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Preparation method of injectable bone repair material

A technology of bone repair and bone powder, applied in medical science, prosthesis, etc., can solve the problems of small pore size and porosity, unfavorable growth of osteoblasts, etc.

Active Publication Date: 2011-06-08
北京科健生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem of small pore size and porosity of calcium sulfate materials in the prior art, which is not conducive to the growth of osteoblasts and blood vessel growth, the present invention provides a preparation method of an injectable bone repair material, the injectable bone repair material Comprising α-calcium sulfate hemihydrate, bone powder particles, biodegradable polymers and nucleating agents, the method includes the steps of: after fully mixing the components of the injectable bone repair material, adding a solidifying solution to make the The solidified liquid and the injectable bone repair material are evenly compounded, wherein the ratio of the solidified liquid to the injectable bone repair material is 0.4-0.8ml of solidified liquid: 1g of the injectable bone repair material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) Grinding and sieving of allogeneic bone meal particles

[0024] The bone meal was ground at low temperature, passed through 75-mesh and 150-mesh sieves in turn, and sieved to obtain bone meal particles with an average diameter of 0.1-0.2 mm, vacuum-packed into a transparent composite bag, and then sterilized with 25 kGy of γ-rays for use.

[0025] 2) Preparation of α-calcium sulfate hemihydrate / allogeneic bone meal particles binary composite injectable material

[0026]α-Calcium sulfate hemihydrate was mixed with allogeneic bone powder particles in a mass ratio of 4:1, and stirred at room temperature for 30 minutes with a magnetic stirrer. After stirring evenly, according to the liquid-solid ratio of 0.5ml / g, fully reconcile the solid powder with distilled water for 1 minute. A minimally invasive injectable bone repair material can be obtained, the injectable time is 17 minutes, and the curing time is 25 minutes. The compressive strength reaches 30MPa. But its por...

Embodiment 2

[0028] 1) Grinding and sieving of allogeneic bone meal particles

[0029] The bone meal was ground at low temperature, passed through 75-mesh and 150-mesh sieves in turn, and sieved to obtain bone meal particles with an average diameter of 0.1-0.2 mm, vacuum-packed into a transparent composite bag, and then sterilized with 25 kGy of γ-rays for use.

[0030] 2) Preparation of solidification solution

[0031] Prepare a 2.5% hyaluronic acid solution with distilled water, stir evenly, and place in a 37°C water bath for 2 hours, and the hyaluronic acid solution is fully swollen.

[0032] 3) Preparation of α-calcium sulfate hemihydrate / allogeneic bone meal particles / hyaluronic acid ternary composite injectable material

[0033] α-Calcium sulfate hemihydrate was mixed with allogeneic bone powder particles in a mass ratio of 4:1, and stirred at room temperature for 30 minutes with a magnetic stirrer. After stirring evenly, according to the liquid-solid ratio of 0.4ml / g, use hyaluron...

Embodiment 3

[0035] 1) Grinding and sieving of allogeneic bone meal particles

[0036] The bone meal was ground at low temperature, passed through 75-mesh and 150-mesh sieves in turn, and sieved to obtain bone meal particles with an average diameter of 0.1-0.2 mm, vacuum-packed into a transparent composite bag, and then sterilized with 25 kGy of γ-rays for use.

[0037] 2) Preparation of solidification solution

[0038] Prepare a 2.5% hyaluronic acid solution with physiological saline, stir it evenly and place it in a water bath at 37°C for 2 hours, and then fully swell the hyaluronic acid solution.

[0039] 3) Preparation of α-calcium sulfate hemihydrate / allogeneic bone meal particles / hyaluronic acid ternary composite injectable material

[0040] Mix α-calcium sulfate hemihydrate and allogeneic bone meal particles in a mass ratio of 4:1, then add 2% calcium sulfate dihydrate, and stir at room temperature for 30 minutes with a magnetic stirrer. After stirring evenly, according to the liq...

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Abstract

The invention provides a preparation method of an injectable bone repair material. The injectable bone repair material comprises alpha-calcium sulfate hemihydrate, bone meal particles, biodegradable polymers, a nucleating agent and a curing solution. After the injectable bone repair material is cured, the compression strength can reach about 30Mpa, the porosity can reach 43.7%, and the pore diameter can be as high as 20-100 micrometers. The curing time of the injectable bone materials is between 7 min and 125 min. Therefore, the injectable bone repair material provided by the invention is suitable for clinical application for minimally invasive bone repair.

Description

technical field [0001] The invention relates to a preparation method of an injectable bone repair material. Background technique [0002] Bone defect is one of the most common diseases in clinical orthopedics. It can be caused by infection, trauma, tumor and congenital diseases. Most of them cannot heal by themselves and need bone grafting. With the aging population and the increase of various traumas, the demand for biomedical materials, especially bone graft materials, continues to grow. Many natural and synthetic materials and compositions have been used for the treatment of bone defects. [0003] Autologous cancellous bone has long been considered the most effective material for bone repair because it is both osteoinductive and non-immunogenic. However, the unfavorable factors such as insufficient sources, increased intraoperative blood loss, and surgical complications limit its clinical application. [0004] Allograft bone and xenograft bone are currently the most co...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/20A61L27/02A61L27/00
Inventor 周静奚廷斐盖增李智峰
Owner 北京科健生物技术有限公司
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