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Prepn process of nanometer tricalcium phosphate powder with slowly released metal ion

A technology of metal ions and tricalcium phosphate, applied in the direction of non-metallic elements, chemical instruments and methods, phosphorus compounds, etc., can solve the problems of limited application, inability to stimulate protein activity, etc., achieve uniform distribution, simple and easy preparation process conditions, The effect of low sintering temperature

Inactive Publication Date: 2006-05-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a bioactive material, β-tricalcium phosphate cannot stimulate protein activity, promote bone growth or inhibit bone resorption after implantation, which limits its further application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Ca(NO 3 ) 2 ·6H 2 O was dissolved in distilled water to form an A solution with a calcium concentration of 2.0M. Zn(NO 3 ) 2 4H 2 O was dissolved in distilled water to form a B solution with a metal concentration of 0.01M. Put (NH 4 ) 2 HPO 4 Dissolve in distilled water and stir to dissolve to form a C solution with a phosphorus concentration of 0.1M. Mix A solution and B solution according to the designed Zn / (Zn+Ca) molar ratio of 0.0001 to form D solution, add polyethylene glycol to D solution, and the molar ratio is polyethylene glycol: Ca(NO 3 ) 2 = 3:1, the polymer is calculated by the number of moles of structural units, and the E solution is formed after dissolution, and the C and E solutions are refrigerated at 5°C. After the temperature is stabilized, add solution C to solution E dropwise at a rate of 2ml / min at 5°C, adjust the pH to about 7 with ammonia water, react for 30 minutes under magnetic stirring after the addition, and the Ca / P ratio is 1....

Embodiment 2

[0028] CaCl 2 ·6H 2 O was dissolved in distilled water to form A solution with a calcium concentration of 5.0M. Mg(NO 3 ) 2 ·6H 2 O was dissolved in distilled water to form a B solution with a metal concentration of 1.0M. Put (NH 4 ) 2 HPO 4 Dissolve in distilled water and stir to dissolve to form a C solution with a phosphorus concentration of 5M. Mix A solution and B solution according to the designed Mg / (Mg+Ca) molar ratio of 0.1 to form D solution, add polyethylene glycol to D solution, and the molar ratio is polyethylene glycol: CaCl 2 = 3:1, the polymer is calculated by the number of moles of structural units, and the E solution is formed after dissolution, and the C and E solutions are refrigerated at 5°C. After the temperature is stabilized, add solution C to solution E dropwise at a rate of 2ml / min at 5°C, adjust the pH to about 12 with ammonia water, react for 30 minutes under magnetic stirring after the addition, and the Ca / P ratio is 1.50. The precipitat...

Embodiment 3

[0030] Ca(NO 3 ) 2 ·6H 2 O was dissolved in distilled water to form an A solution with a calcium concentration of 3.0M. SrC l2 Dissolve in distilled water to form a B solution with a metal concentration of 0.1M. Put (NH 4 ) 2 HPO 4 Dissolve in distilled water and stir to dissolve to form a C solution with a phosphorus concentration of 0.5M. Mix A solution and B solution according to the designed Sr / (Sr+Ca) molar ratio of 0.09 to form D solution, add polyethylene glycol to D solution, and the molar ratio is polyethylene glycol: Ca(NO 3 ) 2 = 1:10, the polymer is calculated by the number of moles of the structural unit, and the E solution is formed after dissolution, and the C and E solutions are refrigerated at 5°C. After the temperature is stabilized, add solution C to solution E dropwise at a rate of 2ml / min at 5°C, adjust the pH to about 10 with ammonia water, react for 30 minutes under magnetic stirring after the addition, and the Ca / P ratio is 1.50. The precipit...

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Abstract

The present invention discloses the preparation process of nanometer tricalcium phosphate powder with slowly released metal ion. The preparation process adopts metal ion compound, calcium containing compound and phosphide as main material, and polyglycol as stabilizer, and includes reaction inside water solution at 0-5 deg.c to produce amorphous calcium phosphate containing metal ion, and the subsequent sintering at 800-1100 deg.c. The said preparation process can obtain nanometer tricalcium phosphate powder with controllable metal ion releasing rate and small particle size, and the nanometer tricalcium phosphate powder is used as bioactive material capable of promoting bone growth and inhibiting bone absorption. The preparation process is simple, feasible, simple in operation, low in cost and easy for industrial production.

Description

technical field [0001] The invention relates to a preparation method of tricalcium phosphate powder used as a biological bone repair or replacement material, in particular to a preparation method of nanometer tricalcium phosphate powder for slow release of metal ions. Background technique [0002] β-TCP is widely used as bone tissue engineering material because of its excellent biocompatibility, osteoconductivity and biodegradability. However, the poor mechanical properties of β-tricalcium phosphate ceramics as hard tissue bearing materials limit its application. Therefore, more research has focused on compounding β-tricalcium phosphate powder with organic matter with good biocompatibility and viscoelasticity. For example, Chinese patent CN1647826 adopts in-situ complexation of collagen and β-phase tricalcium phosphate to deposit nano-scale β-phase tricalcium phosphate powder on the collagen matrix. Chinese patent CN 1389503 provides a new method for preparing chitosan / hyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/12A61L27/40
Inventor 翁文剑苗顺东程逵宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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