The invention discloses a medicine composition for treating the infectious bursal diseases of chickens and a preparation method thereof. The medicine composition for treating the infectious bursal diseases of the chickens is prepared by the following traditional Chinese medicines according to a certain proportion in parts by weight: 40 to 80 parts of dandelion, 60 to 100 parts of isatis leaf, 160 to 240 parts of radix isatidis, 40 to 80 parts of honeysuckle, 20 to 60 parts of baikal skullcap root, 20 to 60 parts of yellow-corktree bark, 20 to 60 parts of wrinkled giant hyssop, 60 to 120 parts of gypsum, 40 to 80 parts of licorice, 25 to 40 parts of organic acid, 40 to 60 parts of weak base, 3 to 6 parts of lubricant and 5 to 10 parts of sweetening agent. The preparation formulation of the composition is effervescent granules. The preparation method comprises the following steps of: pulverizing the bulk drugs, adding water, decocting, carrying out alcohol precipitation on filtrate, concentrating after recovering ethanol from supernatant liquid, and drying so as to obtain an extract; and dividing the extract into two equal parts, adding the organic acid, the lubricant and the sweetening agent into one part so as to prepare acid granules, drying for standby application, adding the weak base, the lubricant and the sweetening agent into the other part so as to prepare alkali granules, drying for standby application, then mixing the two kinds of granules evenly, granulating and packaging so as to obtain the medicine composition for treating the infectious bursal diseases of the chickens. Various medicines in the medicine composition for treating the infectious bursal diseases of the chickens are combined for use. The medicine composition for treating the infectious bursal diseases of the chickens has the effects of invigorating qi, strengthening the spleen, nourishing yin, clearing heat, cooling blood, removing toxic materials and the like. The effect of treating the infectious bursal diseases of the chickens by utilizing the medicine composition for treating the infectious bursal diseases of the chickens is obvious; and moreover, the cost is low, and the toxic or side effect is small.