The invention provides an
isotope production method based on
irradiation of a side reflecting layer of a
pebble-
bed high-temperature gas cooled reactor. The method comprises the following steps: transforming a
neutron source duct and a physical starting device duct in the side reflecting layer of the
pebble-
bed high-temperature gas cooled reactor; designing an
isotope target on the basis of the production requirement of the
isotope to be produced and the reconstructed pore parameters, and adjusting the isotope target according to the safety analysis result of the isotope produced by online
irradiation of the side reflecting layer; designing an isotope
irradiation device for carrying out in-
pile and out-
pile operation on the isotope target, and calculating isotope irradiation theoretical parameters; and loading an isotope target into the modified pore channel through an isotope irradiation device, performing online irradiation according to isotope irradiation theoretical parameters, and discharging the isotope target after irradiation is completed. According to the method, the radioactive isotope is generated through online irradiation of the side reflecting layer of the
pebble-
bed high-temperature gas cooled reactor, so that the application scene of the reactor is enriched, and the utilization efficiency of the reactor is improved.