21 results about "Bioactive coating" patented technology

The invention discloses a preparation method of an acellular matrix containing a bioactive coating, and belongs to the field of medical beauty industry, the key point of the technical scheme is that the preparation method comprises the preparation steps of S1, preparation of the acellular matrix; s2, treating the acellular matrix; s3, rehydrating the decellularized matrix, sequentially immersing the rehydrated decellularized matrix into an activating solution, a collagen solution and an activating solution, reacting, washing the collagen matrix, and freeze-drying to obtain the collagen matrix; s4, adding the anti-inflammatory microcapsules and the growth factor nano-carrier into the hyaluronic acid solution to obtain a mixed solution; s5, the collagen matrix is immersed in an activating solution, after reaction and washing, the surface of the collagen matrix is coated with the mixed solution for reaction, after curing, washing and drying are conducted, and the acellular matrix containing the bioactive coating is obtained.The covalently-connected hyaluronic acid-collagen double-layer structure is constructed on the surface of the acellular matrix, so that biocompatibility and safety are improved; meanwhile, the problems that a traditional acellular matrix is unstable in structure and poor in mechanical strength are solved.

The present invention relates to a freeze-drying process suitable for bioactive coatings, including the following factors: coating pre-freeze treatment: excipient and auxiliary material solution; pre-freezing part: pre-freezing temperature, shelf temperature before feeding, pre-freezing time. Freeze-drying time part: the fastest temperature point of primary sublimation drying, primary sublimation high-speed section drying time, primary sublimation slow section drying time, desorption drying time. Vacuum degree part: primary sublimation air entrainment amount. The method of the present invention is simple, the process is mature and feasible, and the coating product after freeze-drying has a regular appearance and extremely low water content. It overcomes the shortcomings of the existing bioactive coating preparation technology, meets the needs of actual applications, can replace the drying process in the preparation process of most bioactive coatings, ensure the biological activity of the coating, extend the service life of the coating, help the industrial application of the coating, and provide strong support for related research.

A method of coating a metallic substrate includes immersing a metallic substrate in a polymer composition including a conductive 3,4-ethylene dioxythiophene (EDOT) polymer, a gelatin polyelectrolyte, an antibacterial drug, an organic solvent, and an inorganic salt solute, and further coating the polymer composition onto a surface of the metallic substrate by cyclic voltammetry to form a coating on the surface of the metallic substrate. The coating on the metallic substrate is performed such that the gelatin and the antibacterial drug are uniformly distributed throughout the coating, and the coating has a thickness between 7.0 and 15.0 micrometers. The metallic substrate is a stainless steel (SS). An implantable medical device including a metallic substrate coated by the present method.

The invention discloses a high-strength biocompatible titanium wire rope and a preparation device and a preparation method thereof.The high-strength biocompatible titanium wire rope comprises multiple strands of twisted titanium alloy wires, the titanium alloy wires are coated with bioactive coatings through laser cladding, and the titanium alloy wires are prepared through the twisting technology of multi-layer interactive twisting combined with local weaving reinforcement. And under the combined action, the titanium alloy wire has ideal structural stability and high-strength performance. The titanium wire rope can accurately meet the diversified requirements of different medical scenes on the aspects of flexibility, strength, operation convenience and the like of instruments, the titanium wire rope can be excellently competent for both fine tissue suture and high-strength bone fixation, and richer and more efficient tool choices are provided for medical workers.

The utility model discloses a dental implant with high stability, and relates to the technical field of dental implants. The dental implant with high stability comprises an implant module and an abutment module, the implant module comprises an implant main body, an implant neck ring is arranged at the top of the implant main body, double-gradient threads are arranged on the outer surface of the implant main body, a cutting groove is formed in the bottom of the implant main body, and a degradable lubricating layer is arranged on the inner surface of the cutting groove. A conical groove is formed in the implant main body, micro grooves are formed in the outer surfaces of the implant neck ring and the double-gradual-change threads, bioactive coatings are arranged on the inner surfaces of the micro grooves, the abutment module comprises an abutment supporting part, a conical part is arranged at the bottom of the abutment supporting part, a thread mounting part is arranged at the bottom of the conical part, and the implant neck ring and the double-gradual-change threads are integrally formed. According to the dental implant disclosed by the utility model, the stability of the implant is improved, and the dental implant has relatively high practicability.

The invention discloses an antibacterial and anticoagulant bioactive coating and a preparation method thereof, and relates to the technical field of biomedical materials. Comprising the following steps: step 1, adding chitosan into a solvent, and uniformly stirring to obtain a chitosan solution; adding a copper ion source, stirring and chelating to obtain a chitosan chelated copper ion compound solution; 2, tannic acid is added into the chitosan chelated copper ion compound solution, stirring and mixing are conducted, and a mixed solution is obtained; 3, a base material is immersed in the mixed solution, the pH of the mixed solution is adjusted to be alkaline, constant-temperature standing reaction is conducted, washing and drying are conducted, and a finished product with the bioactive coating is obtained. The medical instrument prepared by the method has good antibacterial and anticoagulant effects.

The application belongs to the field of antimicrobial materials, and discloses an antibacterial bioactive coating and a preparation method thereof. The application converts β-cyclodextrin into a dialdehyde derivative through periodic acid oxidation, and copolymerizes the dialdehyde derivative with acrylated chitosan under the initiation of ultraviolet light free radicals to prepare an intelligent copolymer which can be specifically cut by β-cyclodextrinase. Natural plant polyphenols are loaded in the copolymer to realize enzyme-triggered precise release and maintain long-acting antibacterial activity. After coating, the solvent is removed, the micropores are closed, and the molecular-level secondary crosslinking is completed in one step under the treatment of supercritical CO2 environment at 35 MPa and 40 DEG C for 2 hours. Traditional high-temperature drying is not needed, internal stress and crack generation are significantly reduced, and the stability of the pores is improved. The final coating has self-repairing, high adhesion and scrub resistance, and the preparation process is environmentally friendly and efficient, and is suitable for the surface long-acting antibacterial protection of medical devices, food packaging and public facilities.

A transcatheter pulmonary flow restrictor device comprising a disk-shaped body, which is concave on the proximal side and convex on the distal side, made from tightly interwoven ultra-thin mesh wires with shape memory and no substantial gaps to restrict pulmonary blood flow. The disk-shaped body has two symmetrically positioned openings on opposite sides of the disk center for passage of blood flow. The device may further comprise a central screw on the proximal side, an appendage on the distal side opposite the central screw, a heparin-based bioactive coating over the mesh wires, an antibacterial layer within or over the mesh wires, and two radio-opaque markers associated with the openings for proper positioning of the device. Materials of the device vary based on the intended duration of use in the pulmonary arterial branches, including the use of smart, bioresponsive, and biodegradable materials with an inverse relationship between pulmonary arterial pressure and device degradation.

The application discloses a kind of tetragonal phase zirconium oxide / HA nano array bioactive composite coatings grown on zirconium alloy surface and method, belong to zirconium alloy surface treatment technical field, with Zr-2.5Nb alloy as anode, with pulse power constant voltage mode in containing calcium, phosphorus alkaline electrolyte Micro-arc oxidation reaction is carried out, voltage is 300-500V, Ca, P porous calcium stable tetragonal phase ZrO2 coating containing is generated on the surface of Zr-2.5Nb alloy, in 60-140 ℃ alkaline solution First hydrothermal reaction is carried out, then in containing calcium, phosphorus 60-140 ℃ alkaline mixed solution Second hydrothermal reaction is carried out, HA nano array bioactive coating is uniformly grown on the surface of tetragonal phase zirconium oxide coating, can effectively realize the modification to Zr-2.5Nb alloy surface, reach the purpose of promoting its bone integration ability and improving material mechanical property.

This invention discloses a locking bone plate, its preparation equipment, and a preparation method. The locking bone plate includes a bone plate body, a multi-directional micro-motion locking component, a gradient bioactive coating, a stress buffer structure, and a bone-inducing positioning component. The surface of the bone plate body has an anatomically conforming curved surface, with locking holes and micro-motion holes arranged alternately along its length, and a stress buffer structure in the middle. The multi-directional micro-motion locking component is assembled in the micro-motion holes, enabling multi-directional angle adjustment and axial micro-motion of the locking screws. The gradient bioactive coating fully covers the surface of the bone plate body and the walls of each hole, employing a three-layer structure. The bone-inducing positioning component is located on the bone side of the bone plate body that conforms to the bone, used to assist fracture reduction and induce bone cell growth. This invention achieves an organic combination of rigid fixation and multi-directional micro-motion, enhancing bioactivity and bone integration capabilities. It can adapt to complex fracture morphologies, reduce stress shielding, accelerate bone healing, and is safe to use and easy to assemble, possessing extremely high clinical application value.

The invention discloses an intelligent double-response nanometer material artificial bone with a three-layer structure and a preparation method thereof, and relates to the technical field of medical materials, the intelligent double-response nanometer material artificial bone with the three-layer structure sequentially comprises a core support layer, an intelligent response drug layer and a surface bioactive coating from inside to outside; the core support layer contains 55-67 parts of polycaprolactone, 30-40 parts of alpha-tricalcium phosphate and 3-5 parts of magnesium hydroxide; the intelligent response drug layer is pH / temperature double-response nano-micelles loaded in pores of the core support layer and contains 95 to 105 parts of poly (2-(dimethylamino) ethyl methacrylate)-polyglutamic acid block copolymer, 5 to 8 parts of rifampicin and 0.1 to 0.3 part of anti-inflammatory factor; according to the invention, a three-layer composite structure is matched with precise components, so that degradation-regeneration matching and intelligent drug release are realized, a precise process is supplemented to guarantee stable performance, and the artificial bone repair efficiency and the mass production feasibility are improved.

The application is a kind of Ti6Al4V surface diamond doped micro-arc oxidation wear-resistant bioactive coating, which is composed of a ceramic layer mainly of TiO2 and randomly distributed nano-diamond particles formed after micro-arc oxidation on the surface of Ti6Al4V base material, and the Al and V contents in the coating are less than 1.0wt% and 0.1wt% respectively. The preparation method comprises the following steps: configuring sodium silicate, sodium phosphate or beta-glycerophosphorus sodium, sodium hydroxide into electrolyte, adding nano-diamond powder and anti-settling agent to make nano-diamond uniformly dispersed in the electrolyte, and then using micro-arc oxidation technology to prepare low Al and low V diamond doped micro-arc oxidation bioactive coating in the electrolyte. The application scheme is simple and easy to operate, the wear resistance of the coating can be improved by 2-5 times, in addition, the harmful elements Al and V in the coating are low, which is suitable for being used as biomedical implant materials.

The invention relates to the technical field of water treatment, in particular to an immobilized carrier material used for water treatment and used for immobilizing microorganisms and a preparation method of the immobilized carrier material, and the main technical scheme is as follows: the immobilized carrier material comprises a porous Co-Cr-Mo alloy skeleton and a biological activating coating; wherein the porosity of the porous Co-Cr-Mo alloy framework is 60%-80%, the average pore size is 100-500 microns, and the surface of the porous Co-Cr-Mo alloy framework is of a micron-sized dendritic crystal structure; the biological activation coating is a Ca / P-containing oxide layer generated on the surface of the alloy through plasma electrolytic oxidation, the thickness of the coating is 18-50 microns, and a polydopamine-chitosan compound is grafted on the surface of the coating. Through the collaborative design of the porous Co-Cr-Mo alloy skeleton and the functional bioactive coating, and in combination with plasma electrolytic oxidation and polydopamine-chitosan composite grafting technologies, efficient immobilization and activity maintenance of microorganisms are realized, and meanwhile, the carrier is endowed with conductivity and catalytic degradation capability, so that the water treatment performance is remarkably improved.

The invention discloses a bone targeting in-situ bioactive coating implanted into a titanium surface as well as a preparation method and application of the bone targeting in-situ bioactive coating, and belongs to the technical field of biomedical materials. The coating takes an implanted titanium metal material as a matrix, and sequentially comprises a titanium dioxide nanotube loaded with bone targeting ions, a polydopamine middle layer and a polyanion amino acid molecule targeting layer from inside to outside, the preparation method comprises the following steps: (1) constructing a titanium dioxide nanotube; (2) carrying bone targeting ions by adopting a hydrothermal technology; (3) spin-coating a self-polymerization dopamine middle layer; and (4) in-situ grafting of a polyanion amino acid molecular targeting layer. The coating improves the biological activity of the implanted titanium alloy surface, controls the release of Ga < 3 + >, promotes the early adhesion of cells, accelerates the induction of the formation of hydroxyapatite, realizes the early in-situ rapid formation of bone tissues on the implanted titanium interface, and endows the surface with broad-spectrum antibacterial property. The invention provides a new thought for surface modification and biological functionalization of implanted titanium and alloy materials thereof.

An oxidation and grafting method for grafting a bioactive polymer, such as polyNaSS, onto an article, in particular a polymer or ceramic article. The method comprises a step of oxidation by ozonation and a step of grafting by radical polymerisation in a polymerisation station having a first reactor. The two steps of oxidation and grafting are carried out consecutively in different solutions in the reactor of the polymerisation station.

This invention discloses a method for preparing a decellularized matrix with a bioactive coating, belonging to the medical aesthetics industry. The key technical points of the method are the following steps: S1, preparation of the decellularized matrix; S2, treatment of the decellularized matrix; S3, rehydrating the decellularized matrix and then sequentially immersing it in an activation solution, a collagen solution, and another activation solution, followed by washing and freeze-drying to obtain a collagen matrix; S4, adding anti-inflammatory microcapsules and growth factor nanocarriers to a hyaluronic acid solution to obtain a mixed solution; S5, immersing the collagen matrix in the activation solution, reacting and rinsing, coating the mixed solution onto the surface of the collagen matrix, then curing, rinsing, and drying to obtain a decellularized matrix with a bioactive coating. This application improves biocompatibility and safety by constructing a covalently linked hyaluronic acid-collagen bilayer structure on the surface of the decellularized matrix, while also solving the problems of unstable structure and poor mechanical strength of traditional decellularized matrices.

The invention belongs to the technical field of biological materials, and particularly relates to a cell culture substrate and a preparation method and application thereof. The cell culture substrate comprises a matrix, and a polydopamine layer and a bioactive coating which are sequentially wrapped outwards from the matrix side, the base body comprises an electrostatic spinning fiber membrane; the bioactive coating comprises at least one of collagen, fibronectin and gelatin. The polydopamine coating is introduced to provide stable interface adhesion and active binding sites, so that active substances can be firmly anchored on the surface of the material, the problems that a single biological coating is easy to fall off and poor in stability can be solved, and the biological activity and the cell recognition capability of the whole surface are enhanced. After synergistic modification, the cells can sense the microstructure of the substrate fiber layer, continuous topological and mechanical clues can be provided for the cells through contact guidance, and the cells are effectively induced to realize directional adhesion, spreading and functional expression on the surface.

The present invention consists of a coating product made from natural polymers and tomato plant extract, which improves the post-harvest quality of melons by retarding fungal and bacterial growth and extending the shelf life of stored melons, thus preventing economic losses for producers and retailers. This bioactive coating is applied to the fruit by immersion, then allowed to dry before packaging. In this way, the melon can be preserved for longer (up to 30 days) with excellent microbiological quality and delayed ripening. This allows the melon to last longer during transport to its point of sale, or to remain on the shelf longer, with the firmness and microbiological quality desired by the consumer.

The invention relates to the technical field of biological materials, and discloses a bone tissue repair material and a preparation method thereof.According to the material, hydroxyapatite, octacalcium phosphate and silicon-doped beta-tricalcium phosphate are adopted for constructing three-phase ceramic microspheres, a two-stage pore structure is formed through a pore forming agent method, chitosan coating and gradient biomimetic mineralization treatment are sequentially conducted on the surface, and the bone tissue repair material is obtained. And compounding with a strontium-barium double-ion cross-linked sodium alginate-collagen-oxidized chitosan ternary matrix, and adding hemostatic functional microspheres. According to the invention, multiple technical breakthroughs such as in-vivo dynamic mineralization of octacalcium phosphate, strontium-barium double-ion anti-displacement cross-linking, oxidized chitosan covalent cross-linking, gradient mineralization layer interface enhancement, rapid hemostasis of hemostatic microspheres and the like are adopted; the comprehensive technical effects that the mechanical strength of the material is improved, the degradation rate is adjustable, the antibacterial performance is enhanced, the in-vivo stability is remarkably improved, hemostasis is rapid, and the bioactive coating is firm and does not fall off are achieved.

The embodiment of the application discloses rod-like cerium-loaded hydroxyapatite and a preparation method and application thereof.The method comprises the following steps: hydrothermal reaction of a water solution containing a calcium source and gelatin and a water solution containing a phosphorus source and urea is carried out in a stainless steel autoclave, then the rod-like hydroxyapatite is obtained through filtration, washing and drying; the rod-like hydroxyapatite is added into a water solution containing a cerium source, stirred uniformly, dried, and high-temperature calcination is carried out when the moisture on the surface of the material is completely removed, so that the rod-like cerium-loaded hydroxyapatite is obtained. The rod-like cerium-loaded hydroxyapatite provided by the application has good antibacterial performance, good biocompatibility and high biological activity, and has a potential application prospect in the fields of oral enamel repair, enamel mineralization regeneration and bioactive coating. The preparation process of the application is simple, convenient to operate and easy to produce.

The present application belongs to the technical field of polyether ether ketone composite materials, and provides a carbon fiber material with biological activity, a preparation method and a composite material and application thereof.The present application first uses a sizing method combined with a biomimetic method to prepare a carbon fiber reinforced polyether ether ketone composite material, first coats a uniform water-based carboxyl-containing sizing agent layer on a carbon fiber cloth, then immerses the carbon fiber cloth in a simulated body fluid as an organic template of hydroxyapatite, grows a hydroxyapatite bioactive coating layer by using the biomimetic method, and then uses a molding method to prepare the carbon fiber reinforced polyether ether ketone composite material.The method of the present application not only improves the interface performance of the carbon fiber reinforced polyether ether ketone composite material and improves the mechanical strength of the carbon fiber reinforced polyether ether ketone composite material, but also simultaneously endows the carbon fiber reinforced polyether ether ketone composite material with good biological activity and biocompatibility.