40 results about "Amorphous calcium phosphate" patented technology

This invention discloses a composite hydrogel based on a polysaccharide-based hybrid dual network, its preparation method, and its applications, belonging to the field of marine polysaccharide technology. Based on the important role of amorphous calcium phosphate, a precursor in biomineral formation, in mineralization, this invention prepares a multifunctional composite hydrogel with wet bonding, antibacterial, and remineralization functions. This composite hydrogel can achieve rapid and convenient repair of enamel demineralization. This invention prepares oxidized sodium alginate via an alcohol-aqueous phase using the sodium periodate method. Sodium alginate reacts with carboxymethyl chitosan and dopamine through a Schiff base reaction to form dynamic imine bonds, thus preparing an in-situ self-crosslinking hydrogel. Simultaneously, amorphous calcium phosphate is introduced for secondary crosslinking, preparing a dense dual-network composite hydrogel. The composite hydrogel prepared by this invention has an interconnected three-dimensional porous structure, stable mechanical properties, and uniformly dispersed amorphous calcium phosphate in the form of nanospheres. The composite hydrogel prepared by this invention provides an integrated strategy with clinical translational potential for orthodontic enamel demineralization, with broad market prospects.

This invention discloses a method for reducing the stability of amorphous calcium phosphate. The method involves adding an additive solution to an ACP solution; the additive is a calcium- and phosphorus-free inorganic salt that does not react with calcium ions and orthophosphate ions to form a precipitation reaction. This invention, by adding an inorganic salt after the formation of amorphous calcium phosphate, primarily increases the ionic strength of the solution, reduces calcium and phosphorus activity, promotes the dissolution of amorphous calcium phosphate, thereby altering its structure, significantly reducing its stability, and accelerating the formation of hydroxyapatite. Furthermore, this method uses low-cost raw materials, contributing to cost reduction.

The invention discloses a preparation method and application of a citric acid-based polymer stable amorphous calcium phosphate porous scaffold for bone defect repair. The preparation method of the citric acid-based polymer stable amorphous calcium phosphate porous scaffold comprises the following steps: carrying out a polymerization reaction on an amorphous calcium phosphate precursor and citric acid-based poly (1, 8-octylene glycol-citrate) at 80 DEG C for 2-3 days or carrying out a polymerization reaction at 80 DEG C for 3 days and then carrying out a reaction at 120 DEG C for 1 day to obtain the porous scaffold with stable amorphous calcium phosphate characteristics. According to the present invention, the uniform dispersion and the effective and stable combination of the amorphous calcium phosphate precursor particles in the citric acid-based poly (1, 8-octylene glycol-citrate) matrix are achieved, and the biomimetic mineralized bone repair scaffold with characteristics of porous structure, high mechanical strength, controllable degradability and excellent osteogenic activity is successfully constructed. According to the stent, the technical problem of insufficient stability in application of amorphous calcium phosphate is remarkably solved, the osteogenic activity of the material is improved, and the stent has a great application prospect in the field of clinical bone defect repair.

The application provides an anti-friction and corrosion-resistant medical magnesium alloy coating, a preparation method thereof and a medical magnesium alloy. From the surface of the medical magnesium alloy substrate to the outside, the medical magnesium alloy coating comprises a bottom coating and a surface coating which are arranged in sequence; the bottom coating comprises magnesium hydroxide; and the surface coating comprises nano-scale amorphous calcium phosphate. The application uses the magnesium alloy as the substrate, converts the surface layer of the magnesium alloy into a dense magnesium hydroxide layer through an alkali-thermal reaction, and then generates a continuous and dense calcium phosphate coating on the surface of the bottom coating through a hydrothermal reaction to form a composite coating. The composite coating has good biocompatibility and can be completely degraded. In addition, the coating can not only alleviate the problem of too fast degradation of the magnesium alloy, but also has high wear resistance and excellent bonding strength, thereby providing sustained protection for magnesium alloy fixing products.

A composition for treating dentin hypersensitivity, comprising: a first component comprising: (i) a first rheology modifying polymer; (ii) a calcium ion source; (iii) a positively charged basic amino acid; and (iv) an acidifying agent, wherein the first component has a pH in the range of about 2.0 to about 7.0; a second component comprising: (i) a second rheology modifying polymer; (ii) a phosphate ion source; and (iii) an alkalizing agent, wherein the second component has a pH in the range of about 7.0 to about 14.0; wherein the first component and the second component are combined into a mixture such that a cationic amorphous calcium phosphate gel composition is created instantly when the pH of the mixture reaches a pH range of about 7.0 to about 9.5.

The invention relates to a carboxymethyl chitosan-amorphous calcium phosphate composite anti-caries material as well as a preparation method and application thereof, the composite anti-caries material is a composite gel system and comprises carboxymethyl chitosan, amorphous calcium phosphate and glycerol, and hydroxyapatite nanowires can be selectively added into the carboxymethyl chitosan-amorphous calcium phosphate composite anti-caries material. The composite anti-caries material provided by the invention successfully solves the ubiquitous problems of the existing fluoride-free remineralization material that the mineralization efficiency needs to be improved, the clinical operability is poor and the like, and provides a novel fluoride-free scheme which is safe, efficient and convenient to use for prevention and treatment of early caries.

The invention relates to a mineralized protein-based bionic bone repair material as well as a preparation method and application thereof. Ca < 2 + > and PO4 < 3-> are introduced into the silk fibroin solution for a mineralization reaction, so that the amorphous calcium phosphate is directionally deposited on the silk fibroin molecular template, and a silk fibroin-amorphous calcium phosphate nano-composite is generated; after the mineralization reaction is finished, a mineralized product is centrifuged, frozen and freeze-dried, and the bionic bone repair material based on the mineralized protein is obtained. The bionic block material which is compact in structure and excellent in mechanical property can be constructed through high-pressure compression molding at normal temperature. The biomimetic bone repair material based on mineralized protein or a biomimetic block material further prepared on the basis of the scheme of the application shows excellent mechanical properties and structural stability in dry and wet environments, and also has good processability; the method is suitable for personalized bone defect repair and manufacturing of clinical orthopedic implantation instruments such as bone nails, bone plates and interbody fusion cages, and has wide application prospects and transformation values.

The present invention relates to improved phosphopeptide stabilised amorphous calcium phosphate and / or amorphous calcium fluoride phosphate complexes and compositions containing those complexes. Methods of making the complexes of the invention and of treating or preventing oral conditions are also provided. In one aspect, the present invention provides a composition comprising equal to or greater than about 8% w / v stannous associated phosphopeptide (PP) stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complexes wherein the complexes have a stannous ion content of equal to, or greater than, 1 mole of stannous per mole of PP but less than 4 moles of stannous per mole of PP.

The present invention relates to improved complexes of amorphous calcium phosphate and / or amorphous calcium fluoride phosphate stabilised by phosphopeptides / phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental / medical applications (including anti-calculus, anti-erosion / corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion / corrosion and dental hypersensitivity are also provided.

The application discloses a kind of micro bone-blood vessel symbiosis based on gene activation and its preparation method and application.The system includes: the amorphous calcium phosphate nanoparticles of L-arginine, bovine serum albumin and alendronate sodium co-modified loaded BMP-2 mRNA;Methacrylic acid gel hydrogel microspheres encapsulating the nanoparticle;And E7 peptide grafted on the surface of hydrogel microspheres.It is captured by E7 peptide bone marrow mesenchymal stem cells, and delivers BMP-2 mRNA to activate intracellular BMP-2 and endothelial-type nitric oxide synthase expression, while using L-arginine to drive in-situ synthesis of nitric oxide, to synergistically enhance stem cell osteogenic differentiation and promote vascular sprouting ability, realize the vascularization synchronous regeneration of bone defect.The system solves the problem of unstable exogenous nitric oxide donor and bone-vessel regeneration decoupling, and has excellent biocompatibility and bone repair efficiency.

The invention relates to composite gel for remineralization of dog enamel as well as a preparation method and application of the composite gel. The composite gel comprises 5-15 wt% of casein phosphopeptide-amorphous calcium phosphate and 3-10 wt% of nano bioactive glass, and has a porous cluster structure, and the molar ratio of Ca to P is (1.8-2): 1. According to the preparation method, an in-situ coprecipitation process is adopted, and a compound with a uniform structure is formed by controlling the stirring rate and the solution dripping rate. The composite gel is combined with diode laser for use, ion migration and mineral conversion can be promoted, and synergistic interaction is achieved. According to the invention, the problems of low remineralization efficiency and limited mechanical property improvement in the prior art are solved, and the enamel mineralization structure and mechanical property can be effectively recovered on the premise of not damaging tooth tissues.

The application provides a preparation method of a collagen in-situ mineralized scaffold simulating a bone matrix, S1: extraction of type I collagen fibers; S2: preparation of a biomimetic mineralization solution: carboxymethyl chitosan (CMC) is placed in deionized water, after stirring and dissolving, K2HPO4 is added, CaCl2.2H2O is added drop by drop, and is fully dissolved and mixed to form a carboxymethyl chitosan / amorphous calcium phosphate biomimetic mineralization solution (CMC / ACP); S3: preparation of a biomimetic collagen scaffold composed of a simulated mineralized bone matrix: the acid-recombined collagen extracted in step S1 is fully mixed with hyaluronic acid (HA) and is placed in a dialysis bag, an external PBS buffer is used to gradually increase the pH value, after self-assembly for a period of time, the CMC / ACP biomimetic mineralization solution prepared in step S2 is added in the dialysis bag and is fully mixed, after mineralization for a period of time, the content of the dialysis bag is centrifuged to remove supernatant, and is repeatedly washed with deionized water, finally, after centrifugation, the precipitate is frozen overnight, and the biomimetic scaffold is finally obtained through freeze-drying. The application provides the preparation method of the collagen in-situ mineralized scaffold simulating the bone matrix.

This invention relates to the field of biomaterials technology, providing a composite material for biomimetic repair of dental hard tissues, its preparation method, and its application. The preparation method of the composite material includes the following steps: mixing a carboxybetaine-phosphonic acid copolymer with a calcium salt to obtain solution A; adding an aqueous phosphate solution to solution A to carry out an in-situ reaction to obtain the composite material for biomimetic repair of dental hard tissues. In the composite material provided by this application, the carboxybetaine-phosphonic acid copolymer, under the action of calcium phosphate ions, can form an amelogenin-like nanoribbon structure, simultaneously driving amorphous calcium phosphate to undergo supramolecular self-assembly, constructing a composite material conforming to the "self-assembly-mineralization" synergistic mode. This composite material can directionally deposit dense enamel-like enamel pillar structures of hydroxyapatite crystals on the surface of demineralized enamel, efficiently inducing oriented structural regeneration of damaged enamel and significantly restoring the mechanical properties of demineralized enamel.

The application discloses a preparation method and application of a temperature-sensitive injectable plastic mineralization material, and the material can be stored for a long time and is used for inducing tooth mineralization. By combining amorphous calcium phosphate with an amphiphilic surfactant, dispersion and stability of the amorphous calcium phosphate are promoted. The mineralization material obtained by loading synthetic and dried amorphous calcium phosphate particles on the amphiphilic surfactant is in a solid state and cannot be plasticized at room temperature, can be injected and plasticized when heated to a certain temperature, and has a better mineralization effect compared with the dried amorphous calcium phosphate particles. The solid bulk material at room temperature is beneficial to packaging, storage and use. When coated on teeth in the oral cavity, the material gradually melts and dissolves at the normal oral cavity temperature, spontaneously forms high-concentration micelle-loaded amorphous calcium phosphate nanoparticles in a solution on the tooth surface, and plays a mineralization role.

A calcium phosphate-based core-shell structured material, a method for preparing the same, and an oral care composition using the same are provided. The calcium phosphate-based core-shell structured material includes an amorphous calcium phosphate (ACP) core and a β-tricalcium phosphate (β-TCP) shell covering the core. The method includes a first sintering step and a second sintering step. The first sintering step is to sinter an ACP material at between 700° C. and 800° C. to obtain an α-TCP shell. The second sintering step allows the α-TCP shell to form into the β-TCP shell by sintering at between 800° C. and 900° C. The oral care composition includes a calcium phosphate mixture and an orally receivable carrier. The calcium phosphate mixture includes a powder of the calcium phosphate-based core-shell structured material and a tricalcium phosphate powder mixed in a weight ratio from 3:5 to 3:7.

This invention discloses a 3D-printed scaffold with improved bioactivity and in vitro mineralization capacity, its preparation method, and its applications. The scaffold is prepared by layer-by-layer extrusion 3D printing using an ink comprising biphasic calcium phosphate (composed of octacalcium phosphate (OCP) and amorphous calcium phosphate (ACP)), sodium alginate, and a dispersant. This invention uses a mixture of OCP and ACP to form biphasic calcium phosphate (BCP) as the inorganic phase component of the 3D composite scaffold, and sodium alginate (SA) as the organic phase component. Simultaneously, the organic substance sodium alginate (SA) can simulate a blood clot as a temporary matrix, providing mechanical stability and traction for cells migrating from adjacent tissues. Furthermore, it provides a stable environment for new bone replacement during the gradual degradation of the scaffold by cells, offering significant advantages for subsequent scaffold implantation, attracting cell migration, and inducing mineralization.

The invention provides a preparation method of an anti-inflammatory bone repair material for promoting angiogenesis, which comprises the following steps: adding amorphous calcium magnesium phosphate powder into a polylactic acid solution, carrying out ultrasonic treatment to uniformly disperse the amorphous calcium magnesium phosphate powder, and carrying out vacuum freeze drying to obtain the anti-inflammatory bone repair material. The mass ratio of the amorphous calcium magnesium phosphate powder to the polylactic acid is (1: 9)-(1: 1). Amorphous calcium magnesium phosphate is added into polylactic acid, so that a large amount of calcium magnesium phosphorus can be released after implantation, bone defect stem cell osteogenic differentiation and angiogenesis are promoted, and the biocompatibility of polylactic acid is improved. The addition of inorganic matters can accelerate the degradation rate of polylactic acid, and prevent the bone repair material from occupying for a long time to affect the generation of new bones. Meanwhile, the amorphous calcium magnesium phosphate can neutralize an acid environment generated by degradation of polylactic acid, and the inflammatory response of the defect part is relieved.

The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and / or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and / or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.

The invention provides a self-assembled polypeptide material for bionic remineralization of demineralized enamel and application of the self-assembled polypeptide material, and belongs to the technical field of remineralization repair of demineralized enamel. The invention provides a self-assembled polypeptide material for bionic remineralization of demineralized enamel. The self-assembled polypeptide material comprises a self-assembled template unit, an enzyme digestion response unit and a bonding unit which are connected in sequence, the amino acid sequence of the self-assembly template unit is GYINFpSYE; the amino acid sequence of the enzyme digestion response unit is GPQGIWGQ; and the amino acid sequence of the bonding unit is DKTKREEVD. The self-assembled polypeptide material provided by the invention simultaneously realizes a template effect of an organic matter pre-organization, guides directional deposition of calcium and phosphorus ions, slowly degrades the organic matter, reduces organic occupation, and promotes dual effects of directional arrangement and phase change crystallization of amorphous calcium phosphate; the purposes of regularly and orderly arranged hydroxyapatite crystal formation, demineralized enamel structure repair and mechanical property recovery are achieved.

The application discloses a high-strength silk nanofiber reinforced composite membrane and a preparation method thereof. The composite membrane is obtained by laminating and hot-pressing after freeze-drying of a plurality of layers of silk nanofiber reinforced hydrogels. The silk nanofiber reinforced hydrogel is composed of a hydrogel matrix and silk nanofibers and amorphous calcium phosphate particles uniformly distributed in the hydrogel matrix. The hydrogel matrix is a double-network hydrogel formed by cross-linking of silk fibroin and acylated chitosan respectively. The silk nanofiber reinforced composite membrane provided by the application has excellent mechanical properties, meets the mechanical requirements of non-load-bearing parts, can effectively promote the repair of bone defects, and has a hierarchical structure of natural bone, which provides an ideal microenvironment for cell adhesion, proliferation and migration.

The application discloses a non-grain raw material processing method and application of a product thereof in pig feed, and belongs to the technical field of feed processing. The processing method takes leaves of broussonetia papyrifera, citrus peel residues and perilla frutescens meal as raw materials, carries out mixing and crushing, adds water to prepare a slurry, adds calcium dihydrogen phosphate and citrate to control pH, carries out in-situ mineralization to make amorphous calcium phosphate and active components co-precipitate and assemble, and then carries out low-temperature drying to obtain composite particles; the product can be applied to full non-grain pig feed as a core functional component, and is suitable for different formulae of piglets, growing pigs and pregnant sows at different stages. The application discloses a trinity composite structure constructed by taking plant cell walls as a natural template, and solves the problems of easy inactivation and low bioavailability of active components of non-grain raw materials, realizes precise delivery of stomach protection-small intestine release-large intestine regulation, significantly improves pig growth performance, immunization level and reproduction efficiency, and provides an efficient technical scheme for industrialization of full non-grain feed.

The application discloses a kind of mineralization and antibacterial " dual-functionality" nanoparticles and its preparation method and application, first according to amino acid sequence preparation trefoil factor 3 active peptide (Trefoil factor 3, TFF3), then preparation mineralization and antibacterial " dual-functionality" nanoparticles, preparation method is: stable agent, calcium salt and TFF3 additive are dissolved in solvent to obtain calcium-phosphorus mixed solution, amorphous calcium phosphate (Amorphous calcium phosphate, ACP) is synthesized by mixed precipitation method, after adjusting pH value, centrifugal forms nanoparticle, put into vacuum drying oven.The nanoparticle prepared in the application contains amorphous calcium phosphate and has mineralization potential, can provide stable calcium and phosphorus source, induce the mineralization of teeth, TFF3 and calcium ion chelation not only improve the mineralization performance of ACP, but also endow it with antibacterial function, which can be used for the prevention and treatment of dental white spots and early caries.

The invention belongs to the technical field of biological materials and tissue engineering, and particularly relates to a bioactive protein-loaded strontium-doped bionic calcium phosphate coating and a preparation method thereof, and the preparation method comprises the following steps: S1, preparing a base material; s2, immersing the base material into a first solution containing a calcium source and a phosphate radical source, and forming an amorphous calcium phosphate seed layer on the surface of the base material in situ; and S3, transferring the base material into a second solution containing a calcium source, a phosphate radical source, a strontium source and bioactive protein, and carrying out biomimetic mineralization deposition to form the strontium-doped octacalcium phosphate composite coating. The whole preparation process is mild in condition, a common high-temperature, high-pressure and vacuum environment or an external electric field in the prior art does not need to be adopted, the biological activity of the bioactive protein can be better reserved, the prepared coating has a layered or nano-sheet bionic microstructure similar to natural bone minerals, the coating is endowed with extremely high biological activity, and the application range is wide. And the cell adhesion, proliferation and osseointegration process can be promoted.

The invention relates to the technical field of oral care or biomedical materials, and discloses preparation and use of an amorphous calcium phosphate nano-cluster solution, the preparation method comprises the following steps: preparing a first solution and a second solution which are isolated from each other before reaction, respectively containing soluble calcium salt and phosphate, according to the method, gamma-polyglutamic acid or gamma-polyglutamate is taken as a raw material, a double-stabilizer system composed of citric acid or sodium citrate and gamma-polyglutamic acid or gamma-polyglutamate is introduced, the two solutions are sprayed out synchronously through a double-cavity device during use, crystal growth is limited through the synergistic effect of the chelating effect and steric hindrance of the stabilizer, and the amorphous calcium phosphate nano-cluster with the particle size smaller than 20 nm is generated in situ. According to the invention, through physical isolation and instant mixing strategies, the problem that amorphous calcium phosphate is easy to agglomerate and inactivate in an aqueous solution is effectively solved; the obtained nano-cluster has excellent permeability, can go deep into a deep layer of a tooth tissue and is converted into hydroxyapatite in situ, so that enamel remineralization and dentin desensitization are realized.

The present invention relates to improved complexes of amorphous calcium phosphate and / or amorphous calcium fluoride phosphate stabilised by phosphopeptides / phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental / medical applications (including anti-calculus, anti-erosion / corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion / corrosion and dental hypersensitivity are also provided.

The application belongs to the technical field of nanomaterials, and particularly relates to a pH-responsive antibacterial-biomimetic mineralization material and a preparation method and application thereof. + The biomimetic mineralization material is cooperatively assembled by DNA-stabilized silver nanoclusters and amorphous calcium phosphate; the iM + The DNA-stabilized silver nanoclusters are silver nanoclusters synthesized and stabilized by DNA as a template; the iM + The DNA-stabilized silver nanoclusters are silver nanoclusters synthesized and stabilized by DNA as a template; the iM + The DNA is an oligonucleotide containing an i-Motif forming domain, and a nucleotide sequence thereof is shown as SEQ ID NO. 1. The antibacterial-biomimetic mineralization material designed by the application is expected to achieve specific removal of cariogenic plaque without destroying normal oral flora, promote enamel remineralization, and thus achieve the purpose of efficient prevention and treatment of dental caries.

The present invention relates to an amorphous calcium phosphate / bioactive glass composite material (ACP / BG) that combines the short-term ion-releasing ability of ACP with the long-term ion-releasing ability of BG, thereby (i) efficiently remineralizing damaged enamel and (ii) inducing the formation of a new HA layer on the surface of enamel and dentin. The ACP / BG composite material is obtained by embedding BG particles in a matrix of ACP nanoparticles to maximize homogenization between these two components and produce a composite material with high uniformity from the macroscale to the nanoscale. This is achieved by a method including precipitating ACP onto BG particles. The BG particles can be nanoparticles, microparticles, or macroparticles. The particles can also be porous or mesoporous. The present invention also relates to the use of the composite material of the present invention for preventing demineralization and promoting remineralization of teeth. In other words, the composite material disclosed herein is 2+ ions and PO4 3- By releasing ions, it has the ability to restore the structure and maintain the mechanical properties of dental hard tissues, and it can be used as a remineralization agent, mimicking the spontaneous remineralization process induced by saliva. The composite material can also be used for bone regeneration.

The embodiment of the invention discloses anhydrous anti-allergic dental polishing paste and a preparation method thereof. The anhydrous anti-allergic dental polishing paste is prepared from the following components in parts by weight: 0.5 to 2 parts of a thickening agent, 15 to 60 parts of an organic solvent, 5 to 20 parts of a friction agent, 0.1 to 3 parts of a sweetening agent, 0.2 to 2 parts of essence, 10 to 50 parts of amorphous calcium phosphate gel, 0.1 to 1 part of polyvinylpyrrolidone and 0.01 to 0.1 part of tremella polysaccharide. The polishing paste provided by the invention can effectively smooth teeth and has small damage to tooth enamel, meanwhile, the amorphous calcium phosphate gel compounded from tremella polysaccharide is added to strengthen the tooth enamel, the symptom of tooth sensitivity after polishing is reduced, and the polishing paste has a relatively good application prospect.

The application provides a kind of "antibacterial synergistic-mineralization regulation" bifunctional nanomaterial and its preparation method and application, belongs to the technical field of biomedical materials.The application first mixes sodium hydrogen phosphate solution and calcium chloride solution to obtain amorphous calcium phosphate suspension;Then amorphous calcium phosphate suspension and tannic acid solution are mixed to obtain ACP@TA suspension;Finally, ACP@TA suspension and hydroxypropyltrimethylammonium chloride chitosan solution are mixed to obtain bifunctional nanomaterial.Through the electrostatic adsorption of tannic acid and antibacterial layer hydroxypropyltrimethylammonium chloride chitosan to form a crosslinked shell, amorphous calcium phosphate is effectively wrapped, which can significantly delay the crystallization process of amorphous calcium phosphate, ensure long-term calcium and phosphorus ion release, and effectively exert antibacterial function, provide an ideal local microenvironment for the remineralization of dental hard tissue, and ultimately realize the biomimetic mineralization of dental enamel and the deep mineralization of dentin tubules.