85 results about "Epinephrine" patented technology

The disclosure provides a method for systemic delivery of a therapeutically effective amount of epinephrine to a subject comprising orally administering dipivefrin or a dipivefrin salt to the subject. The disclosure also includes a method of treatment of a disease amenable to treatment by in vivo delivery of systemic epinephrine comprising administering dipivefrin or a dipivefrin salt to a subject in need of in vivo delivery of systemic epinephrine. The disease can be a respiratory disorder, anaphylaxis, cancer, or a microbial infection. The disclosure also includes dipivefrin or dipivefrin HCl orally dissolving tablets.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The present disclosure provides for a respiratory delivery device. Particularly, the disclosure provides for a delivery device for use in administering a particulate medicament to a subject's airway and lungs via inhalation. The delivery device may be suitable for emergency medicine for the delivery of active pharmaceutical ingredients including epinephrine.

The invention relates to the technical field of chemical analysis and detection, in particular to a fluorescence determination method for free amino acid in tobacco leaves, based on the fluorescence characteristic of epinephrine-based zinc-doped carbon dots Zn / NA-CDs, free amino acid reacts with phthalic dicarboxaldehyde to generate a Schiff base product, and Zn / NA-CDs and Schiff base have hydrogen bond interaction and charge transfer effect, so that the content of free amino acid in tobacco leaves is determined. Therefore, the Schiff base has a fluorescence sensitization effect on the Zn / NA-CDs, and a free amino acid fluorescence detection method is established. According to the method, the detection limit can reach 0.01 mg / L, and the recovery rate is between 90.52% and 105.33%, so that the method also has high sensitivity to low-concentration free amino acid, can meet the requirement for accurately measuring trace amino acid in tobacco leaves, and has excellent accuracy and reliability. Meanwhile, the method further has the advantages of being easy and convenient to operate, low in cost, environmentally friendly, wide in applicability and the like, a new technical means is provided for tobacco leaf quality detection, and beneficial reference is provided for amino acid determination in other fields.

Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg / mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg / mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg / mL sodium citrate dihydrate, 3.3 mg / mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg / mL of sodium metabisulfite, and 4 μg / mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg / mL of epinephrine and other ingredients.

The present invention provides pharmaceutical formulations of levorotatory-epinephrine, l-epinephrine, more potent and less toxic than existing pharmaceutical formulations of epinephrine, along with methods of producing and using these pharmaceutical formulations of l-epinephrine, including preventing and or treating hypotension and hemostasis under surgical anesthesia.

A complex for blocking dentinal tubules, characterized in that the complex is formed by means of polymerizing catecholamine and metal ions. The catecholamine comprises one or more of dopamine, norepinephrine, tannic acid, gallic acid, phlorotannins, phloroglucinol monomers and epigallocatechin gallate; and the metal ions comprise one or more of V 2+, Cr 2+, Cr 3+, Mn 2+, Mn 3+, Fe 2+, Fe 3+, Co 2+, Ni 2+, Cu 2+ and Sr 2+. A reagent for treating dentin allergy comprises the complex for blocking dentinal tubules, can block nearly 85% of dentinal tubules within 3 minutes, and can form a crystal structure similar to hydroxyapatite after being mineralized in vitro for 7 days. In addition, in 7-day animal experiments with SD rats, results consistent with in-vitro mineralization experiments are also observed. Moreover, the complex can not only be rapidly prepared, but also has antibacterial ability against pathogenic bacteria of dental caries, and also has good biocompatibility.

An intelligent bracelet capable of injecting medications is provided by the present application, including a multi-modal sensor assembly configured to acquire physical data of a wearer, a main control chip configured to detect abnormal physical conditions by adopting a machine learning method according to the physical data, a medication injection device configured to inject medications to the wearer when the abnormal physical conditions are detected, and a bracelet display interface configured to display the physical data and corresponding danger levels. An injection system of micro-electro-mechanical system (MEMS) is incorporated on the basis of the functions of the existing intelligent bracelet to automatically detect the physical indicators and abnormal state of the wearer, and to automatically inject adrenaline medications and give an alarm at the same time.

The application discloses a capillary open-tube chromatographic column preparation method based on a defect engineering metal organic framework-molecular imprinting composite nanomaterial and application, and particularly relates to the field of chemical synthesis and analysis technology. A GLYMO-IDA-silane solution is used to flush a pretreated capillary, so that a carboxyl-modified capillary is obtained. Then, an N,N-dimethylformamide solution containing zirconyl chloride octahydrate, terephthalic acid, L-proline and hydrochloric acid is injected into the cysteine-modified capillary, and under a heating condition, a metal organic framework UiO-66-L-Pro is in-situ grown on the inner wall of the capillary. D-tryptophan and norepinephrine are dissolved in a neutral buffer solution, and after magnetic stirring for 30 min, ferrous sulfate is added and rapidly injected into the UiO-66-L-Pro-modified capillary, and then both ends are sealed, and reaction is carried out at room temperature for 24 h. An acetic acid / SDS solution mixture is used to flush the capillary for 1.5 h to elute the template molecules, and then nitrogen is used to blow dry, so that an MIP@UiO-66-L-Pro@capillary is prepared.

The present invention provides a bioluminescence probe for detecting norepinephrine, its preparation method and use, belonging to the field of biological detection. The bioluminescence probe of the present invention has high selectivity and high responsiveness to norepinephrine, can specifically recognize norepinephrine, has high sensitivity and low detection limit, and can be used for the precise detection of norepinephrine. In the range of pH 1.0 to 7.4, the bioluminescence probe of the present invention has excellent stability and can meet the application requirements under different physiological environments in vivo. At the same time, the norepinephrine bioluminescence probe of the present invention can also visually track exogenous norepinephrine at the in vivo level, and perform dynamic visual analysis on patients with diseases related to abnormal expression of norepinephrine involving nerves, tumors, blood pressure and heart diseases, which is beneficial to the clinical detection of norepinephrine and has broad application prospects.

The invention relates to the technical field of medical models, and discloses a qi deficiency and blood stasis syndrome zebrafish model, a preparation method and application thereof, raw materials of the model comprise an animal model and a modeling agent, the animal model is zebrafish, the animal model is treated by the modeling agent, and the modeling agent comprises verapamil and isoprenaline hydrochloride; the model can be used for evaluating and verifying clinical manifestations of venous sinus extravasated blood and pericardial edema in qi deficiency and blood stasis syndromes, has the advantages of rapidness, high efficiency and economy of in-vitro experiments, and also has the advantages of high predictability, high comparability and the like of in-vivo animal experiments.

Disclosed herein are phenylethanolamine n-methyltransferase (PNMT) inhibitors to regulate adrenaline responses. The inhibitors exhibit high specificity for PNMT over other DNA and protein methyltransferases. Also disclosed are pharmaceutical compositions of the inhibitors and methods of treating various diseases associated with associated with dysregulated epinephrine production.

The invention relates to a zebrafish model for screening arrhythmia drugs and application thereof, and belongs to the technical field of biological medicines. According to the transgenic zebrafish provided by the invention, an appropriate arrhythmia zebrafish model can be screened out through a fluorescence intensity IOD value, the fluorescence intensity is in positive correlation with the transgenic expression quantity, the transgenic expression level can be quickly judged according to the fluorescence intensity, and an appropriate individual can be selected for subsequent experiments. Isoprenaline is an anti-arrhythmia drug which is widely used clinically at present, an isoprenaline treatment experiment verifies the effectiveness of the model for screening the anti-arrhythmia drug, and the model is not only suitable for researching the pathogenesis of hereditary arrhythmia diseases, but also suitable for researching the pathogenesis of the hereditary arrhythmia diseases. Technical support is also provided for research and development of arrhythmia treatment medicines, and important theoretical significance and wide application prospects are achieved.

The invention discloses a pharmaceutical composition for treating yin depletion or anal depletion of cattle and sheep and a preparation method, the composition comprises the following raw materials: 100 ml of veterinary procaine injection, 4-8 g of alum and 0.5-1.5 ml of veterinary epinephrine injection, and the three raw materials cooperate to significantly improve the treatment effect; the medicine used locally directly acts on the prolapsed part, and can quickly relieve pain, diminish swelling and promote restoration. In addition, secondary injury and infection caused by traditional reduction are avoided. The recovery can be generally realized in 2-3 days after the medicine is taken, and the treatment period is greatly shortened; the preparation method of the composition is simple in process and easy to popularize, the composition can be prepared only by mixing the three components in proportion and heating and dissolving the three components, complex chemical synthesis is not needed, the requirements for equipment and operation technologies are not high, and the composition is convenient to popularize and apply in the first-line culture line.

The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

To provide a composition capable of gelling on contact with the eye.SOLUTION: The invention relates to a specific composition comprising at least gellan gum and phenylephrine. The invention also relates to a particular method for producing such a composition and to the uses thereof, in particular as a mydriatic ophthalmic product.SELECTED DRAWING: None

The invention includes a phenylephrine product including an aqueous phenylephrine solution, a tonicity adjusting agent, at least one pH adjusting agent, at least one buffering agent and water for injection, wherein the phenylephrine solution is does not comprise sodium metabisulfite, wherein the phenylephrine product is sterile and ready-to-use and contain an oxygen absorber to keep the oxygen dissolved below 1 ppm. The invention includes methods of making and using the phenylephrine product.

The present invention relates to a guide sheath for peripheral bronchial lesion treatment, comprising a side tube for saline infusion, and injects physiological saline, which has been injected for peripheral bronchial dilation and access, through the side tube so that the physiological saline can efficiently reach a peripheral lung lesion as the physiological saline is injected through the side tube without insertion and removal of the guide sheath as in a conventional procedure, such that the precision and efficiency of a bronchoscopy procedure for diagnosing the peripheral lung lesion can be improved. In a conventional procedure, cold physiological saline or epinephrine for hemostasis could be administered after removal of the guide sheath and biopsy forceps, but the side tube of the guide sheath can administer a solution that assists hemostasis immediately after biopsy such that reduced side effects after the procedure and improved safety for the patient can be expected.

A housing for hypodermic device including a housing assembly, a hypodermic device housed therein, twist off top and bottom caps. The housing assembly includes an upper and lower ends, exterior and interior walls. The exterior and interior walls definine a vacuum sealed in-between space, and the interior wall defines an interior cavity. The top and bottom caps include first and second tabs, respectively. The hypodermic device has proximal and distal ends. The hypodermic device includes auto injectors such as epinephrine auto injector, insulin auto injector or similar. The exterior and interior walls are vacuum sealed layers made of a rigid material that protect the hypodermic device from impact and accidental activation and keep the hypodermic device at a range of temperature for a longer period of time. A ring attachment is adjacent to the upper end, and it secures to backpacks, purses, garments or similar.

The application discloses a preparation method of a capillary electrochromatography open column based on chiral induction covalent organic framework modification, a product and application thereof. The application synchronously realizes chiral induction and acid catalysis through L-(+)-tartaric acid, generates permanent helical chirality of an achiral COF skeleton by relying on a chiral memory effect, and obtains a capillary electrochromatography open column which is excellent in thermal stability, acid and alkali tolerance and cyclic regeneration performance, can baseline separate eight kinds of clinical chiral drugs with large structural differences including amlodipine, propranolol, metoprolol, chlorpheniramine, clenbuterol, terbutaline, verapamil and isopropyl epinephrine, has no attenuation in separation effect for 50 times of sample injection in succession, can be prepared in a large scale, is suitable for routine detection of drug enterprises and hospital laboratories, and directly reveals an enantiomer recognition molecular mechanism through DFT quantitative calculation, thereby providing general theoretical guidance for directional design of high-performance chiral porous interface materials.

The invention discloses a metal organic framework LCU-138, a preparation method thereof and application of the metal organic framework LCU-138 in biomarker detection, the chemical formula of the metal organic framework LCU-138 is ({[Cd (L) 0.5 (bppa) 0.5. H2O]} n), the metal organic framework LCU-138 has a three-dimensional supramolecular structure, L represents anions after deprotonation of a ligand 2 ', 5'-difluoro-[1, 1 ': 4', 1 '-triphenyl]-2, 2' ', 4, 4'-tetracarboxylic acid, and bppa represents a ligand 1, 2-bis (4-pyridyl) ethane. The LCU-138 fluorescent material provided by the invention has good chemical stability, and the frame structure is not damaged after the LCU-138 fluorescent material is soaked in various solvents for 24 hours; biomarkers 2-aminoacetophenone and epinephrine can be efficiently detected, the fluorescence quenching constants (Ksv) of the biomarkers are 1.42 * 10 < 4 > M <-1 > and 5.84 * 10 < 3 > M <-1 > respectively, the detection limits of the biomarkers are 3.57 mu M and 10.32 mu M respectively, and the biomarkers have high sensitivity, high anti-interference performance and rapid detection capacity and can be recycled.

A medicament for use in the treatment of anorectal inflammation in hemorrhoids contains a petroleum base, water, phenylephrine hydrochloride, tocopherol acetate, and micronized sucrose.

The invention provides ketoreductase and application thereof in biosynthesis of phenylephrine hydrochloride, and belongs to the technical field of medicines. The invention provides ketoreductase which has an amino acid sequence as shown in SEQ ID NO.1 and can be used for preparing phenylephrine hydrochloride. The invention also provides a method for preparing phenylephrine hydrochloride by using the ketoreductase. The method comprises the steps of alkylation reaction, enzyme catalysis reaction, debenzylation salification and crystallization. The method provided by the invention has the advantages that the raw materials are cheap and easy to obtain, the operation process is simple, the product yield is high, the ee. Value is high, the product quality meets the standard requirements of Chinese pharmacopoeia and European pharmacopoeia, and the like, is green and environment-friendly, is more beneficial to industrial production, and has very important significance on industrial production of phenylephrine hydrochloride.

The invention belongs to the field of shellfish culture, and particularly relates to a method for efficiently promoting chlamys farreri larva attachment and metamorphosis through noradrenaline. Aiming at the problem of low attachment and metamorphosis rate in the current chlamys farreri breeding process, the invention provides the method for efficiently promoting the attachment and metamorphosis of the chlamys farreri larvae by using the chemical inducer noradrenaline, and a technical support is provided for improving the attachment and metamorphosis rate in the chlamys farreri seedling production process.

The present invention belongs to the field of electrochemistry, specifically a preparation method and application of a polyvinyl alcohol hydrogel-foam carbon-silver / silver chloride reference electrode. The present invention uses foam carbon as the substrate of the reference electrode for the first time, electrochemically deposits and chlorinates the foam carbon to prepare a foam carbon-silver / silver chloride reference electrode with a rod-like structure, and then pours the polyvinyl alcohol hydrogel on the chlorinated electrode surface to obtain a polyvinyl alcohol hydrogel-foam carbon-silver / silver chloride reference electrode with good ion permeability, good conductivity and stable potential. The present invention can significantly improve the conductivity and stability of the electrode, and the stability of this reference electrode is comparable to that of a commercial reference electrode. The electrode prepared by the present invention is applied to the electrochemical detection of epinephrine, and its detection signal is significantly higher than that of a commercial reference electrode, and has good application prospects.

This invention belongs to the field of in vitro detection technology, specifically relating to a chemiluminescent immunoassay kit and its application in immunoassay. The chemiluminescent immunoassay kit provided by this invention uses a first target protein recognition molecule and a second target protein recognition molecule to capture proteins. Horseradish peroxidase on the second target protein recognition molecule undergoes a polymerization reaction with a chemiluminescent reagent and norepinephrine, forming a product enriched with the chemiluminescent reagent. Under the action of an alkaline pH adjuster and hydrogen peroxide, a chemiluminescent signal is directly generated. This eliminates the need for covalent modification of the protein recognition molecule with the chemiluminescent reagent, reducing the loss of biomolecule activity, improving the utilization rate of the protein recognition molecule, facilitating the control of batch-to-batch variations of the chemiluminescent reagent, and effectively improving detection sensitivity. The results of the examples show that the chemiluminescent immunoassay kit provided by this invention improves the detection sensitivity of pTau217 to approximately 0.25 pg / mL.

1. The name of the design product: medicine box (adrenaline). 2. The use of the design product: for medicine box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best shows the design points: front view.

The present invention relates to stable, preservative- and antioxidant-free liquid formulations of phenylephrine and ketorolac for injection.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

The invention relates to the technical field of medicine component extraction, and discloses a medicine for resisting hashimoto thyroiditis disease, the medicine comprises an active component and an auxiliary material, the active component is an andrographis paniculata general flavone extract, andrographis paniculata general flavone is used as a main component, and the andrographis paniculata general flavone can reduce exudation of capillary walls, so that the medicine can be used for preventing and treating the hashimoto thyroiditis disease. The andrographis paniculata total flavone extract has an anti-inflammatory effect, is especially effective for symptoms such as upper respiratory tract and diarrhea caused by bacteria and viruses, shows strong antibacterial and antiviral capabilities, can inhibit ADP-induced human platelet aggregation, shortens the dissolution time of euglobulin, and has a good anti-inflammatory effect. The andrographis paniculata extract has a certain protective effect on myocardial injury caused by isoprenaline and experimental myocardial infarction ischemic injury, and the andrographis paniculata extract can enhance the function of phagocytes and improve the staphylococcus aureus phagocytosis capacity of peripheral blood leukocytes, and is used for enhancing immunity and overcoming immunity diseases.