16 results about "Hydroxyapatite coating" patented technology

The invention relates to the technical field of marine ecological engineering, in particular to a marine coral reef ecological restoration method based on a foamed aluminum base material, which comprises the following steps: preparing a modified foamed aluminum main body structure, constructing a modified bioactive surface layer, filling a modified phase change material capsule, and putting a restoration unit. According to the invention, the foamed aluminum main body structure provides a stable three-dimensional through porous network, and a natural reef habitat environment is simulated; a hydroxyapatite coating or a polymer layer constructed on the surface of the coral bone-imitating material remarkably improves the coral larva attachment and colonization efficiency through coral bone-imitating inorganic components or specific polypeptides respectively; the phase-change material capsules filled inside buffer water temperature fluctuation through phase-change latent heat, a stable micro-thermal environment is provided for coral growth, the functions of all the components are complementary and synergistic, foamed aluminum provides a carrier for surface functionalization, the surface active layer optimizes a biological interface, the internal temperature adjusting unit guarantees ecological suitability, and an efficient repairing system is formed. The coral reef ecological restoration effect is obviously improved.

The utility model discloses an artificial dental implant, which relates to the technical field of implants and comprises a main body, a hydroxyapatite coating is arranged at the lower end of the main body, a root body is arranged at the lower end of the hydroxyapatite coating, and a mounting groove is formed in the middle of the top surface of the main body; according to the utility model, the sleeve is matched with the hydroxyapatite coating, so that the fusion of the sleeve and new tissues is facilitated, and the fusion efficiency of the root body is improved; the L-shaped positioning plate is matched with the positioning block, so that the main body and the root body are conveniently clamped, and the stability of main body connection is improved; and through cooperation of the positioning bolts and the L-shaped positioning plates, the multiple L-shaped positioning plates can be conveniently pushed outwards along with screwing of the positioning bolts, and the stable effect of connection between the main body and the root body is enhanced.

The utility model belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the multi-hole type bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the using process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

The invention discloses a composite sodium hyaluronate microsphere and a preparation method and application thereof.The composite sodium hyaluronate microsphere is of a core-shell structure, an inner core is a cross-linked sodium hyaluronate microsphere, a shell layer is a pure-phase hydroxyapatite coating, calcium and phosphorus elements are enriched in the shell layer, the content of the phosphorus element in the inner core is smaller than 20% of the content of the shell layer, and the content of the calcium element in the shell layer is smaller than 20% of the content of the phosphorus element in the shell layer. And the calcium-phosphorus ratio of the pure-phase hydroxyapatite coating is 1.60 to 2.11. By accurately controlling mineralization phase composition and spatial distribution, a pure-phase hydroxyapatite coating is constructed on the surface of the cross-linked sodium hyaluronate microsphere, so that surface layer confinement distribution is realized, the in-vivo retention rate is remarkably improved, and the enzymolysis withdrawing capability is kept.

The application discloses a precision interception purification method for water treatment, and belongs to the technical field of drinking water purification. The method solves the purification problems of high-turbidity composite suspended particles, low-temperature microorganisms, plant source toxins, inorganic-organic composite colloids and the like of seasonal ice and snow melt water in the western Sichuan plateau and other regions, and is suitable for a low-temperature environment of 2-10 DEG C. The method comprises the following steps: S1, adding a composite modified vermiculite (quaternary ammonium salt modified vermiculite + konjac glucomannan-propylene glycol-Xuelingshi composite freeze-dried powder) to a water source to be treated, stirring and then filtering to obtain supernatant; S2, coating a first coating (quaternary ammonium salt modified vermiculite + calcium-doped fly ash) and a second coating (KH-560 modified diatomite) on a porous ceramic support in sequence to prepare a composite membrane; and S3, passing the permeate into a purification column containing a calcium-doped nano-hydroxyapatite coating alumina layer and a modified mesoporous carbon layer, and then performing ultraviolet irradiation to obtain final effluent. The application realizes precision interception of multiple impurities and improves the safety of plateau drinking water.

This invention provides a bioceramic liner for total hip replacement surgery, belonging to the fields of medical clinical and biomaterials technology. It includes a shaft with a transmission sleeve sleeved on its outer side, and a limiting sleeve sleeve sleeved on the outer side of the transmission sleeve sleeve; and a fixing component for fixing the ceramic liner and assisting in press-fitting the ceramic liner. The fixing component is connected to both the transmission sleeve sleeve and the limiting sleeve sleeve. This invention, by setting a ceramic liner and progressively spraying a titanium layer, a coarse titanium layer, and a hydroxyapatite coating onto the acetabular surface of the ceramic liner, ultimately forms a sandwich structure on the acetabular surface of the ceramic liner. During surgery, it directly presses against the acetabulum, achieving osseointegration. This eliminates the need for an acetabular cup prosthesis, to some extent solving the problems of incorrect assembly of the acetabular cup and ceramic liner caused by existing technologies, as well as deformation during press-fitting of the metal acetabular cup, which leads to increased incidence of ceramic liner breakage and abnormal noise.

The application discloses a mineralized facial implant line and a preparation method thereof, and belongs to the technical field of medical implant materials. The method comprises the following steps: performing microphysical etching on the surface of a high-molecular implant line to form a uniform micro-pit structure; adsorbing a polydopamine film on the etched surface; performing biomimetic mineralization in a supersaturated calcium-phosphorus solution containing zinc ions to form a zinc-doped hydroxyapatite coating; and covalently grafting an enzyme-sensitive drug conjugate on the surface of the coating. The implant line prepared by the method has excellent biocompatibility, strong coating bonding force, good tissue integration capacity and intelligent drug release function, can effectively reduce inflammatory reactions and prevent line body displacement, and improves the durability and safety of facial lifting.

The application discloses a kind of micelles LYTAC engineering biomimetic titanium implants for promoting bone regeneration and its preparation method and application, belong to biomimetic medical instrument technical field.The micelles LYTAC engineering biomimetic titanium implants include titanium matrix, hydroxyapatite coating formed on the surface of the titanium matrix, and multifunctional micelles loaded in the hydroxyapatite coating;The multifunctional micelles include CLP-Apt complex, and the CLP-Apt complex is formed by covalent connection of collagen-like peptide CLP and RANK-CI-M6PR bispecific aptamer Apt through acid-sensitive linker.The application applies LYTAC technology to the surface of titanium implant by constructing HA coating loaded with CLP-Apt micelles.Experiments in vitro and in vivo show that it significantly improves the effect of bone integration under osteoporosis condition, and provides an effective scheme for long-term stability of clinical implant.

The invention discloses a mineralized fiber network composite bone repair aerogel material with early-stage anti-inflammatory and multiple osteogenesis promoting functions and a preparation method of the mineralized fiber network composite bone repair aerogel material. The method comprises the following steps: 1) preparing chitosan fibers by adopting wet spinning, and twisting the chitosan fibers to form fiber bundles; (2) weaving the fiber bundles into fiber webs, and fixing a plurality of fiber webs in a pouring mold in parallel; carrying out surface activation treatment on the fiber by combining a plasma activation process, and forming a Zn < 2 + > doped hydroxyapatite coating on the surface of the fiber by utilizing a hydrothermal method; (3) an alkali-soluble chitosan solution is poured into the pouring mold, and in-situ gelation is carried out; the preparation method comprises the following steps of (1) preparing gel, (2) preparing the gel, (3) preparing the gel, (4) dialyzing the gel, and grafting lipoic acid molecules on the surface of the gel in combination with a surface chemical grafting technology, and (5) introducing a vascular promoting drug into the gel by using an impregnation technology, and freeze-drying to obtain the material. The material has early-stage anti-inflammatory, cell ingrowth promoting and multiple osteogenesis promoting functions, and can be used in the field of bone tissue engineering.

The present application relates to the technical field of composite materials, and particularly relates to a degradable zinc-based composite material for biomedical stents and a preparation method thereof, which comprises the following steps: taking zinc sheets after surface cleaning, coating hydroxyapatite on the surface of the zinc sheets after surface cleaning, stacking the zinc sheets coated with hydroxyapatite and the zinc sheets without hydroxyapatite coating, and rolling the zinc sheets with hydroxyapatite inside the stack; folding the zinc sheets after each rolling pass, and then continuing to roll; repeating the folding-rolling until the desired rolling pass; and after the obtained sample is pressed into a block, performing multi-pass hot rolling, thereby obtaining the degradable zinc-based composite material for biomedical stents. The present application adopts a cumulative roll bonding preparation process, which can effectively improve the combination of hydroxyapatite and zinc, and improve the dispersity of hydroxyapatite in zinc, and can effectively refine the grains and strengthen the matrix, so as to finally obtain a zinc / hydroxyapatite composite material with uniform structure and excellent performance.

The invention provides a porous tantalum dental implant manufacturing method based on AI and 3D printing, and relates to the technical field of stomatology and 3D printing, and the porous tantalum dental implant manufacturing method comprises the following steps: S1, establishing a historical CBCT data set; using the historical CBCT data set to train and construct an oral cavity reconstruction model in an AI modeling platform based on a deep learning algorithm; s2, generating a corresponding oral cavity reconstruction model according to the CBCT of the oral cavity of the patient; the implant three-dimensional model comprises a dental crown, a dental base and an implant matrix; the planting matrix is of a gradient porous structure and is divided into a surface layer area, a transition area and a core area from top to bottom, and the porosity and the aperture of the surface layer area are gradually reduced. S3, adjusting the shape and size of the implant three-dimensional model, and optimizing the implant three-dimensional model; s4, performing 3D printing to obtain an implant; and S5, preparing hydroxyapatite coatings on the outer surface of the planting matrix and the inner wall surfaces of the internal pores. The problems that in the prior art, the elastic modulus of an implant is not matched, the osseointegration efficiency is low, and the adaptability of a restoration is poor are solved.

This invention discloses a medical nano-hydroxyapatite coated porous tantalum implant material and its preparation method. The preparation method includes: etching a graphite carbon skeleton with HCl solution, followed by washing and drying to obtain a porous carbon skeleton, which is then placed in a vapor deposition reaction chamber; passing a treatment gas and a reducing gas through the reaction chamber to perform vapor deposition, thereby depositing a tantalum coating on the surface of the porous carbon skeleton to obtain a porous tantalum metal scaffold; the treatment gas includes a tantalum source and a carrier gas; dissolving a calcium source, a phosphorus source, and sodium chloride in deionized water to obtain a mixed solution, adjusting the pH to 4.3 to obtain an electrolyte; using the porous tantalum metal scaffold as the working electrode and graphite as the counter electrode, electrochemical deposition is performed in the electrolyte using a pulsed current mode to deposit a nano-hydroxyapatite coating on the surface of the porous tantalum metal scaffold, resulting in a medical nano-hydroxyapatite coated porous tantalum implant material with a high porosity >70% and an elastic modulus <30 GPa.

The utility model discloses a composite dental implant component, which relates to the technical field of dental implants and comprises a dental crown, a connecting groove is arranged on the bottom surface of the dental crown, a connecting body is arranged at the lower end of the dental crown, and the connecting body is arranged in the connecting groove; according to the dental crown disclosed by the utility model, the titanium alloy framework is matched with the fixing bolt, so that the connection between the connecting body and the gum is reinforced conveniently, and the stability of the dental crown is improved; through the cooperation of the hydroxyapatite coating and the titanium alloy framework, the titanium alloy framework and a new tissue can be better fused, and the installation stability of the connector is improved; through the cooperation of the fixing bolts and the positioning bolts, the dental crown is convenient to mount, and the mounting efficiency and the mounting effect of the dental crown are improved.

This invention provides a biomimetic mineralized dental bone powder and its preparation method, belonging to the field of dental material preparation technology. The biomimetic mineralized dental bone powder of this invention comprises the following raw material components by weight: 80-90 parts tricalcium phosphate and 10-20 parts hydroxyapatite; wherein the hydroxyapatite is coated on the surface of the tricalcium phosphate by a mineralization coating. The mineralization coating is obtained by mineralizing a mixture of tricalcium phosphate and a mineralizing solution. This invention combines the advantages of both hydroxyapatite and tricalcium phosphate to develop a suitable biomimetic mineralized bone powder material with both degradability and bioactivity. The hydroxyapatite coating in this mineralized bone powder material is beneficial for enhancing the adsorption of related proteins by early osteogenic materials, thereby inducing cell adhesion and proliferation; tricalcium phosphate, as a degradable material, provides excellent conditions for later bone ingrowth.

The invention discloses a preparation method of a corrosion-resistant, wear-resistant and high-compatibility magnesium alloy biological protective coating, belongs to the field of biological coatings, and aims at solving the problem that an existing magnesium alloy coating material is degraded too fast. According to the preparation method, Mg-1. 5Zn-0. 5Ca alloy is selected as a matrix, firstly, a porous oxide layer is prepared on the surface of the magnesium alloy through a micro-arc oxidation process so as to improve the corrosion resistance of the coating, and then a hydroxyapatite coating is prepared on the surface of the oxide layer through a plasma spraying process so as to improve the biocompatibility and wear resistance of the coating. The prepared composite coating has good performance, the process is simple, and industrial production is easy.

The invention discloses a micelle LYTAC engineering bionic titanium implant for promoting bone regeneration as well as a preparation method and application of the micelle LYTAC engineering bionic titanium implant, and belongs to the technical field of bionic medical instruments. The micelle LYTAC engineering bionic titanium implant comprises a titanium substrate, a hydroxyapatite coating formed on the surface of the titanium substrate, and a multifunctional micelle loaded in the hydroxyapatite coating, the multifunctional micelle comprises a CLP-Apt compound, and the CLP-Apt compound is formed by covalent linkage of a collagen-like peptide CLP and an RANK-CI-M6PR bispecific aptamer Apt through an acid sensitive connexon. According to the invention, the LYTAC technology is applied to the surface of the titanium implant by constructing the HA coating loaded with the CLP-Apt micelle. In-vivo and in-vitro experiments show that the osseointegration effect is remarkably improved under the osteoporosis condition, and an effective scheme is provided for long-term stability of clinical implants.