30 results about "Periodontal tissue" patented technology

The invention discloses a histone-derived peptide nano-particle for targeted degradation of cytoplasm cGAS and a preparation method and application thereof, and is characterized in that a polypeptide compound is dissolved in a phosphate buffer, ultrasonic treatment and room temperature standing self-assembly are performed to form nano-particles, and centrifugal purification is performed to obtain the histone-derived peptide nano-particle A4-CMA NPs for targeted degradation of cytoplasm cGAS. The nano-particles (A4 at CMA NPs) can be combined with cytoplasm cGAS in a targeted manner and mediate the cytoplasm cGAS to degrade, so that the activation of a cGAS-STING pathway is blocked, periodontal tissue inflammation and alveolar bone resorption are effectively relieved, and a new strategy is provided for periodontitis treatment.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

This invention discloses a histone-derived peptide nanoparticle targeting the degradation of cytoplasmic cGAS, its preparation method, and its applications. The invention is characterized by: dissolving a peptide complex in phosphate buffer, sonicating, allowing it to self-assemble at room temperature to form nanoparticles, and purifying by centrifugation to obtain histone-derived peptide nanoparticles A4@CMA NPs targeting the degradation of cytoplasmic cGAS. These nanoparticles (A4@CMA NPs) can target and bind to cytoplasmic cGAS, mediating its degradation, blocking the activation of the cGAS-STING pathway, effectively reducing periodontal inflammation and alveolar bone resorption, and providing a new strategy for the treatment of periodontitis.

The present invention relates to a two- or three-layer film composition for periodontal use, comprising a hydrophobic polymer outer layer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The utility model provides a visual periodontal therapeutic apparatus, which mainly comprises a handle, a working part fixed at one end of the handle, an optical lens arranged at the outlet position of a chute at the tail end of the working part in a sliding manner, and a bendable adjusting rod and an adjusting roller which are arranged in the chute. The optical lens is connected with the display device through a cable, so that periodontal internal conditions of a patient can be visually observed; one end of the bendable adjusting rod is connected with the optical lens, and the other end is provided with a rack structure; the adjusting roller is rotatably arranged on the handle and meshed with the rack structure, and part of the adjusting roller is exposed out of the surface of the handle to facilitate shifting. By shifting the adjusting roller, the bendable adjusting rod slides in the sliding groove to drive the optical lens to slide, so that the distance between the optical lens and the working tip of the working part is adjusted. The visual periodontal therapeutic apparatus is simple and convenient to operate, flexible to adjust and convenient for periodontal treatment.

The purpose of the present invention is to improve periodontal inflammation. It is possible to improve periodontal inflammation by using a periodontal inflammation improving composition that contains plasmalogen extracted from a tissue of an animal such as shellfish, ascidians, and aves.

The application discloses a hydrogel composite material CMU-L.p-36@MeHA and a preparation method and application thereof, and belongs to the technical field of biotechnology.The hydrogel composite material CMU-L.p-36@MeHA disclosed by the application loads plant lactobacillus CMU-L.p-36 on a MeHA hydrogel carrier.The CMU-L.p-36@MeHA hydrogel disclosed by the application shows a good treatment effect on rat periodontitis by reducing alveolar bone absorption, reducing expression of inflammatory factor TNF-alpha, promoting ordered arrangement of collagen fibers and repairing periodontal tissues.

Provided is a therapeutic agent for regenerating periodontal tissues also capable of restoring periodontal tissues lost by severe periodontal disease. A therapeutic agent for regenerating periodontal tissues contains a MAP4K selective inhibitor. Alternatively, the MAP4K selective inhibitor is GNE-495 or PF06260933. Alternatively, the therapeutic agent for regenerating periodontal tissues is administered with a growth factor FGF-2. Alternatively, the therapeutic agent for regenerating periodontal tissues is characterized in that the FGF-2 is a recombinant human FGF-2. Alternatively, an agent for enhancing proliferation of periodontal ligament cels contains a MAP4K selective inhibitor. Alternatively, the therapeutic agent for regenerating periodontal tissues is in a liquid form.

The invention relates to a composite in the form of a two-or three-layer film for periodontal use, comprising an outer layer of a hydrophobic polymer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The utility model provides a brace-shaped magnetic resonance oral cavity wireless coil and magnetic resonance imaging equipment. The magnetic resonance oral cavity wireless coil comprises a plurality of wireless resonant rings and a flexible substrate, each wireless resonant ring is of a flexible loop structure, the wireless resonant rings are arranged in an array mode, every two adjacent wireless resonant rings are coupled, the wireless resonant rings are used for receiving magnetic resonance signals, the wireless resonant rings are arranged on the flexible substrate, and the flexible substrate is arranged on the flexible substrate. The flexible substrate is used for being attached to an oral cavity area. The unique tooth socket-shaped structure is tightly attached to oral anatomy, the sensitivity is high, upper and lower dentitions can be imaged at the same time, full-oral scanning is achieved, the process is greatly simplified, the coil has ultrahigh resolution and excellent signal-to-noise ratio, dental crowns, root canals and periodontal tissues can be accurately captured, and excellent soft tissue contrast is provided. The compact and high-adaptability design gives consideration to the comfort and diversified requirements of the patient.

A method for measuring periodontal disease and treating diseases associated therewith includes: obtaining B-mode ultrasound images of a dentition and periodontium of a patient; identifying gingival margin (GM), alveolar bone crest (ABC), cementoenamel junction (CEJ), periodontal ligament (PDL), and gingival edge (GE) biomarkers on the B-mode ultrasound images, the GE biomarker being a part of periodontal soft tissue most distal from a tooth surface; evaluating a metric associated with periodontal disease using one or more of the GM, ABC, CEJ, PDL and GE biomarkers and based at least in part on the evaluating, performing an act that implements and / or adjusts a therapeutic treatment of a periodontal disease.

The present invention discloses a composition containing a hydrangea extract, Thunberginol C, hydrangeic acid, hydrangenol, or a sitologically acceptable salt thereof as an active ingredient for preventing, alleviating, or treating periodontitis. The present invention has the effect of preventing, alleviating, or treating periodontitis by inhibiting inflammation, protecting periodontal tissue, and alleviating bone loss through inhibition against the production of TNF-alpha mRNA, IL-6 mRNA, MMP-3 mRNA, MMP-9 mRNA, MMP-13 mRNA, and PGE2 and the expression of COX-2 mRNA and through an increase in BMD and a decrease in CEJ-ABC, thereby protecting periodontal tissue.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

The present invention relates to a composition for promoting collagen production comprising amidated amino acids, and more specifically, to a composition that promotes collagen production in various cells such as fibroblasts, follicular cells, dermal papilla cells, endothelial cells, chondrocytes, muscle cells, and osteoblasts, thereby preventing, improving, or treating various diseases and lesions that may result from collagen reduction in the skin, hair, blood vessels, cartilage, tendons, connective tissues, muscles, bones, teeth, and periodontal tissues.

The invention discloses an application of Ce6-loaded ultramicro mesoporous silica nanoparticles in preparation of a medicine for treating periodontitis. Nanoparticles Ce6 at-MSN-NH2-30 and Ce6 at-MSN-NH2-200 with different particle sizes are firstly prepared, and further research shows that in an in-vitro experiment, compared with the Ce6 at-MSN-NH2-200, the Ce6 at-MSN-NH2-30 can effectively improve the removal effect on P.g. And a biological membrane thereof in antibacterial photodynamic therapy, effectively inhibit the formation of the biological membrane thereof and improve the antibacterial photodynamic therapy effect. Bacterial biofilms can be permeated more quickly, so that stronger antibacterial and killing effects are achieved; the in-vivo experiment of a rat periodontitis model shows that the Ce6 at-MSN-NH2-30 not only obviously relieves the injury of periodontium and effectively relieves the periodontitis, but also inhibits the further development of the periodontitis. The research of the invention is expected to provide a high-performance photosensitizer material for photodynamic antibacterial treatment of periodontitis.

The chemical composition general formula of the lithium-doped silicon-based hydroxyapatite nanowire is CaxLi20-2x (P1-ySiyO4) 6 (OH) 2, x is more than 0 and less than or equal to 9.09, and y is more than or equal to 0.05 and less than or equal to 0.12. The preparation method of the lithium-doped silicon-based hydroxyapatite nanowire comprises the following steps: firstly, preparing a lithium-doped calcium silicate nanowire by utilizing a hydrothermal method; and then preparing the lithium-doped silicon-based hydroxyapatite nanowire by using a hydrothermal method. According to the preparation method disclosed by the invention, the bionic osteogenesis induction characteristic of a nano-level hydroxyapatite material is combined with the bone metabolism steady state regulation and immune reaction of lithium and silicon elements, and the preparation conditions and chemical components of the material are adjusted, so that the lithium-doped silicon-based hydroxyapatite nanowire doped with the lithium element in a proper proportion is obtained; by regulating and controlling the periodontal tissue immune microenvironment and maintaining the bone metabolism balance, the method is applied to regeneration and repair of the inflammatory periodontal bone defect, and a new thought is provided for tissue engineering immunotherapy of the inflammatory periodontal bone defect.

This invention relates to the field of pharmaceutical technology, specifically disclosing the application of sea buckthorn extract in the preparation of products for the prevention and treatment of periodontitis. The invention uses network pharmacology to predict the potential molecular mechanisms of sea buckthorn extract in preventing and treating periodontitis, and validates these mechanisms in vivo using a rat model of experimental periodontitis. Results show that sea buckthorn extract significantly improves periodontal probing depth and gingival bleeding index in rats with periodontitis, reduces the expression levels of IL-6, TNF-α, IL-1β, and MMP-9 in serum and gingival tissue, and alleviates periodontal inflammation. Simultaneously, sea buckthorn extract upregulates the expression of RUNX2, OCN, OPG, and ALP, downregulates the expression of RANKL and COX-2, inhibits osteoclast formation, improves alveolar bone resorption, and regulates bone homeostasis. This invention provides a new medical application for sea buckthorn extract, which can be used to prepare products for the prevention and / or treatment of periodontitis.

The application discloses a guide plate information collection adhesion and reflection point process method, relates to the field of dental implant surgery, and comprises the following steps: S1, taking teeth, removing the baked porcelain tooth in the mouth of a patient to expose the tooth socket; S2, flushing, flushing the foreign matters in the tooth socket clean; S3, blowing dry, using high-speed flowing air to blow the liquid in the tooth socket dry; S4, brushing a developing agent, brushing the developing agent on the tooth socket and the periodontal tissue using a brushing device. The application has the effect that doctors can accurately manufacture the guide plate.

Disclosed is a preparation method of a collagen matrix membrane and an application thereof. The invention uses animal intestinal casing as a raw material and sequentially includes steps such as decellularization and degreasing to prepare a collagen matrix membrane with excellent mechanical properties and a long degradation cycle. This membrane is more conducive to providing sufficient bone regeneration space and time during the initial healing phase of periodontal disease, better meeting clinical application needs. Additionally, the collagen matrix membrane prepared by the invention is loaded with multiple growth factors beneficial to periodontal tissue growth, thereby facilitating periodontal tissue regeneration and repair, and improving therapeutic efficacy.

This invention relates to a gradient elastic modulus sports protective brace, its preparation method, and its application. The gradient elastic modulus sports protective brace includes at least an impact-resistant layer, a buffer layer, and an adhesive layer with a segmented or continuous gradient distribution of elastic modulus. The adhesive layer is used to adhere to the tooth surface and oral soft tissues, and to help disperse residual impact energy. The buffer layer surrounds the adhesive layer and is used to disperse impact energy. The impact-resistant layer surrounds the buffer layer and is used to resist external impact loads and guide energy inward. The elastic modulus of the impact-resistant layer is greater than that of the buffer layer, and the elastic modulus of the buffer layer is greater than that of the adhesive layer. Compared with existing technologies, this invention, through its gradient elastic modulus distribution design, achieves progressive absorption and effective dissipation of impact energy by the sports brace, significantly reducing the peak force on the user's teeth and periodontal tissues during impact, thereby improving overall protective performance and making it suitable for sports scenarios of varying intensities.

The invention belongs to the technical field of medicine, and particularly relates to application of strictosamide in preparation of a medicine for treating periodontitis, strictosamide is extracted and separated from a nauclea officinalis medicinal material, a periodontitis animal model is constructed, strictosamide is adopted to conduct intervention treatment on the model, and the periodontitis treatment effect is improved. Periodontium is taken to be subjected to TRAP staining, Micro-CT detection and HE staining detection respectively, and it is proved that the strictosamide can specifically regulate and control activation of osteoclasts, pathological alveolar bone resorption caused by periodontitis is effectively inhibited, alveolar bone loss is reduced, meanwhile, damage to the periodontium can be remarkably relieved, bone repair is promoted, and the treatment effect is good. And the disease progress of periodontitis is fundamentally blocked. The experimental result has clinical significance, and a new scheme is provided for clinical treatment of periodontitis.

The application belongs to the field of periodontal tissue damage repair materials, and provides an antibacterial sustained-release microcapsule for treating periodontitis and a preparation method thereof. The antibacterial sustained-release microcapsule for treating periodontitis is composed of a capsule wall and a core material wrapped inside the capsule wall, the capsule wall is composed of a calcium alginate matrix, nanocellulose microcrystals distributed in the calcium alginate matrix, and platinum ions combined with the calcium alginate matrix and the nanocellulose microcrystals, and the core material is an aqueous solution of biocompatible polyelectrolyte containing human periodontal ligament stem cell exosomes. The microcapsule of the application releases the antibacterial component platinum ions and the repair component human periodontal ligament stem cell exosomes in an orderly manner, realizes the sustained release of the repair component on the basis of improving the local inflammatory microenvironment, and is beneficial to promoting the repair and reconstruction of periodontal supporting tissue damage.

The invention belongs to the field of periodontal tissue injury repair materials, and provides an antibacterial sustained-release microcapsule for treating periodontitis and a preparation method thereof. The antibacterial sustained-release microcapsule for treating periodontitis is composed of a capsule wall and a core material wrapped in the capsule wall, and the capsule wall is composed of a calcium alginate matrix, nano-crystalline cellulose microcrystals distributed in the calcium alginate matrix and platinum ions combined with the calcium alginate matrix and the nano-crystalline cellulose microcrystals. The core material is an aqueous solution of biocompatible polyelectrolyte containing human periodontal ligament stem cell exosome. According to the microcapsule disclosed by the invention, an antibacterial component platinum ion and a repairing component human periodontal ligament stem cell exosome are orderly released through the microcapsule, so that slow release of the repairing component is realized on the basis of improving a local inflammation microenvironment, and repairing and reconstruction of periodontal support tissue damage are facilitated.

The invention provides a construction method and application of an intermittent force correction mouse model, and the method comprises the following steps: S1, fixing a mouse: fixing the head of the mouse after anesthesia, and exposing an anterior tooth area; s2, tooth separation: separating incisor teeth on two sides; s3, copper wire placement, wherein the pre-bent copper wire with the specific diameter is placed between the incisor teeth on the two sides; s4, shape adjustment: adjusting the position of the copper wire to ensure that the copper wire is located at the incisor gingival papilla, and reserving an incisor end function space; s5, coating a self-acid etching adhesive on the tooth surface; s6, carrying out light curing; s7, fluid resin fixing and shaping, wherein the copper wires are wrapped with the fluid resin through stacking and shaping; s8, photocuring lasts for a certain time, and the incisor teeth of the mouse are expanded to a preset distance; the animal model provided by the invention can not generate serious acute inflammatory reaction and can avoid excessive compression on periodontium, and the intermittent force correction mouse model without inflammatory reaction constructed by the invention can meet specific research and treatment requirements.

This invention relates to the field of biopharmaceutical technology, specifically to a BTO / PB acoustic pressure electrocatalytic nanoplatform ointment, its preparation method, and its application. The ointment is an injectable BTO / PB acoustic pressure electrocatalytic nanoplatform ointment formed by combining a barium titanate and Prussian blue composite nanomaterial with an ointment. The BTO / PB acoustic pressure electrocatalytic nanoplatform ointment of this invention exhibits excellent biocompatibility. Unlike traditional antibiotics, BTO / PB generates ROS (reactive oxygen species) through an ultrasound-driven catalytic reaction, independent of antibiotics, thus eliminating the risk of drug resistance. It effectively addresses the increasingly serious problem of antibiotic resistance, has a good antibacterial effect against periodontal pathogens, significantly alleviates gingival inflammation, reduces the infiltration of inflammatory cells, lowers the expression of inflammatory factors, and effectively inhibits osteoclast activity, thereby protecting alveolar bone and maintaining the integrity of periodontal tissues.

The present application provides the use of methylcatester for treating periodontitis. The present application also provides a method for preparing a sustained-release drug film containing methylcatester. The sustained-release drug film provided by the present application can inhibit the release of inflammatory factors, inhibit bacterial adhesion, and has a sustained-release time of up to the seventh day, has obvious effect on anti-periodontitis, and can effectively reduce the pathological changes of periodontal tissue.

The invention belongs to the field of medicines, and particularly discloses application of a somatostatin receptor 2 (SSTR2) antagonist in preparation of a medicine for preventing and / or treating periodontitis. In-vivo experiments prove that the SSTR2 antagonist can reduce the expression level of periodontitis markers IL-1beta, TNF-alpha and IL-17, effectively reduce the number of osteoclasts, inhibit alveolar bone resorption and relieve periodontal tissue pathological damage, and has an obvious curative effect on periodontitis. Therefore, the invention provides a brand-new drug action target (SSTR2) and a therapeutic drug for treatment of periodontitis, and opens up a brand-new therapeutic approach.

This invention provides a green preparation method and application for bioactive glass. The preparation method of this invention does not generate nitrogen oxide gases, uses readily available calcium sources, has a simple preparation process with high raw material utilization, and produces no toxic or harmful gases during the preparation process, meeting the requirements of green chemistry. The bioactive glass prepared by this invention exhibits good bioactivity and is preferably used for bone repair, bone wound healing, and periodontal tissue repair.

The invention belongs to the field of stem cell genetic engineering, and provides application of NLRP12 in anti-inflammatory osteogenesis promotion of periodontal ligament stem cells. According to the NLRP12 overexpression PDLSCs, the anti-inflammatory gene is applied to periodontal regeneration treatment, and the anti-inflammatory capacity and the tissue defect repairing capacity after the PDLSCs are transplanted into a body are effectively improved. An exogenous gene is transferred into PDLSCs through a virus vector, stable transfection and efficient and continuous expression of an anti-inflammatory gene are achieved, and the repair effect of periodontitis tissue defects is promoted. In-vitro experiments show that NLRP12 overexpression in an inflammatory microenvironment alleviates the inflammatory response and osteogenic differentiation inhibition of PDLSCs, which shows that the expression of proinflammatory factors IL-6 and IL-8 is down-regulated, the expression levels of anti-inflammatory factors IL-10 and osteogenic related proteins RUNX2, COL1 and BMP2 are up-regulated, ALP dyeing and alizarin red dyeing are deepened, and mineralized nodule formation is increased. The NLRP12 overexpression PDLSCs is applied to a rat experimental periodontitis model in vivo, inflammatory reaction is remarkably relieved, and periodontal tissue regeneration of periodontitis rats is promoted. Mechanism research shows that the NLRP12 alleviates the inflammatory response of PDLSCs and osteogenic differentiation inhibition by inhibiting an NF-kappa B pathway. The NLRP12 overexpression PDLSCs are suitable for repairing periodontal tissue defects, and have a good clinical application prospect.

The invention relates to the technical field of biology, and discloses fermented lactobacillus mucus CQPC202403 and application of the fermented lactobacillus mucus CQPC202403 in preparation of an oral preparation for improving periodontitis, the preservation number of the fermented lactobacillus mucus CQPC202403 in the China Center for Type Culture Collection is CGMCC NO.31106, and the preservation date is June 27, 2024. The fermented lactobacillus mucus CQPC202403 disclosed by the invention can be used for improving the intestinal flora structure, so that the fermented lactobacillus mucus CQPC202403 has a treatment effect on periodontitis. As a probiotic preparation, the traditional Chinese medicine composition can further avoid the problem of drug resistance caused by long-term use of antibiotics, and pathological sections show that the traditional Chinese medicine composition can reduce periodontal tissue inflammatory cell infiltration and promote regular arrangement of collagenous fibers and alveolar bone neogenesis.