10 results about "Periodontal tissue" patented technology

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

The utility model provides a visual periodontal therapeutic apparatus, which mainly comprises a handle, a working part fixed at one end of the handle, an optical lens arranged at the outlet position of a chute at the tail end of the working part in a sliding manner, and a bendable adjusting rod and an adjusting roller which are arranged in the chute. The optical lens is connected with the display device through a cable, so that periodontal internal conditions of a patient can be visually observed; one end of the bendable adjusting rod is connected with the optical lens, and the other end is provided with a rack structure; the adjusting roller is rotatably arranged on the handle and meshed with the rack structure, and part of the adjusting roller is exposed out of the surface of the handle to facilitate shifting. By shifting the adjusting roller, the bendable adjusting rod slides in the sliding groove to drive the optical lens to slide, so that the distance between the optical lens and the working tip of the working part is adjusted. The visual periodontal therapeutic apparatus is simple and convenient to operate, flexible to adjust and convenient for periodontal treatment.

The purpose of the present invention is to improve periodontal inflammation. It is possible to improve periodontal inflammation by using a periodontal inflammation improving composition that contains plasmalogen extracted from a tissue of an animal such as shellfish, ascidians, and aves.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

This invention relates to the field of pharmaceutical technology, specifically disclosing the application of sea buckthorn extract in the preparation of products for the prevention and treatment of periodontitis. The invention uses network pharmacology to predict the potential molecular mechanisms of sea buckthorn extract in preventing and treating periodontitis, and validates these mechanisms in vivo using a rat model of experimental periodontitis. Results show that sea buckthorn extract significantly improves periodontal probing depth and gingival bleeding index in rats with periodontitis, reduces the expression levels of IL-6, TNF-α, IL-1β, and MMP-9 in serum and gingival tissue, and alleviates periodontal inflammation. Simultaneously, sea buckthorn extract upregulates the expression of RUNX2, OCN, OPG, and ALP, downregulates the expression of RANKL and COX-2, inhibits osteoclast formation, improves alveolar bone resorption, and regulates bone homeostasis. This invention provides a new medical application for sea buckthorn extract, which can be used to prepare products for the prevention and / or treatment of periodontitis.

Disclosed is a preparation method of a collagen matrix membrane and an application thereof. The invention uses animal intestinal casing as a raw material and sequentially includes steps such as decellularization and degreasing to prepare a collagen matrix membrane with excellent mechanical properties and a long degradation cycle. This membrane is more conducive to providing sufficient bone regeneration space and time during the initial healing phase of periodontal disease, better meeting clinical application needs. Additionally, the collagen matrix membrane prepared by the invention is loaded with multiple growth factors beneficial to periodontal tissue growth, thereby facilitating periodontal tissue regeneration and repair, and improving therapeutic efficacy.

This invention relates to a gradient elastic modulus sports protective brace, its preparation method, and its application. The gradient elastic modulus sports protective brace includes at least an impact-resistant layer, a buffer layer, and an adhesive layer with a segmented or continuous gradient distribution of elastic modulus. The adhesive layer is used to adhere to the tooth surface and oral soft tissues, and to help disperse residual impact energy. The buffer layer surrounds the adhesive layer and is used to disperse impact energy. The impact-resistant layer surrounds the buffer layer and is used to resist external impact loads and guide energy inward. The elastic modulus of the impact-resistant layer is greater than that of the buffer layer, and the elastic modulus of the buffer layer is greater than that of the adhesive layer. Compared with existing technologies, this invention, through its gradient elastic modulus distribution design, achieves progressive absorption and effective dissipation of impact energy by the sports brace, significantly reducing the peak force on the user's teeth and periodontal tissues during impact, thereby improving overall protective performance and making it suitable for sports scenarios of varying intensities.

This invention relates to the field of biopharmaceutical technology, specifically to a BTO / PB acoustic pressure electrocatalytic nanoplatform ointment, its preparation method, and its application. The ointment is an injectable BTO / PB acoustic pressure electrocatalytic nanoplatform ointment formed by combining a barium titanate and Prussian blue composite nanomaterial with an ointment. The BTO / PB acoustic pressure electrocatalytic nanoplatform ointment of this invention exhibits excellent biocompatibility. Unlike traditional antibiotics, BTO / PB generates ROS (reactive oxygen species) through an ultrasound-driven catalytic reaction, independent of antibiotics, thus eliminating the risk of drug resistance. It effectively addresses the increasingly serious problem of antibiotic resistance, has a good antibacterial effect against periodontal pathogens, significantly alleviates gingival inflammation, reduces the infiltration of inflammatory cells, lowers the expression of inflammatory factors, and effectively inhibits osteoclast activity, thereby protecting alveolar bone and maintaining the integrity of periodontal tissues.

The present application provides the use of methylcatester for treating periodontitis. The present application also provides a method for preparing a sustained-release drug film containing methylcatester. The sustained-release drug film provided by the present application can inhibit the release of inflammatory factors, inhibit bacterial adhesion, and has a sustained-release time of up to the seventh day, has obvious effect on anti-periodontitis, and can effectively reduce the pathological changes of periodontal tissue.

This invention provides a green preparation method and application for bioactive glass. The preparation method of this invention does not generate nitrogen oxide gases, uses readily available calcium sources, has a simple preparation process with high raw material utilization, and produces no toxic or harmful gases during the preparation process, meeting the requirements of green chemistry. The bioactive glass prepared by this invention exhibits good bioactivity and is preferably used for bone repair, bone wound healing, and periodontal tissue repair.