The invention discloses a tungsten-based columnar crystal high-entropy alloy plasma facing material and a preparation method thereof, and belongs to the field of nuclear fusion energy application. The tungsten-based columnar crystal high-entropy alloy is provided with columnar crystal grains with (001) orientation, and the grain size ranges from 10 micrometers to 70 micrometers. The high-entropy alloy comprises, by atomic percent, 20%-35% of W, 10%-25% of Ta, 10%-25% of Cr, 10%-20% of V, 5%-20% of Ti and 5%-20% of Y. The density of the tungsten-based columnar crystal high-entropy alloy can reach 99% or above, the purity of the tungsten-based columnar crystal high-entropy alloy exceeds 99.9%, the size of the columnar crystal can be controlled to be 10-70 microns, and fuel retention in a material after irradiation can be remarkably reduced. According to the tungsten-based columnar crystal high-entropy alloy, due to the high-entropy effect, the migration energy of interstitials and vacancies in the irradiated material is closer, so that the recombination rate of the interstitials and the vacancies is higher, and the neutron irradiation resistance of the material can be remarkably improved.