The invention discloses application of a
gold cluster fluorescent probe in detection of hematopoietic stem cells of
radiation-damaged animals, and belongs to the technical field of nano-drugs. In order to solve the technical problem that in the prior art, accurate detection of
radiation-damaged animal hematopoietic stem cells is difficult, the invention provides application of a
gold cluster fluorescent probe in detection of
radiation-damaged animal hematopoietic stem cells, a
gold cluster fluorescent molecule is composed of an Au atom, other
metal atoms M and an outer ligand L,
coupling the gold cluster fluorescent molecule with an
antibody through a chemical cross-linking method to prepare a gold cluster fluorescent probe coupled with the
antibody; the gold cluster fluorescent probe shows good
biocompatibility, relatively strong
photobleaching resistance, good light stability, high sensitivity and high specificity, has the targeting characteristic of hematopoietic stem cells, can be applied to detection and monitoring of hematopoietic stem cells
in vivo, and can be applied to detection and monitoring of hematopoietic stem cells
in vivo. And detecting the
residual volume of the hematopoietic stem cells after
radiation injury and evaluating the injury condition.