The invention discloses biotechnology skin-whitening cosmetics. The biotechnology skin-whitening cosmetics comprise the following raw materials: ascorbic acid, arbutin, licorice extracts, punica granatum fruit fermentation product extracts produced by fermentation of lactobacillus, lemon extracts, rice chaff extracts, rose extracts, acerola cherry fermentation products produced by fermentation of the lactobacillus, gallnut extracts, oriental cherry extracts, inulin, mycose, ellagic acid and semen coicis extracts. The biotechnology skin-whitening cosmetics depend on pharmacology characteristics of bioactive substances produced by the modern biotechnology, the skin state of a user is conditioned and improved fundamentally, a skin-whitening effect is obvious, fading of foxiness and freckle can be facilitated, uneven skin tone is improved, skin brightness of the user is improved, and the skin-whitening effect is high. The biotechnology skin-whitening cosmetics can effectively restrain activity of monophenyl oxidase, act on various stages of a melanin metabolic path, restrain generation of melanin on the aspect of molecular level and whiten the skin of the user; and a skin-whitening effect is achieved.