Synthetic method for leonurine

A technology of motherwort and synthesis method, which is applied in chemical instruments and methods, preparation of organic compounds, preparation of aminohydroxy compounds, etc., can solve the problems that starting materials are not easy to obtain, difficult to produce on a large scale, and high requirements for reaction conditions, Achieving excellent synthetic route, suitable for large-scale production, and more controllable effects
CN106866464AActive Publication Date: 2017-06-20绵阳市润土农业科技开发有限公司
4 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
绵阳市润土农业科技开发有限公司
Publication Date
2017-06-20

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the technical field of organic chemistry, in particular to a synthetic method for leonurine. Gamma-butyrolactone is used as a starting material to be subjected to ammonolysis to obtain gamma-hydroxybutyric acid amide; the gamma-hydroxybutyric acid amide and acetyl syringic acid are subjected to a condensation reaction; a dehydration reaction and a reduction reaction are carried out to obtain leonurus amine; and the leonurus amine and S-methyl isothiourea sulfate are subjected to a reaction to obtain the leonurine. The target product leonurine is synthetized from the cheap industrial raw materials of the gamma-butyrolactone and the syringic acid used as the starting materials through reactions of ammonolysis, esterification, dehydration, reduction and the like. The reaction conditions are mild and easy to control; the yield is up to 65%; the product purity is 98% or above; and the synthetic method for leonutine provides the production with an excellent synthetic route and is suitable for large-scale production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of organic chemistry, and relates to a method for synthesizing a compound, in particular to a method for synthesizing leonurine. Background technique

[0002] Motherwort is the dry aerial part of LeunornsheterophyLLus Sweet, a plant of the Labiatae family. It is a traditional Chinese medicine species recorded in the Chinese Pharmacopoeia. It has the functions of regulating menstruation, promoting blood circulation and relieving pain. In recent years, relevant clinical experiments have also proved that it has a significant effect on the treatment of cardiovascular diseases.

[0003] Through the research, it is found that the reports on several synthetic methods of Leonurine all have defects of different degrees of process expansion, such as: Zhu Renfa, Wang Xiaoshan, etc., use the Gabriel method and the reduction of hydrazine to prepare Leonurine. During the experiment Due to problems such as the poor solubi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More