Prepn process of nanometer tricalcium phosphate powder with slowly released metal ion

Abstract

The present invention discloses the preparation process of nanometer tricalcium phosphate powder with slowly released metal ion. The preparation process adopts metal ion compound, calcium containing compound and phosphide as main material, and polyglycol as stabilizer, and includes reaction inside water solution at 0-5 deg.c to produce amorphous calcium phosphate containing metal ion, and the subsequent sintering at 800-1100 deg.c. The said preparation process can obtain nanometer tricalcium phosphate powder with controllable metal ion releasing rate and small particle size, and the nanometer tricalcium phosphate powder is used as bioactive material capable of promoting bone growth and inhibiting bone absorption. The preparation process is simple, feasible, simple in operation, low in cost and easy for industrial production.

Description

technical field

[0001] The invention relates to a preparation method of tricalcium phosphate powder used as a biological bone repair or replacement material, in particular to a preparation method of nanometer tricalcium phosphate powder for slow release of metal ions. Background technique

[0002] β-TCP is widely used as bone tissue engineering material because of its excellent biocompatibility, osteoconductivity and biodegradability. However, the poor mechanical properties of β-tricalcium phosphate ceramics as hard tissue bearing materials limit its application. Therefore, more research has focused on compounding β-tricalcium phosphate powder with organic matter with good biocompatibility and viscoelasticity. For example, Chinese patent CN1647826 adopts in-situ complexation of collagen and β-phase tricalcium phosphate to deposit nano-scale β-phase tricalcium phosphate powder on the collagen matrix. Chinese patent CN 1389503 provides a new method for preparing chitosan / hyd...