Disclosed are a high-heat-input welding thick steel plate and a manufacturing method thereof. The manufacturing method includes following steps: a) smelting, refining and continuous casting; b) rolling; and c) cooling. Steel consists of components including, by weight percentage, from 0.05 to 0.09% of C, from 0.10 to 0.30% of Si, from 1.3 to 1.7% of Mn, from 0.005 to 0.03% of Ti, from 0.003 to 0.025% of Nb, from 0.001 to 0.01% of S, smaller than or equal to 0.015% of P, smaller than or equal to 0.006% of N, from 0.0005 to 0.01% of Mg, smaller than or equal to 0.01% of Al, smaller than or equal to 0.003% of Ca, more than one of smaller than or equal to 0.3% of Cu, smaller than or equal to 0.4% of Ni and smaller than or equal to 0.002% of B, and the balance Fe; and Ti/Nb is larger than or equal to 1.2, deoxidant Mn, Si, Al, Ti, Ca and Mg are successively added in a steel liquid deoxidizing process, wherein (Mg+Ca)/Mn is larger than or equal to 0.3 for micrometer impurities with the grain size larger than or equal to 1.0 micrometer in the steel, (Mg+Ca)/Mn is larger than or equal to 0.1 for sub-micron impurities with the grain size ranging from 0.1 micrometer to 1.0 micrometer in the steel, and Ti/Mn is larger than or equal to 0.07. A large quantity of impurities which are distributed in a dispersion manner are formed, growth of austenite grains in a welding heat affected zone can be restrained, growth of intra-granular ferrite is promoted, and the high-heat-input welding performance of the thick plate is greatly improved.