8 results about "Effervescent granules" patented technology

The invention discloses phospholipid liposome effervescent granules and a preparation method thereof, and belongs to the field of food processing. The phospholipid liposome effervescent granules comprise the following raw materials in parts by mass: 10-50 parts of phospholipid, 1-5 parts of an emulsifier, 1-90 parts of a water-soluble auxiliary material, 1-5 parts of an antioxidant, 10-50 parts of an acid source, 10-50 parts of a carbon dioxide source, 1-5 parts of essence and 20-100 parts of water. After the phospholipid liposome effervescent granules provided by the invention are put into water, an effervescent reaction can be instantaneously carried out, and violent fluid shear force and bubbles are generated along with the effervescent granules, so that the phospholipid liposome is promoted to be quickly dissolved, the phospholipid liposome can be completely dissolved, and an obtained water-soluble product has long-acting stability and is free of toxic and side effects. And the water-soluble auxiliary material is added as a protective matrix, so that the structural stability can be maintained while high-content phospholipid is encapsulated, the active components of the phospholipid can be effectively absorbed by a human body, and the effervescent reaction can also cover the uncomfortable mouth feel of the high-content phospholipid.

The invention provides a complex microbial inoculant, effervescent granules and application, and belongs to the technical field of microorganisms. The invention provides a complex microbial inoculant. The complex microbial inoculant comprises bacillus halotolerant SSF1 and bacillus licheniformis LU1. The complex microbial inoculant has relatively high enzyme activity of endo-glucosidase and relatively good cellulose degradation capability. The complex microbial inoculant is used as an active component and can be combined with a disintegrating agent, a lubricating agent, an adhesive and the like to prepare effervescent granules. The obtained effervescent granules are short in disintegration time and large in foaming amount, the pH value of the effervescent granules is close to the pH value of pure water after the effervescent granules are completely disintegrated, the viable count of the complex microbial inoculant can be efficiently kept, and the complex microbial inoculant can maintain high activity. The result of the embodiment shows that when the effervescent granules of the complex microbial inoculant are applied to wheat planting, the growth of wheat can be remarkably promoted, the germination number of wheat can be increased, and the overground part length, the underground part length, the fresh weight root-crown ratio and the dry weight root-crown ratio of wheat can be improved.

The invention relates to the technical field of oral hygiene products, and particularly provides a denture cleaning tablet and a preparation method thereof, the denture cleaning tablet comprises a cleaning layer and a coating layer at least partially coating the surface of the cleaning layer; the coating layer comprises pullulan or pectin; the cleaning layer sequentially comprises an upper layer, a middle layer and a lower layer from top to bottom; wherein the upper layer comprises effervescent particles, a surfactant, an activating agent, a color developing agent, essence, filler, a preservative and a scale inhibitor; the middle layer comprises water-soluble matrix microspheres and a chelating agent; the lower layer comprises a rice bran bioactive component, sodium phytate and an adhesive; in the upper layer, the effervescent granules comprise quick-release granules and slow-release granules, and the mass ratio of the quick-release granules to the slow-release granules is (1.5-2): (1-1.3). According to the denture cleaning sheet, the effective sterilization and microorganism inactivation process is observed through the color development reaction between the color developing agent and the oxidizing agent, the color change in an aqueous solution is changed from blue to green, and the sterilization effect can be detected more visually and rapidly.

The present invention relates to a pharmaceutical composition comprising ibuprofen or a pharmaceutically acceptable derivative thereof and one or more solubilizers in the form: A) an aqueous solution for intravenous administration comprising a sodium salt or lysine salt of ibuprofen, acetaminophen and preferably one or more cyclodextrins; or B) an aqueous solution for intravenous administration wherein the one or more solubilizing agents are one or more essential amino acids and optionally one or more cyclodextrins; or C) a composition for oral administration comprising acetaminophen and cyclodextrin wherein the composition is in the form of i) an effervescent tablet or effervescent granule, or ii) an oral suspension or syrup or oral solution, or iii) a soft capsule.

The present application relates to a kind of calcium carbonate D3 effervescent granules and its preparation method, belong to biological medicine preparation technical field.The present application utilizes calcium carbonate and anhydrous citric acid to prepare granule A, utilizes vitamin D3 and alkali source to prepare basic granule B, then granule A, granule B are mixed with acid source again to obtain calcium carbonate D3 effervescent granules;The present application of calcium carbonate D3 effervescent granules meets water and causes acid-base neutralization reaction, quickly forms suspension;The present application of calcium carbonate D3 effervescent granules does not contain ethanol aqueous solution, anhydrous ethanol, isopropanol and other organic solvents, product safety is higher, production cost is lower;Calcium carbonate D3 effervescent granules accelerate 6 months, character is stable, does not occur acid-base reaction, does not produce carbon dioxide gas, stability is good, solve the effervescent granule in the process of placement, prone to acid-base reaction, produce carbon dioxide, the problem of affecting product quality.

The application discloses a preparation process of effervescent granules of a composition containing phenylephrine hydrochloride, which is prepared by taking phenylephrine hydrochloride as a main active ingredient, and by adding antiallergic agents, expectorants, antitussives, antipyretics, anti-inflammatory agents and combinations thereof. In order to prevent degradation of phenylephrine hydrochloride, the phenylephrine hydrochloride is first wrapped with PEG together with an alkali source, and then mixed with other components to prepare the effervescent granules. The effervescent granules prepared by the method have the advantages of high drug stability, rapid effect, high bioavailability, convenient carrying and low cost, and are suitable for children, the elderly and patients who cannot swallow solid preparations.

The invention discloses red raspberry effervescent granules and a preparation process thereof, and belongs to the technical field of preparation of effervescent granules. The red raspberry effervescent granules disclosed by the invention comprise the following components in percentage by weight based on the total weight of the effervescent granules: 15-25% of red raspberry extract freeze-dried powder, 40-60% of mannitol, 2-6% of an adhesive, 30-40% of a disintegrating agent, 0.5-2% of a flavoring agent and 0.1-1% of an inclusion agent, the preparation method comprises the following steps: uniformly mixing freeze-dried powder of the red raspberry extract, citric acid serving as an acidic disintegrating agent and mannitol serving as a diluent, adding a solution containing an adhesive to prepare wet acid particles, and drying to obtain acid particles; uniformly mixing the included alkaline disintegrating agent sodium bicarbonate with the diluent mannitol, adding the solution containing the adhesive to prepare wet alkali particles, and drying to obtain alkali particles; and uniformly mixing the obtained acid particles, alkali particles and a flavoring agent to obtain the red raspberry extract effervescent particles. The preparation process disclosed by the invention is scientific, reasonable, simple and feasible, low in cost and high in benefit, and provides a certain reference for subsequent development of functional foods.

The application belongs to the technical field of veterinary medicine preparation, and particularly discloses a high-stability veterinary florfenicol effervescent granule and a preparation method thereof, and aims to solve the problem that florfenicol is prone to amide bond hydrolysis and racemization degradation in an acid-base environment of the effervescent granule in the prior art. In the application, a core-shell buffer mesocrystal with sodium phosphate dibasic as the core and citric acid as the shell is used as a drug active chemical protection core, and when water is encountered, the outer shell citric acid is instantaneously dissolved to establish a protective pH microenvironment; and a hydrophilic PEG / hydrogenated vegetable oil coated effervescent acid source is used to realize programmed disintegration. The product has outstanding accelerated stability, and the degradation product is less than 0.5% in 30 days, and the process is simple and controllable.