7 results about "Aminocaproic acid" patented technology

The invention provides a treatment method of 6-aminocapronitrile synthesis reaction residues from caprolactam, which comprises the following steps: firstly, feeding the 6-aminocapronitrile synthesis reaction residues from caprolactam and fresh water into a stirred tank reactor for primary hydrolysis reaction, and fixing a catalyst on a stirring paddle through a metal wire mesh; then the reaction liquid and ammonia gas enter a multi-section gas-liquid two-phase tower reactor and sequentially pass through reaction sections filled with metal oxides, molecular sieves and solid base catalysts, and deep hydrolysis of polymers, decomposition of aminocaproic acid and ammonolysis of caprolactam are achieved. According to the method, the hydrolysis rate is larger than or equal to 94%, the yield of 6-aminocapronitrile is larger than or equal to 90%, the method has the advantages of being capable of deeply hydrolyzing residues, simple in process and continuous in operation, the problems of insufficient hydrolysis and intermittent operation in the prior art are solved, the solid waste discharge amount in the hexamethylenediamine production process is greatly reduced, cost is reduced, economic benefits are improved, and the method is suitable for industrial production. A guarantee is provided for green, environment-friendly and safe production.

The invention belongs to the field of medicines, and particularly relates to application of 6-amido-alpha-aminocaproic acid in preparation of medicines for preventing and / or treating pulmonary fibrosis, and the 6-amido-alpha-aminocaproic acid is a compound with a structure as shown in a formula 1 and pharmaceutically acceptable salt or ester thereof; formula 1; r is alkyl with 1 to 4 carbon atoms. The innovative research shows that the structure of the formula 1 can effectively prevent and treat pulmonary fibrosis.

This invention belongs to the field of biomedicine and relates to a procoagulant polypeptide TPTX and its applications. The procoagulant polypeptide TPTX of this invention can exert its procoagulant and hemostatic effects by specifically inhibiting plasmin activity. Experiments have shown that TPTX exhibits significant dose-dependent procoagulant and hemostatic effects in ferric chloride-induced mouse carotid artery thrombosis models, mouse liver hemorrhage models, mouse tail hemorrhage models, and mouse saphenous vein hemorrhage models, with effects superior to the positive control drug 6-aminocaproic acid. Simultaneously, TPTX can reduce the area of ​​atorvastatin-induced cerebral hemorrhage in zebrafish and improve their motor dysfunction. Mechanistic studies show that TPTX has an inhibitory constant Ki of 17.76 nM on plasmin and has no significant effect on the activity of seven other key serine proteases in the coagulation system, demonstrating a clear target and high selectivity. The procoagulant polypeptide of this invention can be used to prepare hemostatic drugs, possessing the advantages of high efficiency, clear target, and high selectivity, with broad prospects for clinical application.

The invention discloses a liver-protecting kudzu vine root composition and a preparation method and application thereof in the field of medicinal chemistry, and the liver-protecting kudzu vine root composition comprises a kudzu vine root extract, silymarin, a salvia miltiorrhiza extract, vitamins and two traditional Chinese medicine modified raw materials, the two modified raw materials are respectively an ester derivative formed by puerarin and aminobutyric acid and an ester derivative formed by glycyrrhizic acid and aminocaproic acid. The preparation method comprises the following steps: pre-mixing the extracts and the vitamins, adding the two modified raw materials, uniformly mixing, finally adding the pharmaceutic adjuvants, and tabletting and forming. The two modified raw materials are respectively prepared by activating puerarin or glycyrrhizic acid and corresponding aminocarboxylic acid under the action of a specific condensation reagent, condensing and purifying. According to the composition disclosed by the invention, two structurally modified active components are innovatively introduced and have a synergistic effect with a plurality of liver protection raw materials, so that the anti-oxidation, anti-inflammatory and liver protection effects are remarkably enhanced, and the composition can be used for preparing medicines or health-care products for preventing and treating alcoholic liver injury and non-alcoholic fatty liver diseases.

The invention discloses a method for depolymerizing nylon 6 waste into an aminocaproic acid monomer, which comprises the following steps: dispersing the crushed nylon 6 waste into a hydrogen peroxide aqueous solution, adding a titanium silicalite molecular sieve, heating and stirring to depolymerize the nylon 6 to obtain a depolymerization product containing the aminocaproic acid monomer; the mass concentration of the hydrogen peroxide aqueous solution is 0.8%-2.4%; the mass ratio of the titanium silicalite molecular sieve to the nylon 6 waste is (0.02-0.1): 1; the heating temperature is controlled to be 70-90 DEG C. According to the method provided by the invention, the nylon 6 waste can be depolymerized, the reaction condition is mild, the method has the characteristics of low reaction temperature and low pressure, the preparation process is simple and easy to operate, the production cost can be greatly reduced, and the method can be effectively applied to depolymerization of the nylon 6 waste.

The application discloses a preparation method of a Pd / FeAlO3 catalyst for H2 low-temperature catalytic combustion, and relates to the field of synthesis of novel hydrogen combustion catalysts. The application firstly constructs a FeAlO3 carrier, and then loads Pd nanoparticles. In the preparation of the FeAlO3, the solvent of 6-aminocaproic acid is replaced by n-hexane instead of water. In the subsequent reaction, the n-hexane and the aqueous solution form a special two-dimensional phase interface as a soft template. The Pd nanoparticles are carried by the two-dimensional structure soft template, and a better active catalyst can be formed.

An object of the present invention is to provide a novel glycation stress inhibitor having an activity of inhibiting glycation stress occurring in vivo.SOLUTION: The glycation stress inhibitor, the glycation reaction inhibitor or the inflammatory reaction inhibitor for inhibiting the inflammatory reaction caused by AGEs contains one or more kinds selected from the group consisting of glycyrrhizic acids, allantoins, azulenes, pyridoxine hydrochloride, hinokitiols, copper chlorophylls, lysozyme chloride and epsilon-aminocaproic acid. Each agent is useful as an external preparation, an agent for oral cavity, a gingival care agent, and a periodontal disease preventive agent.SELECTED DRAWING: None