102 results about "Periodontal tissue" patented technology

The invention discloses application of cimiprevir in preparation of a bacteriostatic agent and a medicine for preventing and treating periodontitis, and relates to the technical field of disease treatment by using cimiprevir. Studies find that cimiprevir can be combined with EF-Tu protein to inhibit adhesion of the EF-Tu protein to an interface, further inhibit adhesion of bacteria (especially oral streptococcus) to an oral interface and formation of a plaque biofilm, regulate proliferation and growth of the bacteria and play an effective bacteriostatic role, and cimiprevir can be used for preparing a bacteriostatic agent or a preparation for preventing and treating periodontitis; the composition can effectively reduce periodontal tissue damage, reduce alveolar bone absorption and reduce osteoclast infiltration, and is used for preparing a preparation for protecting periodontal tissue or alveolar bone.

The invention discloses combined lactobacillus salivarius CCFM1398 for regulating and controlling bone homeostasis and relieving bone resorption and a metagen of the combined lactobacillus salivarius CCFM1398, and belongs to the technical field of microorganisms. The combined lactobacillus salivarius CCFM1398 provided by the invention is separated from oral dental plaque of healthy teenagers, has the effects of relieving bone resorption and resisting inflammation, and is specifically reflected in that expression of protein level and gene level of MC3T3-E1 cell osteoprotegerin (OPG) is improved in vitro; the bone absorption amount of orthodontic bone absorption rat alveolar bone is reduced, the number of alveolar bone osteoclasts is reduced, and the level of rat serum OPG is improved; the secretion of inflammatory factors TNF-alpha, IL-6 and MPO of the orthodontic bone absorption rat is reduced; and the pathological condition of orthodontic bone absorption rat alveolar bone tissue is improved. Therefore, the combined lactobacillus salivarius has a huge application prospect in products for relieving bone resorption and assisting in inhibiting periodontal tissue inflammation.

The invention discloses injectable composite collagen dispersion liquid and hydrogel thereof, a preparation method and application of the injectable composite collagen dispersion liquid in preparation of drugs for treating periodontitis, the injectable composite collagen dispersion liquid comprises freeze-dried SIS collagen, itaconic anhydride and a photoinitiator, the mass ratio of the freeze-dried SIS collagen to the itaconic anhydride is 1: (1-5), a solvent is a phosphate buffer solution, the injectable composite collagen dispersion liquid is subjected to photoinitiation, and the injectable composite collagen is obtained. To form a hydrogel. The injectable composite collagen dispersion liquid has certain flowability, directly acts on a periodontal lesion of a patient through an injector, and forms hydrogel in situ through short-time photo-initiation, the mechanical properties of the injectable composite collagen dispersion liquid and the hydrogel can meet the mechanical requirements of periodontal tissues, and the injectable composite collagen dispersion liquid has the effect of promoting osteogenesis; therefore, the compound can be applied to preparation of drugs for treating periodontitis.

The invention discloses a histone-derived peptide nano-particle for targeted degradation of cytoplasm cGAS and a preparation method and application thereof, and is characterized in that a polypeptide compound is dissolved in a phosphate buffer, ultrasonic treatment and room temperature standing self-assembly are performed to form nano-particles, and centrifugal purification is performed to obtain the histone-derived peptide nano-particle A4-CMA NPs for targeted degradation of cytoplasm cGAS. The nano-particles (A4 at CMA NPs) can be combined with cytoplasm cGAS in a targeted manner and mediate the cytoplasm cGAS to degrade, so that the activation of a cGAS-STING pathway is blocked, periodontal tissue inflammation and alveolar bone resorption are effectively relieved, and a new strategy is provided for periodontitis treatment.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

This invention discloses a histone-derived peptide nanoparticle targeting the degradation of cytoplasmic cGAS, its preparation method, and its applications. The invention is characterized by: dissolving a peptide complex in phosphate buffer, sonicating, allowing it to self-assemble at room temperature to form nanoparticles, and purifying by centrifugation to obtain histone-derived peptide nanoparticles A4@CMA NPs targeting the degradation of cytoplasmic cGAS. These nanoparticles (A4@CMA NPs) can target and bind to cytoplasmic cGAS, mediating its degradation, blocking the activation of the cGAS-STING pathway, effectively reducing periodontal inflammation and alveolar bone resorption, and providing a new strategy for the treatment of periodontitis.

The technical field of the present invention is medical and dental preparations, and provides a siRNA targeting the PITX2 gene and a medicine and application thereof, wherein the medicine is used to prevent and treat periodontitis, and comprises an siRNA targeting the PITX2 gene, wherein the siRNA specifically binds to and targets the mRNA of the PITX2 gene, thereby blocking the expression of the PITX2 gene, thereby inhibiting the production of inflammatory epithelial cells SAA1+Epi in periodontal tissue. The present invention can significantly reduce the degree of alveolar bone absorption and delay the progression of periodontitis.

The present invention relates to a two- or three-layer film composition for periodontal use, comprising a hydrophobic polymer outer layer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The utility model provides a visual periodontal therapeutic apparatus, which mainly comprises a handle, a working part fixed at one end of the handle, an optical lens arranged at the outlet position of a chute at the tail end of the working part in a sliding manner, and a bendable adjusting rod and an adjusting roller which are arranged in the chute. The optical lens is connected with the display device through a cable, so that periodontal internal conditions of a patient can be visually observed; one end of the bendable adjusting rod is connected with the optical lens, and the other end is provided with a rack structure; the adjusting roller is rotatably arranged on the handle and meshed with the rack structure, and part of the adjusting roller is exposed out of the surface of the handle to facilitate shifting. By shifting the adjusting roller, the bendable adjusting rod slides in the sliding groove to drive the optical lens to slide, so that the distance between the optical lens and the working tip of the working part is adjusted. The visual periodontal therapeutic apparatus is simple and convenient to operate, flexible to adjust and convenient for periodontal treatment.

The invention relates to the field of biological medicine, and discloses a preparation method of a medicine-carrying plugging treatment device based on a digital photocuring 3D printing technology, which comprises the following steps: step 1, importing an initial structure of the plugging treatment device based on oral cavity three-dimensional scanning data into three-dimensional design software, dividing a space region of the initial structure of the plugging treatment device into a plurality of discrete points, and forming a plurality of discrete points; constructing a Thiessen polygonal porous structure based on the discrete points; 2, converting the Thiessen polygonal porous structure into a slice file adaptive to photocuring 3D printing, and importing the slice file into a photocuring 3D printer for layer-by-layer printing to obtain a porous plugging device blank; and step 3, cleaning the porous plugging treatment device green bodies in sequence. Personalized modeling based on oral cavity three-dimensional scanning data, parameterized topological optimization of a Thiessen polygonal porous structure and a digital photocuring 3D printing technology are fused, and pore filling of drug-loaded hydrogel is combined, so that personalized fitting of the plugging treatment device, an alveolar ridge and periodontal tissue is achieved.

The purpose of the present invention is to improve periodontal inflammation. It is possible to improve periodontal inflammation by using a periodontal inflammation improving composition that contains plasmalogen extracted from a tissue of an animal such as shellfish, ascidians, and aves.

The present invention relates to formulations with active oxygen compounds that include active oxygen and other active ingredients for the purposes of care for and / or maintaining and preserving a healthy condition of skin and integumentary systems on the surface of the body of the organism and in the ears, healthy condition of finger- and toenails and of oral cavity, including its mucous membranes, teeth, interdental spaces and periodontal tissues (gingiva) in the oral cavity, i.e. the target areas of the organism. The formulation for skin and integumentary systems on the surface of the body and in the ears and for the finger- and toenails is in the form of a solution, gel, emulsion, lotion, milk, spray, cream, film dressing, liposomes and / or mycelia. The formulation for the oral cavity and related systems and structures, including teeth, interdental spaces and periodontal tissues (gingiva) is in the form of a solution, mouthwash, spray, gel, paste, emulsion, film dressing, liposomes and / or mycelia. These formulations are included in the device for its application on and / or into the said area of the organism.

The invention discloses application of overexpressed AQP1 mitochondria in preparation of products for treating bone defect, stem cells of overexpressed AQP1 are constructed through a lentiviral transfection method, overexpressed AQP1 mitochondria is obtained, and the obtained mitochondria has mitochondrial structure and function integrity and is enriched with AQP1 protein; in an in-vitro experiment, the overexpressed AQP1 mitochondria can inhibit the polarization and osteoclast differentiation capability of macrophages and relieve inflammation; a periodontitis animal model research shows that overexpression AQP1 mitochondrial transplantation can regulate and control a bone immune microenvironment and relieve tissue inflammation damage; the bone resorption can be inhibited, the damage of tissue collagen fibers is reduced, and the bone defect repair and regeneration of diseases such as periodontitis are promoted. Therefore, the overexpressed AQP1 mitochondria can be used for precise treatment of diseases such as periodontal tissue or bone tissue defects, the treatment effect is remarkably superior to that of common mitochondria, and the overexpressed AQP1 mitochondria has good transformation application prospects in the fields of tissue engineering and cell-free treatment.

The invention discloses a Lactobacillus paracasei strain capable of relieving bone resorption and having an anti-inflammatory effect and a metagen thereof, and belongs to the technical field of microorganisms. The lactobacillus paracasei CCFM1394 provided by the invention is separated from oral dental plaque of healthy teenagers, has the effects of relieving bone resorption and resisting inflammation, and is specifically reflected in that the expression of MC3T3-E1 cell osteoprotegerin (OPG) is improved in vitro, and meanwhile, the expression of an RUNX gene of MC3T3-E1 is promoted; therefore, the lactobacillus paracasei has a huge application prospect in products for relieving bone resorption and assisting in inhibiting periodontal tissue inflammation.

The application discloses a hydrogel composite material CMU-L.p-36@MeHA and a preparation method and application thereof, and belongs to the technical field of biotechnology.The hydrogel composite material CMU-L.p-36@MeHA disclosed by the application loads plant lactobacillus CMU-L.p-36 on a MeHA hydrogel carrier.The CMU-L.p-36@MeHA hydrogel disclosed by the application shows a good treatment effect on rat periodontitis by reducing alveolar bone absorption, reducing expression of inflammatory factor TNF-alpha, promoting ordered arrangement of collagen fibers and repairing periodontal tissues.

The utility model provides a saliva suction tube and a saliva suction instrument. The saliva suction tube comprises a tube head, a tube body and a tube tail, along the length direction of the saliva suction tube, the inner diameter of the tube head is gradually increased from the open end of the tube head to the end close to the tube body, and the inner diameter of the tube tail is firstly reduced and then increased from the open end of the tube tail to the end close to the tube body. According to the design, the saliva suction tube is lengthened, the tube tail utilizes the Laval principle, suction is enhanced, the tube head adopts the improved front-end small-caliber design, the device can penetrate into an operation area to suck saliva in time, the sterile principle is guaranteed, suction is enhanced, the saliva suction effect is guaranteed, damage to periodontium of teeth is minimum, the noninvasive effect is achieved, the design is simple, reliability is high, and the device is suitable for popularization and application. The cost is low, and a simple and convenient solution is provided for the condition that the clinical microsurgery cannot meet timely saliva suction.

Provided is a therapeutic agent for regenerating periodontal tissues also capable of restoring periodontal tissues lost by severe periodontal disease. A therapeutic agent for regenerating periodontal tissues contains a MAP4K selective inhibitor. Alternatively, the MAP4K selective inhibitor is GNE-495 or PF06260933. Alternatively, the therapeutic agent for regenerating periodontal tissues is administered with a growth factor FGF-2. Alternatively, the therapeutic agent for regenerating periodontal tissues is characterized in that the FGF-2 is a recombinant human FGF-2. Alternatively, an agent for enhancing proliferation of periodontal ligament cels contains a MAP4K selective inhibitor. Alternatively, the therapeutic agent for regenerating periodontal tissues is in a liquid form.

The invention relates to a composite in the form of a two-or three-layer film for periodontal use, comprising an outer layer of a hydrophobic polymer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The utility model provides a brace-shaped magnetic resonance oral cavity wireless coil and magnetic resonance imaging equipment. The magnetic resonance oral cavity wireless coil comprises a plurality of wireless resonant rings and a flexible substrate, each wireless resonant ring is of a flexible loop structure, the wireless resonant rings are arranged in an array mode, every two adjacent wireless resonant rings are coupled, the wireless resonant rings are used for receiving magnetic resonance signals, the wireless resonant rings are arranged on the flexible substrate, and the flexible substrate is arranged on the flexible substrate. The flexible substrate is used for being attached to an oral cavity area. The unique tooth socket-shaped structure is tightly attached to oral anatomy, the sensitivity is high, upper and lower dentitions can be imaged at the same time, full-oral scanning is achieved, the process is greatly simplified, the coil has ultrahigh resolution and excellent signal-to-noise ratio, dental crowns, root canals and periodontal tissues can be accurately captured, and excellent soft tissue contrast is provided. The compact and high-adaptability design gives consideration to the comfort and diversified requirements of the patient.

The invention relates to the technical field of oral care, and particularly discloses an oral care composition as well as a preparation method and application thereof. The oral care composition comprises metformin and copper ions. According to the oral care composition disclosed by the invention, the metformin and the copper ions are added, so that the oral care composition has a relatively good antibacterial effect and has an effect of relieving inflammation and injury of periodontal tissues, the effect of the oral care composition is superior to that of independently using the metformin or independently using the copper ions, and the oral care composition has a relatively high application value in preparation of medicines for treating periodontal diseases.

The invention relates to the technical field of mouth and tooth cleaning and repairing, and discloses a colloid system for improving the adhesive force of nano-hydroxyapatite and a preparation method and application of the colloid system. Preparing a solution containing a dispersing agent; adding the nano-hydroxyapatite into the solution containing the dispersing agent, and stirring to enable the nano-hydroxyapatite to be fully dispersed; adding a charge modifier into the solution; fumed silica powder is added into the solution; adding divaricate saposhnikovia root and eclipta prostrata extract into the solution, and stirring; finally, adding the colloidal solution and stirring to uniformly distribute the colloidal solution; adjusting the pH value, and filtering to obtain a mixed solution colloid system. When the tooth repairing agent is applied to enamel and periodontium, the adhesive force of nano-hydroxyapatite particles to teeth can be increased, so that the tooth repairing capability is improved. After chemical bonds on the surfaces of the particles are combined with traditional Chinese medicine components, antibacterial and blood coagulation components in the traditional Chinese medicine can be further slowly released to teeth and periodontium.

A method for measuring periodontal disease and treating diseases associated therewith includes: obtaining B-mode ultrasound images of a dentition and periodontium of a patient; identifying gingival margin (GM), alveolar bone crest (ABC), cementoenamel junction (CEJ), periodontal ligament (PDL), and gingival edge (GE) biomarkers on the B-mode ultrasound images, the GE biomarker being a part of periodontal soft tissue most distal from a tooth surface; evaluating a metric associated with periodontal disease using one or more of the GM, ABC, CEJ, PDL and GE biomarkers and based at least in part on the evaluating, performing an act that implements and / or adjusts a therapeutic treatment of a periodontal disease.

The present invention discloses a SIS membrane based on hydroxyapatite coating, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises: selecting a small intestine jejunum segment to prepare a SIS membrane; after the SIS membrane seals the mucosal layer, it is placed in a mineralizing solution and soaked for 1.5 to 3 hours, and after mineralization, washing and freeze-drying are performed to obtain a SIS-HA composite membrane with hydroxyapatite mineralization; and the application of the SIS membrane based on hydroxyapatite coating prepared by the method of the present invention in the preparation of materials for treating periodontal disease. The present invention adopts a pig small intestine jejunum segment to prepare a SIS membrane, and innovatively prepares a SIS-HA membrane with a HA coating by a biomineralization method. The experiment verifies that the membrane has good biocompatibility, is conducive to cell adhesion, proliferation and migration, and has the dual characteristics of immunoregulation and osteogenic induction. Animal experiments have obtained satisfactory periodontal tissue regeneration effects, and the new SIS-HA composite membrane with a HA coating provided by the present invention has broad application prospects in periodontal tissue regeneration.

The present invention discloses a dual-responsive quercetin-caffeic acid phenethyl ester lipid composite gel and its preparation method and application. The present invention first uses microemulsion-lipid cascade drug delivery technology to co-load quercetin and caffeic acid phenethyl ester into liposomes, and then distributes the liposomes in a dual-responsive gel composed of chitosan, poloxamer 407 and poly-N-isopropylacrylamide to construct a dual-responsive quercetin-caffeic acid phenethyl ester lipid composite gel. The composite gel has a temperature-sensitive and pH-sensitive dual-responsive performance, and after administration, quercetin can be preferentially released to achieve rapid anti-inflammatory effects, and then caffeic acid phenethyl ester is released to promote osteogenic differentiation in the periodontal part, which can synergistically play the therapeutic effects of eliminating periodontal tissue inflammation and promoting alveolar bone repair, and provides a new preparation for the treatment of periodontitis.

The present invention discloses a composition containing a hydrangea extract, Thunberginol C, hydrangeic acid, hydrangenol, or a sitologically acceptable salt thereof as an active ingredient for preventing, alleviating, or treating periodontitis. The present invention has the effect of preventing, alleviating, or treating periodontitis by inhibiting inflammation, protecting periodontal tissue, and alleviating bone loss through inhibition against the production of TNF-alpha mRNA, IL-6 mRNA, MMP-3 mRNA, MMP-9 mRNA, MMP-13 mRNA, and PGE2 and the expression of COX-2 mRNA and through an increase in BMD and a decrease in CEJ-ABC, thereby protecting periodontal tissue.

To provide an artificial dental root that is optimal to accelerate the reproduction of paradentium in consideration of the flow of liquid.SOLUTION: An artificial dental root (10) is in the form a circular cylinder with a crown (20) on one end and a root apex (39) on the opposite end. Provided between the crown and the root apex are two or more vertically arranged spheres (31, 32), and a boundary (38) between the spheres is formed of a smooth curved surface concave toward an axis (P) side. As a result of this, repetitive flow of blood in a bone marrow occurs easily, which accelerates formation of a periodontal membrane and reproduces and restores paradentium.SELECTED DRAWING: Figure 2

The invention provides PDA-Ga < 3 + > nanoparticles and a preparation method and application thereof, and is characterized in that the preparation method comprises the following steps: S1, dissolving dopamine hydrochloride and gallium chloride in deionized water, and stirring to obtain a pre-doped solution; s2, adding a buffer solution into the pre-doped solution, controlling the pH value of a reaction system to be alkaline, carrying out a stirring reaction to form a black suspension, and continuing the stirring reaction; and S3, centrifuging and washing the reaction system in the step S2 to obtain the PDA-Ga < 3 + > nanoparticles. The PDA-Ga < 3 + > nanoparticles provided by the invention have multiple characteristics of pH responsiveness, antibacterial property, anti-inflammatory property and bidirectional regulation and control of osteogenesis and osteoclast differentiation, and are expected to realize collaborative treatment of periodontitis, alleviation of inflammatory response of periodontium, reduction of alveolar bone resorption and induction of bone tissue regeneration, so that the success rate of periodontitis treatment is improved.

The invention discloses a direction-variable magnetic tooth traction appliance, relates to the technical field of orthodontics, and aims to solve the problems that the orthodontic force and angle of a traditional appliance cannot be flexibly adjusted, bacteria are easy to breed, the aesthetic property is poor and the like. The appliance comprises a tooth socket, a fixing block with strong magnetism is arranged on the tooth socket, a target block is arranged on an inverted long tooth to be drawn, and the fixing block with strong magnetism is connected with the target block through a magnetic fishbone chain. According to the invention, the design conforming to the physiological structure and growth characteristics of the oral cavity of children is adopted, and the inverted long teeth are drawn to grow in the correct direction by mild and continuous magnetic attraction. The uniform distribution of correction force is ensured, and the damage to fragile periodontal tissues of children is avoided. The medical magnetic material which is safe and non-toxic and has good biocompatibility is selected as the material, so that the safety and comfort of wearing are guaranteed. Meanwhile, adjustability is emphasized in structural design, and correction force and direction can be adjusted at any time according to the growth process of teeth of children.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

To develop a periodontal tissue massager which can adjust the relative magnitude ratio of the action in the arterial system and the action in the lymphatic system of the applied vibrational stimulation, reduce unnecessary vibrations and noise by generating the vibrational stimulation with a simple mechanism and small power, and is applied in the narrow oral environment filled with saliva to simultaneously massage multiple interdental papillae in a closed-mouth state.SOLUTION: According to the present invention, a variable resistor is provided in a vibration motor control circuit of a periodontal tissue massager that uses a vibration motor. Continuous adjustment of the variable resistor is possible within a range to the stop of the vibration motor from the rated output of the vibration motor. The vibration of the vibration motor is transmitted to the oral mucosa by inserting the vibration motor that has the waterproof property to the oral cavity without using a motion conversion mechanism or motion transmission mechanism other than the vibration motor.SELECTED DRAWING: Figure 2