55 results about "Periodontal tissue" patented technology

The invention discloses injectable composite collagen dispersion liquid and hydrogel thereof, a preparation method and application of the injectable composite collagen dispersion liquid in preparation of drugs for treating periodontitis, the injectable composite collagen dispersion liquid comprises freeze-dried SIS collagen, itaconic anhydride and a photoinitiator, the mass ratio of the freeze-dried SIS collagen to the itaconic anhydride is 1: (1-5), a solvent is a phosphate buffer solution, the injectable composite collagen dispersion liquid is subjected to photoinitiation, and the injectable composite collagen is obtained. To form a hydrogel. The injectable composite collagen dispersion liquid has certain flowability, directly acts on a periodontal lesion of a patient through an injector, and forms hydrogel in situ through short-time photo-initiation, the mechanical properties of the injectable composite collagen dispersion liquid and the hydrogel can meet the mechanical requirements of periodontal tissues, and the injectable composite collagen dispersion liquid has the effect of promoting osteogenesis; therefore, the compound can be applied to preparation of drugs for treating periodontitis.

The invention discloses a histone-derived peptide nano-particle for targeted degradation of cytoplasm cGAS and a preparation method and application thereof, and is characterized in that a polypeptide compound is dissolved in a phosphate buffer, ultrasonic treatment and room temperature standing self-assembly are performed to form nano-particles, and centrifugal purification is performed to obtain the histone-derived peptide nano-particle A4-CMA NPs for targeted degradation of cytoplasm cGAS. The nano-particles (A4 at CMA NPs) can be combined with cytoplasm cGAS in a targeted manner and mediate the cytoplasm cGAS to degrade, so that the activation of a cGAS-STING pathway is blocked, periodontal tissue inflammation and alveolar bone resorption are effectively relieved, and a new strategy is provided for periodontitis treatment.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

This invention discloses a histone-derived peptide nanoparticle targeting the degradation of cytoplasmic cGAS, its preparation method, and its applications. The invention is characterized by: dissolving a peptide complex in phosphate buffer, sonicating, allowing it to self-assemble at room temperature to form nanoparticles, and purifying by centrifugation to obtain histone-derived peptide nanoparticles A4@CMA NPs targeting the degradation of cytoplasmic cGAS. These nanoparticles (A4@CMA NPs) can target and bind to cytoplasmic cGAS, mediating its degradation, blocking the activation of the cGAS-STING pathway, effectively reducing periodontal inflammation and alveolar bone resorption, and providing a new strategy for the treatment of periodontitis.

The technical field of the present invention is medical and dental preparations, and provides a siRNA targeting the PITX2 gene and a medicine and application thereof, wherein the medicine is used to prevent and treat periodontitis, and comprises an siRNA targeting the PITX2 gene, wherein the siRNA specifically binds to and targets the mRNA of the PITX2 gene, thereby blocking the expression of the PITX2 gene, thereby inhibiting the production of inflammatory epithelial cells SAA1+Epi in periodontal tissue. The present invention can significantly reduce the degree of alveolar bone absorption and delay the progression of periodontitis.

The present invention relates to a two- or three-layer film composition for periodontal use, comprising a hydrophobic polymer outer layer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The utility model provides a visual periodontal therapeutic apparatus, which mainly comprises a handle, a working part fixed at one end of the handle, an optical lens arranged at the outlet position of a chute at the tail end of the working part in a sliding manner, and a bendable adjusting rod and an adjusting roller which are arranged in the chute. The optical lens is connected with the display device through a cable, so that periodontal internal conditions of a patient can be visually observed; one end of the bendable adjusting rod is connected with the optical lens, and the other end is provided with a rack structure; the adjusting roller is rotatably arranged on the handle and meshed with the rack structure, and part of the adjusting roller is exposed out of the surface of the handle to facilitate shifting. By shifting the adjusting roller, the bendable adjusting rod slides in the sliding groove to drive the optical lens to slide, so that the distance between the optical lens and the working tip of the working part is adjusted. The visual periodontal therapeutic apparatus is simple and convenient to operate, flexible to adjust and convenient for periodontal treatment.

The invention relates to the field of biological medicine, and discloses a preparation method of a medicine-carrying plugging treatment device based on a digital photocuring 3D printing technology, which comprises the following steps: step 1, importing an initial structure of the plugging treatment device based on oral cavity three-dimensional scanning data into three-dimensional design software, dividing a space region of the initial structure of the plugging treatment device into a plurality of discrete points, and forming a plurality of discrete points; constructing a Thiessen polygonal porous structure based on the discrete points; 2, converting the Thiessen polygonal porous structure into a slice file adaptive to photocuring 3D printing, and importing the slice file into a photocuring 3D printer for layer-by-layer printing to obtain a porous plugging device blank; and step 3, cleaning the porous plugging treatment device green bodies in sequence. Personalized modeling based on oral cavity three-dimensional scanning data, parameterized topological optimization of a Thiessen polygonal porous structure and a digital photocuring 3D printing technology are fused, and pore filling of drug-loaded hydrogel is combined, so that personalized fitting of the plugging treatment device, an alveolar ridge and periodontal tissue is achieved.

The purpose of the present invention is to improve periodontal inflammation. It is possible to improve periodontal inflammation by using a periodontal inflammation improving composition that contains plasmalogen extracted from a tissue of an animal such as shellfish, ascidians, and aves.

The present invention relates to formulations with active oxygen compounds that include active oxygen and other active ingredients for the purposes of care for and / or maintaining and preserving a healthy condition of skin and integumentary systems on the surface of the body of the organism and in the ears, healthy condition of finger- and toenails and of oral cavity, including its mucous membranes, teeth, interdental spaces and periodontal tissues (gingiva) in the oral cavity, i.e. the target areas of the organism. The formulation for skin and integumentary systems on the surface of the body and in the ears and for the finger- and toenails is in the form of a solution, gel, emulsion, lotion, milk, spray, cream, film dressing, liposomes and / or mycelia. The formulation for the oral cavity and related systems and structures, including teeth, interdental spaces and periodontal tissues (gingiva) is in the form of a solution, mouthwash, spray, gel, paste, emulsion, film dressing, liposomes and / or mycelia. These formulations are included in the device for its application on and / or into the said area of the organism.

The invention discloses application of overexpressed AQP1 mitochondria in preparation of products for treating bone defect, stem cells of overexpressed AQP1 are constructed through a lentiviral transfection method, overexpressed AQP1 mitochondria is obtained, and the obtained mitochondria has mitochondrial structure and function integrity and is enriched with AQP1 protein; in an in-vitro experiment, the overexpressed AQP1 mitochondria can inhibit the polarization and osteoclast differentiation capability of macrophages and relieve inflammation; a periodontitis animal model research shows that overexpression AQP1 mitochondrial transplantation can regulate and control a bone immune microenvironment and relieve tissue inflammation damage; the bone resorption can be inhibited, the damage of tissue collagen fibers is reduced, and the bone defect repair and regeneration of diseases such as periodontitis are promoted. Therefore, the overexpressed AQP1 mitochondria can be used for precise treatment of diseases such as periodontal tissue or bone tissue defects, the treatment effect is remarkably superior to that of common mitochondria, and the overexpressed AQP1 mitochondria has good transformation application prospects in the fields of tissue engineering and cell-free treatment.

The application discloses a hydrogel composite material CMU-L.p-36@MeHA and a preparation method and application thereof, and belongs to the technical field of biotechnology.The hydrogel composite material CMU-L.p-36@MeHA disclosed by the application loads plant lactobacillus CMU-L.p-36 on a MeHA hydrogel carrier.The CMU-L.p-36@MeHA hydrogel disclosed by the application shows a good treatment effect on rat periodontitis by reducing alveolar bone absorption, reducing expression of inflammatory factor TNF-alpha, promoting ordered arrangement of collagen fibers and repairing periodontal tissues.

The utility model provides a saliva suction tube and a saliva suction instrument. The saliva suction tube comprises a tube head, a tube body and a tube tail, along the length direction of the saliva suction tube, the inner diameter of the tube head is gradually increased from the open end of the tube head to the end close to the tube body, and the inner diameter of the tube tail is firstly reduced and then increased from the open end of the tube tail to the end close to the tube body. According to the design, the saliva suction tube is lengthened, the tube tail utilizes the Laval principle, suction is enhanced, the tube head adopts the improved front-end small-caliber design, the device can penetrate into an operation area to suck saliva in time, the sterile principle is guaranteed, suction is enhanced, the saliva suction effect is guaranteed, damage to periodontium of teeth is minimum, the noninvasive effect is achieved, the design is simple, reliability is high, and the device is suitable for popularization and application. The cost is low, and a simple and convenient solution is provided for the condition that the clinical microsurgery cannot meet timely saliva suction.

Provided is a therapeutic agent for regenerating periodontal tissues also capable of restoring periodontal tissues lost by severe periodontal disease. A therapeutic agent for regenerating periodontal tissues contains a MAP4K selective inhibitor. Alternatively, the MAP4K selective inhibitor is GNE-495 or PF06260933. Alternatively, the therapeutic agent for regenerating periodontal tissues is administered with a growth factor FGF-2. Alternatively, the therapeutic agent for regenerating periodontal tissues is characterized in that the FGF-2 is a recombinant human FGF-2. Alternatively, an agent for enhancing proliferation of periodontal ligament cels contains a MAP4K selective inhibitor. Alternatively, the therapeutic agent for regenerating periodontal tissues is in a liquid form.

The invention relates to a composite in the form of a two-or three-layer film for periodontal use, comprising an outer layer of a hydrophobic polymer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The utility model provides a brace-shaped magnetic resonance oral cavity wireless coil and magnetic resonance imaging equipment. The magnetic resonance oral cavity wireless coil comprises a plurality of wireless resonant rings and a flexible substrate, each wireless resonant ring is of a flexible loop structure, the wireless resonant rings are arranged in an array mode, every two adjacent wireless resonant rings are coupled, the wireless resonant rings are used for receiving magnetic resonance signals, the wireless resonant rings are arranged on the flexible substrate, and the flexible substrate is arranged on the flexible substrate. The flexible substrate is used for being attached to an oral cavity area. The unique tooth socket-shaped structure is tightly attached to oral anatomy, the sensitivity is high, upper and lower dentitions can be imaged at the same time, full-oral scanning is achieved, the process is greatly simplified, the coil has ultrahigh resolution and excellent signal-to-noise ratio, dental crowns, root canals and periodontal tissues can be accurately captured, and excellent soft tissue contrast is provided. The compact and high-adaptability design gives consideration to the comfort and diversified requirements of the patient.

The invention relates to the technical field of mouth and tooth cleaning and repairing, and discloses a colloid system for improving the adhesive force of nano-hydroxyapatite and a preparation method and application of the colloid system. Preparing a solution containing a dispersing agent; adding the nano-hydroxyapatite into the solution containing the dispersing agent, and stirring to enable the nano-hydroxyapatite to be fully dispersed; adding a charge modifier into the solution; fumed silica powder is added into the solution; adding divaricate saposhnikovia root and eclipta prostrata extract into the solution, and stirring; finally, adding the colloidal solution and stirring to uniformly distribute the colloidal solution; adjusting the pH value, and filtering to obtain a mixed solution colloid system. When the tooth repairing agent is applied to enamel and periodontium, the adhesive force of nano-hydroxyapatite particles to teeth can be increased, so that the tooth repairing capability is improved. After chemical bonds on the surfaces of the particles are combined with traditional Chinese medicine components, antibacterial and blood coagulation components in the traditional Chinese medicine can be further slowly released to teeth and periodontium.

A method for measuring periodontal disease and treating diseases associated therewith includes: obtaining B-mode ultrasound images of a dentition and periodontium of a patient; identifying gingival margin (GM), alveolar bone crest (ABC), cementoenamel junction (CEJ), periodontal ligament (PDL), and gingival edge (GE) biomarkers on the B-mode ultrasound images, the GE biomarker being a part of periodontal soft tissue most distal from a tooth surface; evaluating a metric associated with periodontal disease using one or more of the GM, ABC, CEJ, PDL and GE biomarkers and based at least in part on the evaluating, performing an act that implements and / or adjusts a therapeutic treatment of a periodontal disease.

The present invention discloses a composition containing a hydrangea extract, Thunberginol C, hydrangeic acid, hydrangenol, or a sitologically acceptable salt thereof as an active ingredient for preventing, alleviating, or treating periodontitis. The present invention has the effect of preventing, alleviating, or treating periodontitis by inhibiting inflammation, protecting periodontal tissue, and alleviating bone loss through inhibition against the production of TNF-alpha mRNA, IL-6 mRNA, MMP-3 mRNA, MMP-9 mRNA, MMP-13 mRNA, and PGE2 and the expression of COX-2 mRNA and through an increase in BMD and a decrease in CEJ-ABC, thereby protecting periodontal tissue.

To provide an artificial dental root that is optimal to accelerate the reproduction of paradentium in consideration of the flow of liquid.SOLUTION: An artificial dental root (10) is in the form a circular cylinder with a crown (20) on one end and a root apex (39) on the opposite end. Provided between the crown and the root apex are two or more vertically arranged spheres (31, 32), and a boundary (38) between the spheres is formed of a smooth curved surface concave toward an axis (P) side. As a result of this, repetitive flow of blood in a bone marrow occurs easily, which accelerates formation of a periodontal membrane and reproduces and restores paradentium.SELECTED DRAWING: Figure 2

The invention provides PDA-Ga < 3 + > nanoparticles and a preparation method and application thereof, and is characterized in that the preparation method comprises the following steps: S1, dissolving dopamine hydrochloride and gallium chloride in deionized water, and stirring to obtain a pre-doped solution; s2, adding a buffer solution into the pre-doped solution, controlling the pH value of a reaction system to be alkaline, carrying out a stirring reaction to form a black suspension, and continuing the stirring reaction; and S3, centrifuging and washing the reaction system in the step S2 to obtain the PDA-Ga < 3 + > nanoparticles. The PDA-Ga < 3 + > nanoparticles provided by the invention have multiple characteristics of pH responsiveness, antibacterial property, anti-inflammatory property and bidirectional regulation and control of osteogenesis and osteoclast differentiation, and are expected to realize collaborative treatment of periodontitis, alleviation of inflammatory response of periodontium, reduction of alveolar bone resorption and induction of bone tissue regeneration, so that the success rate of periodontitis treatment is improved.

The invention discloses a direction-variable magnetic tooth traction appliance, relates to the technical field of orthodontics, and aims to solve the problems that the orthodontic force and angle of a traditional appliance cannot be flexibly adjusted, bacteria are easy to breed, the aesthetic property is poor and the like. The appliance comprises a tooth socket, a fixing block with strong magnetism is arranged on the tooth socket, a target block is arranged on an inverted long tooth to be drawn, and the fixing block with strong magnetism is connected with the target block through a magnetic fishbone chain. According to the invention, the design conforming to the physiological structure and growth characteristics of the oral cavity of children is adopted, and the inverted long teeth are drawn to grow in the correct direction by mild and continuous magnetic attraction. The uniform distribution of correction force is ensured, and the damage to fragile periodontal tissues of children is avoided. The medical magnetic material which is safe and non-toxic and has good biocompatibility is selected as the material, so that the safety and comfort of wearing are guaranteed. Meanwhile, adjustability is emphasized in structural design, and correction force and direction can be adjusted at any time according to the growth process of teeth of children.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

The present invention relates to a composition for promoting collagen production comprising amidated amino acids, and more specifically, to a composition that promotes collagen production in various cells such as fibroblasts, follicular cells, dermal papilla cells, endothelial cells, chondrocytes, muscle cells, and osteoblasts, thereby preventing, improving, or treating various diseases and lesions that may result from collagen reduction in the skin, hair, blood vessels, cartilage, tendons, connective tissues, muscles, bones, teeth, and periodontal tissues.

The invention discloses an artemisinin compound type composition for inhibiting periodontitis and repairing mucous membranes. The invention relates to the technical field of periodontitis repair compositions. The composition comprises an antibacterial component and formylated hyaluronic acid. According to the artemisinin compound type periodontitis inhibition and mucous membrane repair composition, the antibacterial component can be combined with protein of bacteria to denature the protein of the bacteria, so that the growth and reproduction of the bacteria are inhibited, in treatment of periodontitis, the number of harmful bacteria in the oral cavity can be reduced, meanwhile, the inhibition effect on the bacteria causing periodontitis can be enhanced, and the inflammatory response can be relieved; the sulfonated chitosan, the L-ascorbic acid and other components can promote the tissue repair function, can be adsorbed on the mucous membrane surface in oral mucous membrane repair, provide a support for cell attachment and growth, facilitate migration and proliferation of damaged mucous membrane cells, promote synthesis of collagen, facilitate repair of damaged periodontal tissues and mucous membranes and improve the oral mucous membrane repair effect. The wound healing is accelerated.

The invention discloses an application of Ce6-loaded ultramicro mesoporous silica nanoparticles in preparation of a medicine for treating periodontitis. Nanoparticles Ce6 at-MSN-NH2-30 and Ce6 at-MSN-NH2-200 with different particle sizes are firstly prepared, and further research shows that in an in-vitro experiment, compared with the Ce6 at-MSN-NH2-200, the Ce6 at-MSN-NH2-30 can effectively improve the removal effect on P.g. And a biological membrane thereof in antibacterial photodynamic therapy, effectively inhibit the formation of the biological membrane thereof and improve the antibacterial photodynamic therapy effect. Bacterial biofilms can be permeated more quickly, so that stronger antibacterial and killing effects are achieved; the in-vivo experiment of a rat periodontitis model shows that the Ce6 at-MSN-NH2-30 not only obviously relieves the injury of periodontium and effectively relieves the periodontitis, but also inhibits the further development of the periodontitis. The research of the invention is expected to provide a high-performance photosensitizer material for photodynamic antibacterial treatment of periodontitis.

The present invention relates to a composition for the prevention or treatment of inflammatory diseases, particularly inflammatory periodontal diseases, the composition comprising a steroid sulfatase inhibitor as an active ingredient. The compound of the present invention has the effect of regenerating periodontal tissues by inhibiting inflammatory responses due to periodontal diseases and, at the same time, effectively inhibiting the destruction of inflammatory periodontal tissues, and thus can be usefully administered for the treatment of periodontal diseases.

The application discloses a preparation and application method of a probiotic-loaded electrospun film composition for treating periodontitis, and comprises the following steps: S1, first, an electrospun film (PLGA-nHA) doped with hydroxyapatite nanoparticles (nHA) and polylactic acid (PLGA) is prepared through electrospinning; S2, Lactobacillus plantarum DP189 is cultured; and S3, a preparation of the probiotic-loaded electrospun film. The probiotic-loaded electrospun film composition can improve the symptoms of periodontal tissues of rats, such as reducing inflammatory response, reducing the content of inflammatory factor TNF-alpha, increasing the content of bone saliva protein BSP, and improving the absorption degree of alveolar bone of rats. The probiotic-loaded electrospun film composition can be used for preparing a biological preparation for treating periodontitis, and can also be applied to treating other various diseases in the oral cavity, and has a very wide application prospect.

The chemical composition general formula of the lithium-doped silicon-based hydroxyapatite nanowire is CaxLi20-2x (P1-ySiyO4) 6 (OH) 2, x is more than 0 and less than or equal to 9.09, and y is more than or equal to 0.05 and less than or equal to 0.12. The preparation method of the lithium-doped silicon-based hydroxyapatite nanowire comprises the following steps: firstly, preparing a lithium-doped calcium silicate nanowire by utilizing a hydrothermal method; and then preparing the lithium-doped silicon-based hydroxyapatite nanowire by using a hydrothermal method. According to the preparation method disclosed by the invention, the bionic osteogenesis induction characteristic of a nano-level hydroxyapatite material is combined with the bone metabolism steady state regulation and immune reaction of lithium and silicon elements, and the preparation conditions and chemical components of the material are adjusted, so that the lithium-doped silicon-based hydroxyapatite nanowire doped with the lithium element in a proper proportion is obtained; by regulating and controlling the periodontal tissue immune microenvironment and maintaining the bone metabolism balance, the method is applied to regeneration and repair of the inflammatory periodontal bone defect, and a new thought is provided for tissue engineering immunotherapy of the inflammatory periodontal bone defect.

This invention relates to the field of pharmaceutical technology, specifically disclosing the application of sea buckthorn extract in the preparation of products for the prevention and treatment of periodontitis. The invention uses network pharmacology to predict the potential molecular mechanisms of sea buckthorn extract in preventing and treating periodontitis, and validates these mechanisms in vivo using a rat model of experimental periodontitis. Results show that sea buckthorn extract significantly improves periodontal probing depth and gingival bleeding index in rats with periodontitis, reduces the expression levels of IL-6, TNF-α, IL-1β, and MMP-9 in serum and gingival tissue, and alleviates periodontal inflammation. Simultaneously, sea buckthorn extract upregulates the expression of RUNX2, OCN, OPG, and ALP, downregulates the expression of RANKL and COX-2, inhibits osteoclast formation, improves alveolar bone resorption, and regulates bone homeostasis. This invention provides a new medical application for sea buckthorn extract, which can be used to prepare products for the prevention and / or treatment of periodontitis.