27 results about "Epinephrine" patented technology

Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg / mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg / mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg / mL sodium citrate dihydrate, 3.3 mg / mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg / mL of sodium metabisulfite, and 4 μg / mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg / mL of epinephrine and other ingredients.

The application discloses a capillary open-tube chromatographic column preparation method based on a defect engineering metal organic framework-molecular imprinting composite nanomaterial and application, and particularly relates to the field of chemical synthesis and analysis technology. A GLYMO-IDA-silane solution is used to flush a pretreated capillary, so that a carboxyl-modified capillary is obtained. Then, an N,N-dimethylformamide solution containing zirconyl chloride octahydrate, terephthalic acid, L-proline and hydrochloric acid is injected into the cysteine-modified capillary, and under a heating condition, a metal organic framework UiO-66-L-Pro is in-situ grown on the inner wall of the capillary. D-tryptophan and norepinephrine are dissolved in a neutral buffer solution, and after magnetic stirring for 30 min, ferrous sulfate is added and rapidly injected into the UiO-66-L-Pro-modified capillary, and then both ends are sealed, and reaction is carried out at room temperature for 24 h. An acetic acid / SDS solution mixture is used to flush the capillary for 1.5 h to elute the template molecules, and then nitrogen is used to blow dry, so that an MIP@UiO-66-L-Pro@capillary is prepared.

The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

The present invention relates to a guide sheath for peripheral bronchial lesion treatment, comprising a side tube for saline infusion, and injects physiological saline, which has been injected for peripheral bronchial dilation and access, through the side tube so that the physiological saline can efficiently reach a peripheral lung lesion as the physiological saline is injected through the side tube without insertion and removal of the guide sheath as in a conventional procedure, such that the precision and efficiency of a bronchoscopy procedure for diagnosing the peripheral lung lesion can be improved. In a conventional procedure, cold physiological saline or epinephrine for hemostasis could be administered after removal of the guide sheath and biopsy forceps, but the side tube of the guide sheath can administer a solution that assists hemostasis immediately after biopsy such that reduced side effects after the procedure and improved safety for the patient can be expected.

A housing for hypodermic device including a housing assembly, a hypodermic device housed therein, twist off top and bottom caps. The housing assembly includes an upper and lower ends, exterior and interior walls. The exterior and interior walls definine a vacuum sealed in-between space, and the interior wall defines an interior cavity. The top and bottom caps include first and second tabs, respectively. The hypodermic device has proximal and distal ends. The hypodermic device includes auto injectors such as epinephrine auto injector, insulin auto injector or similar. The exterior and interior walls are vacuum sealed layers made of a rigid material that protect the hypodermic device from impact and accidental activation and keep the hypodermic device at a range of temperature for a longer period of time. A ring attachment is adjacent to the upper end, and it secures to backpacks, purses, garments or similar.

The invention belongs to the field of shellfish culture, and particularly relates to a method for efficiently promoting chlamys farreri larva attachment and metamorphosis through noradrenaline. Aiming at the problem of low attachment and metamorphosis rate in the current chlamys farreri breeding process, the invention provides the method for efficiently promoting the attachment and metamorphosis of the chlamys farreri larvae by using the chemical inducer noradrenaline, and a technical support is provided for improving the attachment and metamorphosis rate in the chlamys farreri seedling production process.

This invention belongs to the field of in vitro detection technology, specifically relating to a chemiluminescent immunoassay kit and its application in immunoassay. The chemiluminescent immunoassay kit provided by this invention uses a first target protein recognition molecule and a second target protein recognition molecule to capture proteins. Horseradish peroxidase on the second target protein recognition molecule undergoes a polymerization reaction with a chemiluminescent reagent and norepinephrine, forming a product enriched with the chemiluminescent reagent. Under the action of an alkaline pH adjuster and hydrogen peroxide, a chemiluminescent signal is directly generated. This eliminates the need for covalent modification of the protein recognition molecule with the chemiluminescent reagent, reducing the loss of biomolecule activity, improving the utilization rate of the protein recognition molecule, facilitating the control of batch-to-batch variations of the chemiluminescent reagent, and effectively improving detection sensitivity. The results of the examples show that the chemiluminescent immunoassay kit provided by this invention improves the detection sensitivity of pTau217 to approximately 0.25 pg / mL.

1. The name of the design product: medicine box (adrenaline). 2. The use of the design product: for medicine box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best shows the design points: front view.

The present invention provides a formulation that includes a therapeutically effective amount of phenylephrine or a pharmaceutically acceptable salt thereof, and a method for preparing the formulation. In some embodiments, the formulation includes a tonicity agent, a citrate buffer, water, and has an initial pH of from 5.6 to 6.0. In other embodiments, the formulation includes a tonicity agent, a citrate buffer, an antioxidant, water, and has an initial pH of from 3.6 to 4.8. The formulation of the invention is sterile, stable, ready-to-administer and packaged into a polymeric syringe.

The application belongs to the field of medicine, and relates to a kind of salvia miltiorrhiza extract and pharmaceutical composition and application thereof, specifically to a kind of novel structure compound in salvia miltiorrhiza and preparation method thereof and application of the compound in preparation of medicine for preventing and treating heart failure disease, especially application in medicine for preventing and treating heart failure caused by myocardial fibrosis. Pharmacological test proves that the compound has obvious protective effect on H9c2 myocardial cell hypoxia injury, and has obvious inhibitory effect on proliferation, migration and activation of myocardial fibroblast AC16 caused by isopropyl epinephrine, and can be used for preparing medicine for preventing and treating heart failure disease.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

This disclosure provides a respiratory delivery device. In particular, this disclosure provides a delivery device used to administer particulate drugs to the target airways and lungs via inhalation. The delivery device may be suitable for emergency medical use for the delivery of active pharmaceutical ingredients, including epinephrine.

The table multifunctional medicine management tray comprises an open tray and partition plates, the partition plates divide the interior of the open tray into a first cavity, a second cavity, a third cavity, a fourth cavity, a fifth cavity and a sixth cavity, the different cavities are used for storing different medicines and objects, and the sixth cavity is used for storing different medicines and objects. In addition, a plurality of cotton piece containing positions are arranged in the first cavity, nurses can soak cotton pieces in epinephrine stock solution and then place the cotton pieces on the cotton piece containing positions, after doctors clamp the cotton pieces, numbers can be dynamically displayed through a number prompt mechanism, and after the operation is finished, the number prompt mechanism can prompt the numbers to be displayed. The number of used cotton pieces can be rapidly determined through prompted numbers and compared with the number of recycled used cotton pieces, closed-loop counting is achieved, the cotton piece loss problem is avoided, the operation safety is improved, and the operation efficiency is optimized.

The present invention relates to a liquid pharmaceutical composition for oral administration in the form of suspension which comprises the combination of ibuprofen and phenylephrine, or a pharmaceutically acceptable salt thereof, as active substances, and hypromellose, xanthan gum, liquid maltitol, glycerine and water. The composition is stable, has good organoleptical properties and shows excellent pharmacokinetic profile, providing quick absorption of the drugs. The present invention also relates to the use of the composition for treating the symptoms of flu and common cold, particularly in adults and in children over 7 years.

The invention relates to a preparation method of a stable rat model for primary dysmenorrhea with syndrome of cold coagulation and blood stasis, belongs to the technical field of animal model construction, and particularly relates to a construction method of a rat model for primary dysmenorrhea according with the pathogenesis characteristics of cold coagulation and blood stasis in traditional Chinese medicine. The model simulates the pathological process of cold evil invasion and uterus stasis and combines a modern medical hormone intervention means to realize the construction of a'disease and syndrome combined 'animal model, and is mainly used for the anti-dysmenorrhea mechanism research and drug screening of traditional Chinese medicine compound, acupuncture and other therapies. The adopted preparation method comprises the steps that 0.4 mg of estradiol benzoate is subcutaneously injected to each rat every day for 12 days, the injection dosage of the first day and the injection dosage of the last day are increased to 2 times, the rats are placed in the environment of-20 DEG C after injection is completed, epinephrine is injected twice every day from the 6th day of molding, and 2 U of oxytocin is injected to each rat intraperitoneal cavity 24 hours after the epinephrine is injected for the last time. The animal model obtained through the method is stable in phenotype and good in repeatability, compared with pure cold or pure irritation, more remarkable pain behaviors and biochemical changes can be obtained in a short period through combination with epinephrine, and pharmacodynamic screening is facilitated.

The invention relates to a specific composition comprising in particular at least gellan gum and phenylephrine. It also relates to a particular method for manufacturing such a composition and its uses in particular as a mydriatic ophthalmic product.

A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.

The invention relates to a method for regulating and controlling production of citrinin from penicillium citrinum by exogenous signal molecules and application of the method in mildew prevention of food and agricultural products. Penicillium citrinum fermentation liquor is analyzed through metabonomics, and key signal molecules of farnesol, tyrosol, linoleic acid, cytidine, tryptophan and noradrenaline for regulating the growth of the penicillium citrinum are screened out. Based on the fact that the signal molecules can be used for regulating and controlling the growth retardation period, the maximum growth rate and the citrinin yield of penicillium citrinum, the action target of each signal molecule is clarified, meanwhile, verification is carried out in a Liupao tea system, the method utilizes a microbial quorum sensing mechanism, precise mildew prevention is achieved through targeted regulation and control of toxin-producing genes, and the application prospect is wide. The method has the characteristics of high efficiency and safety, provides a new environment-friendly method for food safety regulation and control of tea, feed and other related fermented products, and also provides a new view angle and method for research of microbial metabolism regulation and control.

A management system for medication includes an electronic case configured to support a user's medication and a computing device configured to communicate with the case. The case includes one or more sensors, such as a pressure sensor, to produce sensor information indicating whether the medication is disposed in the case, a battery sensor to indicate a charge level of the case, and, in some examples, a location sensor to indicate a location of the case. A controller obtains the sensor information and provides status information to the computing device. The computing device provides notifications based on the status information and, in some examples, automatically or semi-automatically initiates communications to designated emergency contacts in response to determining that medication has been removed from the case. The case can include light sources and a speaker controlled by the controller. An identifier, such as a near-field communication tag, can associate the case with a user. Status information can be shared with additional users (e.g., caregivers). The system is suitable for emergency medications such as epinephrine nasal spray.

The utility model discloses a phenylephrine hydrochloride crystallizing device which comprises a dissolving tank and a crystallizing tank which are communicated with each other, the dissolving tank is communicated with a methanol storage tank, the crystallizing tank is communicated with an ethyl acetate storage tank, the upper part of the crystallizing tank is provided with a material distribution disc, and the material distribution disc is communicated with the ethyl acetate storage tank through a first liquid conveying pipeline; a plurality of material spraying heads are arranged on the material distribution disc; the dissolving tank is communicated with the crystallizing tank through a second liquid conveying pipeline, a spiral material distributing pipe is arranged at the lower part of the crystallizing tank, and a plurality of material outlets are formed in the spiral material distributing pipe; a first stirring device is arranged in the dissolving tank, a second stirring device is arranged in the crystallizing tank, a reflux inlet is formed in the crystallizing tank, the reflux inlet is communicated to the material distribution disc through a reflux pipeline, and a reflux pump and a cooler are arranged on the reflux pipeline. The device is high in heat exchange efficiency, easy to control the crystallization process and good in crystallization effect.

A thermogenic composition prevents the adverse effects of cold exposure and / or mitigates hypothermia. Epinephrine, atropine sulfate, phenylephrine hydrochloride, L-carnitine, vitamin B12, magnesium sulfate, and saline solution are homogeneously mixed to form an injectable formulation for the thermogenic composition. Capsaicinoids, capsinoids, ginger extract, L-citrulline, grains of paradise extract, taurine, caffeine anhydrous, L-theanine, green tea extract, black pepper extract, potassium citrate, sodium citrate, and magnesium citrate anhydrous are heterogeneously mixed to form a capsulated formulation for the thermogenic composition.

The invention relates to the technical field of biology, in particular to a primer pair, a primer probe composition, a PCR premix, a kit and a method for detecting multiple respiratory pathogens. The invention discloses a primer pair with nucleic acid sequences as shown in SEQ ID NO: 1-2, 4-5, 7-8, 10-11, 13-14, 16-17, 19-20, 22-23, 25-26, 28-29, 31-32, 34-35, 37-38 and 40-41. Aiming at a target respiratory pathogen, a specific amplification primer pair is designed and is matched with a proper probe, so that eight-target joint detection can be realized, and the influence of heme, trimethoprim, sulfamethoxazole, amphotericin B, itraconazole, fluconazole, azithromycin, epinephrine and lidocaine hydrochloride in a detection sample can be avoided in the detection process; the anti-interference performance is good, and cross reaction with rhodococcus equi, candida tropicalis and candida krusei does not exist.

The invention provides a method for detecting N-nitrosophenylephrine in phenylephrine hydrochloride bulk drugs or preparations (such as phenylephrine hydrochloride eye drops and compound tropicamide eye drops) based on UPLC (Ultra Performance Liquid Chromatography). When the method is used for detection, the baseline is stable, the separation degree is high, the operation is simple, the result is accurate, the reproducibility is good, the recovery rate is reliable, the detection cost is low, the detection efficiency is high, the consumption of an organic solvent is reduced, the method is more economical and environment-friendly, and a new analysis means is provided for internal quality control of raw material medicines or preparations.

The application provides a preparation method of a hydroxylase-like biomimetic single-atom nanoscale enzyme and application thereof in dopamine electrochemical sensing. The steps are as follows: zinc acetate, copper nitrate solution and 2-methyl imidazole solution are mixed, and copper-doped ZIF-8 precursor 1 is obtained after standing and aging; the precursor 1 is dispersed in a urea solution, a negative pressure environment is applied, and the urea-filled copper-doped ZIF-8 precursor 2 is obtained after centrifugal washing; high-temperature calcination is carried out under argon protection, acid washing is carried out, and freeze-drying is carried out, so that the hydroxylase-like biomimetic single-atom nanoscale enzyme is obtained; and the nanoscale enzyme is ultrasonically mixed with a reduced graphene oxide solution to obtain a nanoscale enzyme composite material. The material designed by the application has an active site similar to dopamine beta-hydroxylase. Under a suitable potential, the material can specifically catalyze the hydroxylation of the beta-position carbon atom of dopamine. Meanwhile, a strong electrochemical signal is generated, so that specific electrochemical detection of dopamine is realized, and obvious distinction from norepinephrine and epinephrine is effectively realized.

The invention provides a preparation method of melanin-cellulose composite gel, which comprises the following steps: respectively dissolving carboxylated cellulose nanofiber and ammoniated micron fiber in a proper amount of water to obtain dispersion liquid; adding amino acid doped noradrenaline nanoparticles and CaCl2 into the dispersion liquid, adding an ethylene and vinyl alcohol copolymer EvOH, and stirring to fully foam, so as to obtain a gel liquid 1; then preparing a part of foaming gel liquid 2 which does not contain amino acid doped noradrenaline nanoparticles; respectively freezing and mixing the gel liquid 1 and the gel liquid 2, and freeze-drying to remove moisture to obtain the aerogel. By preparing the new photo-thermal material, the capturing capacity of the surface of the evaporator on solar energy can be greatly enhanced, and the photo-thermal conversion efficiency can be improved. Meanwhile, due to the design of aerogel, the evaporation performance of the evaporator is also remarkably improved, the problem that the evaporation rate is reduced due to salt accumulation is effectively solved, and good economic and social benefits are achieved.

The application discloses a preparation method of a bladder cancer orthotopic tumor-bearing rat model of blood stasis and toxin syndrome, and has the characteristics that 0.3ml / g of chloral hydrate is injected into the abdominal cavity of an SD rat to perform anesthesia, after the anesthesia takes effect, the rat is fixed in a supine position, the perineum of the rat is disinfected with iodophor, a catheter is slowly inserted into the bladder along the posterior wall of the urethral orifice of the rat to suck out urine, 0.2mL of MNU solution is injected into the bladder of the rat, after the injection is completed, the catheter is withdrawn, and the urethral orifice is gently clamped, the injection is repeated once every two weeks, and the injection is performed four times in total, 0.2ml of adrenaline hydrochloride is subcutaneously injected into the nape of the rat, the injection is performed once every two days, and the injection is continuously performed for eight weeks, the self-tumorigenic model of the bladder cancer model of the rat is constructed, compared with tumor-bearing and ectopic transplantation and other bladder cancer models, the model can better reflect the pathological process of the bladder cancer, the model construction simultaneously considers the syndrome characteristics of the blood stasis and toxin syndrome of traditional Chinese medicine, is beneficial to observation of the pathological process of the blood stasis and toxin type bladder cancer model in the later stage, and can be used for observation of curative effects and indexes after intervention of traditional Chinese medicines.

An animal model of ischemia with non-obstructive coronary arteries and a preparation method therefor, relating to the technical field of medical experiments. The preparation method for the animal model of ischemia with non-obstructive coronary arteries comprises: providing an experimental animal; and injecting sodium laurate and isoproterenol into coronary artery branches of the heart of the experimental animal to obtain an animal model of ischemia with non-obstructive coronary arteries. By injecting sodium laurate and isoproterenol into different coronary artery branches of the heart to prepare the animal model of ischemia with non-obstructive coronary arteries, the problem in existing myocardial ischemia models that non-obstructive myocardial ischemia is difficult to achieve is solved, and the method can achieve non-obstructive myocardial ischemia at different positions of the heart in a targeted manner and is controllable.