1717 results about "Aminobutyric acid" patented technology

The invention relates to a method for preparing health-benefiting fermented soybean meal enriched in small peptides, gamma-aminobutyric acid (GABA), reducing sugar, lactobacillus plantarum and antimicrobial peptide. By utilizing strains of aspergillus oryzae, saccharomyces cerevisiae, bacillus subtilis and lactobacillus plantarum, the small peptides, free amino acids, reducing sugar, GABA and high viable count content in the lactobacillus plantarum in the health-benefiting fermented soybean meal are obtained through the two-stage solid state fermentation method, the small peptides account for 8.01-18 percent, the free amino acids has the content of 80-300mg/g, the reducing sugar reaches 20-80mg/g, the GABA reaches 0.317-0.5mg/g, the viable count content in the lactobacillus plantarum is 2-6.5*1010cfu/g, the antibacterial titer of antimicrobial peptides is 2.0*103-7.0*104 IU/g, and the yield of the health-benefiting fermented soybean meal is 82.03-90 percent. According to the process, the nutrient effect of the soybean meal can be improved, the prepared fermented soybean meal has the antibacterial effect, partial antibiotics can be replaced, the fermented soybean meal is conveniently preserved and saved, the process is simple and feasible, and the fermented soybean meal is green and environment-friendly and has application significance and wide prospect in the feed industry and breeding industry.

The invention discloses a method for producing L-2-aminobutyric acid, and the method comprises the following step: catalyzing L-threonine utilized as a raw material through an enzyme catalysis system consisting of threonine deaminase, L-amino acid dehydrogenase and coenzyme regeneration systems, thus producing the L-2-aminobutyric acid. The method for producing theL-2-aminobutyric acid has the advantages that the raw material is low in price, the property is stable, and the production cost of the L-2-aminobutyric acid can be greatly lowered, the conversion rate and product concentricity are high, no influence caused by byproducts exists, and the method is suitable for industrialization application.

The invention provides a novel high gamma-aminobutyric acid, high flavone fragrant black glutinous germinating brown rice and preparation thereof. The germinating brown rice is produced from material of long-shaped fragrant glutinous black rice, which has gamma-aminobutyric content 89mg/100g, flavone content 8603mg/kg, and protein content 12.4%, wherein the content of amino acid and mineral substances is 3-5 times higher then the ordinary rice. The preparation includes material selecting, husk sieving, sterilizing, cleaning, immersing, sprouting, cleaning, terminating activity of enzyme, microwave drying, checking. The germinating brown rice has thick fragrance of popcorn, great mouth feeling, high content of gamma-aminobutyric acid, flavone and protein, high content of amino acid and mineral, high nutrition value. The germinating brown rice has reasonable materials, easy processing, enhances quality of germinating brown rice, prolongs storage period of the product, has obvious economic value, and provides technological guarantee to popularization of the germinating brown rice as a functional food.

The present invention relates generally to pharmaceutical dosage forms having immediate release and controlled release properties that contain a γ-aminobutyric acid (GABA_B) receptor agonist, e.g., baclofen, for the treatment of medical conditions, which includes spasms, cramping, and tightness of muscles, associated with ailments such as multiple sclerosis or certain spinal injuries.

The invention relates to biaryl-substituted 4-aminobutyric acid derivatives, and a preparation method and application thereof, particularly biaryl-substituted 4-aminobutyric acid derivatives disclosed as Formula (I), and a preparation method and application thereof, an intermediate of biaryl-substituted 4-aminobutyric acid derivatives prepared by cyclization reaction and a pharmaceutical composition containing the biaryl-substituted 4-aminobutyric acid derivatives. The biaryl-substituted 4-aminobutyric acid derivatives have NEP (neutral endopeptidase) inhibition activity, and can be used as an NEP inhibitor.

The invention discloses a preparation method and product of germinated wheat rich in gamma-aminobutyric acid, and the method is used for solving the problems of bad existing effect and unstable yield since GABA is enriched by utilizing tea and rice products according to an existing method for preparing gamma-aminobutyric acid based on a biological concentration method. The method comprises the following steps of: raw material selection, pretreatment, imbibition, temperature control training and germination termination. Wheat seeds are dramatically taken as raw materials, the improvement of GAD enzyme activity in wheat seeds is effectively promoted by controlling germination conditions, a cultivated substrate and the pH value, and meanwhile the GAD activity is ensured by controlling the pH value, the activity of GABA aminopherase is inhibited, and the content of gamma-aminobutyric acid in germinated wheat is greatly improved, so that the nutritive value of wheat is greatly improved. Experimental results show that the content of GABA in the prepared germinated wheat is 31.08 mg per 100 g at most, and achieves domestic and international leading level of similar methods.

The invention provides a sleep improvement composition. The sleep improvement composition is composed of gamma-aminobutyric acid, a spine date seed extract, magnesium and vitamin B6. The invention also provides a preparation of the sleep improvement composition and a preparation method of the sleep improvement composition. The sleep improvement composition contains no hypnotic components, and can effectively calm motion and improve the sleep for high-pressure populations and poor sleepers.

The present invention relates generally to pharmaceutical dosage forms having immediate release and controlled release properties that contain a γ-aminobutyric acid (GABA_B) receptor agonist, e.g., baclofen, for the treatment of medical conditions, which includes spasms, cramping, and tightness of muscles, associated with ailments such as multiple sclerosis or certain spinal injuries.

The invention relates to a substance for curing or relieving pain, and provides application of a gamma-aminobutyric acid A receptor inverse agonist containing alpha 5 subunits in preparing a drug for preventing and improving or curing the pain and also provides a drug composition containing the substance for curing or relieving the pain.

The invention relates to an L-2-reanal biological preparation method, which includes: utilizing L-threonine as raw materials, stirring the L-threonine in water at the temperature of 15-50 DEG C under the catalytic action of L-threonine deaminase and whole cells with a leucine dehydogenase and coenzyme regenerating function, and obtaining L-2-reanal after reaction. In the L-2-reanal biological preparation method, water is used for substituting for buffer salt solution to form a water-phase reaction system, cost of raw materials is reduced, threonine deaminase and whole cells used for catalyzing can be produced in batch by fermentation of microorganisms, are low in cost and wide in sources. Biological enzymatic catalysis reaction is water-phase reaction, transformation conditions of the enzymic method are mild, raw materials are transformed thoroughly, post-treatment is simple, products are separated by isoelectric point crystallization technology and film evaporation separation technology jointly, and the L-2-reanal biological preparation method is capable of recovering water and ammonium formate is low in cost, free of discharge of waste water and waste residues, environment-friendly in process and applicable to industrialized production of the L-2-reanal.

The invention relates to nutrient powder of germinated brown rice and a production process thereof and belongs to the food processing technology field. The invention is characterized in that the germinated brow rice is used as the main material is expanded, crushed, screened, mixed with oatmeal, soybean powder and white granulated sugar, sterilized and packaged, finally the nutrient powder of the germinated brown rice containing health ingredients of gamma-aminobutyric acid (GABA) is made. The germinated brown rice is produced by extrusion and expansion, so the invention has the advantages of no agglomeration and no precipitation during pouring the water into the nutrient powder, convenient use, being easily to be digested and absorbed by human body, and 15 to 20 mg per 100g GABA in the product.

The invention relates to a process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter hydrolyzing the product of said reaction and isolating the products by adjustment of the pH.

A cosmetic skin-care composition containing as the active principle a depigmentationally active combination of (a) an acidic mixture including (i) at least one alpha-hydroxylated acid or a derivative thereof, with the exception of ascorbic acid, and (ii) at least one compound selected from the group which consists of kojic acid, caffeic acid, azelaic acid, aminobutyric acid, fusaric acid, 5-hydroxy 2-hydroxymethyl-gamma-pyridone, and derivatives thereof, and (b) at least one active component of a plant extract from at least one plant selected from white mulberry, liquorice, skull cap, grapefruit, birch, heather, strawberry tree, bearberry, lemon, lettuce, oarweed, cucumber, ginseng, hop, sweet corn, feverfew, sage, soya, elder, spirulina, lime, ferocious aloe, yukinoshita, bloodwort, hoelen, wood rose, alpha-orizanol, burnet, ginkgo biloba, tanlex VB and Eclipsa alba, with the proviso that when the composition contains kojic acid and a liquorice extract, it contains at least one other plant extract component. The use of said composition for preparing a drug or in a cosmetic method is also disclosed.

Fermented soybean foods rich in gamma-aminobutyric acid are produced by fermentation of soybean using Tempe molds. Fermented soybean foods rich in gamma-aminobutyric acid and free amino acids are produced by fermentation of soybean using Tempe molds with anaerobic treatment. Fermented cereal foods rich in gamma-aminobutyric acid and free amino acids are also produced by fermentation of cereals with anaerobic treatment. Rhizopus oligosporus and Rhizopus oryzae are favorably used as the Tempe mold and Koji molds.

The invention belongs to the technical field of rice deep processing, in particular to a production method of a functional rice product which has a special sweet flavor and is rich in Gamma-aminobutyric acid and a product thereof, the rice product is produced by virtue of the activities of high glutamate decarboxylase, amylase and protease in germinated brown rice of an indica type rice or a non glutinous rice. The invention takes the indica type rice or the non glutinous brown rice as a raw material which carries out the steps of cleaning, disinfection, soaking, germination, cleaning, beating into rice milk, heat insulation, transformation, drum drying or spray drying, and the like, to be produced into functional nutrition rice flake or rice powder which is rich in Gamma-aminobutyric acid. Compared with the prior art, the rice product makes full use of the activities of the glutamate decarboxylase, the amylase and the protease in the germinated brown rice; the produced rice product has the special sweet flavor; by calculating based on dry basis, the content of Gamma-aminobutyric acid is high (1,000-1,400mg/100g), and the nutritional value and the digestibility are high. The rice product of the invention can be taken as the functional food for resisting fatigue and reducing blood lipid.

A peptide of the formula IX-A-D-Trp-Ywherein X is hydrogen, glycine, alanine, leucine, isoleucine, valine, N-valine, proline, tyrosine, phenylalanine, tryptophan, D-alanine, D-leucine, D-isoleucine, D-valine, D-N-valine, D-proline, D-tyrosine, D-phenylalanine, D-tryptophan, gamma -aminobutyric acid or xi -aminocaproic acid; A is D-gluptamic acid or D-y-glutamic acid; and Y is glycine, alanine, leucine, isoleucine, valine, N-valine, proline, tyrosine, phenylalanine, tryptophan, D-alanine, D-leucine, D-isoleucine, D-valine, D-N-valine, D-proline, D-tyrosine, D-phenylalanine, D-tryptophn, gamma -aminobutyric acid, xi -aminocaproic acid, hydroxyl, or an amide group.

A nutritive health-care fruit juice is prepared through choosing Korean ganoderma as bacterial strain, preparing culture medium from germinated long-grained non-glutinous rice mild, malt juice and germinated soybean juice for deep ferment, slant culture, stage-one shaker culture, stage-two seeding tank culture, deep fermenting, mixing the fermented liquid with grape jice, apple juice and orange juice, homogenizing, degassing, sterilizing and cooling. Its advantage is rich bioactive substances (ganoderma polyose, gamma-aminobutanoic acid, etc).

The invention relates to a biosynthesized gamma-aminobutyric acid preparation. By weight percentage, the product comprises 5 percent to 60 percent of gamma-aminobutyric acid. The preparation method of the biosynthesized gamma-aminobutyric acid preparation includes the following steps: first, streptococcus lactis strains are inoculated to a seed medium for fermentation composed of glucose, corn steep powder, defatted soybean flour and monosodium glutamate, thus forming fermentation broth; the fermentation broth is drained into a high speed centrifuge to form clear liquid centrifugally; the clear liquid is added with 250 mg/L chitosan at the temperature of 40 DEG C, and stirred for flocculation; the flocculated fermentation broth to be filtered enters a plate-and-frame filter, thus obtaining filtered clear liquid; the filtered clear liquid passes a cationic resin exchange bed for ion exchange; when ion exchange resins are saturated, the liquid is eluted by deionized water to elute all the glutamate; ammonia is used for eluting the liquid and extracting the gamma-aminobutyric acid. The method realizes large scale production of functional food factor GABA, so the method adapts to the production and processing of food with various forms and specifications as well as GABA products of nutritional foods.

A method for preparing yoghourt rich in gamma-aminobutyric acid (GABA) relates to a method for preparing yoghourt and comprises the steps of resuscitating, purifying and activating lactobacillus plantarum NDC75017, lactobacillus bulgaricus 11057 and streptococcus thermophilus CICC 20379, respectively enlarging culture solutions and then mixing to obtain a leavening agent, and inoculating the leavening agent to sterilized milk to ferment. The GABA content in the yoghourt rich in GABA is 151.51mg/100g. High-yield GABA bacterial strains and existing commonly-used bacterial strains are compoundedand then fermented to prepare the yoghourt rich in GABA, all the bacterial strains are food-grade lactic acid bacteria, and the safety is high. In addition, products have double effects, and the yoghourt rich in GABA integrates physiological efficacy of the GABA and health-care effect of yoghourt, namely the yoghourt rich in GABA is provided with special physiological efficacy of the GABA and thehealth-care effect of the yoghourt and is novel health-care yoghourt.

The invention relates to wheat germ and germinated brown rice composite nutritional powder and a production method thereof, and belongs to the technical field of food processing. The production method is characterized in that wheat germ and germinated brown rice are used as main raw materials; and the production method comprises the following steps of: performing microwave enzyme deactivation on the wheat germ, crushing, and sieving to obtain wheat germ powder; puffing the germinated brown rice, crushing, and sieving to obtain germinated brown rice powder; cooking the germinated brown rice, calendering and drying to obtain germinated brown rice flakes; and adding carrot powder, skim milk powder, white granulated sugar powder and spirulina powder, mixing, sterilizing, packing, and thus obtaining the wheat germ and germinated brown rice composite nutritional powder. The composite nutritional powder is rich in wheat germ protein and fat, and also contains health-care components such as wheat germ glutathione, octacosanol and gamma-amino butyric acid (GABA). The composite nutritional powder is rich in nutrition, does not cake during brewing, does not have sediment, is smooth in mouthfeel, good in chewing property and convenient to eat, and is easily digested and absorbed by human body.

The invention discloses a method for preparing germinated brown rice. The method comprises the following steps of: 1) cleaning brown rice serving as a raw material with water, and performing heat treatment on the cleaned brown rice in hot water at the temperature of between 25 and 30DEG C and the pH value of 3.5-4.5 for 3 to 6 minutes; 2) soaking the brown rice subjected to heat treatment in a germination accelerating solution at the temperature of between 25 and 30DEG C for 5 to 7 hours, wherein the germination accelerating solution is prepared from water, and contains 0.01 to 0.03 weight percent manganese sulfate, 0.03 to 0.05 weight percent zinc sulfate and 0.03 to 0.05 weight percent calcium chloride; 3) transferring the soaked brown rice into a germination library for germination; and 4) drying the germinated brown rice to obtain the germinated brown rice product. By the method, the brown rice germination time can be shortened by about 6 hours, the germination percentage is improved by about 8 percent compared with that of the traditional method, the content of GABA (gamma-aminobutyric acid) and reducing sugar in the germinated brown rice is improved, the quality of the product is high, and the edible safety is obviously improved.

The invention relates to a vector, an engineering strain and a method for producing L(+)-2-aminobutyric acid. The vector is a recombinant vector containing a threonine dehydratase coding gene, an L-amino acid dehydrogenase gene and appropriate vector segments. The engineering strain is obtained by transforming host bacteria by the recombinant vector. The L(+)-2-aminobutyric acid is prepared by fermentation culture of the engineering strain. The engineering strain is fermentation-cultured by glucose as a raw material to produce L(+)-2-aminobutyric acid. The method has the advantages of low cost, high product concentration, no by-product, easy product purification, and good industrial application feasibility.