Medicinal silver-loaded metal bioactive coating as well as preparation method and application thereof

A biologically active, metal-based technology, applied in metal material coating technology, coating, medical science, etc., can solve problems such as systemic side effects, blood circulation damage, and increased soft tissue damage, achieving high deposition rate, low ion energy, The effect of little damage

Inactive Publication Date: 2013-01-23
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The difficulty is that if the bone defect is not repaired by surgical bone grafting in the early stage, it may cause delayed union of the fracture and difficulty in forming a connection: for example, the blood supply of the fracture end will be disturbed, which will increase the damage of the soft tissue; there will also be absorption and sclerosis of the bone end, bone Puffiness and atrophy of bone and soft tissue with joint stiffness
The problems caused are: 1. Many pathogenic bacteria can quickly develop drug resistance to antibiotics; 2. Because the blood circulation in the wound site is destroyed, it is difficult to reach the effective antibacterial concentration, and increasing the drug concentration will cause systemic toxic and side effects
V.NeLea et al. prepared hydroxyapatite (HA) coatings by comparing magnetron sputtering and pulsed laser techniques. The results showed that the HA coatings prepared by the two methods were crystalline and had good mechanical properties. However, compared with the pulsed laser method, the coating surface produced by magnetron sputtering is smoother
However, there is no report on the preparation of antibacterial medical metal bioactive coatings loaded with nano-silver particles by magnetron sputtering technology.

Method used

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  • Medicinal silver-loaded metal bioactive coating as well as preparation method and application thereof
  • Medicinal silver-loaded metal bioactive coating as well as preparation method and application thereof
  • Medicinal silver-loaded metal bioactive coating as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 Preparation of silver-loaded titanium alloy bioactive coatings with different thicknesses

[0039] (1) Treatment of metal substrates:

[0040] The substrate used in this method is a circular titanium sheet with a size of Φ12mm×1.5mm. Sand with 800, 1000 and 1200 metallographic sandpaper step by step until the surface is flat and smooth. Place the titanium sheet in deionized water and shake it for 15 minutes, then put it into acetone solution and shake it for 20 minutes, then wash it with deionized water and set it aside.

[0041] (2) Preparation of nano-silver-loaded medical metal bioactive coatings with different thicknesses

[0042] First vacuum the base of the vacuum chamber to below 2.0x10 -3 Pa, the surface of the metal substrate is pre-sputtered and cleaned with argon gas, and the time is 5 minutes. During thin film deposition, argon gas is fed into the vacuum chamber at a certain flow ratio. The sputtering power supply adopts a DC power supply, ...

Embodiment 2

[0046] The preparation of embodiment 2 different particle size nano-silver medical metal object active coatings

[0047] (1) Treatment of metal substrates:

[0048] The substrate used in this method is a circular titanium sheet with a size of Φ12mm×1.5mm. Sand with 800, 1000 and 1200 metallographic sandpaper step by step until the surface is flat and smooth. Place the titanium sheet in deionized water and shake it for 15 minutes, then put it into acetone solution and shake it for 20 minutes, then wash it with deionized water and set it aside.

[0049] (2) Preparation of nano-silver medical metal bioactive coatings with different particle sizes:

[0050] First vacuum the base of the vacuum chamber to below 2.0x10 -3 Pa, the surface of the metal substrate is pre-sputtered and cleaned with argon gas, and the time is 5 minutes. During thin film deposition, argon gas is fed into the vacuum chamber at a certain flow ratio. The sputtering power supply adopts DC power supply, the f...

Embodiment 3

[0052] Embodiment 3 carries the antibacterial property of nano silver medical metal bioactive coating

[0053] According to JC / T 897-2002 Antibacterial Ceramic Products Antibacterial Performance Test Method, the antibacterial test was carried out by plate culture method. We tested Gram-negative and positive bacteria: Escherichia coli and Staphylococcus aureus, and the antibacterial rate=(control group-antibacterial group) / control group×100%. The results are shown in Table 3. The number of colonies in petri dishes loaded with nano-silver medical metal bioactive coatings, such as Figure 4 shown. These results indicate that the nano-silver-loaded titanium alloy bioactive coatings have obvious antibacterial properties.

[0054] table 3

[0055] Sample serial number

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Abstract

A preparation method of a medicinal silver-loaded metal bioactive coating, which is characterized by adopting a magnetron sputtering process, and comprises the following steps of: (1) processing a metallic matrix; (2) processing the metallic matrix before sputtering; (3) preparing the medicinal silver-loaded metal bioactive coating through the magnetron sputtering process, and obtaining the medicinal silver-loaded metal bioactive coating by controlling the precipitating time under the following conditions: a cathode is a high-purity silver target, a working gas is argon, the vacuum of a substrate in a vacuum chamber is 2.0*10<-3>Pa, the power of the target is 40 to 80 W, the frequency is 13.0 to 15.6MHz, and the flow is 30 SCCM. The medicinal silver-loaded metal bioactive coating provided by the invention is stable in property, free from biological toxicity and good in biocompatibility, and realizes antibiosis.

Description

technical field [0001] The invention relates to a preparation method and application of a medical metal bioactive coating, in particular to a preparation method and application of a silver-loaded medical metal bioactive coating. Background technique [0002] Human organs and tissues are often reduced or even lose their original functions due to trauma, disease, functional degeneration or congenital abnormalities. The application of biomedical materials to repair or replace human tissues and functions is a clinically effective medical approach. Titanium alloy is a new type of smart material that not only has a good shape memory effect, but also has phase transition pseudoelasticity. Due to its excellent biocompatibility, non-toxicity, non-carcinogenicity, non-teratogenicity, non-allergic induction, and good affinity with body tissues, it has been widely used in the field of biomedical engineering. The treatment of open fractures and severe bone defects has always been a diff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/54C23C14/35C23C14/16
Inventor 王美艳姜来新何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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