67 results about "Epinephrine" patented technology

Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg / mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg / mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg / mL sodium citrate dihydrate, 3.3 mg / mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg / mL of sodium metabisulfite, and 4 μg / mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg / mL of epinephrine and other ingredients.

The present invention provides pharmaceutical formulations of levorotatory-epinephrine, l-epinephrine, more potent and less toxic than existing pharmaceutical formulations of epinephrine, along with methods of producing and using these pharmaceutical formulations of l-epinephrine, including preventing and or treating hypotension and hemostasis under surgical anesthesia.

A complex for blocking dentinal tubules, characterized in that the complex is formed by means of polymerizing catecholamine and metal ions. The catecholamine comprises one or more of dopamine, norepinephrine, tannic acid, gallic acid, phlorotannins, phloroglucinol monomers and epigallocatechin gallate; and the metal ions comprise one or more of V 2+, Cr 2+, Cr 3+, Mn 2+, Mn 3+, Fe 2+, Fe 3+, Co 2+, Ni 2+, Cu 2+ and Sr 2+. A reagent for treating dentin allergy comprises the complex for blocking dentinal tubules, can block nearly 85% of dentinal tubules within 3 minutes, and can form a crystal structure similar to hydroxyapatite after being mineralized in vitro for 7 days. In addition, in 7-day animal experiments with SD rats, results consistent with in-vitro mineralization experiments are also observed. Moreover, the complex can not only be rapidly prepared, but also has antibacterial ability against pathogenic bacteria of dental caries, and also has good biocompatibility.

The application discloses a capillary open-tube chromatographic column preparation method based on a defect engineering metal organic framework-molecular imprinting composite nanomaterial and application, and particularly relates to the field of chemical synthesis and analysis technology. A GLYMO-IDA-silane solution is used to flush a pretreated capillary, so that a carboxyl-modified capillary is obtained. Then, an N,N-dimethylformamide solution containing zirconyl chloride octahydrate, terephthalic acid, L-proline and hydrochloric acid is injected into the cysteine-modified capillary, and under a heating condition, a metal organic framework UiO-66-L-Pro is in-situ grown on the inner wall of the capillary. D-tryptophan and norepinephrine are dissolved in a neutral buffer solution, and after magnetic stirring for 30 min, ferrous sulfate is added and rapidly injected into the UiO-66-L-Pro-modified capillary, and then both ends are sealed, and reaction is carried out at room temperature for 24 h. An acetic acid / SDS solution mixture is used to flush the capillary for 1.5 h to elute the template molecules, and then nitrogen is used to blow dry, so that an MIP@UiO-66-L-Pro@capillary is prepared.

The present invention provides a bioluminescence probe for detecting norepinephrine, its preparation method and use, belonging to the field of biological detection. The bioluminescence probe of the present invention has high selectivity and high responsiveness to norepinephrine, can specifically recognize norepinephrine, has high sensitivity and low detection limit, and can be used for the precise detection of norepinephrine. In the range of pH 1.0 to 7.4, the bioluminescence probe of the present invention has excellent stability and can meet the application requirements under different physiological environments in vivo. At the same time, the norepinephrine bioluminescence probe of the present invention can also visually track exogenous norepinephrine at the in vivo level, and perform dynamic visual analysis on patients with diseases related to abnormal expression of norepinephrine involving nerves, tumors, blood pressure and heart diseases, which is beneficial to the clinical detection of norepinephrine and has broad application prospects.

The invention relates to the technical field of medical models, and discloses a qi deficiency and blood stasis syndrome zebrafish model, a preparation method and application thereof, raw materials of the model comprise an animal model and a modeling agent, the animal model is zebrafish, the animal model is treated by the modeling agent, and the modeling agent comprises verapamil and isoprenaline hydrochloride; the model can be used for evaluating and verifying clinical manifestations of venous sinus extravasated blood and pericardial edema in qi deficiency and blood stasis syndromes, has the advantages of rapidness, high efficiency and economy of in-vitro experiments, and also has the advantages of high predictability, high comparability and the like of in-vivo animal experiments.

Disclosed herein are phenylethanolamine n-methyltransferase (PNMT) inhibitors to regulate adrenaline responses. The inhibitors exhibit high specificity for PNMT over other DNA and protein methyltransferases. Also disclosed are pharmaceutical compositions of the inhibitors and methods of treating various diseases associated with associated with dysregulated epinephrine production.

The invention relates to a zebrafish model for screening arrhythmia drugs and application thereof, and belongs to the technical field of biological medicines. According to the transgenic zebrafish provided by the invention, an appropriate arrhythmia zebrafish model can be screened out through a fluorescence intensity IOD value, the fluorescence intensity is in positive correlation with the transgenic expression quantity, the transgenic expression level can be quickly judged according to the fluorescence intensity, and an appropriate individual can be selected for subsequent experiments. Isoprenaline is an anti-arrhythmia drug which is widely used clinically at present, an isoprenaline treatment experiment verifies the effectiveness of the model for screening the anti-arrhythmia drug, and the model is not only suitable for researching the pathogenesis of hereditary arrhythmia diseases, but also suitable for researching the pathogenesis of the hereditary arrhythmia diseases. Technical support is also provided for research and development of arrhythmia treatment medicines, and important theoretical significance and wide application prospects are achieved.

The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

The invention includes a phenylephrine product including an aqueous phenylephrine solution, a tonicity adjusting agent, at least one pH adjusting agent, at least one buffering agent and water for injection, wherein the phenylephrine solution is does not comprise sodium metabisulfite, wherein the phenylephrine product is sterile and ready-to-use and contain an oxygen absorber to keep the oxygen dissolved below 1 ppm. The invention includes methods of making and using the phenylephrine product.

The present invention relates to a guide sheath for peripheral bronchial lesion treatment, comprising a side tube for saline infusion, and injects physiological saline, which has been injected for peripheral bronchial dilation and access, through the side tube so that the physiological saline can efficiently reach a peripheral lung lesion as the physiological saline is injected through the side tube without insertion and removal of the guide sheath as in a conventional procedure, such that the precision and efficiency of a bronchoscopy procedure for diagnosing the peripheral lung lesion can be improved. In a conventional procedure, cold physiological saline or epinephrine for hemostasis could be administered after removal of the guide sheath and biopsy forceps, but the side tube of the guide sheath can administer a solution that assists hemostasis immediately after biopsy such that reduced side effects after the procedure and improved safety for the patient can be expected.

A housing for hypodermic device including a housing assembly, a hypodermic device housed therein, twist off top and bottom caps. The housing assembly includes an upper and lower ends, exterior and interior walls. The exterior and interior walls definine a vacuum sealed in-between space, and the interior wall defines an interior cavity. The top and bottom caps include first and second tabs, respectively. The hypodermic device has proximal and distal ends. The hypodermic device includes auto injectors such as epinephrine auto injector, insulin auto injector or similar. The exterior and interior walls are vacuum sealed layers made of a rigid material that protect the hypodermic device from impact and accidental activation and keep the hypodermic device at a range of temperature for a longer period of time. A ring attachment is adjacent to the upper end, and it secures to backpacks, purses, garments or similar.

The invention discloses a metal organic framework LCU-138, a preparation method thereof and application of the metal organic framework LCU-138 in biomarker detection, the chemical formula of the metal organic framework LCU-138 is ({[Cd (L) 0.5 (bppa) 0.5. H2O]} n), the metal organic framework LCU-138 has a three-dimensional supramolecular structure, L represents anions after deprotonation of a ligand 2 ', 5'-difluoro-[1, 1 ': 4', 1 '-triphenyl]-2, 2' ', 4, 4'-tetracarboxylic acid, and bppa represents a ligand 1, 2-bis (4-pyridyl) ethane. The LCU-138 fluorescent material provided by the invention has good chemical stability, and the frame structure is not damaged after the LCU-138 fluorescent material is soaked in various solvents for 24 hours; biomarkers 2-aminoacetophenone and epinephrine can be efficiently detected, the fluorescence quenching constants (Ksv) of the biomarkers are 1.42 * 10 < 4 > M <-1 > and 5.84 * 10 < 3 > M <-1 > respectively, the detection limits of the biomarkers are 3.57 mu M and 10.32 mu M respectively, and the biomarkers have high sensitivity, high anti-interference performance and rapid detection capacity and can be recycled.

A medicament for use in the treatment of anorectal inflammation in hemorrhoids contains a petroleum base, water, phenylephrine hydrochloride, tocopherol acetate, and micronized sucrose.

The invention belongs to the field of shellfish culture, and particularly relates to a method for efficiently promoting chlamys farreri larva attachment and metamorphosis through noradrenaline. Aiming at the problem of low attachment and metamorphosis rate in the current chlamys farreri breeding process, the invention provides the method for efficiently promoting the attachment and metamorphosis of the chlamys farreri larvae by using the chemical inducer noradrenaline, and a technical support is provided for improving the attachment and metamorphosis rate in the chlamys farreri seedling production process.

The present invention belongs to the field of electrochemistry, specifically a preparation method and application of a polyvinyl alcohol hydrogel-foam carbon-silver / silver chloride reference electrode. The present invention uses foam carbon as the substrate of the reference electrode for the first time, electrochemically deposits and chlorinates the foam carbon to prepare a foam carbon-silver / silver chloride reference electrode with a rod-like structure, and then pours the polyvinyl alcohol hydrogel on the chlorinated electrode surface to obtain a polyvinyl alcohol hydrogel-foam carbon-silver / silver chloride reference electrode with good ion permeability, good conductivity and stable potential. The present invention can significantly improve the conductivity and stability of the electrode, and the stability of this reference electrode is comparable to that of a commercial reference electrode. The electrode prepared by the present invention is applied to the electrochemical detection of epinephrine, and its detection signal is significantly higher than that of a commercial reference electrode, and has good application prospects.

This invention belongs to the field of in vitro detection technology, specifically relating to a chemiluminescent immunoassay kit and its application in immunoassay. The chemiluminescent immunoassay kit provided by this invention uses a first target protein recognition molecule and a second target protein recognition molecule to capture proteins. Horseradish peroxidase on the second target protein recognition molecule undergoes a polymerization reaction with a chemiluminescent reagent and norepinephrine, forming a product enriched with the chemiluminescent reagent. Under the action of an alkaline pH adjuster and hydrogen peroxide, a chemiluminescent signal is directly generated. This eliminates the need for covalent modification of the protein recognition molecule with the chemiluminescent reagent, reducing the loss of biomolecule activity, improving the utilization rate of the protein recognition molecule, facilitating the control of batch-to-batch variations of the chemiluminescent reagent, and effectively improving detection sensitivity. The results of the examples show that the chemiluminescent immunoassay kit provided by this invention improves the detection sensitivity of pTau217 to approximately 0.25 pg / mL.

1. The name of the design product: medicine box (adrenaline). 2. The use of the design product: for medicine box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best shows the design points: front view.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

The present invention provides a formulation that includes a therapeutically effective amount of phenylephrine or a pharmaceutically acceptable salt thereof, and a method for preparing the formulation. In some embodiments, the formulation includes a tonicity agent, a citrate buffer, water, and has an initial pH of from 5.6 to 6.0. In other embodiments, the formulation includes a tonicity agent, a citrate buffer, an antioxidant, water, and has an initial pH of from 3.6 to 4.8. The formulation of the invention is sterile, stable, ready-to-administer and packaged into a polymeric syringe.

The application belongs to the field of medicine, and relates to a kind of salvia miltiorrhiza extract and pharmaceutical composition and application thereof, specifically to a kind of novel structure compound in salvia miltiorrhiza and preparation method thereof and application of the compound in preparation of medicine for preventing and treating heart failure disease, especially application in medicine for preventing and treating heart failure caused by myocardial fibrosis. Pharmacological test proves that the compound has obvious protective effect on H9c2 myocardial cell hypoxia injury, and has obvious inhibitory effect on proliferation, migration and activation of myocardial fibroblast AC16 caused by isopropyl epinephrine, and can be used for preparing medicine for preventing and treating heart failure disease.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

This disclosure provides a respiratory delivery device. In particular, this disclosure provides a delivery device used to administer particulate drugs to the target airways and lungs via inhalation. The delivery device may be suitable for emergency medical use for the delivery of active pharmaceutical ingredients, including epinephrine.

The present invention belongs to the technical field of biotechnology, and specifically discloses an exogenous injection neurotransmitter that promotes mussel byssus secretion, and a screening method and application thereof. The present invention conducted a neurotransmitter-targeted analysis of the foot tissue of thick-shelled mussels at different stages of byssus secretion, and found that the relative content of neurotransmitters serotonin (5-HT) and epinephrine (EPI) increased significantly during the foot exploration stage (P<0.05), indicating that 5-HT and EPI may be involved in regulating byssus secretion. By exogenously injecting 5-HT and EPI into the adductor muscle of mussels, it was found that after 10 injections, the byssus secretion of 5-HT and EPI increased significantly. ‑3 After 72h of MEPI, the amount of mussel byssus secretion was significantly higher than that of the control group (P<0.05), but 5-HT injection had no significant effect on promoting byssus secretion (P>0.05). Based on this, the present invention achieves the increase of mussel byssus secretion amount by injecting exogenous neurotransmitters, which lays an important foundation for studying the secretion mechanism of mussel byssus and its physiological regulation.

A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second polymer includes an alginate. The second coating has a hemostatic agent dispersed in the second polymer such that the second polymer releases the hemostatic agent as the second polymer degrades. The hemostatic agent is selected from epinephrine, tranexamic acid, chitosan and oxidized regenerated cellulose. In some embodiments, systems and methods are disclosed.

The utility model relates to the technical field of trachea cannulas, in particular to a disposable trachea cannula cuff shell. The technical problems that in the using process of the trachea cannula, it is found that when the air tightness of a cuff is checked, it is not obvious through simple cuff whipping and verification, and when the trachea cannula is inserted, the cuff often makes contact with teeth and rubs the teeth to a certain degree, and the teeth possibly scratch the cuff are solved. According to the technical scheme, the disposable trachea cannula cuff shell comprises a trachea cannula body, a top connecting assembly, a tube core, a cuff sealing protection assembly, an insertion connecting tube and a whipping connecting tube. Under the protection of the cuff sealing protection assembly, the air tightness detection device can achieve the effect of rapidly detecting the air tightness, lidocaine and epinephrine can be injected, stimulation to an airway is reduced, spasm is relieved, meanwhile, a certain tube moistening effect is achieved, the air tightness detection of the cuff body is more accurate, and the cuff body can be prevented from being polluted by the external environment.

The invention relates to the technical field of feeds, and particularly discloses an anti-stress feed for lambs. The feed comprises the following raw materials in parts by weight: 200 parts of corn, 100 parts of soybean meal, 50 parts of cottonseed meal, 200 parts of corn germ meal, 200 parts of alfalfa meal, 40 parts of pine needle meal, 50 parts of palm meal, 10 parts of a yeast culture, 22 parts of stone powder, 10 parts of montmorillonite, 8 parts of baking soda, 6 parts of table salt, 0.5 part of tannic acid, 0.5 part of bacillus subtilis, 0.5 part of compound enzyme, 0.1 part of a mildew preventive, 0.1 part of an antioxidant, 4 parts of 70 lysine and 0.3 part of a radix astragali crude extract. According to the feed formula, the immune function and endocrine balance of lamb organisms are effectively adjusted, and secretion of cortisol, epinephrine and other stress hormones in the stress state is reduced; meanwhile, the feed effectively guarantees nutritional ingredients, accelerates the growth speed of the lambs, reduces the digestive system burden of the lambs, and is simple in preparation process and convenient to popularize and apply.

The table multifunctional medicine management tray comprises an open tray and partition plates, the partition plates divide the interior of the open tray into a first cavity, a second cavity, a third cavity, a fourth cavity, a fifth cavity and a sixth cavity, the different cavities are used for storing different medicines and objects, and the sixth cavity is used for storing different medicines and objects. In addition, a plurality of cotton piece containing positions are arranged in the first cavity, nurses can soak cotton pieces in epinephrine stock solution and then place the cotton pieces on the cotton piece containing positions, after doctors clamp the cotton pieces, numbers can be dynamically displayed through a number prompt mechanism, and after the operation is finished, the number prompt mechanism can prompt the numbers to be displayed. The number of used cotton pieces can be rapidly determined through prompted numbers and compared with the number of recycled used cotton pieces, closed-loop counting is achieved, the cotton piece loss problem is avoided, the operation safety is improved, and the operation efficiency is optimized.

The present invention belongs to the technical field of preparation of new materials, and discloses a binuclear phthalocyanine modified iron molybdate composite material, preparation, detection method and sensor. The preparation method comprises: modifying the binuclear phthalocyanine on the prepared iron molybdate by a two-step hydrothermal method, and preparing a binuclear phthalocyanine modified iron molybdate composite material as a peroxidase mimetic enzyme for rapid colorimetric sensing of adrenaline. The iron molybdate in the present invention is easy to prepare, quick and easy to obtain. The present invention uses the prepared binuclear phthalocyanine modified iron molybdate composite material for rapid colorimetric detection of adrenaline. The binuclear phthalocyanine modified iron molybdate composite material prepared by the present invention is used for rapid colorimetric detection of adrenaline, and the detection limit can be as low as micromolar level, the detection speed is fast, and the operation is simple.

The invention discloses a traditional Chinese medicine charcoal medicine for resisting myocardial infarction, belongs to the technical field of medicines, and relates to a charcoal medicine prepared from labiatae plants, in particular to a new application of a charcoal medicine prepared from radix salviae miltiorrhizae in preparation of a medicine for resisting acute myocardial infarction. Animal pharmacological experiments show that the radix salviae miltiorrhizae charcoal has a definite protective effect on acute myocardial infarction caused by isoprenaline hydrochloride, and can reduce the myocardial enzyme levels (CK, CK-MB, LDH and AST) in serum, increase the levels of SOD, MDA, GSH and CAT in myocardial tissue and improve the activity of Na < + >-K < + >-ATP enzyme and Ca < 2 + >-Mg < 2 + >-ATP enzyme in the myocardial tissue.