupole mass spectrometry. According to the method, the pretreatment mode is convenient to operate, the detection process is fast, and the detection result is accurate.

The invention belongs to the technical field of acne rosacea treatment, and discloses a preparation method and application of a composition for treating acne rosacea, the composition for treating acne rosacea contains a moutan bark extract and a coptis chinensis extract, and also contains a lucid ganoderma extract, a cinnamon extract, paeoniflorin and syringic acid. The inflammatory response of rosacea is closely related to the expression of two core inflammatory factors, namely TNF-alpha and TLR4, and the invention consciously aims at the TLR4-TNF-alpha inflammatory axis multi-target design, inhibits the expression of TLR4 and TNF-alpha, and blocks the'start-amplification 'chain of inflammation, thereby inhibiting the recurrence of inflammation. In addition, the composition for treating rosacea provided by the invention can also improve capillary dysfunction, effectively inhibit microbial growth, and prevent and treat rosacea from multiple dimensions.

The invention provides syringic acid as well as preparation, a pharmaceutical composition and medical application thereof. The purity of the syringic acid is 95% or above, and the syringic acid can be extracted from motherwort. The syringic acid disclosed by the invention has a good dissolving effect on fibrin in thrombus formation, is relatively high in blood-brain barrier transmittance, has thrombus dissolving and antithrombotic effects, and can be used for preparing medicines for treating thrombotic diseases. The syringic acid can be processed into oral preparations such as tablets, capsules, granules, dripping pills and other common preparations or sustained release preparations, injection preparations such as injection freeze-dried powder injections, and external preparations such as ointments or emulsifiable paste according to a conventional production process of pharmaceutics, and is used for treating thrombotic diseases, especially cerebral thrombosis diseases.

The invention provides an electrochemical method for pairwise synthesizing syringic acid and adiponitrile. The method comprises the following steps: 1) mixing syringaldehyde, an alkaline electrolyte, an alcohol solvent, an alkyl glycoside surfactant and water, and adding the mixture into an anode chamber of an electrolytic cell; (2) acrylonitrile, phosphate, borate, a quaternary ammonium base surfactant and water are mixed and added into a cathode chamber of the electrolytic cell; and 3) heating the electrolyte in the cathode chamber and the anode chamber of the electrolytic cell, then carrying out an electrolytic reaction, carrying out electrochemical oxidation on syringaldehyde at the anode to synthesize syringic acid, enabling hydrated hydrogen ions to enter the cathode chamber across a membrane, and synthesizing adiponitrile with acrylonitrile at the cathode. The syringic acid synthesis method is clean, environmentally friendly and low in cost, meanwhile, the problem of anode corrosion in the operation process of electrosynthesis of adiponitrile is solved, and the tail gas safety risk caused by oxygen evolution of an anode for synthesis of adiponitrile is eliminated. The method has the advantages of simple steps, high total product yield, low equipment investment, low operation risk, mild reaction conditions, less three wastes and low energy consumption, and is suitable for wide industrial application.

The invention provides a drug-drug co-amorphous substance co-carrying analgesic active components of syringic acid and rotundine. The prescription of the drug-drug co-amorphous substance does not contain any carrier or auxiliary material, the preparation method is simple, convenient and efficient, special processes and equipment are not needed, the cost is low, and industrialization is easy. The co-amorphous substance prepared by the invention not only can significantly improve the water solubility of syringic acid and rotundine, but also can improve the transdermal performance of drugs, and is beneficial to development of double-drug co-loaded efficient oral or external compound products.

The invention provides a construction method of a UPLC characteristic spectrum of a cortex juglandis mandshuricae medicinal material, a standard decoction and a formula granule, which comprises the following steps: dissolving a test raw material with a solvent, and extracting to obtain a to-be-detected solution; determining the liquid to be detected by adopting a high performance liquid chromatography to obtain UPLC characteristic spectrums of the cortex juglandis mandshuricae medicinal material, the standard decoction and the formula granules; chromatographic conditions of the high performance liquid chromatography are as follows: a chromatographic column is a C18 column; a mobile phase A is an acetonitrile solution, a mobile phase B is a 0.1% formic acid aqueous solution, and gradient elution is carried out. According to the method, a high performance liquid chromatography is adopted, an acetonitrile-0. 1% formic acid solution is selected as a mobile phase for gradient elution, protocatechuic acid, vanillic acid, syringic acid, ellagic acid, rutin and quercitrin are taken as reference substances, and a UPLC characteristic spectrum method for the cortex juglandis mandshuricae medicinal material, standard decoction and formula granules is established. And more scientific technical means are provided for controlling the medicinal quality of the cortex juglandis mandshuricae medicinal material, standard decoction and formula granules.

The present application relates to the technical field of detection of phenolic acid, and discloses a quantitative detection method of phenolic acid components in rape root exudates based on UPLC-MS / MS, wherein the phenolic acid in the rape root exudates is p-hydroxybenzoic acid, vanillic acid, syringic acid, ferulic acid and hesperidin. The method comprises the following steps: (1) mixing freeze-dried rape root exudate powder with an extraction solvent, fully shaking and mixing, centrifuging the obtained mixture to obtain root exudate extract; (2) preparing a mixed mother liquor of p-hydroxybenzoic acid, vanillic acid, syringic acid, ferulic acid and hesperidin standard substances, and drawing a standard curve; (3) determining the root exudate extract prepared in step (1) in a UPLC-MS / MS multiple reaction monitoring mode according to the operation method and conditions of step (2). The method can be used for rapid quantitative detection of phenolic acid components in rape root exudates.

The present invention discloses an electrode material for electrochemical synthesis of nitrogen-containing aromatic compounds, as well as a preparation method and application thereof. The novel electrocatalytic electrode material is made of a rich copper salt as a raw material, and biomass-derived syringic acid is introduced as a ligand to obtain a novel syringic acid copper-based MOFs nanomaterial, which is applied to the electrocatalytic reaction of aromatics and nitrogen-containing inorganic salts. Under mild conditions, in an aqueous solution, electrochemical C-H activation and C-N coupling reactions are achieved. Moreover, the catalyst exhibits high catalytic activity, selectivity and stability in the electrochemical synthesis of nitrogen-containing aromatic compounds. Therefore, the nanomaterial disclosed in the present invention has broad application prospects in the electrocatalytic synthesis of high-value-added products such as nitrogen-containing aromatic ring compounds, as well as in sewage treatment, lignin solid waste conversion, fuel cells and other energy conversion devices.

The invention discloses a preparation method and application of a plant extract fermentation product for promoting anti-aging of cats, and belongs to the technical field of animal health care product preparation. Comprising a metabolite (LA20FM) of a brown algae extract which has an anti-aging function and is fermented by bifidobacterium adolescentis LifeAge20 and other raw materials, including one or more of D-sphingosine, luteolin, epigallocatechin, syringic acid, leucine, fucosterol, resveratrol, nicotinamide and glutathione. The metabolite of the brown algae extract fermented by the bifidobacterium adolescentis LifeAge20 disclosed by the invention has a remarkable effect in the anti-aging aspect, and can improve the content of nicotinamide adenine dinucleotide in vascular endothelial cells of cats, the angiogenesis capability and the antioxidant capability; the activity of beta-galactosidase in cells and the content of senescence phenotype markers are reduced, and a multi-channel anti-aging effect is realized. The LA20FM and additives are added to prepare the health-care agent, so that the health-care agent is more beneficial to anti-aging of pets and has a wide application prospect.

The invention relates to the technical field of baijiu, in particular to grain-flavored seasoning wine and a production method thereof, wet grains are collected and soaked in water, pretreatment is performed, and then water metering operation is performed by using the wet grains and the soaked in water. In order to improve the gelatinization degree and moisture of the fermented grains in the production of the white spirit, the operation of metering water in the retort after the wine is finished or before the wine is taken out of the retort and metering water after the wine is taken out of the retort is adopted, meanwhile, part of grain moistening water flows out of a grain pile after the grain moistening operation is finished, the grain moistening water contains rich anthocyanin and other grain aroma fermentation substrates, and the grain moistening water is used for metering water; grain moistening and water returning are achieved, generation of syringic acid and ferulic acid flavonoid compounds is promoted, finally, the syringic acid and ferulic acid flavonoid compounds are converted into polyphenol compounds and aromatic compounds, and a unique grain fragrance base of the Maotai liquor is formed.

A metal complex comprising: (a) a pharmaceutically acceptable central metal; (b) a DNA methyltransferase (DNMT) inhibitor; and (c) 2,5-dihydroxyterephthalic acid (DTA) and / or syringic acid (SA).

The application discloses a method for rapidly detecting 30 compounds in tea, such as catechins, flavonoids, anthocyanins, phenolic acids and amino acids, wherein the 30 compounds are gallic acid, theobromine, GC, protocatechuic acid, theophylline, EGC, theanine, chlorogenic acid, caffeine, catechin, syringic acid, caffeic acid, vanillic acid, epicatechin, EGCG, delphinidin, salicylic acid, GCG, p-coumaric acid, cyanidin, ferulic acid, sinapic acid, rutin, ECG, pelargonidin, myricetin, theaflavin, quercetin, apigenin and kaempferol. The application can realize simultaneous rapid qualitative and quantitative detection of the 30 compounds, and provides technical support for development of active substances in tea.

The invention discloses a Ganhai Weikang capsule specific chromatogram based on a multi-component material basis as well as a construction method and application thereof, and belongs to the technical field of quality control and evaluation of Chinese patent medicines. A high performance liquid chromatography-high resolution mass spectrometry method is adopted for detection, and glycyrrhizic acid, liquiritin, liquiritigenin, apiose liquiritin, naringenin, chlorogenic acid, syringic acid, protocatechuic acid, hesperidin, narirutin, p-coumaric acid and kaempferide are taken as reference substances; the specific chromatogram is successfully constructed by detecting different batches of Ganhai Weikang capsules. The method for detecting the specific chromatogram of the Ganhai Weikang capsule, established by the invention, is simple and convenient to operate, high in precision and rapid in analysis, can realize efficient and synchronous detection of 12 characteristic components, and has good stability, accuracy and reproducibility. According to the method, synchronous and rapid analysis of multiple components is realized, the detection efficiency is remarkably improved, and reliable scientific basis and technical support are provided for quality control and clinical curative effect guarantee of the Ganhai Weikang capsules.

The invention provides a motherwort phenolic acid extract with a thrombolysis effect as well as a preparation method and application of the motherwort phenolic acid extract. The method provided by the invention can effectively extract the effective part with fibrinolysis effect in motherwort; the herba leonuri phenolic acid extract is mainly prepared from vanillic acid, syringic acid, trans-ferulic acid, cis-ferulic acid and 3, 4, 5-trimethyl gallic acid, and the total content of the herba leonuri phenolic acid extract is not lower than 70%. The herba leonuri phenolic acid extract has a good dissolving effect on fibrin in thrombosis, has thrombus dissolving and antithrombotic effects, and can be processed into various common preparations or sustained release preparations such as oral preparations such as tablets, capsules, granules and dropping pills according to a conventional production process of pharmaceutics; injection preparations such as injection freeze-dried powder injections and external preparations such as ointment and emulsifiable paste are used for treating thrombotic diseases (including cerebral thrombosis and subcutaneous blood stasis).

The invention relates to the technical field of composite materials, in particular to a preparation method of a polyurethane nylon composite continuous fiber material, syringic acid is added as an antibacterial agent during preparation of antibacterial waterborne polyurethane, and the syringic acid has broad-spectrum antibacterial activity and can effectively inhibit growth of various bacteria and fungi, so that the antibacterial property of the polyurethane nylon composite continuous fiber material is improved; therefore, the composite fiber material is endowed with good antibacterial performance; nano silicon dioxide modified graphene oxide, modified nano calcium carbonate and modified talcum powder are added into the antibacterial waterborne polyurethane, and the nano additives can effectively enhance the mechanical properties of a polyurethane matrix, such as tensile strength, wear resistance and hardness, and improve the dispersity and stability of the material at the same time; the nano silicon dioxide modified graphene oxide provides excellent antibacterial performance, the modified nano calcium carbonate and the modified talcum powder are beneficial to improving the rigidity and the heat resistance of the material, and the mechanical performance of the composite fiber material can be improved after the antibacterial waterborne polyurethane and the nylon 6 are blended.

The invention discloses a low caffeine nerve stimulation tea wine based on bung aged wine and a preparation method thereof, the low caffeine nerve stimulation tea wine is mainly prepared by blending cherry bung aged tea wine and litchi bung aged tea wine with different baking degrees, the mass ratio of pinocembrin to syringic acid to apigenin in the wine body is (1.4-3.5): 1: (1-3), the mass ratio of chrysin to vanillic acid is 1: (0.06-0.35), and the mass ratio of the pinocembrin to the syringic acid to the apigenin is (1.4-3.5): 1: (1-3). The mass ratio of the quercetin to the dihydroquercetin to the isofraxidin is (1.5-4): 1: (0.5-2), and the total content of the pinocembrin, the syringic acid, the apigenin, the chrysin, the vanillic acid, the quercetin, the dihydroquercetin and the isofraxidin in the wine is 50-400mg / 100mL. By combining and matching the functional components in the wood and the proportion of the functional components, the antagonistic effect on caffeine nerve stimulation in the tea wine is achieved.