140 results about "Radiation damage" patented technology

The present application relates to the field of medicine, and particularly to the application of schisantherin B in the preparation of a medicine for preventing or treating radiation damage of the intestinal tract. The present application finds that schisantherin B has a protective effect on the intestinal tract after irradiation, and experiments prove that schisantherin B can reduce the pathological damage degree of the intestinal tract after irradiation, including increasing the length of intestinal villi and the number of crypts, maintaining the stability of the intestinal mucosal barrier, reducing the content of inflammatory factors in the intestinal tissue, restoring the activity of the intestinal epithelial cells after irradiation, and inhibiting the apoptosis. Meanwhile, schisantherin B can reduce the iron death caused by irradiation. Therefore, schisantherin B has a wide application prospect as a potential radiation protection agent in the treatment of radiation-induced intestinal injury and drug development.

The utility model provides an interactive experience teaching aid simulating a level gage for science popularization. The interactive experience teaching aid comprises an experiment container and a U-shaped pipe communicated with the bottom of the experiment container. The immersion liquid sensor is arranged on the side of the U-shaped pipe, and a sensing head of the immersion liquid sensor can be inserted into the U-shaped pipe; the simulated radioactive source and the simulated detector are detachably connected with the container support frame of the experimental container; the experiment container is communicated with a U-shaped pipe, so that the experiment container is flush with the liquid level of an inner cavity of the U-shaped pipe, when the amount of the injected liquid material reaches a threshold value set for science popularization demonstration teaching, an induction head of the immersion inductor makes contact with the liquid material in the inner cavity of the U-shaped pipe, and then the immersion inductor sends a signal to the simulated detector electrically connected with the immersion inductor. The buzzer and the light of the simulated detector flicker to remind an operator that injection of liquid materials is stopped when the threshold value set by teaching is reached, and the simulated radioactive source is only the same as a real radioactive source in appearance and does not have radioactivity, so that radiation damage to the operator is avoided.

The application discloses an online proton imaging ion spectrometer diagnosis system, relates to the fields of plasma physics and nuclear detection, and comprises an online proton imaging module, an online Thomson ion spectrometer module and a shielding aiming module; the shielding aiming module comprises a shielding cavity and an aiming laser pen; the online proton imaging module comprises a metal filter, a first scintillator and two proton imaging acquisition assemblies; the proton imaging acquisition assembly comprises a first optical fiber panel attached to the first scintillator and a first CMOS sensor attached to the first optical fiber panel; the online Thomson ion spectrometer module comprises an ion beam deflection mechanism and an ion spectrum diagnosis acquisition assembly; the ion spectrum diagnosis acquisition assembly comprises a light-proof aluminum film, a second scintillator, a second optical fiber panel and a second CMOS sensor which are sequentially and superposedly arranged. The application reduces the size of the whole system, can simultaneously carry out online proton imaging and ion energy spectrum diagnosis, and can effectively prevent radiation damage to the CMOS chip.

The invention discloses application of ellagic acid in preparation of a medicine or a biological product for preventing or relieving ultraviolet radiation damage and aging, and belongs to the technical field of biological medicine and radiation protection. Experimental verification shows that ellagic acid with effective concentration can promote expression of antioxidant related genes, reduce expression of inflammation response genes and expression of apoptosis related genes, eliminate active oxygen and inhibit lipid peroxidation reaction, so that oxidative damage, inflammatory reaction and apoptosis caused by ultraviolet radiation are effectively relieved, and the anti-inflammatory effect of ellagic acid is improved. The stress tolerance of an organism is improved, and the aging health risk induced by ultraviolet radiation is relieved; the medicine or biological product can be applied before and / or after exposure of ultraviolet radiation, and is suitable for preventing or relieving oxidative damage and cell aging caused by ultraviolet radiation. The invention provides a new way for developing safe and effective ultraviolet radiation protection and anti-aging preparations.

The invention relates to an evaluation method and system for a non-metallic material irradiation damage effect. The evaluation method comprises the following steps: constructing a geometric model according to material attributes of the non-metallic material, wherein the material attributes comprise chemical bonds; performing a simulation irradiation test on the geometric model by using a preset irradiation simulation environment and a preset irradiation physical model; calculating the bond breaking probability of the chemical bond according to the energy deposition information in the simulated irradiation test process; and obtaining the damage index of the non-metallic material according to the bond breaking probability. The evaluation efficiency and accuracy of the irradiation damage effect of the non-metallic material in the complex irradiation environment can be improved.

The application discloses a method, device and equipment for detecting the operation state of a ventricular assist device, and belongs to the technical field of medical instruments. The ventricular assist device comprises a driving device and an intervention pump. The driving device is used for driving the intervention pump to operate. The method comprises the following steps: acquiring current data of the driving device in a working state; in the case that the current data indicates that the load of the driving device is increased, performing operation state classification identification on the ventricular assist device according to the change condition of the current data in a first time period; and issuing alarm information corresponding to an identification result, wherein the identification result indicates an abnormal operation state causing the load increase. The method can timely prompt the cause of the abnormal load increase without the aid of a medical contrast imaging device, realizes automatic identification of the abnormal operation state, reduces the safety risk and protects the life safety of an assisted object, and reduces the radiation damage to the human body when the medical contrast imaging device is working.

The application provides a heterojunction bipolar transistor defect detection method, which comprises the following steps: acquiring a C-V curve and a 1 / C 2 -V curve of a heterojunction bipolar transistor at a preset voltage; determining the change of the C-V curve and the 1 / C 2 -V curve in a first preset voltage range; and controlling a C-V test module or an I-V test module of deep level transient spectroscopy to detect defects of the heterojunction bipolar transistor according to the change. The heterojunction bipolar transistor defect detection method has the beneficial effects that the different test modules of deep level transient spectroscopy can detect the defect types and defect states of the heterojunction bipolar transistor, and the internal defect properties and radiation damage mechanisms of the heterojunction bipolar transistor can be analyzed in depth.

The utility model relates to a medical scanning system and a water mold tool for SPECT correction of the medical scanning system. Comprising a water mold, a skeleton and a radioactive source. The framework comprises a plurality of supporting pieces, the supporting pieces are connected with one another and define a polyhedral geometric structure with a containing cavity, and the water mold is arranged in the containing cavity; the radioactive source comprises a long line source, a point source and a short line source, one of the long line source, the point source and the short line source is selected to be arranged on the framework, and the long line source is longer than the short line source; wherein the support piece comprises a first support piece, the length of the first support piece is adjustable, a fixed point is formed at the joint of any two connected support pieces, and one of the long line source, the point source and the short line source is selectively fixed on the first support piece or the fixed point. According to the water mold tool, uniformity calibration of the probe or the collimator, registration correction of the SPECT equipment and the CT equipment and posture and sensitivity correction of the probe can be achieved at the same time, time and labor are saved during calibration, and radiation damage to operators can be reduced.

The invention relates to the technical field of terminal sterilization and filtration in a radiopharmaceutical preparation process, in particular to a filter membrane sterilization and filtration device and system. Comprising the steps that a state sensing module collects liquid medicine radioactive activity data and filter membrane structure strain data and generates real-time data flow; the twinborn modeling module constructs a filter membrane digital twinborn body, and outputs an accumulated radiation damage prediction result through data assimilation; the prediction decision module generates a filtering parameter optimization sequence by using a deep reinforcement learning agent; the control execution module adjusts the flow velocity of the liquid medicine through fuzzy self-adaptive PID control and feed-forward compensation; and the verification feedback module performs an integrity test and transmits data back to the twin modeling module to realize model parameter correction. All the modules form a closed-loop control system through a high-speed data bus, so that the damage of radiation to a filter membrane material is effectively inhibited, and the integrity and the sterile guarantee level of a membrane structure in the filtering process are maintained.

The invention discloses application of ellagic acid in preparation of a medicine for preventing or treating ionizing radiation injury, and belongs to the technical field of biological medicine and radiation protection. Experiments prove that ellagic acid with an effective concentration can inhibit lipid peroxidation, enhance the activity of glutathione transferase and superoxide dismutase and promote the expression of antioxidant related genes such as sod-1, sod-2, gst-1 and gst-29 and immune related genes such as lys-1, irg-1, irg-2 and mul-1, so that the ellagic acid with an effective concentration can inhibit lipid peroxidation and improve the activity of glutathione transferase and superoxide dismutase. Therefore, oxidative damage, inflammatory response, reduced stress tolerance, accelerated aging and shortened service life caused by ionizing radiation exposure are relieved, and the compound can be applied to preparation of drugs for preventing or treating ionizing radiation damage and is suitable for nuclear accident emergency protection, space radiation protection of astronauts and adjuvant therapy of tumor radiotherapy patients. The invention provides a theoretical basis for developing an efficient and low-toxicity ionizing radiation protective agent based on ellagic acid, and has a wide application prospect.

A kind of quick bag sealing device and method for narrow space radioactive atmosphere isolation, including quick detachable inspection area, equipment back loading area, disassembly operation area;Wherein quick detachable inspection area, equipment back loading area, disassembly operation area all have sealing;And the top of quick detachable inspection area, equipment back loading area is equipped with crane hook reserved interface;Disassembly operation area side has PE operation glove, bottom has operation hole reserved interface.This application can significantly reduce the risk of radioactive material leakage by effective sealing mechanism, protect the operating personnel from radiation damage, while preventing radioactive aerosol from polluting the external environment.Using multiple sealing technology, including buckle and heat sealing, ensures zero leakage of radioactive atmosphere, meets strict radiation protection standards.Effective sealing and isolation measures reduce the possibility of radioactive material release into the environment, help maintain ecological safety.

This invention discloses a radiation effect simulation method for SRAM-type FPGAs. It combines device-level and circuit-level modeling simulation to simulate the combined effects of total dose and single-event effects on the FPGA, analyzing the impact of various radiation effects on the FPGA's operating state. This method solves the problems of limited accelerator resources, difficulty in adjusting irradiated particle energy, and high economic costs. It helps to understand the changes in internal micro-parameters of the device and reveal the damage mechanism, enabling the evaluation of the device's radiation damage sensitivity. It provides technical support for FPGA radiation resistance evaluation and hardening design, and is economical and convenient. It can be used to evaluate the radiation resistance of devices, contributing to improved device reliability in aerospace engineering applications.

This invention discloses a specialized laser welding machine for leg tube connectors, comprising a frame on which are mounted a tooling and rotating assembly, a leg tube pressing assembly, a welding torch control assembly, and an ejection mechanism. The tooling and rotating assembly includes a hollow rotating platform, a servo motor, and tooling components. The leg tube pressing assembly includes a top plate, guide columns, a cylinder, a lifting plate, and an upper positioning block. The welding torch control assembly includes a servo motor, a ball screw assembly, a welding lifting plate, and an adjustable welding torch assembly with adjustable position, angle, and posture. This invention provides a specialized laser welding machine for leg tubes and leg tube connectors, enabling automated welding between the connectors and the leg tubes. Workers are kept away from the welding point, reducing laser radiation damage to the eyes and skin. Welding fumes and gases can be removed by a vacuum cleaner. This invention positions the upper and lower ends of the leg tubes to ensure product verticality and dimensional stability. The ejection mechanism easily removes the welded product from the positioning block.

The invention provides a GEO electric propulsion satellite orbital transfer process solar cell radiation effect rapid evaluation method, which comprises the following steps that: firstly, a solar cell radiation damage space distribution database is constructed through space radiation effect analysis software, and the database comprises daily average equivalent 1MeV electron flux distribution data under different orbit heights, inclination angles and cover glass thicknesses; generating satellite space track data according to an electric propulsion orbital transfer strategy; counting accumulated operation time of the satellite in each height and dip angle interval according to a preset interval; and finally, multiplying and accumulating the daily average equivalent 1MeV electron flux corresponding to each interval by the accumulated running time to quickly obtain the accumulated equivalent 1MeV electron flux in the whole orbital transfer process. Therefore, the problem of long calculation time consumption of a traditional method is solved, and rapid evaluation support can be provided for radiation mitigation optimization design of the orbital transfer strategy.

The utility model provides a kind of test equipment of radiation angle of ray source, applied to radiation imaging technical field, comprising: detector clamping device, control device and shielding device, detector clamping device is structured as can rotate within preset angle, suitable for clamping detector;Control device is connected with detector clamping device communication;Shielding device is set between detector clamping device and control device. Detector clamping device can rotate within preset angle can drive detector to any position within preset angle, whereby, detector can record the radiation dose of the radiation of to-be-measured ray source to any position within preset angle range, to calculate the radiation angle of the ray source to be tested according to radiation angle algorithm. The efficiency of the detector clamping device driving the detector to collect radiation dose is high, and the accuracy is high. The shielding device is set between the detector clamping device and the control device to shield the radiation damage of the rays to the detection personnel.

The invention discloses a radiation refrigeration fiber membrane as well as a preparation method and application thereof. The fiber membrane comprises the following components: a polylactic acid-perfluoropolyether block copolymer, fluoroalkylated silicon dioxide and aluminum oxide in a mass ratio of 1.0: (0.05-0.50): (0.05-0.10). Fluorinated components are introduced to the surfaces of a polymer matrix and inorganic filler particles through chemical bonding, so that the radiation refrigeration performance of the composite material is improved and strengthened, the composite material is endowed with a super-hydrophobic function, the anti-pollution capacity of the material is improved, and the material can effectively bear long-term exposure in the sun and resist ultraviolet radiation damage; the scheme that the matrix and the inorganic filler are subjected to fluorination modification at the same time also overcomes the defect that the mechanical property of the composite material is insufficient due to poor compatibility of the two components; the fiber membrane is prepared through an electrostatic spinning method, the problem that a coating in a traditional coating material is prone to failure and damage is solved, and the service life of the composite material is prolonged.

The invention discloses a seleno-heptamethine indocyanine compound and a preparation method and application thereof.The seleno-heptamethine indocyanine compound is of a structure shown in the formula Se-Cys, the seleno-heptamethine indocyanine compound can be specifically accumulated in cell mitochondria, excessive reactive oxygen species (ROS) generated by radiation-induced mitochondria is efficiently removed, and the compound can be used for preparing a medicine for treating the mitochondria. Therefore, the radiation damage of normal cells is reduced. Meanwhile, the compound has an ROS concentration-dependent near-infrared fluorescence enhancement effect, and can synchronously realize the effects of monitoring the ROS level in real time, avoiding excessive oxidation resistance, reducing the toxicity of anti-radiation drugs and the like.

The invention discloses a product for treating radiation damage. According to the application, GP532 is subjected to random mutation, a phage mutation library is established, and the mutation library is activated and screened by using TLR5-dependent NF-kappa B, so that 9E1 is obtained. 9E1 shows dose-dependent stimulation of TLR5 dependent NF-kB activation in vitro; an effective prevention effect is shown in an in-vivo mouse radiation injury model, and a new way is provided for effective treatment of radiation injury.

This invention relates to a method and system for treating interface contaminants in a mixing and clarification tank, belonging to the field of nuclear fuel reprocessing. The method involves conveying interface contaminants to the final stage mixing and clarification tank via top-tank operation, separating the organic phase, and then returning the liquid containing interface contaminants from the final stage mixing and clarification tank to the organic phase inlet of the first stage mixing and clarification tank. The interface contaminants are dispersed by the agitation of the pump impeller within the mixing and clarification tank, thereby redissolving radioactive materials in the liquid. This invention utilizes in-situ treatment of interface contaminants and recovery of radioactive elements in a mixing and clarification tank, significantly reducing the accumulation of radioactivity in interface contaminants, mitigating radiation damage from organic solvents, and is simple to operate without requiring additional treatment equipment.

The application discloses a method for testing anti-radiation damage performance of calcium fluoride crystal. The method adopts X-ray radiation to irradiate calcium fluoride crystal, and judges the anti-radiation damage performance of the crystal according to an X-ray radiation dose for inducing color center absorption peak of the calcium fluoride crystal and a color center absorption coefficient of a characteristic absorption peak induced by radiation.

The application discloses a kind of on-orbit repair methods of space radiation damage of spaceborne photoelectric detector, comprising: disconnecting the power supply of TEC in photoelectric detector;Reverse voltage is applied to TEC;Chip temperature is maintained for a predetermined time;Disconnect the power supply of reverse application to TEC, end annealing repair;Normal on the power supply of TEC.The application utilizes the reverse heating of TEC of photoelectric detector, realizes the on-orbit real-time annealing repair of radiation damage, can dissipate interface charge to repair ionization damage, and can also repair lattice defects, the method only needs to set TEC reverse heating program, can extend the on-orbit working life and reliability of detector, and has broad application prospect.

This application relates to the field of pharmaceutical technology, and in particular to a topical ointment formulation and its preparation method. The formulation uses Sonicate as the active ingredient, combined with petrolatum, liquid paraffin, a solubilizing and penetration-enhancing system, and emulsifiers as excipients, to form an O / W type cream, an oil-based or water-soluble ointment. The preparation process employs a low-temperature dosing method at 40°C to ensure drug activity and inhibit crystallization. This application achieves high-concentration retention in local skin tissue through topical administration, significantly reducing radiation damage scores and pathological damage, while resulting in extremely low systemic plasma exposure, avoiding the systemic toxicity of oral administration, and providing a safe and efficient means for the clinical prevention and treatment of radiation-induced skin damage.

The present application provides a neutron capture therapy system, which can reduce or avoid the radiation damage and radiation leakage caused by the neutron and other radiation generated by the neutron capture therapy system to the treatment table positioning device. The neutron capture therapy system of the present application comprises a charged particle beam generating unit, a beam transmission unit, a neutron beam generating unit, a treatment table and a treatment table positioning device. The treatment table positioning device comprises a linear shaft and a mechanical arm. The mechanical arm is arranged between the linear shaft and the treatment table for supporting and positioning the treatment table. The linear shaft comprises a slide rail fixed to the building and a support connected with the mechanical arm. The support drives the treatment table and the mechanical arm to slide along the slide rail. The neutron capture therapy system further comprises a shielding device of the treatment table positioning device. The shielding device comprises a slide rail cover.

The application discloses an ultrathin diamond clamping device, which comprises, from top to bottom, a graphite pressing block, a polycrystalline diamond limiting sheet, a polycrystalline diamond bottom sheet, a graphite bottom plate and graphite screws for fixing the above-mentioned elements; the polycrystalline diamond limiting sheet is provided with at least one rectangular notch, and the limiting groove for positioning the ultrathin diamond crystal sheet is formed by the rectangular notch and the polycrystalline diamond bottom sheet; the graphite pressing block covers the ultrathin diamond crystal sheet, the graphite screws pass through the graphite pressing block, the polycrystalline diamond limiting sheet and the polycrystalline diamond bottom sheet in sequence and are connected with the graphite bottom plate, the graphite pressing block is extruded by twisting the graphite screws, pressure is applied to the ultrathin diamond crystal sheet to realize clamping. According to the application, the ultrathin diamond clamping device has the advantages of low thermal load, small clamping stress, small radiation damage and the like, reliably supports the stable and efficient generation of the seed laser by the monochromator, and finally helps to realize the high-stability operation of the fully-coherent free electron laser.

The invention provides a shewanella-cerium oxide nano-cluster compound, a preparation method thereof and application of the shewanella-cerium oxide nano-cluster compound in preparation of anti-radiation drugs, and belongs to the technical field of anti-radiation materials. According to the invention, a shewanella bioelectronic interface is combined with a CeO2 semiconductor nanomaterial, and when CeO2 forms an interface with shewanella and other electroactive bacteria with EET capability, metal-carrier interaction (MSI) can critically regulate and control an electronic structure of a catalytic active site. The shewanella-cerium oxide nano-cluster compound disclosed by the invention can be used for improving ion conversion between Ce < 3 + > and Ce < 4 + >, so that free radicals brought by radiation damage are reduced, and the damage of radiation to an organism is reduced. Besides, the shewanella-cerium oxide nano-cluster compound disclosed by the invention has excellent antioxidant activity, can regulate and control the intestinal microenvironment while efficiently removing various free radicals, has obvious improvement on intestinal protection after radiation irradiation, and can improve the survival rate of biological organisms.

A device has a substrate comprising first, second and third layers of a crystalline material such as silicon. The second layer is between the first and third layers. A radiation damage centre (RDC) is located in the second layer. In some embodiments the RDC is optically coupled to an optical resonator The second layer has an isotopic composition that is different from that of the first and third layers. The RDC may be formed by ion implantation. The RDC may be addressable independently of any RDCs located outside of the second layer as a result of characteristics of the RDC that vary depending on the isotopic composition of the environment of the RDC. Methods for making and testing devices are also described.

The invention provides a method for analyzing the influence of a barrier layer defect of a high-mobility device on electrical characteristics, and relates to the technical field of electronic components, and the method comprises the steps: carrying out the numerical simulation of a physical process of a particle with preset energy entering an AlGaN / GaN HEMTs device, and obtaining a displacement energy loss spectrum; determining irradiation experiment parameters, and testing the AlGaN / GaN HEMTs device based on the irradiation experiment parameters to obtain a test sample and corresponding electrical performance data before and after irradiation; performing I-DLTS test and EDS scanning on the test sample to obtain a test result; the displacement energy loss spectrum, the corresponding electrical performance data before and after irradiation and the test result are analyzed, the influence of the AlGaN barrier layer defects on the electrical characteristics of the AlGaN / GaN HEMTs device is obtained, and a theoretical basis is provided for improving the radiation tolerance and reliability of the device through deep analysis of a radiation damage mechanism.

The invention relates to the technical field of biological medicine, in particular to application of nobiletin in prevention and treatment of ionizing radiation damage. The nobiletin provided by the invention is extracted from plants, is of a natural flavonoid structure, has high compatibility with endogenous metabolites of a human body, and has good biocompatibility. Animal experiments prove that when the medicine is administrated at the optimal effective dose (200mg / kg) and 12 hours before irradiation, no obvious toxic reaction is shown, the immunogenicity is low, the medicine is suitable for long-term or conventional radiation protection application, the common problems of adverse reaction and accumulated toxicity in synthesis of protective medicines are solved, and meanwhile, the medicine can be in the optimal action state when being exposed to radiation, so that the medicine can be applied to radiation protection for a long time. The survival time of irradiated mice is remarkably prolonged, acute radiation injury pathological symptoms such as intestinal edema and villus shortening are effectively improved, intestinal crypt regeneration and stem cell proliferation are promoted, and reliable radiation protection efficiency is shown.

The invention relates to the technical field of experimental animal models, in particular to an establishment method and application of a rat radioactive cataract model. According to the invention, a rat cataract model induced by irradiation of X-rays with different doses (10 Gy, 20 Gy and 30 Gy) is constructed. Through multi-dimensional evaluation such as general situation observation, slit lamp inspection and histopathologic analysis, the influence of ionization radiation (IR) on the crystalline lens is systematically observed. The animal model successfully reproduces pathological manifestations of different radiation-damaged crystalline lenses, and an experimental basis is provided for further research on pathogenesis of radiation-induced cataract.

This invention discloses an external fixation device for fracture reduction and its manufacturing method. The device includes at least two fixation blocks, each pair connected by a telescopic rod. Each fixation block and the end of the telescopic rod are universally connected, and each fixation block has a threaded pin hole. The telescopic length of the telescopic rod and the rotation angle of each fixation block are determined based on the image data of the affected limb from the pre-placed threaded pin, enabling the external fixation device to guide the reduction and fix the reduced limb. This device provides guidance for manual reduction and fixation after reduction, avoiding unnecessary radiation damage and trauma, while improving the efficiency and accuracy of manual reduction by doctors and enhancing the therapeutic effect of fracture reduction.