Injection moldable bone repair composite material and preparation method thereof

Abstract

The invention relates to an injection moldable bone repair composite material and a preparation method and a using method thereof. The composite material is a powder material consisting of a copolymer of multiple amino acids and a sulfate component of calcium, the sulfate component of the calcium accounts for 60-95% of total weight of the component material, and the balance is the copolymer of the multiple amino acids. The sulfate component of the calcium comprises alpha-hemihydrated calcium sulfate which accounts for 15%-60% of the total weight of the composite material and the balance of other sulfates of the calcium. The copolymer of the multiple amino acids is formed by polymerizing epsilon-aminocaproic acid and at least two types of other amino acids, and the molar ratio of each amino acid in the other amino acids is not less than 1% of the total weight of the amino acids. When in preparation, an intermediate parent body is obtained by in-situ polymerization and composition of other sulfates of the calcium and the amino acid monomers under inert gas protection and heating, and the composite material is prepared by smashing and then being composed with the alpha-hemihydrated calcium sulfate. The composite material powder is mixed with curing liquid, and then the composite material can be used by injection. The composite material can be fast molded after the injection and has the strength which is equivalent to that of cancellous bone, good biocompatibility and adjustable degradation speed, thereby being applicable to fixation and repair of clinical orthopedic complicated and irregular traumas.

Description

technical field [0001] The invention relates to a medical composite material which can be used as a bone tissue repair and reconstruction material, in particular to a bone repair composite material which can be used for injection and rapid prototyping and its preparation and use method. Background technique [0002] Due to trauma, infection, tumor or congenital diseases and other reasons, it can cause bone defects or atrophy in people of all ages, especially the elderly, which will cause serious dysfunction and deformity. Although the use of autologous bone or allogeneic bone has its own advantages in the clinical operation of bone defect and osteonecrosis repair, there are also many problems and difficulties. Therefore, people have been looking for other substitutes for bone repair / reconstruction. [0003] Most of the bone repair materials currently on the market, including natural polymer materials, synthetic polymer materials, inorganic materials and composite materials, ...

AI Technical Summary

Problems solved by technology

However, the degradation rate of injectable calcium sulfate bone substitutes cannot be adjusted, and the absorption rate in the body is relatively fast. It is not suitable for repairing large bone defects and bone defects with long healing time, and is generally not used for the treatment of diaphysis fracture defects. , not to use it instead of internal fixation or external fixation

[0006] Although injectable calcium phosphate has good biocompatibility and osteoconductivity, and can be freely plasticized, its shortcomings of high brittleness, slow degradation, uncontrollable degradation rate, and insufficient mechanical properties also limit its clinical application.

Some gel-type injectable bone repair materials can hardly provide any mechanical strength

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