321results about How to "Effective stimulation" patented technology

The invention relates generally to methods and apparatus for inducing hypothermia in an animal. Known methods for inducing hypothermia all involve cooling the outside or inside of an animal, sometimes in conjuction with drugs that disable the animal's homeostatic responses. The present invention is directed to a method and apparatus for applying heat to the hypothalamus of a warm-blooded animal in order to utilize the physiological mechanisms that regulate body temperature to effect a compensatory cooling response, thereby lowering body temperature. It is new and unsuggested in the art to apply heat in an effort to reduce body temperature. The invention effects the desired lowering of body temperature by the method od raising the temperature of the hypothalamus, a brain structure situated in humans just above the pituitary gland responsible for temperature regulation, by warming a nasal passage, or a sinus, such as the sphenoid sinus that is nearest to the hypothalamus, or by direct warming of the hypothalamus, or a combination of these.

An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

The subject invention is directed to new and useful neurostimulation systems that include an implantable pulse generator dimensioned and configured for implantation in the skull of a patient. The implantable pulse generator has an electrode operatively associated with a distal end portion thereof and can be provided with adjustment means, such as an adjustable biasing member or spring arranged between the electrode to the distal end portion of the pulse generator. The subject invention is also directed to systems involving networked neurostimulators that are configured and adapted to work jointly in accordance with prescribed treatment protocol to effect a desired recovery from brain injury. Such networked neurostimulation systems are particularly advantageous for effecting relatively large and / or relatively distant regions of the brain. The subject invention is further directed to systems and methods for motor-evoked potential (MEP)-based neuromodulation. Further, AC and / or DC stimulation can be utilized, depending on the precise implementation.

The invention relates generally to methods and apparatus for inducing hypothermia in an animal. Known methods for inducing hypothermia all involve cooling the outside or inside of an animal, sometimes in conjuction with drugs that disable the animal's homeostatic responses. The present invention is directed to a method and apparatus for applying heat to the hypothalamus of a warm-blooded animal in order to utilize the physiological mechanisms that regulate body temperature to effect a compensatory cooling response, thereby lowering body temperature. It is new and unsuggested in the art to apply heat in an effort to reduce body temperature. The invention effects the desired lowering of body temperature by the method of raising the temperature of the hypothalamus, a brain structure situated in humans just above the pituitary gland responsible for temperature regulation, by warming a nasal passage, or a sinus, such as the sphenoid sinus that is nearest to the hypothalamus, or by direct warming of the hypothalamus, or a combination of these.

The invention relates generally to methods of treating cancer and other diseases by modulating body temperature. Heat may directed to the hypothalamus of a warm-blooded animal to cool the animal, utilizing the physiological mechanisms that regulate body temperature to effect a compensatory cooling response, thereby lowering body temperature (hypothermia), and rendering other methods of lowering body temperature more effective. Heat may be withdrawn from the hypothalamus of an animal, cooling the hypothalamus, inducing a compensatory increase in body temperature (hyperthermia), and rendering other methods of raising body temperature more effective. Body temperature may be directly modulated by heat-exchange catheter positioned within a blood vessel of a patient. The invention relates generally to methods of treating cancer by inducing hypothermia by directing heat to the hypothalamus, optionally maintaining cancerous tissue at or near to normal body temperature, and optionally applying another cancer treatment. This other cancer treatment may be radiation therapy, chemotherapy, a combination of radiation and chemotherapy, or some other cancer treatment. The invention relates generally to methods of treating diseases including cancer, viral infections, and other diseases, comprising inducing hyperthermia by cooling the hypothalamus, and optionally applying another treatment, for example radiation, chemotherapy, antiviral therapy, or a combination of therapies.

A method for treating a patient to promote bone growth, comprising: administering to the patient a therapeutic amount of a bone remodeling agent effective to stimulate bone growth, and a dietary supplement comprising calcium and phosphorus, in a therapeutic amount effective to prevent a deficiency in the amount of calcium or phosphorus available for bone growth.

A transcranial electrical stimulation device 1 having a wearing equipment 2 detachably worn onto a patient's head and at least a pair of electrodes 4 attached to the wearing equipment 2, the device for electrically stimulating a motor area of a patient's cerebral cortex by outputting current from the electrode 4 connected to a current generator. An engagement part 6 capable of engaging the wearing equipment 2 to a scalp with a thread-like body 8 is provided to the wearing equipment 2, and the electrode 4 is attached to the wearing equipment 2 protrudably to the head side of the electrode 4, and tip of the electrode 4 is capable of subcutaneously piercing through the head. It is unnecessary to bore a patient's skull outer layer with a drill, and a mounting of the electrode can be performed in a short time. The electrodes can be accurately positioned at predetermined positions of a patient's head, and the motor area of a cerebral cortex can be effectively stimulated.

The invention discloses an oil-in-water emulsion free of surfactant. The emulsion comprises a metabolizable oil phase, a water phase and oil-water amphipathic solid particles dispersed in the water phase and having biocompatibility, wherein the oil phase comprises squalene or / and tocol; the water phase is any one or a combination of at least two of purified water, water for injection, aqueous liquid of glycerol, buffered saline liquid and clinically available infusion liquid; and the average grain diameter of the solid particles is at nanometer-to-micron grade. The emulsion can be used as a vaccine adjuvant or a medicine delivery or controlled release carrier; the properties of the emulsion can be controlled and regulated; the obtained emulsion is stable; the use of a surfactant is avoided; and harm to the human body and pollution on the environmental can be reduced.

Filler clothes 3, which intersect with each other at a section corresponding to the middle point between the interspinal point and patellar midpoint of a human body, are formed on a front section of a bottom garment 1. The filler clothes 3which are formed in this manner stimulates the rectus femoris muscle 14 which is a part of the quadriceps of a wearer. When the quadriceps is stimulated while walking, the legs can be kicked backward significantly in a natural fashion, whereby the gluteus maximus muscles can be used efficiently.

A small lightweight yet strong frame (12) housing multiple flexible axles (22) which in turn support foam rubber roller balls (16), which roll about an axis creating: massage, intersegmental traction, trigger point therapy, and active exercise to the back of the user. These axles (22) are made more efficient by the placement of bushings (26) where they are contained by frame (12). Foam rubber balls (16) contain sleeves (30) which promote free rotation. A sliding head rest (38) is provided for comfort and is also used to facilitate optional concomitant neck and back treatment and multiple tension adjustments (46) (36) are provided for varying resistance to glide.

The present invention relates to a composition comprsing a peptide immunogen useful for the prevention and treatment of Alzheimer's Disease. More particularly, the peptide immunogen comprises a main functional / regulatory site, an N-terminal fragment of Amyloid β (Aβ) peptide linked to a helper T cell epitope (Th) having multiple class II MHC binding motifs. The peptide immunogen elicit a site-directed immune response against the main functional / regulatory site of the Aβ peptide and generate antibodies, which are highly cross-reactive to the soluble Aβ1-42 peptide and the amyloid plaques formed in the brain of Alzheimer's Disease patients. The antibodies elicited being cross reactive to the soluble Aβ1-42 peptide, promote fibril disaggregation and inhibit fibrillar aggregation leading to immunoneutralization of the “soluble Aβ-derived toxins”; and being cross-reactive to the amyloid plaques, accelerate the clearance of these plaques from the brain. Thus, the composition of the invention comprising the peptide immunogen is useful for the prevention and treatment of Alzheimer's Disease.

A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate [UTP], dinucleotides, cytidine 5′-triphosphate [CTP], adenosine 5′-triphosphate [ATP], or their therapeutically useful analogs and derivatives, in an amount effective to stimulate tear fluid secretion and enhance drainage of the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.

The invention discloses a three-dimensional flexible neural microelectrode and a manufacturing method thereof. The microelectrode uses a flexible polymer as a base material, and performs progressive electroplating through a circular pattern design of a metal seed layer to form smooth three-dimensional convex features. The electrode site structure can not only ensure good contact between the electrode site and the nerve cells, but also avoid damage to the nerve tissue caused by the sharp edges and corners of the raised electrode sites in the existing three-dimensional neural microelectrode. In addition, through the composite electroplating process in the electroplating process, that is, nano-scale dispersants are added to the electroplating solution to form a submicron-scale microporous structure on the surface of the electrode, increasing the surface area of ​​the electrode site, thereby enhancing the current output capability of the electrode and ensuring the nerve. Effective stimulation of microelectrodes under the constraints of biosafety conditions. The three-dimensional flexible neural microelectrode provided by the invention can be widely used in the fields of neurological disease treatment, neurological rehabilitation, neurobiological basic research and the like.

The invention is directed to techniques for electrode placement around a heart. A harness having one or more attachment sites may be secured around the heart, and electrodes may be secured at the attachment sites as desired by the physician for the patient. The electrodes may be, for example, pacing and sensing electrodes, defibrillation electrodes, or any combination thereof. The harness holds the electrodes in place and also impedes the progress of ventricular dilation. The electrodes attached to the harness may be used for any of several purposes, such as cardiac resynchronization, selective defibrillation, measurement of impedance, pacing and cardioversion.

A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject, comprising an attachment mechanism for extending around the torso of the subject and a main locating element provided on the attachment mechanism for locating a central electrode of the at least three electrodes adjacent the umbilicus of the subject. Two secondary locating elements are also provided on the attachment mechanism disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode. Application of at least one pulsed signal to the subject through the respective central and side electrodes stimulates the abdominal muscles of the subject.

The invention provides a device for inducing a plurality of vestibular illusions. The device comprises a revolving chair device for changing the input signals of the semicircular canals of human body vestibular organs, a head shaking device for changing the input signals of the semicircular canals of the human body vestibular organs, a vestibular electrical stimulation device for changing the input signals of the semicircular canals of the human body vestibular organs and otolith, and a control computer for controlling the revolving speed and the revolving time of the revolving chair device, the shaking manner, the angular velocity and the shaking time of the head shaking device, and the type and the strength of the stimulating current and the stimulating time of the vestibular electrical stimulation device, and displaying related parameters in real time. According to the device for inducing the plurality of vestibular illusions, the devices are used independently or combined in use to effectively induce a plurality of vestibular illusions of a human body such as somatogyral illusion, coriolis illusion and somatogravie illusion; as a result, the device can be applied to the ground-based simulation of the vestibular illusions of pilots, and further can be applied to related training about the floor space disorientation of the pilots, and therefore, accidents caused by space disorientation can be reduced.

Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.

A beauty device (1) includes a light irradiation section (5) that irradiates light of a predetermined wavelength; and an ion generating section (7) that generates an ion. The light irradiation section (5) is placed at one side surface of a main body and the ion generating section (7) is placed at the other side surface of the main body. The light irradiation section (5) includes a plurality of light source modules (25A, 25B) arranged in a predetermined array. Each light source module includes a plurality of light emitting diodes (20a, 20b, 20c, 20d) that are arranged in a predetermined array to emit light of two or more wavelengths.

This invention provides methods, devices and device components for sensing, imaging and characterizing changes in the composition of a probe region. More particularly, the present invention provides methods and devices for detecting changes in the refractive index of a probe region positioned adjacent to a sensing surface, preferably a sensing surface comprising a thin conducting film supporting surface plasmon formation. In addition, the present invention provides methods and device for generating surface plasmons in a probe region and characterizing the composition of the probe region by generating one or more surface plasmon resonances curves and / or surface plasmon resonance images of the probe region.

The invention provides a method for combining a yellow fluorescent powder used for a white light LED and belongs to the preparation technique of rare earth fluorescent powders. The chemical formula thereof is (Y1-x-yMyCex)3Al5O12, wherein M is one chosen from Tb, Gd, Sm and Yb, x is more than or equal to 0 but less than or equal to 0.1 and y is more than or equal to 0 but less than or equal to 0.1. The method comprises the following steps of: weighting yttrium salt, M salt, cerium salt, aluminum salt according to the element measurement and a defined amount of surface active agent and fluxing agent, fully mixing the reactants, the surface active agent and a defined amount of ligand, ball-milling while adding proper lubricant, filtering, washing and drying so as to acquire a precursor, mixing the precursor with the fluxing agent, and burning in a reducing atmosphere so as to acquire the needed fluorescent powder. The method for combining the fluorescent powder of the invention has the advantages of low burning temperature, short time, high production efficiency, small grain size, narrow distribution, excellent lighting performance and capable of being efficiently aroused by the blue light LED chip.

The invention discloses a display device. The display device comprises a backlight source, an optical switch and a substrate; a plurality of photoluminescence membrane subpixels and scattering membrane subpixels are arranged between the optical switch and the substrate; and light emitted by the backlight source passes through the photoluminescence membrane subpixels and scattering membrane subpixels to form red, green, blue and / or transition color among red, green and blue. The irradiance of a photoluminescence membrane has a wide visual angle; and the color is not changed along an observation angle. The scattering membrane subpixels scatter the incident exciting light to change the transmitting direction of the exciting light and obtain the wide visual angle; and more than one selective reflecting membrane can be arranged between the photoluminescence membrane and the scattering membrane so as to substantially improve the utilization rate of irradiance.

A feed additive for increasing the resistance of animal to diseases is prepared from the fragments of the plants in pinaceae through pulverizing and extracting in hot water. Its contains polyphenol compound and polyose for regulating the balance between floras in animal's intestinal tract.

The embodiments of the invention provide a snore stopping device. The snore stopping device comprises a sleep information acquisition module used for acquiring actual sleep information of a user; a processing module used for comparing the actual sleep information acquired by the sleep information acquisition module with a normal sleep information range, and capable of generating a trigger signal when the actual sleep information goes beyond the normal sleep information range; and an electric stimulation module used for contacting the skin of the user and generating an electric stimulation signal according to the trigger signal. The snore stopping device can effectively cause the snoring user to change his / her sleeping posture, so as to achieve the snore stopping effect.

The invention belongs to health care products and particularly relates to compound essential oil capable of protecting and developing hairs and a preparation method thereof. The preparation method comprises steps of placing rosewood oil, ylang oil, rosemary oil, ginger oil, cinnamon oil and curcuma oil in a container; stirring to enable all raw materials to be fully mixed evenly; then adding jojoba oil; stirring; fully diluting and fusing; splitting charging and sealing; and achieving the compound essential oil. The compound essential oil uses various plant essential oil for matching scientifically, can well play effects of the plant essential oil due to the synergistic effect, has significant nutrition required for growth of hairs, can quickly activate hair follicles to fast resolve subcutaneous fat and dredge capillaries of scalps to enable active ingredients to quickly reach the hair follicles to achieve the purposes of protecting hairs, raising hairs, preventing alopecia and the like, and is suitable for various hairs and scalps with various characteristics, free of anaphylactic reactions and side effect after being used, quick in effect and good in effects of hair developmentand hair care.

The invention provides a manufacturing process of a quantum dot diffusion plate, and the diffusion plate. According to the manufacturing process of the quantum dot diffusion plate, PMMA is prepared by adding a quantum dot diffusant into MMA. The diffusion plate comprises a plate body and a water oxygen barrier layer; the outer surface of the plate body is coated with the water oxygen barrier layer; quantum dots and light diffusion agents are dispersed in the plate body uniformly.

The present invention is related to a formulation based on micronized natural calcite mineral consisting of: A. mineral part which is characterized: (i) by the particle size with diameter smaller than 5 μm, where the distribution of particle size is such that minimum of 10% of particles are with diameter under 900 nm, with total surface of particles greater than 3.2 m2 / g, and with total porous volume greater than 0.012 cm3 / g, and by composition: (ii) CaCO3, MgCO3, FeCO3, MnCO3, ZnCO3 and SiO2 in mixtures where CaCO3 is presented in amount from 10% to 99% of mineral part; and B. adjuvant selected from the group consisting of: wetting agent, drift-control agent at application by spraying, humic acid salt, amino-acids salts, complex of plant micro-nutrients, vitamin, plant hormone, nitrogen fertilizer, potassium salt, borate salt, molybdate salt, plant extract, chlorophyll, yeast extract, or mixture of these substances; where A. and B. form an aqueous suspension wherein percentage of A. and B. is lower than 5% by weight. The formulation from this invention is used as a plant booster and mineral fertilizer for stimulation of photosynthetic process in plants, stimulation of plants growth, reinforcement of plant resistance to physiological and anhydrous stress, reinforcement of resistance to different plant diseases, for improvement of nutrient absorption, for increasing crop yields, and for plant nutrition.

The invention relates to a fluorescent lamp, preferably a low pressure mercury discharge lamp for stimulating previtamin D3 production. The lamp has a discharge tube with a discharge gas filling. The inside wall of the discharge tube is covered with a phosphor coating for converting short wave UV radiation of the ionized discharge gas into longer wave UV radiation. The discharge tube is closed at both ends and provided with electrodes which are held and lead through a base cap at both ends. The base caps of the lamp are provided with contact pins for connecting the lamp to an electrical power supply.According to the improvement of the invention the UV light radiating coating of the discharge tube comprisesa first phosphor for emitting light waves in the UVB spectrum anda second phosphor for emitting light waves in the visible light spectrum and for suppressing the emitted light in the UVB spectrum.

The invention, relating to the technical field of phosphor, particularly discloses a phosphor represented by (M1-xRex)3Al5-ySiyO12-y-zNy+z, wherein M represents one or more elements of Y, Lu, Gd, and Tb, Re represents one or two elements of Eu, Ce and Pr, x is no larger than 0.1, y is no less than 0 and no larger than 1.0, and z is no less than 0 and no larger than 1.2, the initial raw materials comprise a pure oxide of M, a pure oxide of Re, nano alpha-Al2O3, a nitride and analytically pure HBO3 / NH4F / LiF as a sintering aid which accounts for 1 wt% of the weight of the initial raw materials, and the nitride is nano amorphous Si3N4. Compared with the prior art, by using the nano amorphous Si3N4 to introduce the Si4+-N3-bond, the synthetic phosphor can keep high luminous efficiency and thermostability while the emission spectrum is continuously red shifted.

A training machine is provided comprising a base (6) arranged for placement on the floor (4), a movable member (32) provided on the base (6) to be moved by the training action, and a load exerting means (8) for exerting a load to control the movement of the movable member (32). The load exerting means (8) has a weight assembly (22) thereof arranged to be lifted vertically by the movement of the movable member (32) as resisting the gravity and particular is accompanied with a counter-force exerting means (70) arranged at the weight assembly (22) and / or the movable member (32) for exerting a returning force on the movable member (32) at the timing of shift from the upward movement to the downward movement of the weight assembly (22). The counter-force exerting means (70) comprises, for example, coil springs (72, 74) and movement stoppers (76, 78) for restricting the movement of the coil springs (72, 74).