Method for preparing similar bone bioactivity coatings medical material by galvano-chemistry method

A bioactive and electrochemical technology, applied in the field of preparing bone-like bioactive coating medical materials, can solve the problems of long healing period, slow bonding, poor effect, etc., and achieves simple preparation process conditions, easy industrialization, and preparation process. The effect of conditional ease

Inactive Publication Date: 2008-04-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pure hydroxyapatite coating has limited biological activity and cannot stimulate the proliferation and differentiation of osteoblasts, thereby promoting osteogenesis.
This makes the implant slow to integrate with the bone tissue in the body, resulting in a long healing period and poor results

Method used

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  • Method for preparing similar bone bioactivity coatings medical material by galvano-chemistry method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Ca(NO 3 ) 2 ·6H 2 O and NH 4 h 2 PO 4 Dissolve in distilled water, and prepare A solution with a calcium concentration of 4.5mM and a phosphorus concentration of 9mM.

[0019] Dissolve collagen in hydrochloric acid solution, mix with solution A, and stir to form solution B, so that the concentration of collagen in solution B is 0.2 g / L. And the pH value of the solution was adjusted to 5.0 with ammonia water, which was used as an electrolyte solution. The medical titanium alloy implant is used as the cathode, the platinum is used as the anode, and the saturated calomel electrode is used as the reference electrode. Immerse in the electrolyte solution. The temperature of the electrolyte solution is 37°C. The working distance between the positive and negative electrodes is 2cm, and the constant current mode is used to maintain the current at 15mA. , after 1 hour of deposition, the medical titanium alloy implant was taken out for cleaning, and after drying, the bone-li...

Embodiment 2

[0021] Ca(NO 3 ) 2 ·6H 2 O and KH 2 PO 4 Dissolve in distilled water, and prepare A solution with a calcium concentration of 42mM and a phosphorus concentration of 25mM.

[0022] Dissolve collagen in acetic acid solution, mix with solution A, and stir to form solution B, so that the concentration of collagen in solution B is 0.5 g / L. Adjust the pH of the solution to 3.5 with Tris buffer solution as the electrolyte solution. The medical cobalt-chromium-molybdenum alloy implant is used as the cathode, the platinum is used as the anode, and the silver chloride electrode is used as the reference electrode. Immerse in the electrolyte solution. The temperature of the electrolyte solution is 18°C. The working distance between the positive and negative electrodes is 20cm, and the constant voltage mode is used to maintain the voltage. After deposition for 0.5h, the medical cobalt-chromium-molybdenum alloy implant was taken out for cleaning, and the bone-like bioactive coating medi...

Embodiment 3

[0024] CaCl 2 and NaH 2 PO 4 Dissolve in distilled water, and prepare A solution with calcium concentration of 2mM and phosphorus concentration of 1mM.

[0025] Dissolve collagen in hydrochloric acid solution, mix with solution A, and stir to form solution B, so that the concentration of collagen in solution B is 3g / L. The pH of the solution was adjusted to 5.0 with ammonia water as the electrolyte solution. The medical titanium alloy implant is used as the cathode, the platinum is used as the anode, and the saturated calomel electrode is used as the reference electrode. Immerse in the electrolyte solution. The temperature of the electrolyte solution is 50°C. The working distance between the positive and negative electrodes is 2cm, and the constant current mode is used to maintain the current at 10mA. , After 24 hours of deposition, the medical titanium alloy implant was taken out for cleaning, and after drying, the bone-like bioactive coating medical material was obtained....

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Abstract

The invention discloses bone-like bioactive coating medical material which is prepared by adopting an electrochemical method. The invention adopts an electrolytic deposition method and imitates the forming process of a natural bone. Electrolyte solution contains calcium, a phosphorous compound and bone matrix collagen, a medical metal transplant body is taken as a working electrode, platinum is taken as a reference electrode, the electrode reaction causes partial pH value of the electrolyte solution around the medical metal transplant body to ascend, thereby leading collagen to be gelatinized, in cooperation with the deposition of calcium phosphate mineral, the bone-like bioactive coating is formed on the medical metal surface. Through the adoption of the invention method, the bioactive coating acquired on the surface of the metal transplant body is similar to the natural bone in the component and the structure, and has favorable biological activity, thus the disadvantages that the biological activity of the business use hydroxyapatite coating is limited, the required curing time is long, etc. are solved. The preparation process of the invention is simple, highly effective and easy to be industrialized.

Description

technical field [0001] The invention relates to a method for preparing bone-like bioactive coating medical materials by an electrochemical method. Background technique [0002] Due to their good biocompatibility and mechanical properties, medical metal implants are widely used as orthopedic and dental replacement materials to restore the physiological functions of patients. However, medical metals are bioinert materials that cannot promote tissue growth and form a strong bond with tissue. Therefore, biomaterials modified on the surface of medical metals are gaining attention by various methods. For example, Chinese patent CN1316274 uses electrolytic deposition to prepare hydroxyapatite coatings on metal surfaces, and Chinese patent CN1587442 uses electrolytic deposition to prepare nano-ordered hydroxyapatite biological coatings. However, the pure hydroxyapatite coating has limited biological activity and cannot stimulate the proliferation and differentiation of osteoblasts...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32C25D9/04
Inventor 翁文剑苗顺东程逵宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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