48 results about "Epinephrine" patented technology

Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg / mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg / mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg / mL sodium citrate dihydrate, 3.3 mg / mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg / mL of sodium metabisulfite, and 4 μg / mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg / mL of epinephrine and other ingredients.

The application discloses a capillary open-tube chromatographic column preparation method based on a defect engineering metal organic framework-molecular imprinting composite nanomaterial and application, and particularly relates to the field of chemical synthesis and analysis technology. A GLYMO-IDA-silane solution is used to flush a pretreated capillary, so that a carboxyl-modified capillary is obtained. Then, an N,N-dimethylformamide solution containing zirconyl chloride octahydrate, terephthalic acid, L-proline and hydrochloric acid is injected into the cysteine-modified capillary, and under a heating condition, a metal organic framework UiO-66-L-Pro is in-situ grown on the inner wall of the capillary. D-tryptophan and norepinephrine are dissolved in a neutral buffer solution, and after magnetic stirring for 30 min, ferrous sulfate is added and rapidly injected into the UiO-66-L-Pro-modified capillary, and then both ends are sealed, and reaction is carried out at room temperature for 24 h. An acetic acid / SDS solution mixture is used to flush the capillary for 1.5 h to elute the template molecules, and then nitrogen is used to blow dry, so that an MIP@UiO-66-L-Pro@capillary is prepared.

The invention relates to a zebrafish model for screening arrhythmia drugs and application thereof, and belongs to the technical field of biological medicines. According to the transgenic zebrafish provided by the invention, an appropriate arrhythmia zebrafish model can be screened out through a fluorescence intensity IOD value, the fluorescence intensity is in positive correlation with the transgenic expression quantity, the transgenic expression level can be quickly judged according to the fluorescence intensity, and an appropriate individual can be selected for subsequent experiments. Isoprenaline is an anti-arrhythmia drug which is widely used clinically at present, an isoprenaline treatment experiment verifies the effectiveness of the model for screening the anti-arrhythmia drug, and the model is not only suitable for researching the pathogenesis of hereditary arrhythmia diseases, but also suitable for researching the pathogenesis of the hereditary arrhythmia diseases. Technical support is also provided for research and development of arrhythmia treatment medicines, and important theoretical significance and wide application prospects are achieved.

The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

The invention includes a phenylephrine product including an aqueous phenylephrine solution, a tonicity adjusting agent, at least one pH adjusting agent, at least one buffering agent and water for injection, wherein the phenylephrine solution is does not comprise sodium metabisulfite, wherein the phenylephrine product is sterile and ready-to-use and contain an oxygen absorber to keep the oxygen dissolved below 1 ppm. The invention includes methods of making and using the phenylephrine product.

The present invention relates to a guide sheath for peripheral bronchial lesion treatment, comprising a side tube for saline infusion, and injects physiological saline, which has been injected for peripheral bronchial dilation and access, through the side tube so that the physiological saline can efficiently reach a peripheral lung lesion as the physiological saline is injected through the side tube without insertion and removal of the guide sheath as in a conventional procedure, such that the precision and efficiency of a bronchoscopy procedure for diagnosing the peripheral lung lesion can be improved. In a conventional procedure, cold physiological saline or epinephrine for hemostasis could be administered after removal of the guide sheath and biopsy forceps, but the side tube of the guide sheath can administer a solution that assists hemostasis immediately after biopsy such that reduced side effects after the procedure and improved safety for the patient can be expected.

A housing for hypodermic device including a housing assembly, a hypodermic device housed therein, twist off top and bottom caps. The housing assembly includes an upper and lower ends, exterior and interior walls. The exterior and interior walls definine a vacuum sealed in-between space, and the interior wall defines an interior cavity. The top and bottom caps include first and second tabs, respectively. The hypodermic device has proximal and distal ends. The hypodermic device includes auto injectors such as epinephrine auto injector, insulin auto injector or similar. The exterior and interior walls are vacuum sealed layers made of a rigid material that protect the hypodermic device from impact and accidental activation and keep the hypodermic device at a range of temperature for a longer period of time. A ring attachment is adjacent to the upper end, and it secures to backpacks, purses, garments or similar.

The invention discloses a metal organic framework LCU-138, a preparation method thereof and application of the metal organic framework LCU-138 in biomarker detection, the chemical formula of the metal organic framework LCU-138 is ({[Cd (L) 0.5 (bppa) 0.5. H2O]} n), the metal organic framework LCU-138 has a three-dimensional supramolecular structure, L represents anions after deprotonation of a ligand 2 ', 5'-difluoro-[1, 1 ': 4', 1 '-triphenyl]-2, 2' ', 4, 4'-tetracarboxylic acid, and bppa represents a ligand 1, 2-bis (4-pyridyl) ethane. The LCU-138 fluorescent material provided by the invention has good chemical stability, and the frame structure is not damaged after the LCU-138 fluorescent material is soaked in various solvents for 24 hours; biomarkers 2-aminoacetophenone and epinephrine can be efficiently detected, the fluorescence quenching constants (Ksv) of the biomarkers are 1.42 * 10 < 4 > M <-1 > and 5.84 * 10 < 3 > M <-1 > respectively, the detection limits of the biomarkers are 3.57 mu M and 10.32 mu M respectively, and the biomarkers have high sensitivity, high anti-interference performance and rapid detection capacity and can be recycled.

The invention belongs to the field of shellfish culture, and particularly relates to a method for efficiently promoting chlamys farreri larva attachment and metamorphosis through noradrenaline. Aiming at the problem of low attachment and metamorphosis rate in the current chlamys farreri breeding process, the invention provides the method for efficiently promoting the attachment and metamorphosis of the chlamys farreri larvae by using the chemical inducer noradrenaline, and a technical support is provided for improving the attachment and metamorphosis rate in the chlamys farreri seedling production process.

The present invention belongs to the field of electrochemistry, specifically a preparation method and application of a polyvinyl alcohol hydrogel-foam carbon-silver / silver chloride reference electrode. The present invention uses foam carbon as the substrate of the reference electrode for the first time, electrochemically deposits and chlorinates the foam carbon to prepare a foam carbon-silver / silver chloride reference electrode with a rod-like structure, and then pours the polyvinyl alcohol hydrogel on the chlorinated electrode surface to obtain a polyvinyl alcohol hydrogel-foam carbon-silver / silver chloride reference electrode with good ion permeability, good conductivity and stable potential. The present invention can significantly improve the conductivity and stability of the electrode, and the stability of this reference electrode is comparable to that of a commercial reference electrode. The electrode prepared by the present invention is applied to the electrochemical detection of epinephrine, and its detection signal is significantly higher than that of a commercial reference electrode, and has good application prospects.

This invention belongs to the field of in vitro detection technology, specifically relating to a chemiluminescent immunoassay kit and its application in immunoassay. The chemiluminescent immunoassay kit provided by this invention uses a first target protein recognition molecule and a second target protein recognition molecule to capture proteins. Horseradish peroxidase on the second target protein recognition molecule undergoes a polymerization reaction with a chemiluminescent reagent and norepinephrine, forming a product enriched with the chemiluminescent reagent. Under the action of an alkaline pH adjuster and hydrogen peroxide, a chemiluminescent signal is directly generated. This eliminates the need for covalent modification of the protein recognition molecule with the chemiluminescent reagent, reducing the loss of biomolecule activity, improving the utilization rate of the protein recognition molecule, facilitating the control of batch-to-batch variations of the chemiluminescent reagent, and effectively improving detection sensitivity. The results of the examples show that the chemiluminescent immunoassay kit provided by this invention improves the detection sensitivity of pTau217 to approximately 0.25 pg / mL.

1. The name of the design product: medicine box (adrenaline). 2. The use of the design product: for medicine box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best shows the design points: front view.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

The present invention provides a formulation that includes a therapeutically effective amount of phenylephrine or a pharmaceutically acceptable salt thereof, and a method for preparing the formulation. In some embodiments, the formulation includes a tonicity agent, a citrate buffer, water, and has an initial pH of from 5.6 to 6.0. In other embodiments, the formulation includes a tonicity agent, a citrate buffer, an antioxidant, water, and has an initial pH of from 3.6 to 4.8. The formulation of the invention is sterile, stable, ready-to-administer and packaged into a polymeric syringe.

The application belongs to the field of medicine, and relates to a kind of salvia miltiorrhiza extract and pharmaceutical composition and application thereof, specifically to a kind of novel structure compound in salvia miltiorrhiza and preparation method thereof and application of the compound in preparation of medicine for preventing and treating heart failure disease, especially application in medicine for preventing and treating heart failure caused by myocardial fibrosis. Pharmacological test proves that the compound has obvious protective effect on H9c2 myocardial cell hypoxia injury, and has obvious inhibitory effect on proliferation, migration and activation of myocardial fibroblast AC16 caused by isopropyl epinephrine, and can be used for preparing medicine for preventing and treating heart failure disease.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

This disclosure provides a respiratory delivery device. In particular, this disclosure provides a delivery device used to administer particulate drugs to the target airways and lungs via inhalation. The delivery device may be suitable for emergency medical use for the delivery of active pharmaceutical ingredients, including epinephrine.

A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second polymer includes an alginate. The second coating has a hemostatic agent dispersed in the second polymer such that the second polymer releases the hemostatic agent as the second polymer degrades. The hemostatic agent is selected from epinephrine, tranexamic acid, chitosan and oxidized regenerated cellulose. In some embodiments, systems and methods are disclosed.

The invention relates to the technical field of feeds, and particularly discloses an anti-stress feed for lambs. The feed comprises the following raw materials in parts by weight: 200 parts of corn, 100 parts of soybean meal, 50 parts of cottonseed meal, 200 parts of corn germ meal, 200 parts of alfalfa meal, 40 parts of pine needle meal, 50 parts of palm meal, 10 parts of a yeast culture, 22 parts of stone powder, 10 parts of montmorillonite, 8 parts of baking soda, 6 parts of table salt, 0.5 part of tannic acid, 0.5 part of bacillus subtilis, 0.5 part of compound enzyme, 0.1 part of a mildew preventive, 0.1 part of an antioxidant, 4 parts of 70 lysine and 0.3 part of a radix astragali crude extract. According to the feed formula, the immune function and endocrine balance of lamb organisms are effectively adjusted, and secretion of cortisol, epinephrine and other stress hormones in the stress state is reduced; meanwhile, the feed effectively guarantees nutritional ingredients, accelerates the growth speed of the lambs, reduces the digestive system burden of the lambs, and is simple in preparation process and convenient to popularize and apply.

The table multifunctional medicine management tray comprises an open tray and partition plates, the partition plates divide the interior of the open tray into a first cavity, a second cavity, a third cavity, a fourth cavity, a fifth cavity and a sixth cavity, the different cavities are used for storing different medicines and objects, and the sixth cavity is used for storing different medicines and objects. In addition, a plurality of cotton piece containing positions are arranged in the first cavity, nurses can soak cotton pieces in epinephrine stock solution and then place the cotton pieces on the cotton piece containing positions, after doctors clamp the cotton pieces, numbers can be dynamically displayed through a number prompt mechanism, and after the operation is finished, the number prompt mechanism can prompt the numbers to be displayed. The number of used cotton pieces can be rapidly determined through prompted numbers and compared with the number of recycled used cotton pieces, closed-loop counting is achieved, the cotton piece loss problem is avoided, the operation safety is improved, and the operation efficiency is optimized.

The present invention relates to a liquid pharmaceutical composition for oral administration in the form of suspension which comprises the combination of ibuprofen and phenylephrine, or a pharmaceutically acceptable salt thereof, as active substances, and hypromellose, xanthan gum, liquid maltitol, glycerine and water. The composition is stable, has good organoleptical properties and shows excellent pharmacokinetic profile, providing quick absorption of the drugs. The present invention also relates to the use of the composition for treating the symptoms of flu and common cold, particularly in adults and in children over 7 years.

The invention relates to a preparation method of a stable rat model for primary dysmenorrhea with syndrome of cold coagulation and blood stasis, belongs to the technical field of animal model construction, and particularly relates to a construction method of a rat model for primary dysmenorrhea according with the pathogenesis characteristics of cold coagulation and blood stasis in traditional Chinese medicine. The model simulates the pathological process of cold evil invasion and uterus stasis and combines a modern medical hormone intervention means to realize the construction of a'disease and syndrome combined 'animal model, and is mainly used for the anti-dysmenorrhea mechanism research and drug screening of traditional Chinese medicine compound, acupuncture and other therapies. The adopted preparation method comprises the steps that 0.4 mg of estradiol benzoate is subcutaneously injected to each rat every day for 12 days, the injection dosage of the first day and the injection dosage of the last day are increased to 2 times, the rats are placed in the environment of-20 DEG C after injection is completed, epinephrine is injected twice every day from the 6th day of molding, and 2 U of oxytocin is injected to each rat intraperitoneal cavity 24 hours after the epinephrine is injected for the last time. The animal model obtained through the method is stable in phenotype and good in repeatability, compared with pure cold or pure irritation, more remarkable pain behaviors and biochemical changes can be obtained in a short period through combination with epinephrine, and pharmacodynamic screening is facilitated.

The present invention relates to a liquid pharmaceutical composition for oral administration in the form of a suspension, comprising a combination of ibuprofen and phenylephrine or pharmaceutically acceptable salts thereof as active ingredients, as well as hypromellose, xanthan gum, liquid maltitol, glycerol, and water. The composition is stable, has good organoleptic properties, and exhibits an excellent pharmacokinetic profile, providing rapid absorption of the drug. The present invention also relates to the use of the composition for treating symptoms of influenza and the common cold, particularly in adults and children over 7 years of age.

The invention relates to a specific composition comprising in particular at least gellan gum and phenylephrine. It also relates to a particular method for manufacturing such a composition and its uses in particular as a mydriatic ophthalmic product.

A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.

A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.

A clinical care system that integrates and analyzes patient data and applies rules to recommend potential treatments. A potential application is detection and management of shock, using hemodynamic data collected from devices such as a right heart catheter. The system may calculate confidence levels for each rule and present high-ranked treatment options to clinicians along with their confidence levels. Confidence levels for treatments may change continuously as a patient's condition evolves. For shock, features extracted from measured data may include for example a cardiac index (cardiac output divided by patient body surface area), systemic vascular resistance, and mean arterial pressure; treatment recommendations derived from these (and other) features may include administration of various medications such as epinephrine and vasopressin, installation of a ventricular assist device, transfusion, and volume resuscitation. Machine learning may be used to match recommendations to current clinical practice, or to optimize patient outcomes.

The invention relates to a method for regulating and controlling production of citrinin from penicillium citrinum by exogenous signal molecules and application of the method in mildew prevention of food and agricultural products. Penicillium citrinum fermentation liquor is analyzed through metabonomics, and key signal molecules of farnesol, tyrosol, linoleic acid, cytidine, tryptophan and noradrenaline for regulating the growth of the penicillium citrinum are screened out. Based on the fact that the signal molecules can be used for regulating and controlling the growth retardation period, the maximum growth rate and the citrinin yield of penicillium citrinum, the action target of each signal molecule is clarified, meanwhile, verification is carried out in a Liupao tea system, the method utilizes a microbial quorum sensing mechanism, precise mildew prevention is achieved through targeted regulation and control of toxin-producing genes, and the application prospect is wide. The method has the characteristics of high efficiency and safety, provides a new environment-friendly method for food safety regulation and control of tea, feed and other related fermented products, and also provides a new view angle and method for research of microbial metabolism regulation and control.

A management system for medication includes an electronic case configured to support a user's medication and a computing device configured to communicate with the case. The case includes one or more sensors, such as a pressure sensor, to produce sensor information indicating whether the medication is disposed in the case, a battery sensor to indicate a charge level of the case, and, in some examples, a location sensor to indicate a location of the case. A controller obtains the sensor information and provides status information to the computing device. The computing device provides notifications based on the status information and, in some examples, automatically or semi-automatically initiates communications to designated emergency contacts in response to determining that medication has been removed from the case. The case can include light sources and a speaker controlled by the controller. An identifier, such as a near-field communication tag, can associate the case with a user. Status information can be shared with additional users (e.g., caregivers). The system is suitable for emergency medications such as epinephrine nasal spray.

The application discloses a method for detecting adrenaline by using a colorimetric-fluorescent dual-mode sensor based on Cu-MB with high laccase activity and high fluorescence performance, and comprises the following steps: constructing a dual-function copper-based nanoscale enzyme Cu-MB; constructing a colorimetric-fluorescent dual-mode adrenaline sensor; mixing and incubating EP with different concentrations and Cu-MB to react, measuring the ultraviolet absorption curve of the sample at a wavelength of 350-650 nm, taking the concentration of EP as the abscissa and the absorbance value at 485 nm as the ordinate, and establishing an ultraviolet standard curve of EP; measuring the fluorescence emission curve of the sample at a wavelength of 380-600 nm under an excitation wavelength of 350 nm, taking the concentration of EP as the abscissa and the fluorescence intensity value at 435 nm as the ordinate, and establishing a fluorescence standard curve of EP; and measuring the maximum ultraviolet absorbance value and the fluorescence intensity value of the sample to be detected, and substituting the values into the ultraviolet standard curve or the fluorescence standard curve of EP respectively to obtain the concentration of EP in the sample to be detected.