74 results about "Anaphylactic reactions" patented technology

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The invention provides recombinant VIII type humanized collagen and application thereof, and the recombinant VIII type humanized collagen is of a triple helix structure, has good cell adhesion activity, does not generate immunological rejection and anaphylactic reaction when being applied to a human body, is a brand new human body synthetic biological material, and has good application prospects.

Intranasal dry powder epinephrine compositions are described herein. The compositions include epinephrine or a pharmaceutically acceptable salt thereof, as well as a stabilizing agent and a carrier. The stabilizing agent is operable to include citric acid, or a pharmaceutically acceptable salt derived therefrom. Such intranasal compositions as described herein are useful in the treatment of health conditions which threaten the central nervous system (CNS) and impede the actions of alpha and beta-adrenergic receptors. Such health conditions include anaphylaxis, bronchospasms, respiratory impairment, organophosphate poisoning, and major adverse cardiac events (MACE).

The invention provides a Chinese large language model safety evaluation system and method based on dynamic extension and a bottom-taking mechanism, and belongs to the field of natural language processing and artificial intelligence. On the basis of an existing benchmark test data set, an attack test data set is generated by combining a large language model with multiple attack methods, and attack test data is generated for a request rejected to respond by the model by utilizing a fine-tuned expert model through a bottom-out mechanism; constructing a corresponding false positive test data set, inputting the attack test data set and the false positive test data set into the Chinese large language model to be evaluated, and reasoning to obtain an output result; and finally, carrying out multi-dimensional evaluation on an output result and automatically generating a report. The method has good expandability and adaptability, a test data set can be dynamically expanded, emerging security threats can be followed up, and anaphylaxis and generation of harmful content can be effectively avoided; and a more flexible, comprehensive and efficient solution is provided for security assessment of the Chinese large language model.

The invention provides a specific binding polypeptide of a targeted cell membrane receptor Fc epsilon RI alpha and application of the specific binding polypeptide. The amino acid sequence of the polypeptide is shown in any one of (I) SEQ ID NO: 1-6; (II) an amino acid sequence with at least 90% identity as shown in any one of SEQ ID NO: 1-6, and is specifically combined with a cell membrane receptor Fc epsilon RI alpha. Experimental results show that the Fc [epsilon] RI [alpha] specific binding polypeptide can inhibit IgE-mediated mast cell dependent anaphylaxis to a certain extent, which prompts that the Fc [epsilon] RI [alpha] specific binding polypeptide has a certain inhibition effect on IgE-mediated I-type anaphylaxis, and lays a foundation for further research and development of novel biological targeting drugs for treating allergic diseases.

A use of oleanolic acid-28-O-β-D-glucopyranoside in the preparation of an anti-colitis drug is provided. The oleanolic acid-28-O-β-D-glucopyranoside has significant anti-ulcerative-colitis activity compared with parent nucleus oleanolic acid and other analogues, and has equivalent efficacy compared with Mesalazine, a first-line drug for the clinical treatment of inflammatory bowel disease, and can also avoid salicylic acid anaphylaxis possibly caused by Mesalazine western medicine treatment, thereby achieving a good application prospect.

The utility model relates to the technical field of underpants, and discloses an underpants capable of reducing friction to a human body, which comprises an underpants body, a skin-fitting lining layer is arranged on the inner side of a waist opening and / or two leg openings on the underpants body, and the skin-fitting lining layer is connected with the underpants body through an elastic connecting point or an elastic connecting wire. After the underpants are worn, the positions of the skin-fitting lining layer and the underpants body are relatively fixed, and in the action traction process, when the underpants body and the skin-fitting lining layer move relatively, the elastic connecting points or the elastic connecting wires are stretched by a certain length to overcome the traction force, so that the skin-fitting lining layer and the skin of the human body are kept stable and do not move; friction of the underpants to the waist and legs of a human body is improved, and anaphylaxis caused by friction of people with sensitive skin is reduced or avoided. The utility model has the characteristics of simple structure, low cost, strong practicability and good use effect.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

This invention relates to methods for reducing or preventing anaphylaxis to non-allergenic antigens with compositions comprising immunosuppressants, and related compositions.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

The invention discloses antibiotic-free hydrogel for nursing staphylococcus aureus infection as well as a preparation method and application of the antibiotic-free hydrogel. The hydrogel is prepared from metal ion compounds such as zinc ions, copper ions and iron ion compounds, a natural high polymer material and an antioxidant as raw materials, and has the advantages of efficient antibacterial property, high safety, long-acting slow release and the like. An in-vitro antibacterial experiment shows that the sterilizing rate of the metal ion compound on staphylococcus aureus can reach 90%-99.9%; animal experiments prove that the hydrogel can effectively relieve inflammatory reaction of infected parts, and skin irritation experiments show that the product is free of irritation and anaphylactic reaction. The invention provides a safe and effective nonreactive solution for nursing of staphylococcus aureus infection.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The invention relates to the field of medicines, in particular to application of LKB1 / AMPK pathway-based fucoidan in preparation of anti-type I anaphylaxis medicines. The LKB1 / AMPK pathway is activated by the alginate, so that mast cell degranulation is effectively inhibited, mast cell mediated cell anaphylaxis is further effectively inhibited, and the alginate can be used for preparing anti-anaphylaxis related drugs.

The invention provides a linear or cyclic polypeptide and a derivative or analogue thereof, wherein the linear or cyclic polypeptide is used for mobilizing a stress-inducing protein (sestrin) from GATOR / mTOR to sMAC in a non-aging cell; the polypeptide comprises or consists of an amino acid sequence derived from a stress-inducing protein or a truncated sequence thereof. These polypeptides are useful in the treatment of conditions requiring immediate intervention, such as acute diseases, sepsis caused by pathogen infection, or anaphylaxis, such as allergic shock, as immunotherapeutic agents for the treatment of cancer, and for autoimmune diseases.

The present disclosure relates to systems and methods for detection of food allergy in a subject. In particular, the disclosure provides systems and methods for early detection of oral food challenge (OFC)-related anaphylaxis by measuring transepidermal water loss (TEWL).

The invention relates to the technical field, in particular to a preparation method of a low-VOC (volatile organic compound) hot-melt pressure-sensitive adhesive. Opening a heating jacket of the reaction kettle, and raising the temperature to 150-160 DEG C; the preparation method comprises the following steps: adding a thermoplastic elastomer, a stabilizer and part of a plasticizer into a reaction kettle, heating for 20-30 minutes, starting to stir, and vacuumizing for 20-30 minutes; opening the cover every 10 minutes to confirm the molten state of the thermoplastic elastomer until the thermoplastic elastomer is completely molten; and adding the tackifying resin and the residual plasticizer into the reaction kettle, continuously vacuumizing and stirring for 10-20 minutes, and pouring out to obtain the low-VOC hot-melt pressure-sensitive adhesive, thereby solving the problems that the traditional hot-melt pressure-sensitive adhesive always releases a certain amount of volatile organic compounds (VOC) in the production and use processes, the VOCs not only pollute the environment, but also directly influence the health of a human body, and the production cost is low. And long-term contact may cause respiratory diseases, anaphylaxis and even carcinogenic risks.

The invention discloses a far infrared thermal nano fabric and a preparation method thereof.The fabric comprises a far infrared layer and a skin-friendly layer, the far infrared layer is made of polyester fibers filled with nano thermal radiation particles, and the nano thermal radiation particles are modified nano tourmaline particles with the surfaces coated with polylactic acid layers; and the textile raw material of the skin-friendly layer is light-transmitting yarns. According to the invention, the surface of the tourmaline particle is coated with the polylactic acid layer, so that the biocompatibility of the particle is improved, and the adhesive force and stability of the particle on the fiber are remarkably improved in cooperation with a blended spinning technology, so that the far infrared performance of the particle can be maintained for a long time. Besides, the skin-friendly layer is arranged on the inner side of the far-infrared layer, so that the problems that an existing far-infrared fabric is not good in comfort and possibly causes anaphylactic reaction due to the fact that the existing far-infrared fabric is in direct contact with the skin for use are effectively solved; and meanwhile, the skin-friendly layer adopts the silk yarn interwoven layer in a specific form, so that the whole far infrared performance is basically not influenced.

The present application relates to the technical field of skin care products, and discloses a composition with the effect of soothing sensitive skin, which is composed of the following components in mass percentage: plant extract 10-12%, skin repair factor 2-3%, jasmine hydrolat 10%, humectant 6-7%, and the balance being water. The composition with the effect of soothing sensitive skin has significant soothing effect, which is close to the soothing effect of common hormone ointments on the market. The composition can significantly reduce inflammatory factors, has good anti-inflammatory effect, simultaneously repairs damaged skin, enhances the moisturizing function, and enhances the skin barrier through the moisturizing and repairing effect. The composition has the effect of resisting anaphylaxis by reducing the content of trypsin and inhibiting the allergic reaction of mast cells. Human patch test and fish embryo development toxicity test prove that the composition with the effect of soothing sensitive skin has no skin adverse reactions and no development toxicity, is mild, safe and non-irritating, and is suitable for preparing skin care products for adults and infants.

The invention provides a traditional Chinese medicine composition for treating primary dysmenorrhea and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 3-15 parts of rhizoma corydalis, 6-15 parts of angelica sinensis, 3-15 parts of ligusticum wallichii, 3-10 parts of rhizoma zingiberis, 1.5-6 parts of fennel and 3-12 parts of cassia twigs, and the traditional Chinese medicine composition is prepared from, by weight, 3-15 parts of rhizoma corydalis, 6-15 parts of angelica sinensis, 3-15 parts of ligusticum wallichii, 3-10 parts of rhizoma zingiberis, 1.5-6 parts of fennel and 3-12 parts of cassia twigs. The traditional Chinese medicine composition is prepared by grinding and uniformly mixing the raw materials, all the components have a synergistic effect, and the traditional Chinese medicine composition has the effects of resisting inflammation, resisting oxidative stress, regulating the estrogen level, improving the pathological morphology of the uterus and easing pain, and has a remarkable effect on treating primary dysmenorrhea; the traditional Chinese medicine composition is used for treating primary dysmenorrhea in the form of a traditional Chinese medicine patch, and by combining traditional Chinese medicine application and thermal therapy, local skin blood flow can be remarkably increased, the diffusivity and solubility of medicine in cuticle can be improved, the skin absorption capacity can be enhanced, the medicine absorption and permeation amount can be increased, local blood circulation can be improved, and pain can be relieved; and no anaphylactic reaction is caused to the skin.

The invention relates to the field of allergic rhinitis, and discloses an application of sodium hyaluronate in preparation of an external medicine for treating allergic rhinitis. Based on actual clinical efficacy verification, the mechanism of sodium hyaluronate playing efficacy is that sodium hyaluronate can be used for preparing an external medicine for treating allergic rhinitis; sodium hyaluronate is used for reducing drainage lymph nodes in an atopic individual area and generating specificity I gE by nasal submucosa plasma cells, blocking contact between allergens and the surface specificity I gE of sensitized mast cells or sensitized basophilic granulocytes in a sensitized body, stopping development of anaphylaxis and promoting subduing of nasal mucosa inflammation, so that allergy symptoms are eliminated, and the nasal mucosa inflammation eliminating effect is achieved. According to the embodiment of the invention, the result of treating AR by adopting HA nasal drops shows that an obvious effect is achieved 1-2 days after the medicine is taken, the medicine takes effect quickly, the safety is relatively high, and the medicine can be used as a new product for industrial reproducible production.

The invention belongs to the field of medicine, and provides an aprepitant micelle composition and a preparation method thereof, the aprepitant micelle composition is composed of an active component aprepitant and auxiliary materials such as phospholipid, cholic acid or a salt thereof, a nano-micelle stabilizer, a pH regulator and the like, the dosage form is a freeze-dried powder injection, and the solubility of the aprepitant is remarkably improved; the combination of the nano-micelle stabilizer can significantly improve the stability of the preparation, avoids the use of a large amount of soybean oil for solubilization, and reduces the risk of hyperlipidemia. Ethanol is not contained, so that ethanol anaphylaxis is avoided, and the safety of clinical medication can be remarkably improved. After the freeze-dried powder injection is redissolved, a hot-pressing sterilization mode can be adopted, so that the sterile guarantee level is remarkably improved, and the clinical medication risk is reduced. The aprepitant micelle composition is prepared by adopting a tert-butyl alcohol-water freeze-drying method, the process is simple and convenient, large-scale production is easy, a common freeze-dried powder injection production line can be adopted, special equipment such as a high-pressure homogenizer and a special fat emulsion production line are not needed, and the production cost can be remarkably reduced.

According to an embodiment of the present invention, a method for detecting allergens using smart tooth and IoT is provided. The method includes obtaining real-time environmental allergen context data, wherein the obtained real-time environmental allergen context data includes visual data and sensor data. Features are extracted from the obtained real-time environmental allergen context data, including at least one detected environmental allergen type, an environmental allergen exposure pathway, and an environmental allergen concentration. A real-time unique allergic reaction risk score is generated for a user based on analysis of a user allergic risk profile and the extracted features from the obtained real-time environmental allergen context data. A real-time warning is generated to the user when the generated unique allergic reaction risk score exceeds a predetermined threshold.

The invention discloses a glomus huanghuai CRN effect protein as well as a coding gene and application thereof, the glomus huanghuai CRN effect protein is CRN4, and the amino acid sequence of the glomus huanghuai CRN effect protein is shown as SEQ ID NO.2. The invention further discloses a preparation method of the glomus huanghuai CRN effect protein. According to the invention, a gene CRN4 which is derived from glomus huanghuai and can trigger a plant anaphylactic reaction (HR) is obtained through a large amount of screening. The protein comprises a conservative LXLFLAK structural domain, and is a typical CRN effect protein. HR reaction can be stimulated, plant immunity is triggered, plants are induced to generate disease-resistant reaction, and great significance is achieved for developing environment-friendly disease-resistant strategies.

The invention discloses a method for preparing low-sensitization protein peptide through microwave combined enzymolysis composite modification and application, and relates to the technical field of food processing. The treatment method comprises the following steps: preparing protein powder into a solution, adding tea polyphenol into the solution, and uniformly mixing to prepare a protein solution; carrying out microwave modification treatment on the protein solution; adding compound protease into the protein solution subjected to microwave treatment for enzymolysis and enzyme deactivation; and filtering the enzymolysis product, and drying the filtrate to obtain the low-sensitization protein peptide. According to the method, microwave and enzymolysis combined composite modification is adopted, so that the sensitization of protein can be reduced, the reaction time is shortened, and the method is simple in process, free of pollution and high in safety. In the enzymolysis process, active peptide substances which are easy to digest and absorb, can enhance immunity and delay senescence are synchronously generated, and tea polyphenol added in the formula can synergistically relieve anaphylactic reaction and play an anti-oxidation role, so that multi-element synergy of desensitization, function enhancement and flavor optimization is realized, and the added value and market application potential of the product are improved.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to application of a compound in preparation of an anti-allergic reaction medicine. The compound provided by the invention can effectively inhibit mast cell degranulation so as to inhibit generation of IgE-mediated I-type anaphylaxis, so that the compound is used as an anti-drug anaphylaxis preparation to provide more possible treatment schemes for clinical drug anaphylaxis treatment.

The present invention relates to a novel lipid derivative compound comprising an oligo-gamma-glutamic acid, a lipid nanoparticle composition comprising the same, and the like. According to the present invention, the compound can form lipid nanoparticles by replacing PEGylated lipids, and thus can prevent side effects such as anaphylaxis and has excellent in vivo stability.

Compositions and methods for treating diseases and conditions mediated by the high affinity IgE receptor (FcεRI) are provided. Also provided are antisense oligomers for modulating splicing of mRNA encoding a MS4A6A protein, optionally in addition to antisense oligomers for modulating splicing of mRNA encoding the FcεRIβ protein, thereby down-regulating cell-surface expression of FcεRI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation; for inhibiting anaphylaxis reactions in individuals, for treating allergic conditions in individuals, for reducing the incidence of allergic reactions in individuals, for treating individuals at risk of developing anaphylactic reactions, and for treating mast cell-related diseases in individuals.

The invention relates to the field of home textiles. A preparation method of a textile anti-allergy material comprises the following steps: step 1, mixing polymer polyol and absolute ethyl alcohol, then adding maleic anhydride, methacrylic acid and hydroxyethyl acrylate, then adding isocyanate, then adding a mixture of polyvinyl alcohol and sorbitol, and then adding dibenzoyl peroxide to obtain a product A; 2, firstly, diatomite powder is added into water; then, adding a pH regulator solution; then, polyhydric alcohol is added, and a product B is obtained; and 3, mixing the product A with the product B to obtain the textile anti-allergy material. The obtained anti-allergy fabric has the capacity of inhibiting or removing allergens and reducing anaphylactic reaction, meanwhile, the softness, the air permeability and the skin-friendly performance of the fabric are kept, and it is ensured that the added anti-allergy components cannot generate irritation or side effects on the skin of the human body.

The present application relates to the technical field of orthopedic artificial joint design and manufacturing, in particular to an intervertebral disc prosthesis and a preparation method thereof. The first plate body of the intervertebral disc prosthesis is provided with a semispherical groove on the side away from the first fixing seat; the second plate body is provided with a connecting slot on the side away from the second fixing seat; the nucleus pulposus prosthesis comprises a semispherical convex surface and a base, the semispherical convex surface is movably connected with the semispherical groove, and the base is connected with the connecting slot; the surfaces of the first plate body and the second plate body are both provided with gradient trabeculae, and the surfaces of the semispherical groove and the semispherical convex surface in contact with each other are both metal ceramic interfaces formed by zirconium-niobium surface oxidation. The upper end plate of the intervertebral disc prosthesis can keep relative movement with the nucleus pulposus prosthesis, and the contact friction interface of the relative movement is a metal ceramic interface formed by zirconium-niobium surface oxidation, so that the friction surface can reduce abrasion to the greatest extent, the wear resistance of the prosthesis is improved, the service life of the prosthesis is prolonged, the loosening of the prosthesis is improved, the metal allergic reaction and metal artifacts are reduced.

The present invention relates to a method for producing 1B or 1D omega-5 gliadin-deleted wheat and wheat produced thereby, and, specifically, to a method for producing and selecting 1B or 1D omega-5 gliadin gene-deleted wheat by using radiation. The method for producing 1B or 1D omega-5 gliadin-deleted wheat, according to the present invention, enables the production of a radiation breeding-based non-GMO mutant wheat or wheat breeding parental line while retaining agronomic traits similar to those of a wild-type wheat variety, and thus wheat with reduced toxicity to wheat-dependent exercise-induced anaphylaxis (WDEIA) can be produced for use in the production of processed wheat foods and the like, or a parental line for breeding wheat varieties with reduced toxicity to WDEIA can be produced.