990 results about "Specific activity" patented technology

A system for detecting non-verbal acoustic energy generated by a subject is provided. The system includes a sensor mountable on or in a body region of the subject, the sensor being capable of sensing the non-verbal acoustic energy; and a processing unit being capable of processing the non-verbal acoustic energy sensed by the sensor and deriving an activity related signature therefrom, thereby enabling identification of a specific activity associated with the non-verbal acoustic energy.

A method and apparatus for providing personalized information content over telephones is described. The creation of a voice portal is supported by the invention. Embodiments of the invention use telephone identifying information such as the calling party's number to identify, or create, user profiles for customization. The personalized content is specific to that user based on her / his telephone identifying information and may be further customized based on the current time, current date, the calling party's locales, and / or the calling party's dialect and speech patterns. Also, the telephone identifying information may support targeted advertising, content, and purchasing recommendations specific to that user. The system may use a voice password and / or touch-tone login system when appropriate to distinguish the caller or verify the caller's identity for specific activities. Typically, embodiments of the invention will immediately present a caller personalized content based on her / his profile using the appropriate dialect as well as the caller's preferred content. Profiles can be constructed as the caller uses embodiments of the invention as well as through explicit designation of preferences. For example, as the user selects topics, as well as particular content, a record of actions can be maintained. This record of actions can be used to provide suggestions and direct the personalization of the system for the user.

A system for detecting non-verbal acoustic energy generated by a subject is provided. The system includes a sensor mountable on or in a body region of the subject, the sensor being capable of sensing the non-verbal acoustic energy; and a processing unit being capable of processing the non-verbal acoustic energy sensed by the sensor and deriving an activity related signature therefrom, thereby enabling identification of a specific activity associated with the non-verbal acoustic energy.

An 8-oxoadenine compound useful as an immuno-modulator having specific activity against Th1 / Th2, specifically a prophylactic and therapeutic agent for a topical application for allergic diseases, viral diseases and cancers, which is represented by the following formula (1): wherein A is a group of a formula represented by the formula (2): wherein R2 is a substituted or unsubstituted alkyl group and so on, R3 is hydrogen atom or an alkyl group, R is a halogen atom and so on, n is 0˜2, X1 is oxygen atom, Z is straight or branched chain alkylene, and R1 is an alkyl group which is optionally substituted by hydroxy group, an alkoxy group, alkoxycarbonyl group and so on, or its pharmaceutically acceptable salt.

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

In a method of producing isotopes in a light water power reactor, one or more targets within the reactor may be irradiated under a neutron flux to produce one or more isotopes. The targets may be assembled into one or more fuel bundles that are to be loaded in a core of the reactor at a given outage. Power operations in the reactor irradiate the fuel bundles so as to generate desired isotopes, such as one or more radioisotopes at a desired specific activity or stable isotopes at a desired concentration.

The present invention provides methods of increasing the half-life and / or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and / or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provides methods for producing such factor VIII mutants. The invention also provides polynucleotides encoding the mutant factor VIII, and methods of treating hemophilia using the polypeptides and polynucleotides of the invention.

The present invention provides uracil-DNA glycosylase (UDG) gene originating from Psychrobacter sp. HJ147, and amino acid sequences deduced from the gene; expression and purification of Psp HJ147 UDG gene in Escherichia coli; and characterization of UDG obtained therefrom, and the use thereof in a polymerase chain reaction (PCR). The UDG according to the present invention has a specific activity of excising uracil bases in a uracil-containing DNA substrates at a low temperature, and is easily heat-inactivated. It thus can effectively eliminate cross contamination and carry-over contamination of PCR templates often occurring after a PCR process using dUTP. Therefore, it is useful for increasing preciseness (elimination of false positives), purity and amplification efficiency of PCR.

The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and / or increased specific activity using saccharide substrates.

The present invention provides systems and methods that measure and analyze a user's movement during a specific activity, then provide immediate, focused feedback as to how the user can modify the movement.

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles

A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest. The sensory data logged on a computing device (computer, data logger etc.), date and time stamped, is analyzed using specialist data analysis software tools that check for the applicable task / activity detection rules. The methods are particularly useful for the continued in-home assessment of subjects living alone to evaluate their progress in response to medical intervention drug or physical therapy or decline in abilities that may be the indicator of the onset of disease over time. Measuring the frequency of each activity, the time required to accomplish an activity or a subtask and the number of activities / subtasks performed continuously over time can add extremely valuable quantification extensions to the existing ADL and IADL evaluation instruments, as it will not only reveal important information setting up a baseline for activity levels for each activity, but will also easily allow the detection of any drift from these personalized norms.

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsinlike activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus, such as a detectable label. Along with therapeutic utilities, these peptide based compounds can be used in assays useful for screening, monitoring, diagnostic and / or dosing purposes.

Purified enzymatic compositions are provided having alpha-amidating enzymes capable of catalyzing the conversion of a peptidyl compound having a C-terminal glycine residue to a corresponding peptidyl amide having an amino group in place of the C-terminal glycine. The purified compositions have specific activities above 25 mU per mg protein and are sufficiently free of proteases to allow effective catalysis of even peptidyl compounds having L-amino acids. Biologically important alpha-amidated products such as calcitonin and other regulatory hormones are efficiently produced using the alpha-amidation reaction catalyzed by the enzymes. Purification by size exclusion chromatography in combination with strong anion exchange chromatography results in homogeneous enzyme species which are used to prepare antibodies specific for the alpha-amidating enzyme. A gene capable of expressing the alpha-amidating enzyme is ligated into an expression vector and transformed into a host cell capable of expressing the gene.

An apparatus and method for managing inter-personal activities to facilitate matchmaking between single individuals, by instructing each individual what to do and with whom during a series of game sessions. Singles join a forum in which a plurality of activities contained in a database are individually assigned to participants, who confidentially express their preferences for specific activities and for other participants with whom to conduct activities. Expressed preferences are not disclosed to other individuals, but are input to a secure computer system that assigns the activities. Participants' wish-lists influence assignments made by the computer, and random factors provide variety and protect privacy by obscuring the effect of the wish-lists. After each assignment, participants can update their wish-list to affect further assignments.

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles.

A solution is provided to monitor Web browsing activity across an Internet based network of affiliated Web sites and to enable the Web sites to detect and to force re-authentication upon users who have had a period of network-wide inactivity longer than a site-specific maximum allowable inactivity period. The network comprises at least one network authentication server (NAS) which maintains a network-wide activity tracking (NATr) cookie. The NATr cookie comprises a set of network-wide activity tracking (NATr) parameters for each registered user. Each of the Web sites maintains a site-specific activity tracking (SATr) cookie which comprises a set of site-specific activity tracking (SATr) parameters for each registered user. The NATr parameters for each user are reset whenever the user authenticates to the network. When a user requests a page from a site, an NAS forces the user to re-authenticate when the NAS determines that the user's network-wide inactivity duration is longer than the site's maximum allowable inactivity period.

Aspects of this disclosure relate to systems and methods for conducting sport-specific activities. Illustrated systems may be adjustable to permit a performance of different sport-specific activities. Further aspects relate to using sensor data to evaluate a user's performance and determine sport-specific fitness parameters. Various fitness parameters may measure reactive agility and / or the physiological state of the user, such as when in an exhausted state. Illustrated systems may have structures with an output device and a sensor. The structure may include a vertically-arranged planar surface to form a wall. Several structures may be configured to form a boundary. The boundary may be automatically adjustable, for example, depending on one or more specific fitness routines to be implemented. Calculated fitness parameters may be visually mapped on the structures of the system.

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus, such as a detectable label. Along with therapeutic utilities, these peptide based compounds can be used in assays useful for screening, monitoring, diagnostic and / or dosing purposes.

In a real environment, it is grasped in what condition the worker has conducted the activity, and in what condition the worker has created a file, and the quality of the entire activity from the activity start to the activity end is provided as an index. An action index indicative of an action state of the worker who operates a computer is calculated, and the action index is associated with a specific activity of the worker as activity quality information representative of the quality of activity.

This application describes systems and methods of forming a decision tree that simultaneously classifies multiple properties of items, and systems and methods of using the decision tree to simultaneously predicting multiple unknown properties of an item. In one embodiment, the decision tree has a top generic layer of nodes that are generic to all properties, a middle K layer of nodes that split on a property type descriptor K, and a bottom specific layer of nodes that are specific to some properties. In addition to simultaneously predicting multiple properties of new items, the decision tree may also aid users in uncovering relationships between properties and in determining what descriptors may represent a generic quality, and what descriptors may represent property-specific activity.

The present invention provides a game controlling method for use in a touch panel medium. The medium includes a touch panel device and a processor device. The game includes a controlled virtual object displayed on the touch panel device, and the processor device is loaded with different programs specifically corresponding to different numbers of the initial points of touch. Upon receiving a touch signal indicative of the number of the initial points of touch from the touch panel device, one of the programs specifically corresponding to the number of the initial points of touch is executed to make the controlled virtual object demonstrate a specific activity. At least one of the programs should make the controlled virtual object continue to demonstrate the activity for a predetermined period of time after the touch is released.