85 results about "Bone graft materials" patented technology

An interbody spinal implant / fusion cage and implant inserter system for facilitating interbody fusion in the lumbar spine using bone graft while reducing the number of passes made through the patient's disc space and the sensitive surrounding tissue by integrating bone graft delivery into the inserter system. The system combines insertion of the interbody implant with bone graft delivery directly into the disc space. The system includes the interbody implant, an interbody cover plate, an implant inserter assembly, a cover plate inserter, a bone graft plunger and a bone graft funnel. The inserter assembly includes a large rectangular cannula which attaches to a large rectangular posterior opening in the interbody implant instead of a round cannula. The rectangular cannula approximates the shape of the annulotomy and provides a larger cross-sectional area for passage of a much larger quantity of bone graft material without jamming. Related methods and kits are also disclosed.

The invention discloses a piezoelectric double-network hydrogel coating modified titanium material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The piezoelectric double-network hydrogel coating modified titanium material provided by the invention comprises a titanium substrate, an adhesion layer and a piezoelectric double-network hydrogel coating, wherein the adhesion layer and the piezoelectric double-network hydrogel coating are compounded on the titanium substrate; the adhesion layer is compounded on the titanium substrate, and the adhesion layer is positioned between the titanium substrate and the piezoelectric double-network hydrogel coating; and the piezoelectric double-network hydrogel coating is prepared from methacrylic acid modified gelatin, sodium alginate and whitmanite nanoparticles. According to the prepared modified titanium material, electric signals can be generated on the surface of the piezoelectric material under the action of polarization or stress, recovery of charge transfer of a bone defect part is facilitated, a good electroactive microenvironment is created for bone regeneration, the osseointegration capacity of the modified titanium material is enhanced, and bone regeneration is effectively promoted; the method has a wide application prospect in preparation of bone graft materials and bone repair materials.

A kit of parts from which selection is made to form an intervertebral fusion device. The kit of parts comprises a plurality of different endplates and a core component. Each of the plurality of different endplates is configured to be received in an intervertebral space defined between first and second vertebrae. The core component is configured to engage with each of the plurality of endplates and a selected one of the plurality of endplates when the selected endplate and the core component are received in the intervertebral space. Each of the plurality of endplates defines a bone graft aperture which is open at top and bottom surfaces of the endplate and extends between the top and bottom surfaces, the thus defined bone graft apertures being of substantially the same dimensions as one another when the plurality of endplates are in plan view. The core component defines a bone graft material holding space having a holding space opening in one of a core component top surface and a core component bottom surface of the core component. The holding space opening is of substantially the same dimensions as each of the bone graft apertures when the core component is in plan view. The holding space opening is substantially coextensive with the bone graft aperture of the selected endplate in plan view and when the core component is engaged with and in registration with the selected endplate.

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

A tissue graft delivery system and associated devices are described. The tissue graft delivery devices utilized a conveyor belt moved by an actuator mechanism to shuttle a tissue graft, such as bone graft material, from a chute containing the graft into a surgical site, such as an intervertebral disc space. The interactive system and devices eliminate graft packing, inefficient tissue delivery, and other difficulties arising from friction between the bone graft material and graft contact surfaces of existing prior art systems, such as bone funnels.

The invention discloses a composite bone graft material based on bletilla striata polysaccharide and autologous tooth bone meal as well as a preparation method and application of the composite bone graft material. The preparation method comprises the following steps: preparing bletilla striata polysaccharide, namely BSP, from bletilla striata; the method comprises the following steps: pretreating extracted teeth, and crushing to obtain autologous tooth bone powder, namely AutoBT; dissolving the BSP in water, and uniformly stirring to obtain a BSP solution; the AutoBT is poured into the BSP solution, and after standing and stirring, an AutoBT solution loaded with BSP is obtained; and carrying out vacuum drying on the AutoBT solution loaded with the BSP, and carrying out ultraviolet sterilization to obtain the composite bone graft material. The material can be applied to repairing of oral cavity bone defects, bletilla striata polysaccharide has the effects of resisting inflammation, inhibiting bacteria, promoting osteogenesis and inhibiting osteoclast, the bone steady state unbalance state in the periodontitis environment is effectively reversed, meanwhile, autologous tooth bone powder accelerates bone tissue regeneration and integration by means of the natural bionic structure and high porosity of the autologous tooth bone powder, and the bone tissue regeneration effect is improved. The risks of postoperative infection and immunological rejection are reduced.

The utility model discloses an absorbable net-shaped device for fixing bone grafting materials, and relates to the technical field of medical oral cavity, the absorbable net-shaped device comprises a woven net and bone nails, the woven net is made of absorbable biological materials, tightening ropes are arranged at four corners of the woven net, and each tightening rope is correspondingly wound on one bone nail. The bone nail is rotationally nailed into the dentale, the woven net is tightened to fix the bone grafting material, meanwhile, the woven net is an absorbable biological material and does not need to be taken out through a special operation in the later period, and the pain of a patient and the medical burden are greatly relieved.

[Solution] An expandable intervertebral spacer system has upper and lower plates forming a cage. The top, bottom, and sides of the cage have openings for receiving bone graft material. At least one angled section extends from the upper or lower plate into the cage. The upper and lower plates are connected to each other by a hinge at the proximal end of the cage. The cage is expanded by inserting a push rod from the proximal end of the cage against the angled section, forcing the upper and lower plates apart at a desired angle. A locking mechanism at the distal end of the cage uses a ratcheting mechanism to secure the plates apart. In this ratcheting mechanism, a torsion spring biases a movable strut against a fixed strut, which cooperates with sawtooth engagement on the movable and fixed struts to secure the upper and lower plates apart.

The utility model relates to the technical field of medical instruments, in particular to a bone graft material forming and cutting device. A bone graft material forming and cutting device comprises a shell, an observation plate, a sealing door, guide plates, a loading frame, a first electric sliding rail and the like, a hollow cavity is formed in the shell from the left side to the middle, the observation plate is installed on the front side of the shell, the sealing door is rotationally connected to the left side of the shell, and the guide plates are fixedly connected to the bottom of the cavity in a bilateral symmetry mode; a loading frame is slidably connected to the upper portion of the guide plate, and first electric sliding rails are installed on the rear side wall of the cavity in a bilateral symmetry mode. A three-dimensional motion system composed of the first electric sliding rail, the second electric sliding rail and the third electric sliding rail is arranged, automatic control is achieved in cooperation with the controller, the high-precision non-contact cutting effect on bone graft materials is achieved, the closed design is adopted, the pollution risk possibly caused by traditional mechanical cutting is reduced, and the cutting efficiency is improved. And the quality and the safety of the material are ensured.

One embodiment of the present invention provides a method of producing a fibrous non-demineralized bone graft material, the method comprising: a step of removing soft tissue, blood, and bone marrow from bone; a dehydration step of immersing, in an aqueous ethanol solution, the bone from which the soft tissue, blood, and bone marrow have been removed, and stirring same; a primary defatting step of immersing and stirring the dehydrated bone in diethyl ether; a step of crushing the bone subjected to the primary defatting into fibrously processed bone; a step of screening the fibrously processed bone; a hydration step of immersing and stirring the screened fibrously processed bone in ethanol; a secondary defatting step of immersing and stirring the hydrated fibrously processed bone in hydrogen peroxide; a washing step of washing the fibrously processed bone subjected to the secondary defatting; and a freeze-drying step.

The invention relates to a preparation method of a plastic bone grafting material and the plastic bone grafting material.The preparation method comprises the following steps that a, phenyl phosphate lithium salt is dissolved in a phosphoric acid buffer salt solution to obtain a mixed solution, and Ge MA is dissolved in the mixed solution to obtain a Ge MA gel solution; b, bone meal and the Ge MA gel solution are subjected to a cross-linking effect, so that the bone meal and the Ge MA gel solution are fully mixed, then light source irradiation is conducted, the bone meal hydrogel bone grafting material is obtained, and the particle size of the bone meal is 0.25-0.5 mm. According to the preparation method of the plastic bone grafting material, provided by the invention, the bone meal and the Ge MA gel solution are subjected to cross-linking and then subjected to light source irradiation, so that the bone meal and the hydrogel are uniformly mixed, the compatibility of an organic phase and a bone meal particle interface is good, and the prepared plastic bone grafting material is relatively high in plasticity and good in osteoinductivity; and the cell adhesion rate is high.

One embodiment of the present specification provides a method for preparing a low-crystallinity calcium phosphate-based antibacterial bone graft material, comprising the steps of: (a) adding a calcium precursor and a phosphate precursor at one time to synthesize calcium phosphate; (b) putting the calcium phosphate into an antibacterial substance precursor solution to react; (c) a step of freeze-drying the product of step (b); (d) a step of mixing the product of step (c) with a shape control agent and performing press molding to prepare a molded body; and (e) a step in which the shape control agent of the molded body is removed in a solvent having a temperature equal to or higher than the boiling point and then dried.

The invention discloses a digital auxiliary PRF bone meal complex preparation method applied to periodontal minimally invasive surgery, belongs to the technical field of PRF bone meal complex preparation, and overcomes the defects that in the prior art, PRF bone meal complex and minimally invasive surgery combination is ineffective, and MIST curative effect improvement is limited due to poor adaptability of bone grafting materials. The method comprises the following steps: constructing a matched three-dimensional oral cavity model according to multi-source oral cavity data of a patient; reconstructing and cutting the three-dimensional oral cavity model to obtain an operation area surface data model; performing optimization and manufacturing adaptation processing on the surface data model of the operation area to obtain a three-dimensional digital model of the subbony pocket form female die; according to the three-dimensional digital model, preparing a subosseous pocket form female die, and preparing the PRF bone powder complex matched with the subosseous pocket in the subosseous pocket form female die.

The invention discloses a traditional Chinese medicine ingredient modified bone graft material and a preparation method thereof, and relates to the technical field of bone graft materials. The feed additive is prepared from the following raw materials: calcined bone meal and a traditional Chinese medicine extract, the traditional Chinese medicine extract comprises a radix salviae miltiorrhizae extract and / or a radix scutellariae extract. The preparation method comprises the following steps: preparing calcined bone meal, preparing simulated body fluid and preparing the modified bone graft material. The product material can be applied to a dental bone grafting material. The traditional Chinese medicine extract is loaded on the bone material, and the bone material is modified, so that the bone graft material with good biocompatibility, osteogenesis promoting capability and better osteogenesis induction potential can be obtained.

The invention discloses a surface modified titanium stent with a magnetic hydrogel coating and a preparation method and application of the surface modified titanium stent, and belongs to the technical field of biomedical materials. The surface modified titanium scaffold with the magnetic hydrogel coating comprises a titanium substrate, a polydopamine coating and a hydrogel precursor solution coating, wherein the polydopamine coating and the hydrogel precursor solution coating are compounded on the titanium substrate; the polydopamine coating is positioned between the titanium substrate and the hydrogel precursor solution coating; the hydrogel precursor solution is prepared from freeze-dried GelMA, Fe3O4 nanoparticles and ammonium persulfate. The prepared surface modified titanium scaffold with the magnetic hydrogel coating has excellent mechanical properties and stability, and can improve the ALP activity level of cells, improve the collagen secretion level and promote mineralization in the stem cell osteogenic differentiation process through an external magnetic field with certain strength, so that the bone regeneration process is accelerated, and the osteogenic differentiation effect is improved. The method has a wide application prospect in preparation of bone graft materials and bone repair materials.

The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

The utility model provides an interbody fusion cage which comprises a body and threads formed on the outer surface of the body, and is characterized in that the interbody fusion cage is provided with an opening groove used for containing bone grafting materials, the opening groove is spirally arranged along the outer surface of the interbody fusion cage, the interbody fusion cage comprises a front end portion and a rear end portion, the front end portion is in a circular truncated cone shape, and the rear end portion is in a circular truncated cone shape. The rear end part is cylindrical, the threaded teeth of the front end part are provided with front end threaded tooth tips pointing to the front end, and the threaded teeth of the rear end part are provided with rear end threaded tooth tips pointing to the rear end. Therefore, the correct distance between the upper vertebral body and the lower vertebral body is guaranteed, and meanwhile bony fusion between the vertebral bodies is effectively promoted.

The invention discloses an anisotropic hydrogel fiber coating modified titanium material and a preparation method thereof, and belongs to the technical field of medical instrument surface coating preparation. The anisotropic hydrogel fiber coating modified titanium material comprises a titanium substrate, an adhesion layer and a hydrogel fiber coating, wherein the adhesion layer and the hydrogel fiber coating are compounded on the titanium substrate; the adhesion layer is compounded on the titanium substrate, and the adhesion layer is positioned between the titanium substrate and the hydrogel fiber coating; the hydrogel fiber coating is prepared from methacryloyl gelatin, silk fibroin and nano-hydroxyapatite through electrostatic spinning. The prepared modified titanium material can keep high water content, viscoelasticity and hydrophilicity, meanwhile, a stable micro-orientation structure and a hydrogel fiber structure with good cell compatibility are obtained, endogenous cells can be collected in situ, osteogenic differentiation of the cells is effectively promoted, and the osteogenic differentiation rate of the cells is increased. The method has a wide application prospect in preparation of bone graft materials and bone repair materials.

Disclosed herein are components, systems, and methods delivery bone graft material to a treatment site. Specifically, embodiments of a bone graft delivery system are disclosed that include a cannula defining a lumen, and a sled defining a channel. A first portion of the sled forms a lateral opening extending into the channel perpendicular to a length of the sled, and a second portion of the sled includes an injector coupler. The sled is operably couplable to the cannula such that the first sled portion is positioned within the lumen and the second sled portion is positioned outside the lumen. Embodiments of the bone graft delivery system include a plunger sized to be insertable into the lumen through the channel, and a push step that slidably receives the plunger. Also disclosed are methods of use of the bone graft delivery system.

The present invention relates to a spinal fusion implant and, more specifically, to a spinal fusion implant, which is inserted between neighboring vertebrae so as to promote bone growth. Provided in one embodiment of the present invention is the spinal fusion implant comprising: a frame structure, which is disposed between the neighboring vertebrae, forms a truss structure, and supports the vertebrae; and a porous structure which fills at least a portion of the inner space of the frame structure, and which comes into contact with the neighboring vertebrae. The present invention can include: the frame structure disposed between the neighboring vertebrae so as to support the vertebrae; and the porous structure which fills at least a portion of the inner space of the frame structure, and which confines a bone graft material injected into the inner space.

A maxillofacial device includes a substructure with a shape that is custom made to a patient's maxillofacial area; a framework coupled to the substructure, the framework and substructure being made of a single continuous material or a combination of materials, the framework having a plurality of grid elements; and one or more plate fixations coupled to the substructure. The framework has a shape that is custom made to fit the patient's maxillary sinus area. The framework is configured to be surrounded by a bone graft material, wherein the substructure and framework provide rigidity and stiffness for the bone graft material.

A maxillofacial device includes a substructure with a shape that is custom made to a patient's maxillofacial area; a framework coupled to the substructure, the framework and substructure being made of a single continuous material or a combination of materials, the framework having a plurality of grid elements; and one or more plate fixations coupled to the substructure. The framework has a shape that is custom made to fit the patient's maxillary sinus area. The framework is configured to be surrounded by a bone graft material, wherein the substructure and framework provide rigidity and stiffness for the bone graft material.

The present invention relates to the use of bone graft particles in the preparation of a porous bone graft material comprising an acid-containing self-setting adhesive composition. The bone graft particles have a porous core, the outer surface of which is at least partially covered by an outer layer. The core comprises a core material selected from the group consisting of a heterograft, a bone xenograft, and a bone allograft, or mixtures thereof. And the outer particle layer comprises carbonate.

Graft materials made from citric acid-based materials are disclosed. The graft material has particular applicability in forming biodegradable scaffolds, and it generally includes a composition comprising (i) a citric acid component, (ii) a polyol, and (iii) a particulate inorganic material.

Tools adapted for spinal surgery are provided. More specifically, provided herein are apparatuses, systems, kits and methods for accurate, rapid and reliable placement of surgical cages or other medical implants in a patient's spine, and delivery of bone graft material thereto.

A system for performing posterior spinal fusion at a zygopophyseal joint comprises an implant device (1) and a fixture device (2) thereof. The implant device (1) is in the form of an element comprising an opening (12) for receiving bone graft material, intended to be inserted into a pre-prepared lacuna (5) at a zygopophysis joint to be fixed, while the fixation device is in the form of a transarticular screw (2) for pressurizing the implant device (1) in the lacuna, comprising a threaded distal end portion (20) intended to be screwed into at least the bone material (3) downstream of the implant device (1), the proximal end portion (21) of which is shaped to abut against or be screwed into the bone material (4) upstream of the implant device (1).

Provided herein are formulations for treating bone graft materials prior to implantation. Treating the bone graft materials with the formulations disclosed herein can restore the physiological and biochemical characteristics of bone. The bone graft can be a bone allograft. Also provided herein are methods for preparing the formulations and methods for preparing a bone graft for transplantation.

A spinal disc implant including a body defined by a plurality of interwoven or braided nitinol strands. The body includes a first end and a second end. The nitinol strands come together at the first end and are secured with a first fitting. The nitinol strands also come together at the second end and are secured with a second fitting. The second fitting can include a snare hook. The braided nitinol skeleton is internally assembled within the intervertebral disc. The implant is filled with liquid, gel or silicone when utilized as a motion preserving nucleus pulpous implant. The implant is filled with bone graft material when utilized as an inter-body fusion implant. An instrument and technique that provides a minimally invasive “needle based” solution to address degenerative disc disease with enhanced structural integrity of the spine compared to conventional surgical devices and techniques.

The present invention relates to methods for bioresorbable and biodegradable casings having both micropores and macropores for providing shape, structure and containment to different bone grafting materials. Kits and methods of use are also described.