26 results about "Hydroxyapatite coating" patented technology

This invention discloses a composite coating for the tooth surface of an atlantoaxial PEEK interbody fusion cage, relating to the field of medical materials technology. The composite coating for the atlantoaxial PEEK interbody fusion cage comprises a transition layer covering the tooth surface of the atlantoaxial PEEK interbody fusion cage and a hydroxyapatite coating on the surface of the transition layer; the transition layer is obtained by mixing modified nano-hydroxyapatite and modified PEEK; the hydroxyapatite coating is obtained by plasma spraying of nano-hydroxyapatite. This application sets a transition layer between the PEEK and the hydroxyapatite coating, effectively addressing the problem of easy coating detachment due to the difference in physicochemical properties between the PEEK and hydroxyapatite coatings. The composite coating prepared in this application improves the bonding strength between the coating and the substrate, and the prepared material can be used in biological organisms for a long time.

The invention relates to the technical field of marine ecological engineering, in particular to a marine coral reef ecological restoration method based on a foamed aluminum base material, which comprises the following steps: preparing a modified foamed aluminum main body structure, constructing a modified bioactive surface layer, filling a modified phase change material capsule, and putting a restoration unit. According to the invention, the foamed aluminum main body structure provides a stable three-dimensional through porous network, and a natural reef habitat environment is simulated; a hydroxyapatite coating or a polymer layer constructed on the surface of the coral bone-imitating material remarkably improves the coral larva attachment and colonization efficiency through coral bone-imitating inorganic components or specific polypeptides respectively; the phase-change material capsules filled inside buffer water temperature fluctuation through phase-change latent heat, a stable micro-thermal environment is provided for coral growth, the functions of all the components are complementary and synergistic, foamed aluminum provides a carrier for surface functionalization, the surface active layer optimizes a biological interface, the internal temperature adjusting unit guarantees ecological suitability, and an efficient repairing system is formed. The coral reef ecological restoration effect is obviously improved.

The utility model discloses an artificial dental implant, which relates to the technical field of implants and comprises a main body, a hydroxyapatite coating is arranged at the lower end of the main body, a root body is arranged at the lower end of the hydroxyapatite coating, and a mounting groove is formed in the middle of the top surface of the main body; according to the utility model, the sleeve is matched with the hydroxyapatite coating, so that the fusion of the sleeve and new tissues is facilitated, and the fusion efficiency of the root body is improved; the L-shaped positioning plate is matched with the positioning block, so that the main body and the root body are conveniently clamped, and the stability of main body connection is improved; and through cooperation of the positioning bolts and the L-shaped positioning plates, the multiple L-shaped positioning plates can be conveniently pushed outwards along with screwing of the positioning bolts, and the stable effect of connection between the main body and the root body is enhanced.

The invention relates to the crossing field of biomedical engineering, micro-nano-scale biomechanics and a micro-fluidic chip technology, in particular to a micro-fluidic chip based on a bone fossa bionic structure and an experimental method. The chip is formed by bonding and assembling a first cover plate and a second cover plate; a semi-ellipsoid first bone fossa cavity and a first bone tubule fluid channel communicated with the semi-ellipsoid first bone fossa cavity are etched in the first cover plate, a second bone fossa cavity and a second bone tubule fluid channel are symmetrically etched in the second cover plate, and hydroxyapatite coatings are sprayed on the inner walls of the two cavities. And the first cover plate and the second cover plate are bonded to form a complete ellipsoid bone fossa cavity and a bone tubule fluid cavity channel. According to the invention, the problems of abnormal cell morphology of traditional two-dimensional culture, mechanical stimulation deficiency of static three-dimensional culture and insufficient matrix bionic degree are solved, and a high bionic platform is provided for mechanical research of bone cells.

The utility model belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the multi-hole type bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the using process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

The invention discloses a composite sodium hyaluronate microsphere and a preparation method and application thereof.The composite sodium hyaluronate microsphere is of a core-shell structure, an inner core is a cross-linked sodium hyaluronate microsphere, a shell layer is a pure-phase hydroxyapatite coating, calcium and phosphorus elements are enriched in the shell layer, the content of the phosphorus element in the inner core is smaller than 20% of the content of the shell layer, and the content of the calcium element in the shell layer is smaller than 20% of the content of the phosphorus element in the shell layer. And the calcium-phosphorus ratio of the pure-phase hydroxyapatite coating is 1.60 to 2.11. By accurately controlling mineralization phase composition and spatial distribution, a pure-phase hydroxyapatite coating is constructed on the surface of the cross-linked sodium hyaluronate microsphere, so that surface layer confinement distribution is realized, the in-vivo retention rate is remarkably improved, and the enzymolysis withdrawing capability is kept.

The invention discloses a multi-dimensional bionic scaffold with a space-time synergistic osteogenesis function and a preparation method. The bionic scaffold comprises loofah, a hydroxyapatite coating and polyvinyl alcohol hydrogel, the preparation method comprises the following steps: immersing natural towel gourds in a NaClOacetic acid solution, boiling to obtain white towel gourds, and then alternately immersing the white towel gourds in a calcium solution and a phosphorus solution to obtain an intermediate product WLH; adding Mg-MOFs synthesized by a hydrothermal method into a polyvinyl alcohol solution to obtain a hydrogel precursor solution; and immersing WLH into the hydrogel precursor solution, and carrying out vacuum, freezing and unfreezing circular treatment to obtain the loofah-shaped multi-dimensional bionic scaffold. The invention has the following beneficial effects: the scaffold has a cortical-cancellous structure and mechanical characteristics simulating a natural bone, and has good biocompatibility and biological functions of immunoregulation-angiogenesis-osteogenesis induction coupling.

The application discloses a precision interception purification method for water treatment, and belongs to the technical field of drinking water purification. The method solves the purification problems of high-turbidity composite suspended particles, low-temperature microorganisms, plant source toxins, inorganic-organic composite colloids and the like of seasonal ice and snow melt water in the western Sichuan plateau and other regions, and is suitable for a low-temperature environment of 2-10 DEG C. The method comprises the following steps: S1, adding a composite modified vermiculite (quaternary ammonium salt modified vermiculite + konjac glucomannan-propylene glycol-Xuelingshi composite freeze-dried powder) to a water source to be treated, stirring and then filtering to obtain supernatant; S2, coating a first coating (quaternary ammonium salt modified vermiculite + calcium-doped fly ash) and a second coating (KH-560 modified diatomite) on a porous ceramic support in sequence to prepare a composite membrane; and S3, passing the permeate into a purification column containing a calcium-doped nano-hydroxyapatite coating alumina layer and a modified mesoporous carbon layer, and then performing ultraviolet irradiation to obtain final effluent. The application realizes precision interception of multiple impurities and improves the safety of plateau drinking water.

This invention provides a bioceramic liner for total hip replacement surgery, belonging to the fields of medical clinical and biomaterials technology. It includes a shaft with a transmission sleeve sleeved on its outer side, and a limiting sleeve sleeve sleeved on the outer side of the transmission sleeve sleeve; and a fixing component for fixing the ceramic liner and assisting in press-fitting the ceramic liner. The fixing component is connected to both the transmission sleeve sleeve and the limiting sleeve sleeve. This invention, by setting a ceramic liner and progressively spraying a titanium layer, a coarse titanium layer, and a hydroxyapatite coating onto the acetabular surface of the ceramic liner, ultimately forms a sandwich structure on the acetabular surface of the ceramic liner. During surgery, it directly presses against the acetabulum, achieving osseointegration. This eliminates the need for an acetabular cup prosthesis, to some extent solving the problems of incorrect assembly of the acetabular cup and ceramic liner caused by existing technologies, as well as deformation during press-fitting of the metal acetabular cup, which leads to increased incidence of ceramic liner breakage and abnormal noise.

The utility model relates to the field of medical instruments, in particular to an external fixing device with a micro-motion assembly and a hydroxyapatite coating fixing nail, which comprises a support, three clamping block assemblies and the micro-motion assembly. The three clamping block assemblies are used for clamping at least one hydroxyapatite coating fixing nail respectively, the micro-motion assembly is configured to output kinetic energy to the second assembly when receiving electric energy, and when the second assembly is in a movable state relative to the support, the micro-motion assembly is used for driving the second assembly to move according to a preset path. The preset path is a swing path and / or a linear path. The broken bone is actively driven through the micro-motion assembly, the second assembly and the hydroxyapatite coating fixing nail clamped on the second assembly, so that the broken bone driven by the second assembly and the hydroxyapatite coating fixing nail clamped on the second assembly can generate fine displacement, and the broken end of the driven broken bone can form stress stimulation, so that the broken bone can be driven to move stably and stably. The fracture healing time is shortened, and the fracture healing treatment efficiency is high.

The application discloses a mineralized facial implant line and a preparation method thereof, and belongs to the technical field of medical implant materials. The method comprises the following steps: performing microphysical etching on the surface of a high-molecular implant line to form a uniform micro-pit structure; adsorbing a polydopamine film on the etched surface; performing biomimetic mineralization in a supersaturated calcium-phosphorus solution containing zinc ions to form a zinc-doped hydroxyapatite coating; and covalently grafting an enzyme-sensitive drug conjugate on the surface of the coating. The implant line prepared by the method has excellent biocompatibility, strong coating bonding force, good tissue integration capacity and intelligent drug release function, can effectively reduce inflammatory reactions and prevent line body displacement, and improves the durability and safety of facial lifting.

The application discloses a kind of micelles LYTAC engineering biomimetic titanium implants for promoting bone regeneration and its preparation method and application, belong to biomimetic medical instrument technical field.The micelles LYTAC engineering biomimetic titanium implants include titanium matrix, hydroxyapatite coating formed on the surface of the titanium matrix, and multifunctional micelles loaded in the hydroxyapatite coating;The multifunctional micelles include CLP-Apt complex, and the CLP-Apt complex is formed by covalent connection of collagen-like peptide CLP and RANK-CI-M6PR bispecific aptamer Apt through acid-sensitive linker.The application applies LYTAC technology to the surface of titanium implant by constructing HA coating loaded with CLP-Apt micelles.Experiments in vitro and in vivo show that it significantly improves the effect of bone integration under osteoporosis condition, and provides an effective scheme for long-term stability of clinical implant.

The invention discloses a mineralized fiber network composite bone repair aerogel material with early-stage anti-inflammatory and multiple osteogenesis promoting functions and a preparation method of the mineralized fiber network composite bone repair aerogel material. The method comprises the following steps: 1) preparing chitosan fibers by adopting wet spinning, and twisting the chitosan fibers to form fiber bundles; (2) weaving the fiber bundles into fiber webs, and fixing a plurality of fiber webs in a pouring mold in parallel; carrying out surface activation treatment on the fiber by combining a plasma activation process, and forming a Zn < 2 + > doped hydroxyapatite coating on the surface of the fiber by utilizing a hydrothermal method; (3) an alkali-soluble chitosan solution is poured into the pouring mold, and in-situ gelation is carried out; the preparation method comprises the following steps of (1) preparing gel, (2) preparing the gel, (3) preparing the gel, (4) dialyzing the gel, and grafting lipoic acid molecules on the surface of the gel in combination with a surface chemical grafting technology, and (5) introducing a vascular promoting drug into the gel by using an impregnation technology, and freeze-drying to obtain the material. The material has early-stage anti-inflammatory, cell ingrowth promoting and multiple osteogenesis promoting functions, and can be used in the field of bone tissue engineering.

The present application relates to the technical field of composite materials, and particularly relates to a degradable zinc-based composite material for biomedical stents and a preparation method thereof, which comprises the following steps: taking zinc sheets after surface cleaning, coating hydroxyapatite on the surface of the zinc sheets after surface cleaning, stacking the zinc sheets coated with hydroxyapatite and the zinc sheets without hydroxyapatite coating, and rolling the zinc sheets with hydroxyapatite inside the stack; folding the zinc sheets after each rolling pass, and then continuing to roll; repeating the folding-rolling until the desired rolling pass; and after the obtained sample is pressed into a block, performing multi-pass hot rolling, thereby obtaining the degradable zinc-based composite material for biomedical stents. The present application adopts a cumulative roll bonding preparation process, which can effectively improve the combination of hydroxyapatite and zinc, and improve the dispersity of hydroxyapatite in zinc, and can effectively refine the grains and strengthen the matrix, so as to finally obtain a zinc / hydroxyapatite composite material with uniform structure and excellent performance.

The invention provides a porous tantalum dental implant manufacturing method based on AI and 3D printing, and relates to the technical field of stomatology and 3D printing, and the porous tantalum dental implant manufacturing method comprises the following steps: S1, establishing a historical CBCT data set; using the historical CBCT data set to train and construct an oral cavity reconstruction model in an AI modeling platform based on a deep learning algorithm; s2, generating a corresponding oral cavity reconstruction model according to the CBCT of the oral cavity of the patient; the implant three-dimensional model comprises a dental crown, a dental base and an implant matrix; the planting matrix is of a gradient porous structure and is divided into a surface layer area, a transition area and a core area from top to bottom, and the porosity and the aperture of the surface layer area are gradually reduced. S3, adjusting the shape and size of the implant three-dimensional model, and optimizing the implant three-dimensional model; s4, performing 3D printing to obtain an implant; and S5, preparing hydroxyapatite coatings on the outer surface of the planting matrix and the inner wall surfaces of the internal pores. The problems that in the prior art, the elastic modulus of an implant is not matched, the osseointegration efficiency is low, and the adaptability of a restoration is poor are solved.

This invention discloses a medical nano-hydroxyapatite coated porous tantalum implant material and its preparation method. The preparation method includes: etching a graphite carbon skeleton with HCl solution, followed by washing and drying to obtain a porous carbon skeleton, which is then placed in a vapor deposition reaction chamber; passing a treatment gas and a reducing gas through the reaction chamber to perform vapor deposition, thereby depositing a tantalum coating on the surface of the porous carbon skeleton to obtain a porous tantalum metal scaffold; the treatment gas includes a tantalum source and a carrier gas; dissolving a calcium source, a phosphorus source, and sodium chloride in deionized water to obtain a mixed solution, adjusting the pH to 4.3 to obtain an electrolyte; using the porous tantalum metal scaffold as the working electrode and graphite as the counter electrode, electrochemical deposition is performed in the electrolyte using a pulsed current mode to deposit a nano-hydroxyapatite coating on the surface of the porous tantalum metal scaffold, resulting in a medical nano-hydroxyapatite coated porous tantalum implant material with a high porosity >70% and an elastic modulus <30 GPa.

The invention relates to the technical field of surface modification of medical instrument materials, and discloses a copper-containing hydroxyapatite coating on the surface of a titanium-based scaffold and a preparation method thereof.The preparation method comprises the following steps that a calcium source solution, a phosphorus source solution and a copper source solution are mixed, the molar ratio of the sum of the calcium element and the copper element to the phosphorus element is controlled to be 1.67, stirring is conducted, and then the copper-containing hydroxyapatite coating is obtained; a mixed solution is obtained, and the pH of the mixed solution is adjusted to 4.4-4.6; by taking the mixed solution as electrolyte, preparing an amorphous copper-containing hydroxyapatite intermediate coating on the surface of the titanium-based stent by adopting an electrochemical deposition method; and putting the titanium-based stent with the amorphous copper-containing hydroxyapatite intermediate coating deposited on the surface into an alkaline solution for crystallization reaction, and then cleaning to be neutral to obtain the copper-containing hydroxyapatite coating on the surface of the titanium-based stent. The copper-containing hydroxyapatite (Cu-HA) coating is constructed on the surface of the titanium-based stent through electrochemical deposition, so that the antibacterial property and the osteogenic property are synergistically improved.

The invention relates to the field of medical instruments, in particular to a spinal internal fixation system which comprises a prosthesis with a specific structure, one of a hydroxyapatite coating, a zirconia ceramic coating and the like is arranged on the surface of the prosthesis, and the prosthesis comprises a pedicle screw, a connecting seat, an adjusting screw plug, a locking screw plug, a fixing rod, an attaching seat, a spring and the like. The pedicle screw is provided with a specific connecting portion, a middle portion and a head portion, the middle portion is provided with cortical bone threads, the head portion is provided with cancellous bone threads, the adjusting screw plug and the locking screw plug can clamp the fixing rod, the attaching base can be rotationally connected with the adjusting screw plug and attached to the fixing rod, the connecting base is provided with a sliding groove matched with the attaching base to slide, and the adjusting screw plug is provided with an embedding groove for the attaching base to be rotationally embedded. The spine internal fixation system has the technical effects of being excellent in performance, reasonable in structure and good in adaptability.

The utility model discloses a composite dental implant component, which relates to the technical field of dental implants and comprises a dental crown, a connecting groove is arranged on the bottom surface of the dental crown, a connecting body is arranged at the lower end of the dental crown, and the connecting body is arranged in the connecting groove; according to the dental crown disclosed by the utility model, the titanium alloy framework is matched with the fixing bolt, so that the connection between the connecting body and the gum is reinforced conveniently, and the stability of the dental crown is improved; through the cooperation of the hydroxyapatite coating and the titanium alloy framework, the titanium alloy framework and a new tissue can be better fused, and the installation stability of the connector is improved; through the cooperation of the fixing bolts and the positioning bolts, the dental crown is convenient to mount, and the mounting efficiency and the mounting effect of the dental crown are improved.

The application relates to an intelligent controllable super-deformation nose prosthesis, belonging to the field of plastic surgery medical instruments, which combines an inner concave hollow omega-shaped structure frame main body shell layer, a Janus interface outer coating and intelligent response materials to construct an anatomic-structure-function integrated nose prosthesis, performs micropore design and hydroxyapatite coating on the ventral side of the nose prosthesis to form a high-adhesion and high-stability nose prosthesis structure, performs smooth design and spermidine coating on the dorsal side of the nose prosthesis to inhibit envelope formation and avoid envelope constraint, combines the inner concave hollow omega-shaped structure design to realize super-orientation deformation performance, and the application of the intelligent response materials can realize non-invasive deformation adjustment through a temperature signal during or after surgery to meet the clinical requirements of intraoperative and postoperative fine adjustment. The nose prosthesis can be applied to plastic surgery, postoperative modification, repair and reconstruction scenes to meet higher-level medical and aesthetic requirements.

The invention discloses a precise interception and purification method for water treatment, belongs to the technical field of drinking water purification, solves the purification problem of high-turbidity composite suspended particles, low-temperature microorganisms, plant source toxins, inorganic-organic composite colloids and the like of seasonal ice and snow melt water in areas such as West Sichuan plateau and the like, and is suitable for a low-temperature environment of 2-10 DEG C. The method comprises the following steps: S1, adding compound modified vermiculite (quaternary ammonium salt modified vermiculite + konjac glucomannan-propylene glycol-arenaria kansuensis composite freeze-dried powder) into a water source to be treated, stirring, filtering, and taking supernate; s2, sequentially soaking a porous ceramic support body with a first coating (quaternary ammonium salt modified vermiculite and calcium-doped fly ash) and a second coating (KH-560 modified diatomite and the like) to prepare a composite membrane; and S3, introducing the permeate into a purification column containing a calcium-doped nano-hydroxyapatite coating aluminum oxide layer and a modified mesoporous carbon layer, and carrying out ultraviolet radiation to obtain final effluent. Precise interception of multiple impurities is achieved, and the safety of plateau drinking water is improved.

The invention discloses a Zn-based composite material loaded with a nano-catalyst as well as a preparation method and application of the Zn-based composite material. The Zn-based composite material loaded with the nano-catalyst is composed of a Zn substrate, the nano-catalyst and a hydroxyapatite coating, wherein holes are densely distributed in the surface layer of the Zn substrate, the nano-catalyst is embedded into the holes, and the hydroxyapatite coating is arranged on the Zn substrate; the nano-catalyst is an M / NC composite material, wherein M is selected from Fe and / or Se. According to the Zn-based composite material loaded with the nano-catalyst, the nano-catalyst is embedded into the holes in the surface layer of the Zn substrate, and then the nano-catalyst is ingeniously packaged in the holes through the hydroxyapatite coating, so that slow and continuous release is achieved, and the antibacterial and anticancer effects are achieved; and due to introduction of the hydroxyapatite coating, explosion release of zinc ions is inhibited, the corrosion resistance of the zinc alloy is enhanced, good biocompatibility is shown, cell viability is remarkably improved, and adhesion is good.

The invention relates to the technical field of polypropylene, and particularly discloses antibacterial reinforced polypropylene applied to children products, preparation of the antibacterial reinforced polypropylene and a modified inorganic antibacterial agent. The modified inorganic antibacterial agent comprises a composite antibacterial component and hydroxyapatite coating the composite antibacterial component, the composite antibacterial material comprises nano zinc oxide and nano silver particles. The highest bacteriostasis rates of the polypropylene to staphylococcus aureus, escherichia coli and candida albicans are 99.53%, 99.48% and 99.44% respectively, the highest bending strength, bending modulus, tensile strength and notch impact strength are 133MPa, 5100MPa, 85.5 MPa and 132.7 J / m respectively, and the antibacterial property and mechanical strength of the polypropylene are improved.

This invention provides a biomimetic mineralized dental bone powder and its preparation method, belonging to the field of dental material preparation technology. The biomimetic mineralized dental bone powder of this invention comprises the following raw material components by weight: 80-90 parts tricalcium phosphate and 10-20 parts hydroxyapatite; wherein the hydroxyapatite is coated on the surface of the tricalcium phosphate by a mineralization coating. The mineralization coating is obtained by mineralizing a mixture of tricalcium phosphate and a mineralizing solution. This invention combines the advantages of both hydroxyapatite and tricalcium phosphate to develop a suitable biomimetic mineralized bone powder material with both degradability and bioactivity. The hydroxyapatite coating in this mineralized bone powder material is beneficial for enhancing the adsorption of related proteins by early osteogenic materials, thereby inducing cell adhesion and proliferation; tricalcium phosphate, as a degradable material, provides excellent conditions for later bone ingrowth.

The invention discloses a preparation method of a corrosion-resistant, wear-resistant and high-compatibility magnesium alloy biological protective coating, belongs to the field of biological coatings, and aims at solving the problem that an existing magnesium alloy coating material is degraded too fast. According to the preparation method, Mg-1. 5Zn-0. 5Ca alloy is selected as a matrix, firstly, a porous oxide layer is prepared on the surface of the magnesium alloy through a micro-arc oxidation process so as to improve the corrosion resistance of the coating, and then a hydroxyapatite coating is prepared on the surface of the oxide layer through a plasma spraying process so as to improve the biocompatibility and wear resistance of the coating. The prepared composite coating has good performance, the process is simple, and industrial production is easy.

The invention discloses a micelle LYTAC engineering bionic titanium implant for promoting bone regeneration as well as a preparation method and application of the micelle LYTAC engineering bionic titanium implant, and belongs to the technical field of bionic medical instruments. The micelle LYTAC engineering bionic titanium implant comprises a titanium substrate, a hydroxyapatite coating formed on the surface of the titanium substrate, and a multifunctional micelle loaded in the hydroxyapatite coating, the multifunctional micelle comprises a CLP-Apt compound, and the CLP-Apt compound is formed by covalent linkage of a collagen-like peptide CLP and an RANK-CI-M6PR bispecific aptamer Apt through an acid sensitive connexon. According to the invention, the LYTAC technology is applied to the surface of the titanium implant by constructing the HA coating loaded with the CLP-Apt micelle. In-vivo and in-vitro experiments show that the osseointegration effect is remarkably improved under the osteoporosis condition, and an effective scheme is provided for long-term stability of clinical implants.