The invention discloses a reinforced reactive injectable bone cement and a preparation method thereof. The bone cement comprises the following components: tricalcium phosphate, polylactic acid, calcium sulphate, coral powder, ferulic acid, silk fibroin, talcum powder, barium sulfate, cervus and cucumis polypeptide, gastrodin, vitamin C, zinc oxide, tantalum oxalate, PEEK(polyether-ether-ketone), polyvinylpyrrolidone, methyl-beta-cyclodextrin, maleyl chitosan and normal saline. The injectable bone cement provided by the invention is excellent in syringeability, the compressive strength and the bending strength are high, and the mechanical property requirements of a bone repair material are met. In addition, the bone cement provided by the invention is good in cell compatibility, is relatively good in osteoconduction, is convenient for promoting the self-healing repair of bone tissue, and improves the firmness in the combination of the bone cement and bone, thereby well meeting clinic application requirements.