111 results about "Anaphylactic reactions" patented technology

Provided herein are epinephrine spray formulations. Also provided herein are methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatment.

Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided.

Provided herein are epinephrine spray formulations. Also provided herein are methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatment.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The invention provides recombinant VIII type humanized collagen and application thereof, and the recombinant VIII type humanized collagen is of a triple helix structure, has good cell adhesion activity, does not generate immunological rejection and anaphylactic reaction when being applied to a human body, is a brand new human body synthetic biological material, and has good application prospects.

Intranasal dry powder epinephrine compositions are described herein. The compositions include epinephrine or a pharmaceutically acceptable salt thereof, as well as a stabilizing agent and a carrier. The stabilizing agent is operable to include citric acid, or a pharmaceutically acceptable salt derived therefrom. Such intranasal compositions as described herein are useful in the treatment of health conditions which threaten the central nervous system (CNS) and impede the actions of alpha and beta-adrenergic receptors. Such health conditions include anaphylaxis, bronchospasms, respiratory impairment, organophosphate poisoning, and major adverse cardiac events (MACE).

The invention belongs to the technical field of biological medicines, and discloses a probiotic and prebiotic composition for improving intestinal microecology and assisting in resisting food allergy, and the composition comprises bifidobacterium longum and oligosaccharide in a mass ratio of (1-3): (1-3). The probiotic and oligosaccharide composition provided by the invention is clear in mechanism and wide in application range, and the effect of relieving food anaphylactic reaction is achieved by enhancing intestinal barriers and regulating intestinal flora. And under the participation of the oligosaccharide, the anti-allergic effect of the probiotics is obviously enhanced. The invention can solve the problem that the existing anti-allergic medicine treats both symptoms and root causes, simplifies the composition, defines the action mechanism of the composition, and expands the range of applicable people.

The invention discloses a preparation method of a negundo chastetree fruit microcapsule and application of the negundo chastetree fruit microcapsule in mosquito-repellent finishing of fabrics. Vitex negundo essential oil is used as a core material, an emulsifier and a wall material are investigated, it is determined that Tween-80 is used as the emulsifier, gelatin and sodium alginate are used as the wall material, a complex coacervation method and calcium chloride cross-linking curing are adopted, and freeze drying is performed to obtain the Vitex negundo microcapsule. By optimizing the emulsifier addition amount, the total wall material concentration, the core-wall ratio and the like, the embedding rate of the prepared rhizoma polygonati microcapsule can reach 75% or above, the particle size is smaller than 2 microns, and the rhizoma polygonati microcapsule can be stably and uniformly dispersed in water. The negundo chastetree fruit microcapsule is prepared into a finishing liquid which is used for after-finishing of fabrics, can endow the fabrics with good mosquito repelling performance, and is fresh in smell and free of anaphylactic reaction.

The invention belongs to the technical field of biological medicines, and particularly relates to application of quercetin combined with curcumin in preparation of an anti-allergic reaction medicine. Through a large number of researches, the inventor finds that combined administration of quercetin and curcumin with a specific concentration can effectively inhibit mast cell degranulation, and the inhibition rate of mast cell degranulation reaches 90% or more, so that I-type anaphylaxis mediated by immune globulin E is inhibited, especially systemic anaphylaxis, and the curative effect is good. The compound can be used for preparing anti-anaphylaxis drugs. The drug combination scheme provided by the invention has important significance and wide application prospect in drugs for treating or preventing anaphylactic reactions.

The disclosure herein relates to the innovative epinephrine formulations in aqueous solution of medicinal products that enhance the physicochemical stabilities of epinephrine and extend the product shelf life. In some instances, the formulations comprise epinephrine or a salt thereof, a complexing agent, and a “non-sulfite” antioxidant. The epinephrine formulations substantially demonstrated the superior physicochemical stabilities to conventional sulfite formulation of commercial medications currently available. In some instances, sulfite-free formulations further provide further benefit (e.g., safety benefits) to sulfite-sensitive patients. The compositions, methods for preparing the formulations, and methods of using the same (e.g., in the treatment of anaphylaxis) are also provided.

The invention provides a Chinese large language model safety evaluation system and method based on dynamic extension and a bottom-taking mechanism, and belongs to the field of natural language processing and artificial intelligence. On the basis of an existing benchmark test data set, an attack test data set is generated by combining a large language model with multiple attack methods, and attack test data is generated for a request rejected to respond by the model by utilizing a fine-tuned expert model through a bottom-out mechanism; constructing a corresponding false positive test data set, inputting the attack test data set and the false positive test data set into the Chinese large language model to be evaluated, and reasoning to obtain an output result; and finally, carrying out multi-dimensional evaluation on an output result and automatically generating a report. The method has good expandability and adaptability, a test data set can be dynamically expanded, emerging security threats can be followed up, and anaphylaxis and generation of harmful content can be effectively avoided; and a more flexible, comprehensive and efficient solution is provided for security assessment of the Chinese large language model.

The invention provides a specific binding polypeptide of a targeted cell membrane receptor Fc epsilon RI alpha and application of the specific binding polypeptide. The amino acid sequence of the polypeptide is shown in any one of (I) SEQ ID NO: 1-6; (II) an amino acid sequence with at least 90% identity as shown in any one of SEQ ID NO: 1-6, and is specifically combined with a cell membrane receptor Fc epsilon RI alpha. Experimental results show that the Fc [epsilon] RI [alpha] specific binding polypeptide can inhibit IgE-mediated mast cell dependent anaphylaxis to a certain extent, which prompts that the Fc [epsilon] RI [alpha] specific binding polypeptide has a certain inhibition effect on IgE-mediated I-type anaphylaxis, and lays a foundation for further research and development of novel biological targeting drugs for treating allergic diseases.

A use of oleanolic acid-28-O-β-D-glucopyranoside in the preparation of an anti-colitis drug is provided. The oleanolic acid-28-O-β-D-glucopyranoside has significant anti-ulcerative-colitis activity compared with parent nucleus oleanolic acid and other analogues, and has equivalent efficacy compared with Mesalazine, a first-line drug for the clinical treatment of inflammatory bowel disease, and can also avoid salicylic acid anaphylaxis possibly caused by Mesalazine western medicine treatment, thereby achieving a good application prospect.

The utility model relates to the technical field of underpants, and discloses an underpants capable of reducing friction to a human body, which comprises an underpants body, a skin-fitting lining layer is arranged on the inner side of a waist opening and / or two leg openings on the underpants body, and the skin-fitting lining layer is connected with the underpants body through an elastic connecting point or an elastic connecting wire. After the underpants are worn, the positions of the skin-fitting lining layer and the underpants body are relatively fixed, and in the action traction process, when the underpants body and the skin-fitting lining layer move relatively, the elastic connecting points or the elastic connecting wires are stretched by a certain length to overcome the traction force, so that the skin-fitting lining layer and the skin of the human body are kept stable and do not move; friction of the underpants to the waist and legs of a human body is improved, and anaphylaxis caused by friction of people with sensitive skin is reduced or avoided. The utility model has the characteristics of simple structure, low cost, strong practicability and good use effect.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The invention discloses a method for detecting related substances in an amoxicillin raw material and a preparation thereof, and relates to the technical field of pharmaceutical analysis, HPLC conditions are as follows: the elution gradient is 0-5 min: 100% mobile phase A; in 5-25 min, 100%-94% of the mobile phase A and 0-6% of the mobile phase B are adopted; 25-40 min, 94%-84% of the mobile phase A and 6%-16% of the mobile phase B are adopted; 40-50 minutes: 84% of the mobile phase A and 16% of the mobile phase B; 50-51min: 84% of the mobile phase A, 100% of the mobile phase A and 16-0% of the mobile phase B; and in 51-60 min, 100% of the mobile phase A is adopted. The method for detecting the related substances of the amoxicillin related varieties, which is recorded and published by various Chinese pharmacopoeias and literatures, is confirmed, and a set of more effective high performance liquid chromatography is established and verified by screening and optimizing liquid phase conditions such as chromatographic columns and mobile phases, particularly chromatographic column brands, fillers, models and the like; the quality control can be simultaneously carried out on process impurities, degradation impurities, polymers and other organic impurities of amoxicillin raw materials and preparations thereof, so that the occurrence of adverse reactions such as anaphylaxis and the like is reduced, and the safety and effectiveness of medication are ensured.

This invention relates to methods for reducing or preventing anaphylaxis to non-allergenic antigens with compositions comprising immunosuppressants, and related compositions.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

The invention discloses antibiotic-free hydrogel for nursing staphylococcus aureus infection as well as a preparation method and application of the antibiotic-free hydrogel. The hydrogel is prepared from metal ion compounds such as zinc ions, copper ions and iron ion compounds, a natural high polymer material and an antioxidant as raw materials, and has the advantages of efficient antibacterial property, high safety, long-acting slow release and the like. An in-vitro antibacterial experiment shows that the sterilizing rate of the metal ion compound on staphylococcus aureus can reach 90%-99.9%; animal experiments prove that the hydrogel can effectively relieve inflammatory reaction of infected parts, and skin irritation experiments show that the product is free of irritation and anaphylactic reaction. The invention provides a safe and effective nonreactive solution for nursing of staphylococcus aureus infection.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The invention belongs to the technical field of biological medicines and microorganisms, and particularly relates to a parabacteroides couchneri MRD02 and application thereof, the parabacteroides couchneri is Parabacteroides couchneri MRD02, the preservation number is GDMCC No.64793, and the preservation unit is Guangdong Province Microbial Culture Collection Center. The invention further discloses a preparation method of the parabacteroides couchneri MRD02 and application of the parabacteroides couchneri MRD02. The Parabacteroides goldsteinii MRD02 disclosed by the invention can be used for remarkably inhibiting joint swelling and systemic inflammation of rheumatoid arthritis of mice, and the inhibiting effect of the Parabacteroides goldsteinii MRD02 is remarkably superior to that of other parabacteroides strains; meanwhile, due to the fact that the usage amount of the Parabacteroides goldsteinii MRD02 is small, gastrointestinal reactions of nausea, vomiting or diarrhea are not found in the Parabacteroides goldsteinii MRD02, and anaphylactic reactions are also not found in the Parabacteroides goldsteinii MRD02.

The invention relates to the field of medicines, in particular to application of LKB1 / AMPK pathway-based fucoidan in preparation of anti-type I anaphylaxis medicines. The LKB1 / AMPK pathway is activated by the alginate, so that mast cell degranulation is effectively inhibited, mast cell mediated cell anaphylaxis is further effectively inhibited, and the alginate can be used for preparing anti-anaphylaxis related drugs.

The invention provides a linear or cyclic polypeptide and a derivative or analogue thereof, wherein the linear or cyclic polypeptide is used for mobilizing a stress-inducing protein (sestrin) from GATOR / mTOR to sMAC in a non-aging cell; the polypeptide comprises or consists of an amino acid sequence derived from a stress-inducing protein or a truncated sequence thereof. These polypeptides are useful in the treatment of conditions requiring immediate intervention, such as acute diseases, sepsis caused by pathogen infection, or anaphylaxis, such as allergic shock, as immunotherapeutic agents for the treatment of cancer, and for autoimmune diseases.

The present disclosure relates to systems and methods for detection of food allergy in a subject. In particular, the disclosure provides systems and methods for early detection of oral food challenge (OFC)-related anaphylaxis by measuring transepidermal water loss (TEWL).

The invention relates to the technical field, in particular to a preparation method of a low-VOC (volatile organic compound) hot-melt pressure-sensitive adhesive. Opening a heating jacket of the reaction kettle, and raising the temperature to 150-160 DEG C; the preparation method comprises the following steps: adding a thermoplastic elastomer, a stabilizer and part of a plasticizer into a reaction kettle, heating for 20-30 minutes, starting to stir, and vacuumizing for 20-30 minutes; opening the cover every 10 minutes to confirm the molten state of the thermoplastic elastomer until the thermoplastic elastomer is completely molten; and adding the tackifying resin and the residual plasticizer into the reaction kettle, continuously vacuumizing and stirring for 10-20 minutes, and pouring out to obtain the low-VOC hot-melt pressure-sensitive adhesive, thereby solving the problems that the traditional hot-melt pressure-sensitive adhesive always releases a certain amount of volatile organic compounds (VOC) in the production and use processes, the VOCs not only pollute the environment, but also directly influence the health of a human body, and the production cost is low. And long-term contact may cause respiratory diseases, anaphylaxis and even carcinogenic risks.

The invention discloses a far infrared thermal nano fabric and a preparation method thereof.The fabric comprises a far infrared layer and a skin-friendly layer, the far infrared layer is made of polyester fibers filled with nano thermal radiation particles, and the nano thermal radiation particles are modified nano tourmaline particles with the surfaces coated with polylactic acid layers; and the textile raw material of the skin-friendly layer is light-transmitting yarns. According to the invention, the surface of the tourmaline particle is coated with the polylactic acid layer, so that the biocompatibility of the particle is improved, and the adhesive force and stability of the particle on the fiber are remarkably improved in cooperation with a blended spinning technology, so that the far infrared performance of the particle can be maintained for a long time. Besides, the skin-friendly layer is arranged on the inner side of the far-infrared layer, so that the problems that an existing far-infrared fabric is not good in comfort and possibly causes anaphylactic reaction due to the fact that the existing far-infrared fabric is in direct contact with the skin for use are effectively solved; and meanwhile, the skin-friendly layer adopts the silk yarn interwoven layer in a specific form, so that the whole far infrared performance is basically not influenced.

The present application relates to the technical field of skin care products, and discloses a composition with the effect of soothing sensitive skin, which is composed of the following components in mass percentage: plant extract 10-12%, skin repair factor 2-3%, jasmine hydrolat 10%, humectant 6-7%, and the balance being water. The composition with the effect of soothing sensitive skin has significant soothing effect, which is close to the soothing effect of common hormone ointments on the market. The composition can significantly reduce inflammatory factors, has good anti-inflammatory effect, simultaneously repairs damaged skin, enhances the moisturizing function, and enhances the skin barrier through the moisturizing and repairing effect. The composition has the effect of resisting anaphylaxis by reducing the content of trypsin and inhibiting the allergic reaction of mast cells. Human patch test and fish embryo development toxicity test prove that the composition with the effect of soothing sensitive skin has no skin adverse reactions and no development toxicity, is mild, safe and non-irritating, and is suitable for preparing skin care products for adults and infants.

The invention provides a traditional Chinese medicine composition for treating primary dysmenorrhea and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 3-15 parts of rhizoma corydalis, 6-15 parts of angelica sinensis, 3-15 parts of ligusticum wallichii, 3-10 parts of rhizoma zingiberis, 1.5-6 parts of fennel and 3-12 parts of cassia twigs, and the traditional Chinese medicine composition is prepared from, by weight, 3-15 parts of rhizoma corydalis, 6-15 parts of angelica sinensis, 3-15 parts of ligusticum wallichii, 3-10 parts of rhizoma zingiberis, 1.5-6 parts of fennel and 3-12 parts of cassia twigs. The traditional Chinese medicine composition is prepared by grinding and uniformly mixing the raw materials, all the components have a synergistic effect, and the traditional Chinese medicine composition has the effects of resisting inflammation, resisting oxidative stress, regulating the estrogen level, improving the pathological morphology of the uterus and easing pain, and has a remarkable effect on treating primary dysmenorrhea; the traditional Chinese medicine composition is used for treating primary dysmenorrhea in the form of a traditional Chinese medicine patch, and by combining traditional Chinese medicine application and thermal therapy, local skin blood flow can be remarkably increased, the diffusivity and solubility of medicine in cuticle can be improved, the skin absorption capacity can be enhanced, the medicine absorption and permeation amount can be increased, local blood circulation can be improved, and pain can be relieved; and no anaphylactic reaction is caused to the skin.

The invention relates to a gouty arthritis acute-stage traditional Chinese medicine cold compress patch as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine cold compress patch for the acute stage of gouty arthritis is prepared from the following raw materials in parts by mass: 25 to 35 parts of radix et rhizoma rhei, 45 to 55 parts of mirabilite, 15 to 25 parts of herba speranskiae tuberculatae, 15 to 25 parts of rhizoma arisaematis preparata, 15 to 25 parts of rhizoma curcumae longae, 15 to 25 parts of herba violae, 25 to 35 parts of herba taraxaci, 25 to 35 parts of rhizoma smilacis glabrae, 25 to 35 parts of fructus gardeniae, 15 to 25 parts of cortex phellodendri and 15 to 25 parts of radix gentianae macrophyllae. The traditional Chinese medicine cold compress patch for the acute stage of the gouty arthritis can effectively relieve red, swollen and heat pain of the acute stage of the gouty arthritis, and is convenient to prepare, easy to store and less in anaphylactic reaction.

The present disclosure provides a metered dose inhaler (MDI) comprising an API formulation suitable for administration to a patient in need thereof by inhalation, as well as methods and uses of the MDI.