39 results about "Hydroxyapatite coating" patented technology

This invention discloses a composite coating for the tooth surface of an atlantoaxial PEEK interbody fusion cage, relating to the field of medical materials technology. The composite coating for the atlantoaxial PEEK interbody fusion cage comprises a transition layer covering the tooth surface of the atlantoaxial PEEK interbody fusion cage and a hydroxyapatite coating on the surface of the transition layer; the transition layer is obtained by mixing modified nano-hydroxyapatite and modified PEEK; the hydroxyapatite coating is obtained by plasma spraying of nano-hydroxyapatite. This application sets a transition layer between the PEEK and the hydroxyapatite coating, effectively addressing the problem of easy coating detachment due to the difference in physicochemical properties between the PEEK and hydroxyapatite coatings. The composite coating prepared in this application improves the bonding strength between the coating and the substrate, and the prepared material can be used in biological organisms for a long time.

The invention relates to the technical field of marine ecological engineering, in particular to a marine coral reef ecological restoration method based on a foamed aluminum base material, which comprises the following steps: preparing a modified foamed aluminum main body structure, constructing a modified bioactive surface layer, filling a modified phase change material capsule, and putting a restoration unit. According to the invention, the foamed aluminum main body structure provides a stable three-dimensional through porous network, and a natural reef habitat environment is simulated; a hydroxyapatite coating or a polymer layer constructed on the surface of the coral bone-imitating material remarkably improves the coral larva attachment and colonization efficiency through coral bone-imitating inorganic components or specific polypeptides respectively; the phase-change material capsules filled inside buffer water temperature fluctuation through phase-change latent heat, a stable micro-thermal environment is provided for coral growth, the functions of all the components are complementary and synergistic, foamed aluminum provides a carrier for surface functionalization, the surface active layer optimizes a biological interface, the internal temperature adjusting unit guarantees ecological suitability, and an efficient repairing system is formed. The coral reef ecological restoration effect is obviously improved.

The invention discloses a method for preparing a non-polymer coating of a pure magnesium intravascular stent, and relates to the technical field of medical instruments, and the method comprises the following steps: pretreatment: immersing the pure magnesium intravascular stent into a diluted hydrochloric acid solution for ultrasonic cleaning, removing a surface oxidation film and impurities, then washing the pure magnesium intravascular stent with deionized water until the pure magnesium intravascular stent is neutral, and drying the pure magnesium intravascular stent for later use; micro-arc oxidation: taking the pretreated bracket as an anode, taking a stainless steel plate as a cathode, putting the bracket and the stainless steel plate in electrolyte, applying pulse voltage for treatment, and generating a ceramic oxide layer with the thickness of 5-20 microns on the surface of the bracket; and bioactive coating: immersing the stent subjected to micro-arc oxidation into the suspension, and depositing by adopting an electrophoretic deposition method to form a hydroxyapatite coating with the thickness of 1-5 microns. According to the non-polymer coating method for the pure magnesium intravascular stent, no polymer is used in the whole coating process, inflammatory reaction possibly caused by the polymer and degradation products of the polymer is avoided, and the biological safety of the stent is improved.

The utility model discloses an artificial dental implant, which relates to the technical field of implants and comprises a main body, a hydroxyapatite coating is arranged at the lower end of the main body, a root body is arranged at the lower end of the hydroxyapatite coating, and a mounting groove is formed in the middle of the top surface of the main body; according to the utility model, the sleeve is matched with the hydroxyapatite coating, so that the fusion of the sleeve and new tissues is facilitated, and the fusion efficiency of the root body is improved; the L-shaped positioning plate is matched with the positioning block, so that the main body and the root body are conveniently clamped, and the stability of main body connection is improved; and through cooperation of the positioning bolts and the L-shaped positioning plates, the multiple L-shaped positioning plates can be conveniently pushed outwards along with screwing of the positioning bolts, and the stable effect of connection between the main body and the root body is enhanced.

An intelligent controllable super-deformation nose prosthesis belongs to the field of plastic surgery medical instruments and is characterized in that a concave hollow omega-shaped structure frame main body shell layer, a Janus interface outer coating and an intelligent response material are combined to construct a'anatomy-structure-function 'integrated nose prosthesis, a micropore design and a hydroxyapatite coating are performed on the ventral side of the nose prosthesis, and the micro-pore design and the hydroxyapatite coating are performed on the ventral side of the nose prosthesis. A nose prosthesis structure with high fitness and high stability is formed, smooth design and spermidine coating are carried out on the back side of the nose prosthesis, so that envelope formation is inhibited, envelope constraint is avoided, and the super-directional deformation performance is achieved in combination with the design of the concave hollow omega-shaped structure. By applying the intelligent response material, non-invasive deformation adjustment can be carried out through temperature signals in an operation or after the operation, and the clinical requirements of fine adjustment in the operation and after the operation are met. The nasal prosthesis can be applied to the scenes of plastic surgery, postoperative modification, repair and reconstruction and the like, and the higher-level medical and aesthetic requirements are met.

The utility model provides a 3D printing device applied to hydroxyapatite, and relates to the technical field of printing devices.The 3D printing device comprises a device box, a printing platform is arranged on the inner side wall of the device box, and a heating rod is arranged at the position, close to the printing platform, of the inner side wall of the device box; a temperature sensor is arranged on the inner side wall of the device box and located at the top end of the printing platform, a plurality of ventilation holes are formed in the bottom of the device box at equal intervals, a fan is arranged at the bottom in the device box, the periphery of the fan and the ventilation holes is sleeved with a protective cover, and a dustproof net is arranged at the top end of the protective cover. Compared with an existing 3D printing device applied to hydroxyapatite, the 3D printing device applied to hydroxyapatite has the advantages that a hydroxyapatite coating can be printed more conveniently and rapidly, the situation that the bonding force between layers is poor can be effectively prevented, and the bonding tightness and practicability of the hydroxyapatite coating printed by the 3D printing device applied to hydroxyapatite are improved.

The invention relates to the crossing field of biomedical engineering, micro-nano-scale biomechanics and a micro-fluidic chip technology, in particular to a micro-fluidic chip based on a bone fossa bionic structure and an experimental method. The chip is formed by bonding and assembling a first cover plate and a second cover plate; a semi-ellipsoid first bone fossa cavity and a first bone tubule fluid channel communicated with the semi-ellipsoid first bone fossa cavity are etched in the first cover plate, a second bone fossa cavity and a second bone tubule fluid channel are symmetrically etched in the second cover plate, and hydroxyapatite coatings are sprayed on the inner walls of the two cavities. And the first cover plate and the second cover plate are bonded to form a complete ellipsoid bone fossa cavity and a bone tubule fluid cavity channel. According to the invention, the problems of abnormal cell morphology of traditional two-dimensional culture, mechanical stimulation deficiency of static three-dimensional culture and insufficient matrix bionic degree are solved, and a high bionic platform is provided for mechanical research of bone cells.

The utility model belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the multi-hole type bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the using process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

The invention discloses a composite sodium hyaluronate microsphere and a preparation method and application thereof.The composite sodium hyaluronate microsphere is of a core-shell structure, an inner core is a cross-linked sodium hyaluronate microsphere, a shell layer is a pure-phase hydroxyapatite coating, calcium and phosphorus elements are enriched in the shell layer, the content of the phosphorus element in the inner core is smaller than 20% of the content of the shell layer, and the content of the calcium element in the shell layer is smaller than 20% of the content of the phosphorus element in the shell layer. And the calcium-phosphorus ratio of the pure-phase hydroxyapatite coating is 1.60 to 2.11. By accurately controlling mineralization phase composition and spatial distribution, a pure-phase hydroxyapatite coating is constructed on the surface of the cross-linked sodium hyaluronate microsphere, so that surface layer confinement distribution is realized, the in-vivo retention rate is remarkably improved, and the enzymolysis withdrawing capability is kept.

The invention discloses a multi-dimensional bionic scaffold with a space-time synergistic osteogenesis function and a preparation method. The bionic scaffold comprises loofah, a hydroxyapatite coating and polyvinyl alcohol hydrogel, the preparation method comprises the following steps: immersing natural towel gourds in a NaClOacetic acid solution, boiling to obtain white towel gourds, and then alternately immersing the white towel gourds in a calcium solution and a phosphorus solution to obtain an intermediate product WLH; adding Mg-MOFs synthesized by a hydrothermal method into a polyvinyl alcohol solution to obtain a hydrogel precursor solution; and immersing WLH into the hydrogel precursor solution, and carrying out vacuum, freezing and unfreezing circular treatment to obtain the loofah-shaped multi-dimensional bionic scaffold. The invention has the following beneficial effects: the scaffold has a cortical-cancellous structure and mechanical characteristics simulating a natural bone, and has good biocompatibility and biological functions of immunoregulation-angiogenesis-osteogenesis induction coupling.

The application discloses a precision interception purification method for water treatment, and belongs to the technical field of drinking water purification. The method solves the purification problems of high-turbidity composite suspended particles, low-temperature microorganisms, plant source toxins, inorganic-organic composite colloids and the like of seasonal ice and snow melt water in the western Sichuan plateau and other regions, and is suitable for a low-temperature environment of 2-10 DEG C. The method comprises the following steps: S1, adding a composite modified vermiculite (quaternary ammonium salt modified vermiculite + konjac glucomannan-propylene glycol-Xuelingshi composite freeze-dried powder) to a water source to be treated, stirring and then filtering to obtain supernatant; S2, coating a first coating (quaternary ammonium salt modified vermiculite + calcium-doped fly ash) and a second coating (KH-560 modified diatomite) on a porous ceramic support in sequence to prepare a composite membrane; and S3, passing the permeate into a purification column containing a calcium-doped nano-hydroxyapatite coating alumina layer and a modified mesoporous carbon layer, and then performing ultraviolet irradiation to obtain final effluent. The application realizes precision interception of multiple impurities and improves the safety of plateau drinking water.

The present invention relates to a method for surface treatment of orthopedic implants based on femtosecond laser. The surface treatment method comprises the following steps: cleaning and drying the surface of the orthopedic implant substrate; performing femtosecond laser treatment on the surface of the orthopedic implant substrate to form regularly arranged microstructures on the substrate surface; wherein, the orthopedic implant substrate comprises a metal substrate, a bioceramic substrate and a polymer material substrate; the microstructures include one or more of grooves, dot matrices or grids; performing plasma spraying of a biological coating on the surface of the orthopedic implant substrate after femtosecond laser treatment to finally obtain a surface-modified orthopedic implant; wherein, the biological coating comprises a titanium coating and a hydroxyapatite coating. Compared with the prior art, the present invention significantly improves the bonding force between the plasma-sprayed biological coating and the orthopedic implant substrate, and broadens the types of applications of the orthopedic implant substrate.

The invention provides a biological ceramic lining for an artificial hip joint replacement operation, and belongs to the technical field of medical clinical and biological materials. Comprising a shaft rod, the outer side of the shaft rod is sleeved with a transmission sleeve rod, and the outer side of the transmission sleeve rod is sleeved with a limiting sleeve rod; and the fixing assembly is used for fixing the ceramic lining and assisting in press-fit installation of the ceramic lining, and the fixing assembly is connected with the transmission sleeve rod and the limiting sleeve rod. The ceramic lining is arranged, the titanium layer, the coarse titanium layer and the hydroxyapatite coating are sprayed on the acetabular surface of the ceramic lining step by step, finally, a sandwich structure is formed on the acetabular surface of the ceramic lining, the sandwich structure is directly in press fit with the acetabulum in the operation, osseointegration is achieved, an acetabular cup prosthesis does not need to be used any more, and the manufacturing cost is reduced. The problems that in the prior art, an acetabular cup and a ceramic lining are mistakenly assembled, deformation is caused when the metal acetabular cup is pressed and matched, and consequently the ceramic lining is broken, and the abnormal sound occurrence rate is increased are solved to a certain extent.

This invention provides a bioceramic liner for total hip replacement surgery, belonging to the fields of medical clinical and biomaterials technology. It includes a shaft with a transmission sleeve sleeved on its outer side, and a limiting sleeve sleeve sleeved on the outer side of the transmission sleeve sleeve; and a fixing component for fixing the ceramic liner and assisting in press-fitting the ceramic liner. The fixing component is connected to both the transmission sleeve sleeve and the limiting sleeve sleeve. This invention, by setting a ceramic liner and progressively spraying a titanium layer, a coarse titanium layer, and a hydroxyapatite coating onto the acetabular surface of the ceramic liner, ultimately forms a sandwich structure on the acetabular surface of the ceramic liner. During surgery, it directly presses against the acetabulum, achieving osseointegration. This eliminates the need for an acetabular cup prosthesis, to some extent solving the problems of incorrect assembly of the acetabular cup and ceramic liner caused by existing technologies, as well as deformation during press-fitting of the metal acetabular cup, which leads to increased incidence of ceramic liner breakage and abnormal noise.

The utility model relates to the field of medical instruments, in particular to an external fixing device with a micro-motion assembly and a hydroxyapatite coating fixing nail, which comprises a support, three clamping block assemblies and the micro-motion assembly. The three clamping block assemblies are used for clamping at least one hydroxyapatite coating fixing nail respectively, the micro-motion assembly is configured to output kinetic energy to the second assembly when receiving electric energy, and when the second assembly is in a movable state relative to the support, the micro-motion assembly is used for driving the second assembly to move according to a preset path. The preset path is a swing path and / or a linear path. The broken bone is actively driven through the micro-motion assembly, the second assembly and the hydroxyapatite coating fixing nail clamped on the second assembly, so that the broken bone driven by the second assembly and the hydroxyapatite coating fixing nail clamped on the second assembly can generate fine displacement, and the broken end of the driven broken bone can form stress stimulation, so that the broken bone can be driven to move stably and stably. The fracture healing time is shortened, and the fracture healing treatment efficiency is high.

The application discloses a mineralized facial implant line and a preparation method thereof, and belongs to the technical field of medical implant materials. The method comprises the following steps: performing microphysical etching on the surface of a high-molecular implant line to form a uniform micro-pit structure; adsorbing a polydopamine film on the etched surface; performing biomimetic mineralization in a supersaturated calcium-phosphorus solution containing zinc ions to form a zinc-doped hydroxyapatite coating; and covalently grafting an enzyme-sensitive drug conjugate on the surface of the coating. The implant line prepared by the method has excellent biocompatibility, strong coating bonding force, good tissue integration capacity and intelligent drug release function, can effectively reduce inflammatory reactions and prevent line body displacement, and improves the durability and safety of facial lifting.

The invention discloses a preparation method for in-situ growth of a hydroxyapatite coating on the surface of a titanium rod based on a hydrothermal method, and belongs to the technical field of biomedical materials. According to the method, by optimizing a hydrothermal reaction process, a hydroxyapatite coating with high bonding strength and excellent biological activity is formed on the surface of a titanium substrate, and the osseointegration performance of the titanium implant is remarkably improved. The process is simple and environment-friendly, and the obtained HA coating is firmly combined with the titanium substrate, has good biological activity and mechanical stability, can promote adhesion and growth of bone cells, and is suitable for long-term implantation instruments such as artificial joints and tooth root implants.

The present invention discloses a one-step method for preparing a multi-element doped hydroxyapatite implant coating, which comprises the following steps: Step (1), placing a phosphorus source in deionized water, stirring until the solution is clear and transparent, and then standing for hydrolysis to obtain solution A; Step (2), dissolving a calcium source in deionized water and stirring until dissolved to obtain solution B; Step (3), adding nitrates or acetates of elements to be doped into solution B, stirring and mixing until dissolved to obtain solution C; Step (4), under the condition of stirring at room temperature, dropping solution C into solution A. After the dropping of solution C is completed, continue to stir and mix for aging. After the aging is completed, a spraying solution is obtained; Step (5), spraying the spraying solution onto a pretreated substrate by solution plasma spraying to prepare a multi-element doped hydroxyapatite implant coating. The present invention can solve problems such as low purity and low crystallinity of the doped hydroxyapatite coating.

The invention belongs to the technical field of medical implant preparation, and particularly relates to a preparation and biological evaluation method of a porous titanium alloy medical implant. The preparation method of the porous titanium alloy medical implant comprises the following steps: S1, preparing a porous titanium artificial tooth root implant; s2, preparing a hydroxyapatite coating of the porous titanium artificial tooth root implant by adopting an electrochemical method; s3, carrying out fatigue test on the porous titanium artificial tooth root implant with the hydroxyapatite coating; s4, preparing a composite nano coating of the porous titanium artificial tooth root implant by adopting an electrochemical method; and S5, carrying out physicochemical and biological analysis on the obtained porous titanium artificial tooth root implant with the composite nano coating. The composite nano coating is applied to surface modification of the porous titanium alloy, the advantages of respective technologies are exerted, osteoblast proliferation and differentiated protein molecules can be remarkably induced, bone induction and bone conduction are enhanced, and bone defect repair and angiogenesis are promoted.

The application discloses a kind of micelles LYTAC engineering biomimetic titanium implants for promoting bone regeneration and its preparation method and application, belong to biomimetic medical instrument technical field.The micelles LYTAC engineering biomimetic titanium implants include titanium matrix, hydroxyapatite coating formed on the surface of the titanium matrix, and multifunctional micelles loaded in the hydroxyapatite coating;The multifunctional micelles include CLP-Apt complex, and the CLP-Apt complex is formed by covalent connection of collagen-like peptide CLP and RANK-CI-M6PR bispecific aptamer Apt through acid-sensitive linker.The application applies LYTAC technology to the surface of titanium implant by constructing HA coating loaded with CLP-Apt micelles.Experiments in vitro and in vivo show that it significantly improves the effect of bone integration under osteoporosis condition, and provides an effective scheme for long-term stability of clinical implant.

The invention discloses a mineralized fiber network composite bone repair aerogel material with early-stage anti-inflammatory and multiple osteogenesis promoting functions and a preparation method of the mineralized fiber network composite bone repair aerogel material. The method comprises the following steps: 1) preparing chitosan fibers by adopting wet spinning, and twisting the chitosan fibers to form fiber bundles; (2) weaving the fiber bundles into fiber webs, and fixing a plurality of fiber webs in a pouring mold in parallel; carrying out surface activation treatment on the fiber by combining a plasma activation process, and forming a Zn < 2 + > doped hydroxyapatite coating on the surface of the fiber by utilizing a hydrothermal method; (3) an alkali-soluble chitosan solution is poured into the pouring mold, and in-situ gelation is carried out; the preparation method comprises the following steps of (1) preparing gel, (2) preparing the gel, (3) preparing the gel, (4) dialyzing the gel, and grafting lipoic acid molecules on the surface of the gel in combination with a surface chemical grafting technology, and (5) introducing a vascular promoting drug into the gel by using an impregnation technology, and freeze-drying to obtain the material. The material has early-stage anti-inflammatory, cell ingrowth promoting and multiple osteogenesis promoting functions, and can be used in the field of bone tissue engineering.

The present application relates to the technical field of composite materials, and particularly relates to a degradable zinc-based composite material for biomedical stents and a preparation method thereof, which comprises the following steps: taking zinc sheets after surface cleaning, coating hydroxyapatite on the surface of the zinc sheets after surface cleaning, stacking the zinc sheets coated with hydroxyapatite and the zinc sheets without hydroxyapatite coating, and rolling the zinc sheets with hydroxyapatite inside the stack; folding the zinc sheets after each rolling pass, and then continuing to roll; repeating the folding-rolling until the desired rolling pass; and after the obtained sample is pressed into a block, performing multi-pass hot rolling, thereby obtaining the degradable zinc-based composite material for biomedical stents. The present application adopts a cumulative roll bonding preparation process, which can effectively improve the combination of hydroxyapatite and zinc, and improve the dispersity of hydroxyapatite in zinc, and can effectively refine the grains and strengthen the matrix, so as to finally obtain a zinc / hydroxyapatite composite material with uniform structure and excellent performance.

The invention relates to the technical field of preparation of polyaryletherketone coatings, in particular to a method and a system for preparing a hydroxyapatite coating by compounding laser induction and hydrothermal synthesis on the surface of polyaryletherketone. The method comprises the following steps: immersing a polyether-ether-ketone material into a calcium-phosphorus solution, irradiating the surface of the polyether-ether-ketone material by using laser, so that the surface of the polyether-ether-ketone material is slightly melted, the slightly melted part of the surface of the polyether-ether-ketone material reacts with calcium ions in the calcium-phosphorus solution to generate a composite coating, and heating the calcium-phosphorus solution to form the composite coating. And depositing a hydroxyapatite coating on the surface of the composite coating through a hydrothermal synthesis method. According to the method, the surface is subjected to micro melting through laser irradiation and reacts with calcium ions to generate the composite coating, the bonding strength between the polyether-ether-ketone material and the coating is enhanced in the process, the thickness and uniformity of the coating can be accurately controlled by adjusting laser parameters and hydrothermal synthesis conditions, and the method integrates the laser technology and the hydrothermal synthesis technology and is suitable for large-scale production. The technological process is simple and feasible, and large-scale production and application are facilitated.

The invention provides a porous tantalum dental implant manufacturing method based on AI and 3D printing, and relates to the technical field of stomatology and 3D printing, and the porous tantalum dental implant manufacturing method comprises the following steps: S1, establishing a historical CBCT data set; using the historical CBCT data set to train and construct an oral cavity reconstruction model in an AI modeling platform based on a deep learning algorithm; s2, generating a corresponding oral cavity reconstruction model according to the CBCT of the oral cavity of the patient; the implant three-dimensional model comprises a dental crown, a dental base and an implant matrix; the planting matrix is of a gradient porous structure and is divided into a surface layer area, a transition area and a core area from top to bottom, and the porosity and the aperture of the surface layer area are gradually reduced. S3, adjusting the shape and size of the implant three-dimensional model, and optimizing the implant three-dimensional model; s4, performing 3D printing to obtain an implant; and S5, preparing hydroxyapatite coatings on the outer surface of the planting matrix and the inner wall surfaces of the internal pores. The problems that in the prior art, the elastic modulus of an implant is not matched, the osseointegration efficiency is low, and the adaptability of a restoration is poor are solved.

This invention discloses a medical nano-hydroxyapatite coated porous tantalum implant material and its preparation method. The preparation method includes: etching a graphite carbon skeleton with HCl solution, followed by washing and drying to obtain a porous carbon skeleton, which is then placed in a vapor deposition reaction chamber; passing a treatment gas and a reducing gas through the reaction chamber to perform vapor deposition, thereby depositing a tantalum coating on the surface of the porous carbon skeleton to obtain a porous tantalum metal scaffold; the treatment gas includes a tantalum source and a carrier gas; dissolving a calcium source, a phosphorus source, and sodium chloride in deionized water to obtain a mixed solution, adjusting the pH to 4.3 to obtain an electrolyte; using the porous tantalum metal scaffold as the working electrode and graphite as the counter electrode, electrochemical deposition is performed in the electrolyte using a pulsed current mode to deposit a nano-hydroxyapatite coating on the surface of the porous tantalum metal scaffold, resulting in a medical nano-hydroxyapatite coated porous tantalum implant material with a high porosity >70% and an elastic modulus <30 GPa.

The invention relates to the technical field of implantable medical instruments, in particular to a magnesium alloy bone fracture plate and a preparation method thereof.According to the technical scheme, the magnesium alloy bone fracture plate comprises a substrate material, a bone tissue contact face, a bone tissue outer side face and an outer layer protective film, the substrate material is made of magnesium-zinc-calcium-manganese alloy, the zinc content is 1-7%, the calcium content is 0.5-1%, the manganese content is 0.1-0.5%, and the balance is magnesium; and the balance magnesium. The bone tissue contact surface is composed of a micro-arc oxidation layer containing cerium oxide nanoparticles; the bone tissue outer side surface is composed of a hydroxyapatite coating containing a corrosion inhibitor 8-hydroxyquinoline, sodium silicate and sodium dodecyl benzene sulfonate; and the outer-layer protective film is formed by wrapping the surface of the bone fracture plate with a poly (p-xylylene chloride) coating through a chemical vapor deposition method. According to the novel magnesium alloy bone fracture plate and the preparation method thereof, through alloy component design and surface modification, local pitting corrosion is effectively prevented, and the long-term fixing stability of the bone fracture plate is kept.

The invention discloses a method for constructing an antibacterial peptide-loaded nanotube hydroxyapatite coating on the surface of polyetherketoneketone. The method comprises the following steps: S1, polishing and cleaning the surface of the polyetherketoneketone; s2, carrying out acid etching sulfonation treatment on the surface of the polyether ketone ketone to obtain PEKK-S; s3, preparing an HA nanotube; s4, dopamine is dissolved in the Tris-HCL buffer solution, and a dopamine solution A is formed; preparing another dopamine solution with the same concentration, and adding the HA nanotube and the antibacterial peptide to obtain a mixed solution B; pEKK-S is soaked in the dopamine solution A, and the solution A and the mixed solution B are placed in a vibrator to be vibrated for 12-24 h; pEKK-S is taken out from the dopamine solution A, cleaned, dried, completely soaked in the mixed solution B, placed in a vibrator to be vibrated for 12-24 h, cleaned and dried, polyether ketone ketone with the surface containing the antibacterial peptide-loaded nanotube hydroxyapatite coating is obtained, the antibacterial peptide can be stably and enduringly released, and therefore the antibacterial effect is improved, and bone tissue recovery is promoted.

The invention relates to the technical field of surface modification of medical instrument materials, and discloses a copper-containing hydroxyapatite coating on the surface of a titanium-based scaffold and a preparation method thereof.The preparation method comprises the following steps that a calcium source solution, a phosphorus source solution and a copper source solution are mixed, the molar ratio of the sum of the calcium element and the copper element to the phosphorus element is controlled to be 1.67, stirring is conducted, and then the copper-containing hydroxyapatite coating is obtained; a mixed solution is obtained, and the pH of the mixed solution is adjusted to 4.4-4.6; by taking the mixed solution as electrolyte, preparing an amorphous copper-containing hydroxyapatite intermediate coating on the surface of the titanium-based stent by adopting an electrochemical deposition method; and putting the titanium-based stent with the amorphous copper-containing hydroxyapatite intermediate coating deposited on the surface into an alkaline solution for crystallization reaction, and then cleaning to be neutral to obtain the copper-containing hydroxyapatite coating on the surface of the titanium-based stent. The copper-containing hydroxyapatite (Cu-HA) coating is constructed on the surface of the titanium-based stent through electrochemical deposition, so that the antibacterial property and the osteogenic property are synergistically improved.

The invention relates to the field of medical instruments, in particular to a spinal internal fixation system which comprises a prosthesis with a specific structure, one of a hydroxyapatite coating, a zirconia ceramic coating and the like is arranged on the surface of the prosthesis, and the prosthesis comprises a pedicle screw, a connecting seat, an adjusting screw plug, a locking screw plug, a fixing rod, an attaching seat, a spring and the like. The pedicle screw is provided with a specific connecting portion, a middle portion and a head portion, the middle portion is provided with cortical bone threads, the head portion is provided with cancellous bone threads, the adjusting screw plug and the locking screw plug can clamp the fixing rod, the attaching base can be rotationally connected with the adjusting screw plug and attached to the fixing rod, the connecting base is provided with a sliding groove matched with the attaching base to slide, and the adjusting screw plug is provided with an embedding groove for the attaching base to be rotationally embedded. The spine internal fixation system has the technical effects of being excellent in performance, reasonable in structure and good in adaptability.

The utility model discloses a composite dental implant component, which relates to the technical field of dental implants and comprises a dental crown, a connecting groove is arranged on the bottom surface of the dental crown, a connecting body is arranged at the lower end of the dental crown, and the connecting body is arranged in the connecting groove; according to the dental crown disclosed by the utility model, the titanium alloy framework is matched with the fixing bolt, so that the connection between the connecting body and the gum is reinforced conveniently, and the stability of the dental crown is improved; through the cooperation of the hydroxyapatite coating and the titanium alloy framework, the titanium alloy framework and a new tissue can be better fused, and the installation stability of the connector is improved; through the cooperation of the fixing bolts and the positioning bolts, the dental crown is convenient to mount, and the mounting efficiency and the mounting effect of the dental crown are improved.