988 results about "Pullulan" patented technology

The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of active drugs through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.

The invention is a hard capsule comprising pullulan in an amount of 85% to 90% by weight, potassium chloride in an amount of 1.0% to 1.5% by weight, carrageenan in an amount of 0.1% to 0.4% by weight, one or more surfactants in an amount of 0.1% to 0.2% by weight and water in an amount of 10% to 15% by weight. Additionally the invention is related to new uses of pullulan containing containers.

The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin, as well as other therapeutic agents either with or without nitroglycerin, through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.

Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films are effective at killing the plaque-producing germs that cause dental plaque, gingivitis and bad breath. The film can also contain pharmaceutically active agents. Methods for producing the films are also disclosed.

A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided.

A microneedle device (1) includes a plurality of microneedles (3) on a microneedle substrate (2), which are capable of piercing the skin. A portion of or entire surface of the microneedles (3) and/or the microneedle substrate (2) has a coating including a coating carrier in a solid state. The coating carrier includes a high molecular weight pharmaceutical compound and polysaccharides compatible with the high molecular weight pharmaceutical compound. Herein, as the polysaccharide, for example, pullulan or hydroxypropylcellulose can be used.

The invention provides a multifunctional aerogel material for blood component protection and a preparation method of the multifunctional aerogel material. Gellan gum, hyaluronic acid, Pullulan, Lubrajel CG andpoly(gamma-glutamic acid), derivatives or a mixture thereof are taken as a skeleton to act with a novellight-sensitive material, aerogel or a precursor for preparation of the ready-to-useaerogel material, and then multifunctional ready-to-useaerogel composite is prepared from the ready-to-useaerogel material as well as raw materials includingglucose, a novel solvent, a novel fixing agent, a buffering agent, a stabilizer, a novel preservative, a surfactant, a high-molecular compound, essential oil, an antioxidant and the likewith a three-spectral-line high-energy photocuring method by utilizing a high polymer material such as hyaluronic acid and the like as the skeleton. The material has the characteristics of being convenient to use, green, environment-friendly and the like, the whole blood component treated with the material keeps good cellular morphology, is stored for a long time, reducesbatch-to-batch difference and is an ideal additive for a whole blood controlling product and other products, and the material can also be applied to collection, storage and transfer of tissue cells as well as fields of cosmetics, food, drugs and the like.

The invention provides a modified membrane fabric and a preparation method and application of the modified membrane fabric. The surface of the modified membrane fabric is coated with a polymer or polymer dispersion, and the polymer in the polymer or polymer dispersion may be polysaccharide, polypeptide and protein, may be an artificial polymerized polymer or may be a modified natural high polymer material or a mixture thereof, including but not limited to one or more selected from the group consisting of gelatins (such as gelatin and gelatin hydrolysate), cellulose ethers (e.g., carboxymethyl cellulose and hydroxyethyl methyl cellulose), modified starches (e.g., pullulan and hydroxypropyl starch), PVP, PVA, hyaluronic acids, albumin, chitosan, dextran, Arabic gum, xanthan gum, carrageenan, pectin, konjac gum, agar, Carbomer, carrageenin, polyvinylpyrrolidone, polyacrylamide, polyacrylate and polyacrylic acid and its derivatives. When the modified membrane fabric comes across water in use, the polymer on the surface of the modified membrane fabric can bond with water molecules to form a water retention system which has better retention performance compared with pure water and enables an evaporation speed to be slower and retention performance on the skin to be better.

The present invention discloses a hollow hard capsule and its preparation method. It is made up by adopting prolanpolysaccharide as main body material and adding gelling agent, coagulant aids, surfactant and humectant through a certain preparation process. Said invention also provides the concrete steps of its preparation method.

The invention relates to a reprocessed cheese capable of being preserved at normal temperature and a preparation method thereof. The method comprises the following steps of: cutting, melting, mixing and stirring natural cheese serving as a main raw material; adding water, an emulsifying agent and the like into the natural cheese; heating the natural cheese for melting; after performing ultra-high-temperature (UHT) flash sterilization, filling an obtained cheese melt into a sterilized cellulose sausage casing while the cheese melt is hot; cooling the cheese melt to the temperature of between 20 and 40 DEG C; stripping off the sausage casing by using a bacteria-free stripping machine; spraying edible Pullulan, CMC and sodium alga acid in a ratio of 10-20:0-10:0-10 on the cheese melt to form an outer film; spraying or coating smoke solution; packaging by using edible glutinous rice paper; and packing and preserving by kinking aluminum foil sugar paper. The method has the characteristics of simple and easy implementation and easy operation; the outer sheath of a product is of a smoke color; and the inside of the product presents cream yellow like the natural cheese and has slightly smoke color and flavor. Based on the theory, the development of various application products such as breakfast grain cheese, jelly cheese and the like can be performed; and mouthfeel, texture, nutrition and the like meet the requirements of consumers.

The invention provides mutant aureobasidium pullulans TKPM00006 for massively producing beta-poly(malic acid) and a method for producing poly(malic acid) by using the mutant through fermentation. The strain is the mutant for producing beta-poly(malic acid) with high yield, which is cultured by multiple groups of composite mutagenesis technology based on beta-poly(malic acid) producing TKPM10017 screened in the soil of Wang Taibao orchard, Yinchuan, Ningxia Hui Autonomous Region, China. Under the optimization condition, the yield of beta-poly(malic acid) reaches 18.4+/-1.3g/l.

The present invention has as its object to provide a band-seal to manufacture a leak-tight, stable hard capsule preparation not being susceptible to deformation after having filled pharmaceuticals, foods, healthy foods, etc. in a hard capsule comprising a polyvinyl alcohol copolymer or pullulan as a base, and in more particular, relates to a band-seal intended for use in the hard capsule comprising a polyvinyl alcohol copolymer or pullulan as a base, characterized in that the band-seal is incorporated with at least one or not less than two of the below-described (a) to (c): (a) A polyvinylpyrrolidone with a molecular weight of 100,000 to 4,000,000, (b) A polyvinylpyrrolidone with a molecular weight of 10,000 to 80,000 in the proportion of not more than 90% by weight against the total weight of the band-seal; and (c) A copolymer from 1-vinyl-2-pyrrolidone and vinyl acetate.

The invention discloses a hard-shell capsule based on pullulan. Based on the total weight of the hard-shell capsule, the hard-shell capsule comprises the following components in percentage by weight: 80-90% of pullulan, 1-10% of hydrophilic gel, 0.1-1% of plasticizer, 0.001-0.1% of water retaining agent, 0.001-3% of surfactant and 8-12% of water. The hard-shell capsule disclosed by the invention can replace a gelatin hard-shell capsule, thereby avoiding the pollution possibly brought by an animal product. The hard-shell capsule disclosed by the invention has the advantages of stable property,good moisture resistance and good transparency; the probabilities of the frangibility and deepening of color are reduced during long-term storage; and the uptake rate of the filling of a medicine is improved.

The invention discloses an essence particle additive as well as a preparation method and an application thereof. The particle additive consists of a particle carrier, cigarette essence and a polymeric membrane, wherein the particle carrier is used for loading the cigarette essence, and the polymeric membrane is used for coating the particle carrier loaded with the cigarette essence; the particle carrier is composed of calcium carbonate particles, a molecular sieve, tea dust, microcrystalline cellulose or cellulose microspheres; the cigarette essence is isoamyl alcohol, phenethyl alcohol, menthol, linalool, terpinol or limonene; and the polymeric membrane is prepared from sodium alginate tech grade, carboxymethyl cellulose, hydroxyethyl cellulose or pullulan. According to the physical form of the cigarette essence, the essence particle additive can be prepared by a liquid-state method and a solid-state method. When being applied to the flavoring of a cigarette filter and the production of a cigarette, the essence particle additive has the beneficial effects that when the cigarette is not sucked, the volatilization and diffusion of the essence are restrained, and when the cigarette is sucked, the essence can be uniformly released without the dependence on external forces.

The invention discloses a pullulan enzymatic mutant with high specific activity and high thermal stability and a preparation method of the pullulan enzymatic mutant, and belongs to the field of genetic engineering and enzyme engineering. The invention improves the specific activity and the thermal stability of pullulan enzyme by site-specific mutagenesis, and provides a mutation scheme through which the catalytic specific activity and the thermal stability of the pullulan enzyme derived from debranch bacillus are improved. At least one property of the pullulan enzymatic mutant is changed: (1) the optimal reaction temperature is increased, (2), the thermal stability on the condition that the pH is 4.0 to 5.0 is improved; and (3) the specific activity on the condition that the pH is 4.0 to 5.0 is improved. The pullulan enzymatic mutants are more suitable for the production process of starch saccharification as compared with wild type pullulan enzyme.

The invention discloses a method for preparing folic acid coupled acetyl pullulan polysaccharide and the nanoparticles thereof, a preparation of drug-loaded nanoparticles which take the compound as the carrier and the role of the drug-loaded nanoparticles on the tumor cells. Firstly, the water soluble pullulan polysaccharide is converted to hydrophobic polymers by acetylation, so as to be conductive to the preparation of the nanoparticles and the loading of a hydrophobic drug, and the tumor cells with the high expression of the folate receptor can be targeted after the coupling of the folic acid by esterification. The drug-loaded nanoparticles are prepared by taking epirubicin as a model drug and adopting the solvent dispersion method, and the role of the drug-loaded nanoparticles on the tumor cells are evaluated by the in vitro cell uptake test. The results show that the method for preparing the folic acid-acetyl pullulan polysaccharide nanoparticles by the solvent dispersion method is simple, the reproducibility is good, the expanded production is easy, the drug-loading ratio is high, and the drug-loaded nanoparticles can be taken into the tumor cells by the route of the folate receptor.

The invention relates to a fermenting method for producing pullulanuse polysaccharide, which is characterized in that the method comprises following steps: firstly, preparing seed culture medium, secondly, preparing fermenting initial culture medium, thirdly, inoculating liquid seeds into the fermenting initial culture medium, wherein the inoculation amount is 3-8%, the fermentation stirring speed is 200-500rpm, the fermentation temperature is 29 DEG C +- 1 DEG C, the ventilation volume is 0.5-10V/V, and the bed pressure is 0.01-0.02MPa, fourthly, complementarily adding the other carbon source after fermenting for 24 hours, wherein the adding amount is 40-80g/L and the adding liuqid is sucrose solution or glucose solution or starch hydrolysate whose pH value is 40-60, and continuingly fermenting for 60-72 hours after adding the carbon source, fifthly, flocculating, hyper-filtrating, barrier-separating, concentrating and drying the fermenting liquid and obtaining the pullulanuse polysaccharide whose molecular weight is between 20-60 million daltons. The invention has simple technique and significant effects and prominently shortens the fermenting time, the fermenting time is 80-100 hours, the production efficiency is increased greatly, energy is saved, the yield rate of product is greatly improved, and the yield can reach by 50%.

The production process of high purity malt sugar products, including malt sugar syrup, malt sugar alcohol and solid malt sugar, includes the following steps: adding high temperature alpha-amylase into starch milk, spray liquefication, cooling, adding beta-amylase, pullulan enzyme and maltotriose hydrolase for synergetic hydrolysis, and adding medium temperature amylase to saccharify to obtain malt sugar syrup, which may be further processed to obtain other products. The present invention has simple technological process and low production cost, and expands the use of malt sugar syrup.

The invention relates to an oxygen-separating and degradable thin plastic film which contains the following raw constituents in parts by weight: 100 parts of low-density polyethylene, 50-70 parts of PBM (Plant Base Master batch), 20-40 parts of pullulan, 2-4 parts of antioxidant, and 0.5-1 part of ultraviolet light absorber. The excellent mechanical property of the thin film is guaranteed by utilizing the characteristics of LDPE (Low-Density Polyethylene), the environment friendliness of the thin film material is realized by utilizing the degradability of the PBM and the pullulan; the oxygen separating property of the thin film material is increased by utilizing the high oxygen separating property of the pullulan; the whole compatibility of the thin film material is increased by utilizing the structural similarity of starch and the pullulan as carbohydrates; and the oxygen separating property, the degradability and the like can be adjusted and controlled by controlling the blending proportion of LDPE/PBM/Pullulan systems.

The invention relates to a fire-retardant polyethylene cable material with mould-proof function, which is characterized by comprising the following components by weight portion: 45 to 70 portions of high density polyethylene resin, 30 to 55 portions of linear low density polyethylene resin, 2.35 to 2.85 portions of carbon black, 35 to 65 portions of fire retardant, 3 to 6 portions of lubricant, 0.5 to 2 portions of antioxidant, and 1 to 2 portions of antibacterial agent. The method for preparing the fire-retardant polyethylene cable material with the mould-proof function comprises the following steps: weighing raw materials according to a formulation, mixing the materials, and performing the processes of extruding, granulating and drying the materials to prepare the mould-proof fire-retardant polyethylene cable material. The mould-proof fire-retardant polyethylene cable material can effectively inhibit the growth, the forming and the reproduction of eight types of mould fungi including aspergillus niger, aspergillus terreus, aureobasidium pullulans which can easily grow on a cable under the condition that the original performances and the cabling process of the fire-retardant polyethylene cable material are not influenced, thus the cable is prevented from being infringed by the mould fungi, and a number of unnecessary loss and hidden hazards to the society are avoided.

The invention relates to the technical field of refreshing, in particular to a fruit and vegetable coating antistaling agent, aiming at providing the fruit and vegetable coating antistaling agent which has low cost, green initiative and convenient application. The invention has the following technical scheme in particular: each liter of the fruit and vegetable coating antistaling agent contains 5-50g of pullulan sugar, 0.2-2g of preservatives, 1-20g of sorbitol, 5-50g of hydrophobizing agent, 1-30g of surfactant and the balance of solvent. The invention has the following advantages: the film-forming agent used in the invention contains less usage of the pullulan sugar, thus the cost is lowered; the hydrophobizing agent is added without the influence of condensed water. The preparation of the coating agent and the operation of the coating have simple steps and strong operability.

The present invention relates to utilizing saccharide metabolism to produce extracellular water soluble polysaccharide and belongs to the field of bioengineering technology. The present invention provides strain, named Aureobasidium pullulans G-58 and with the preservation number of CGMCC No. 1234. The pullulan producing process with the strain includes fermentation culture, fermented liquid post-treatment, heat treatment, decolorizing, precipitation, desalting, drying and other steps. The pullulan product has light color, high polysaccharide content, excellent viscoelasticity, excellent emulsifying performance and plasticity, and no toxicity and harm, and may be used widely in food, medicine, cosmetics, etc.

The invention relates to the technical field of cosmetics, in particular to a composite with efficacies of water locking and moisturizing, a face mask and a face mask preparation method. The composite with the efficacies of water locking and moisturizing is prepared from, by weight, 4-8 parts of glycine betaine, 2-4 parts of trehalose, 1-2 parts of glycine soja seed extract, 5-10 parts of chamomilla recutita flower extract, 5-10 parts of carbamide, 0.5-1 part of allantoin, 0.1-0.5 part of hyaluronan, 0.2-0.5 part of sodium hyaluronate, 0.2-0.5 part of hydrolyzed sclerotium gum, 0.2-0.5 part of pullulan, 0.1-0.5 part of carbomer, 20-30 parts of glycerin and 40-70 parts of water. The composite with the efficacies of water locking and moisturizing is specially designed for water locking and moisturizing of skin and has the advantages of safety, effectiveness, easiness in absorption and applicability to addition to general cosmetics.