96 results about "Ellagic acid" patented technology

The invention discloses an EGFR (epidermal growth factor receptor) targeted nano-drug carrier and a preparation method thereof, the EGFR targeted nano-drug carrier comprises drug-loading nanoparticles, an erythrocyte membrane coating the drug-loading nanoparticles and GE11 peptide connected to the erythrocyte membrane, and the drug-loading nanoparticles are formed by connecting tannic acid, ellagic acid and 1, 4-phenyldiboronic acid through boric acid ester bonds. The EGFR targeted nano-drug carrier disclosed by the invention can be enriched at an EGFR overexpressed tumor site in a targeted manner, and can be effectively prevented from being cleared by an immune system, and the drug loaded by the drug-loaded nanoparticles is released in a high-active oxygen environment, so that the treatment effect on tumors can be improved, and the toxic and side effects on normal tissues can be reduced; and photothermal therapy and chemotherapy effects can be simultaneously generated under NIR illumination, and the anticancer efficiency can be remarkably improved through the synergistic effect of the photothermal therapy and the chemotherapy.

The invention relates to the technical field of fermentation, in particular to fermented lonicera caerulea juice capable of reducing astringency and increasing the content of organic calcium as well as a preparation method and application of the fermented lonicera caerulea juice. The fermented lonicera caerulea juice disclosed by the invention is prepared from the following components in parts by mass: 95 to 105 parts of lonicera caerulea pulp, 0.5 to 1 part of eggshell powder and 1 to 4 parts of fermentation bacteria. The calcium content in the fermented lonicera caerulea juice prepared by the method disclosed by the invention can be up to 2000mg / L, bitter and astringent substances such as ellagic acid and secologanin are effectively reduced, the bitter and astringent taste is improved, and the roundness and aroma acceptance of the whole taste are improved. The obtained lonicera caerulea fermented juice is pleasant in flavor, balanced in nutrition, high in calcium content and suitable for development of functional beverages and healthy food.

The invention relates to a preparation method of a nano waterproof fabric. According to the method, ellagic acid is introduced in the self-polymerization process of dopamine for in-situ reduction, a polydopamine bonding layer and a silver nanoparticle anchoring layer are synchronously constructed on the surface of nano silicon dioxide, and then perfluorodecyltriethoxysilane is catalyzed by silver nanoparticles for a regioselective click chemical reaction, so that the nano silicon dioxide is obtained. The multifunctional bionic core-shell particles with catalytic activity and super-hydrophobicity are prepared. The particles are compounded with a fluorosilicone copolymer containing dynamic disulfide bonds, a fluorosilicone polymer containing boric acid ester groups and a tannic acid-metal complex to form a double-dynamic cross-linking finishing agent system. After a fabric is subjected to ultraviolet / ozone pretreatment, discontinuous polydopamine nanodot arrays are formed on the surfaces of fibers through short-time dopamine polymerization to serve as catalytic sites, then interface priority crosslinking is triggered by utilizing the sites, and finally, dynamic keys are driven to cooperatively exchange through ultraviolet light fixation and heat treatment, so that the intelligent dynamic waterproof membrane is formed.

The invention relates to the technical field of traditional Chinese medicines, in particular to a processing method and a quality control method for toxicity reduction and efficacy enhancement of radix cynanchi bungei. According to the method, the content of alangiine, the content of ellagic acid, the common peak area of characteristic peaks and the content of water-soluble extracts in the wine-roasted berberis scenting decoction pieces are measured by adopting a high performance liquid chromatography (HPLC) method, and subjective assignment is carried out on the characters of the wine-roasted berberis scenting decoction pieces by combining Delphi evaluation to serve as evaluation indexes; the method comprises the following steps: determining the weight coefficient of each index by adopting an analytic hierarchy process-index repeatability correlation mixed weighting method (AHP-CRITIC), and screening the optimal wine roasting process of the Zhuang medicine Tibetan scene by combining the three factors of the frying temperature, the frying time and the yellow wine amount with star point design (CCD)-effect surface (RSM) according to the coefficients. And finally determining the optimal process of stir-frying the radix berberidis with wine as follows: the stir-frying temperature is 150 DEG C, the stir-frying time is 16min, the amount of yellow rice wine is 10%, and moistening is performed for 24h.

The invention discloses an ellagic acid-copper metal organic framework nano material, a preparation method thereof and application of the nano material as an anti-tumor drug carrier. According to the nano material, natural polyphenol ellagic acid is used as an organic ligand, copper ions are used as a metal center, and a three-dimensional supramolecular frame structure is formed through coordination. The preparation method comprises the following steps: mixing an N-methyl pyrrolidone solution of ellagic acid with a methanol solution of copper sulfate, and stirring and reacting at room temperature to efficiently synthesize the copper sulfate. The nano material has excellent antibacterial activity and efficient anti-tumor drug loading capacity, has the intelligent drug release characteristic of dual response of pH and glutathione, and can accurately release drugs in a tumor microenvironment. The nano material provided by the invention can be used as an anti-tumor drug carrier, synchronously realizes anti-tumor and antibacterial dual effects, effectively prevents and treats bacterial infection complications in tumor treatment, and provides a new material for developing a new strategy for tumor synergistic treatment.

The invention provides a novel application of a raspberry extract. It is found through tests that any one of isoquercitrin, ellagic acid, vanillic acid, oleanolic acid, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, tiliroside, tormentic acid and raspberry extract can remarkably improve the activity of the human ovarian granular cells or remarkably improve the oxidative stress level, and the activity of the human ovarian granular cells can be remarkably improved. According to the present invention, the ovarian function can be effectively protected by the eight components, the ovarian function can be effectively protected by the eight components, or the mitochondrial membrane potential level can be significantly regulated and controlled, or the estrogen level in the microenvironment can be effectively maintained, such that the ovarian function can be effectively protected by the eight components, and the raspberry extract containing the eight components. The invention provides a new choice for ovarian function protection products, and also provides a new application for the substances.

The invention relates to the technical field of cosmetics, and discloses a herbal probiotic composition with whitening and anti-aging effects and a preparation method thereof. The herbal probiotic composition is prepared from alpha-arbutin, licoflavone, bakuchiol, resveratrol, ellagic acid, a metagen complex, skin micro-ecological prebiotics, sodium phytate, ferulic acid, rosemary polyphenol, polycystic liposome and the balance of a carrier suitable for skin. The herbal probiotic composition disclosed by the invention realizes stable co-delivery of hydrophilic and lipophilic activities and effective retention of cuticles under mild pH, synergistically inhibits blackness, resists oxidation and supports microecology, and improves the effective content and batch-to-batch consistency in the shelf life through metal ion accessibility control, so that the whitening and anti-aging effects are improved.

An object of the present disclosure is to provide a novel method for producing an ellagic acid-containing composition, the method capable of improving the solubility of ellagic acid. The present embodiment is a method for producing an ellagic acid-containing composition, including: a step of providing a solution containing at least an aqueous medium and a raw material derived from a plant of the genus Terminalia, containing ellagic acid; and a step of heat-treating the solution. The present embodiment is the production method, further including a step of a hydrolysis treatment to hydrolyze ellagitannin contained in the raw material to produce additional ellagic acid, wherein the hydrolysis-treated solution is heat-treated.

The invention discloses application of ellagic acid in preparation of a medicine or a biological product for preventing or relieving ultraviolet radiation damage and aging, and belongs to the technical field of biological medicine and radiation protection. Experimental verification shows that ellagic acid with effective concentration can promote expression of antioxidant related genes, reduce expression of inflammation response genes and expression of apoptosis related genes, eliminate active oxygen and inhibit lipid peroxidation reaction, so that oxidative damage, inflammatory reaction and apoptosis caused by ultraviolet radiation are effectively relieved, and the anti-inflammatory effect of ellagic acid is improved. The stress tolerance of an organism is improved, and the aging health risk induced by ultraviolet radiation is relieved; the medicine or biological product can be applied before and / or after exposure of ultraviolet radiation, and is suitable for preventing or relieving oxidative damage and cell aging caused by ultraviolet radiation. The invention provides a new way for developing safe and effective ultraviolet radiation protection and anti-aging preparations.

The invention relates to low-sugar gum soft sweets and a preparation method thereof. The soft sweets comprise the following raw materials in parts by weight: 18-35% of a pectin compound, 40-50% of a sweetening agent, 3-5% of a plasticizer, 0.3-0.8% of malic acid, 0.2-0.5% of sodium citrate and the balance of deionized water. Wherein the pectin compound comprises the following raw materials in percentage by weight: 10-20% of a cation matrix, 15-25% of an anion matrix, 5-10% of a neutral matrix and the balance of deionized water; the cation matrix comprises chitosan hydrochloride and calcium salt, the anion matrix comprises the following raw materials: low-methoxyl pectin, high-methoxyl pectin, ellagic acid and cumaric acid, and the neutral matrix is locust bean gum. The cation matrix, the anion matrix and the neutral matrix of the pectin compound cooperate to make up the defects of weak structure, poor water retention, easy aging and the like caused by sucrose deficiency in a low-sugar environment, so that the soft sweets have both elasticity and toughness.

The invention relates to a novel beverage and a preparation method thereof. Comprising the following components in percentage by weight: 0.05%-0.6% of a double-petal red rose distillation extracting solution, 0.05%-0.6% of food-grade hyaluronic acid, 0.05%-0.6% of xylitol or erythritol, 0.1%-0.3% of a butterfly bean flower extracting solution, 0.05%-0.2% of a turmeric root extracting solution, 0.03%-0.1% of mint leaf essence, 0.1%-0.4% of chia seed powder, 0.2%-0.5% of aloe juice, 0.1%-0.3% of a pomegranate extracting solution, 0.05%-0.2% of a green tea extracting solution, 0.02%-0.1% of citric acid and the balance of water. Hyaluronic acid and rose hydrolat are added, so that the oral liquid has the effects of moisturizing, resisting aging, soothing liver-qi stagnation and relieving and reducing pressure after being orally taken, aloe polysaccharide and chia seeds form a stable colloidal network, satiety and skin repair capacity are improved, low sugar and low burden are achieved, pomegranate ellagic acid has the effects of resisting inflammation, natural color matching with butterfly bean flowers is achieved, visual interest is enhanced, green tea catechin and curcumin are compounded to resist oxidation, promote metabolism and strengthen immunity, and the oral liquid has the effects of promoting metabolism and improving immunity. And the defects of irritation, single nutrition and the like of the traditional beverage are overcome.

The invention discloses application of ellagic acid in preparation of a medicine for preventing or treating ionizing radiation injury, and belongs to the technical field of biological medicine and radiation protection. Experiments prove that ellagic acid with an effective concentration can inhibit lipid peroxidation, enhance the activity of glutathione transferase and superoxide dismutase and promote the expression of antioxidant related genes such as sod-1, sod-2, gst-1 and gst-29 and immune related genes such as lys-1, irg-1, irg-2 and mul-1, so that the ellagic acid with an effective concentration can inhibit lipid peroxidation and improve the activity of glutathione transferase and superoxide dismutase. Therefore, oxidative damage, inflammatory response, reduced stress tolerance, accelerated aging and shortened service life caused by ionizing radiation exposure are relieved, and the compound can be applied to preparation of drugs for preventing or treating ionizing radiation damage and is suitable for nuclear accident emergency protection, space radiation protection of astronauts and adjuvant therapy of tumor radiotherapy patients. The invention provides a theoretical basis for developing an efficient and low-toxicity ionizing radiation protective agent based on ellagic acid, and has a wide application prospect.

The invention provides a raspberry NFYA3 gene and application of the raspberry NFYA3 gene in raspberry secondary metabolism. The amino acid sequence of the NFYA3 gene is as shown in SEQ ID NO. 1, and the nucleotide sequence for coding the gene is as shown in SEQ ID NO. 2. The gene can regulate and control synthesis of secondary metabolites, especially ellagic acid, in transgenic plants. The overexpressed NFYA3 gene significantly enhances the synthesis of ellagic acid in raspberry, and has wide agricultural and medicinal values.

To provide a whitening composition that has excellent whitening effects. [Solution] The present invention provides a whitening composition comprising eugenin, ellagic acid, and gallic acid, wherein the content of ellagic acid per 1 part by mass of eugenin is 5 parts by mass or more and 15 parts by mass or less, and the content of gallic acid per 1 part by mass of eugenin is 10 parts by mass or more and 30 parts by mass or less. Furthermore, the content of ellagic acid in the whitening composition is X EA [Mass %], gallic acid content is X GA When expressed as [mass %], 0.34 ≤ X EA / X GA It is preferable that the condition ≤0.80 is met. Furthermore, it is preferable that the sum of the content of eugenin, ellagic acid, and gallic acid in the whitening composition is 1.41% by mass or more and 1.85% by mass or less.

The invention discloses an environment-friendly bio-based chinlon core-spun yarn and a preparation method thereof, and belongs to the technical field of bio-based high polymer materials and functional textile materials. The chinlon core-spun yarn comprises synergistically modified bio-based nylon-6, ellagic acid, an antioxidant, nano titanium dioxide, an antistatic agent and a lubricant; wherein the synergistically modified bio-based nylon-6 is a multi-network synergistically enhanced system formed by in-situ construction of a boron-oxygen heterocyclic structure, a dynamic sulfydryl exchange structure and an interface anchoring structure by bio-based nylon-6, phenylboronic acid, catechol, 2, 3-dimercaptosuccinic acid and gamma-aminopropyltriethoxysilane under a melting condition; the ellagic acid participates in the interchain multiple hydrogen bond and pi action through the rigid polyphenol conjugated structure of the ellagic acid, so that molecular-level synergistic regulation is realized. Under the condition of not increasing the load of the inorganic filler, the tensile strength and the thermal stability of the yarn are remarkably improved, the thermal shrinkage rate is reduced, the ultraviolet resistance and the thermo-oxidative aging durability are improved, and good environmental friendliness and industrial application prospects are achieved.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for simultaneously determining the contents of various components in Shuanling antidiarrheal granules based on a UPLC-QQQ-MS / MS. The contents of 18 components in the Shuanling antidiarrheal granules are simultaneously determined by using an ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer. The 18 components comprise adenosine, gallic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, liquiritin, ellagic acid, kaempferitrin, narirutin, hesperidin, baicalin, oroxylin A-7-O-beta-D-glucuronide, wogonin, baicalein, wogonin, pachymic acid B and pachymic acid A. The invention further discloses a preparation method of the pharmaceutical composition. Through the UPLC-QTRAP-MS / MS combined technology, the technical prejudice that single component depends on in quality control of the traditional Chinese medicine compound preparation is broken through, the key problems that multiple components in a complex matrix are difficult to separate, low-content components are difficult to detect and the like are solved, efficient, accurate and synchronous determination of 18 components is achieved, and the method is suitable for large-scale popularization and application. A new reference path is opened up for modernized quality control of the traditional Chinese medicine compound preparation.

The invention relates to the technical field of biological medicine, and particularly discloses application of Xinjiang pomegranate rind ellagic acid in caries prevention, in-vivo and in-vitro experiments prove that the ellagic acid can effectively inhibit floating growth and biofilm formation of streptococcus mutans, streptococcus sobrinus and streptococcus sanguis, MICs of the ellagic acid are 4 mmol / L, 2 mmol / L and 1 mmol / L respectively, and MBICs of the ellagic acid are 8 mmol / L, 4 mmol / L and 1 mmol / L respectively; meanwhile, the ellagic acid can obviously inhibit the acid production capacity of the cariogenic bacteria, the generation of water-insoluble exopolysaccharides and the adhesion to hydroxyapatite; in a rat caries model, by locally applying 1-8 mmol / L ellagic acid, the number of streptococcus in the oral cavity can be reduced in a dose-dependent manner, the caries damage degree of smooth surfaces of molar teeth and fossa and fissure can be relieved, the effect of the ellagic acid is equivalent to that of positive control drugs chlorhexidine and sodium fluoride under the high dose (8 mmol / L), and the ellagic acid shows good biological safety. Therefore, ellagic acid can be used for preparing safe and effective anti-caries drugs or oral care products.

The invention discloses low-odor and high-smoothness polyethylene resin as well as a preparation method and application thereof. The polyethylene resin comprises the following components in parts by mass: 100 parts of polyethylene resin A, 0.5-5 parts of smooth master batch, 0.5-5 parts of an initiator and 0-5 parts of an antioxidant, the smooth master batch is prepared by melting and blending raw materials including polyethylene resin B, a slipping agent, a grafting agent and a compatilizer; the slipping agent is selected from fatty acid amides, preferably one or more of oleamide, erucyl amide and octadecanamide; the grafting agent is selected from one or two of gallic acid and ellagic acid.

The invention belongs to the technical field of emulsion gel preparation, and discloses stable high-internal-phase Pickering emulsion gel only based on ellagic acid particles and 3D printing application of the stable high-internal-phase Pickering emulsion gel. The preparation method of the emulsion set comprises the following steps: dispersing ellagic acid powder in water, performing ultrasonic treatment to obtain a suspension, then centrifuging the suspension, collecting supernate, and drying to obtain ellagic acid nanoparticles; weighing the ellagic acid nano-particles, putting the ellagic acid nano-particles into a non-polar solvent, and mixing to obtain an oil dispersion liquid of the ellagic acid nano-particles; and mixing the prepared oil dispersion liquid with water, and carrying out high-speed shearing emulsification to obtain the stable high-internal-phase Pickering emulsion gel only based on ellagic acid particles. According to the invention, the single ellagic acid nanoparticles are used as a stable medium for the first time, so that the process complexity and safety risk caused by multi-component compounding are avoided, and the simplification and greenization of system components are realized.

The invention discloses a hemostatic and anti-inflammatory dressing patch, which comprises a base layer, a colloid dressing layer and release paper, and is characterized in that the colloid dressing layer is composed of specific active ingredients and colloid dressing. The active component is prepared from asiaticoside, panax notoginseng saponins, ellagic acid, gallic acid and paeonol according to a specific weight part ratio. The core of the preparation method is as follows: aiming at active ingredients with different properties, firstly performing differential pretreatment, then mixing with a gel matrix composed of carbomer-940, polyvinylpyrrolidone K90 and the like through a step-by-step drug loading process, and finally performing cross-linking curing through medium-wave infrared preheating and ultraviolet irradiation to form a stable interpenetrating network hydrogel structure. Through component compounding and process innovation, the technical problems that multiple active components are poor in compatibility, prone to inactivation and uncontrollable in release in a matrix are effectively solved, the product has the multiple synergistic effects of rapid hemostasis, powerful anti-inflammation, lasting analgesia and healing promotion, and the performance of the product is remarkably superior to that of an existing product.

The invention relates to the technical field of plant extraction, in particular to a rose extract. The rose extract comprises at least one of monomer ellagic acid, urolithin M5 and apigenin. The preparation method comprises the following steps: uniformly mixing rose powder with the ternary synergistic solvent, carrying out ultrasonic treatment for 10-60 minutes under the ultrasonic power of 150-250 W, and then stirring for 1-5 hours at the temperature of 20-50 DEG C; centrifuging and collecting supernate to obtain the rose extract. The rose flower extract provided by the invention has relatively strong inhibition capability on human pancreatic lipase.

The invention relates to the technical field of traditional Chinese medicine analysis, in particular to a construction method of a wine-fried radix berberidis fingerprint spectrum. According to the method, an ellagic acid solution is used as a contrast solution, and HPLC determination is performed on multiple batches of wine-fried scenery test sample solutions, so that the wine-fried scenery fingerprint spectrum is obtained. According to the method, specific chemical components in the wine-fried scenery are detected, so that the fingerprint spectrum is constructed, and the quality control of the wine-fried scenery is better realized. Meanwhile, by establishing the HPLC fingerprint spectrums of 14 batches of wine-fried scenery, the difference conditions of the fingerprint spectrums of different batches of wine-fried scenery are compared, and reference is provided for establishment and quality control of wine-fried scenery quality standards. The wine-roasted landscape fingerprint spectrum constructed by the construction method disclosed by the invention is used as a quality evaluation standard, has the advantages of accuracy and reliability, and can provide reference and basis for wine-roasted landscape research.

The invention provides an ellagic acid composition and application thereof. The ellagic acid composition comprises the following components in percentage by mass: 0.5%-1% of ellagic acid, 25%-40% of polyol, 5%-10% of hydroxypropyl cyclodextrin and the balance of water, and is prepared by a specific process. According to the ellagic acid composition, the water solubility and stability of ellagic acid can be remarkably improved, the excellent antioxidant and whitening activity is achieved, and the application range of ellagic acid in the field of cosmetics is greatly widened.

The invention discloses a one-dimensional metal organic framework material for photocatalytic CO2 reduction as well as a preparation method and application of the one-dimensional metal organic framework material, zinc ions and ellagic acid hydroxyl construct firm planar four-coordination, so that the one-dimensional metal organic framework material has excellent stability; the one-dimensional metal organic framework material has the advantages that the one-dimensional metal organic framework material is coordinated with two water in the longitudinal direction to form a stable six-coordination structure, so that the one-dimensional metal organic framework material has open metal sites and shows excellent photocatalytic performance; the generation rates of CO and H2 reduction through photocatalysis of CO2 can reach 7.26 mmol / h / g and 0.04 mmol / h / g respectively, and the selectivity to CO is as high as 98.94%. According to the preparation method disclosed by the invention, a natural product ellagic acid massively existing in the nature is adopted as an organic ligand, so that additional synthesis of the organic ligand is avoided, the synthesis period of the MOF material is short, the cost is reduced, and the MOF material is environment-friendly; in addition, a solvothermal method is adopted for synthesis of MOF, the process is mature, reaction conditions are mild and easy to control, and single crystals and gram-grade products can be prepared.

The invention relates to the technical field of culture medium manufacturing, in particular to a ford nervilia leaf tissue culture rhizome proliferation culture medium and a preparation method of the ford nervilia leaf tissue culture rhizome proliferation culture medium. The proliferation material is prepared from the following components in parts by weight: 2 to 4 parts of 6-benayl aminopurine, 0.3 to 0.7 part of naphthylacetic acid, 0.3 to 0.6 part of indolebutyric acid, 4 to 6 parts of gibberellin, 95 to 105 parts of novel coconut juice extract, 18 to 22 parts of novel pomegranate extract, 250 to 350 parts of cane sugar, 60 to 70 parts of agar and 3 to 5 parts of activated carbon. The improved pomegranate rind extract is subjected to ultrasonic and purification composite treatment, more antioxidant components such as ellagic acid and gallic acid are released, the antioxidant components, fermentation-enhanced amino acid and a nano silicon / selenium compound in the improved coconut juice extract form a dual antioxidant barrier, free radicals in plant cells are actively removed, oxidative damage is reduced, and the anti-aging effect is achieved. The hormone combination is precisely proportioned, so that lateral bud germination and stem elongation can be promoted.

This reagent for coagulation time measurement contains ellagic acid and at least one of a polymer and an amino acid lacking an aromatic ring. The content of the amino acid contained in the reagent for coagulation time measurement is preferably 20,000-270,000 parts by mass with respect to 100 parts by mass of the ellagic acid content. The content of the polymer contained in the reagent for coagulation time measurement is preferably 10-1,000 parts by mass with respect to 100 parts by mass of the ellagic acid content, and the reagent for coagulation time measurement does not contain phenol.

The present invention relates to the beneficial effect of Chebulinic acid (CA) and its enriched standardized fraction (CAEF) isolated / prepared from the fruits of Terminalia chebula for the management of Benign Prostatic Hyperplasia respectively. Further, it relates to a novel, convenient and economically viable method for the isolation of chebulinic acid (CA) and ellagic acid (EA) from the dried and powdered fruits of T. chebula without using any expensive and tedious chromatographic techniques such as HPLC, column chromatography, resins etc.

The invention provides a preparation method of gecko health-care wine, which comprises the following steps: disinfecting cleaned gecko with 50-degree white spirit, and carrying out wall-breaking crushing together with auxiliary medicinal materials, the auxiliary medicinal materials comprise radix ginseng rubra, radix rehmanniae preparata, fructus lycii, rhizoma dioscoreae, radix achyranthis bidentatae, rhizoma cibotii, fructus corni, deer glue, radix astragali, semen cuscutae, tortoise-shell glue, rhizoma gastrodiae, cortex eucommiae, fructus alpiniae oxyphyllae, herba epimedii, spica prunellae, radix angelicae sinensis, cortex cinnamomi, mulberry, herba cistanche, radix polygoni multiflori, fructus rubi and herba cynomorii Sub-packaging the crushed mixture into breathable medicine bags; baijiu with the alcoholic strength of 50 degrees or above is injected into a ceramic wine jar, and the medicine bag is added; soaking for 10 days, and gently turning the medicine bag once every day during soaking; and filtering and sub-packaging to obtain finished wine. 24 medicinal materials are scientifically matched according to monarch, minister, assistant and guide, the blood oxygen saturation degree is improved, the problems of fatigue, sleep quality, respiratory function and kidney qi deficiency are solved in a multi-target mode, the mulberry ellagic acid attenuation technology is adopted, the content of free anthraquinone in polygonum multiflorum is reduced, the fishy smell of mulberry and fructus lycii is neutralized, and palatability is improved.

The invention discloses an ellagic acid composite solid dispersion and a preparation method thereof. The preparation method comprises the following steps: S1, respectively preparing a fucoidin aqueous solution and an ellagic acid ethanol suspension; s2, mixing the two solutions to obtain a mixed solution; s3, adding the modified polysorbate 20 and the chitosan-CPP compound, and performing ultrasonic stirring; s4, ball milling; and S5, carrying out reduced pressure rotary evaporation to remove the solvent, drying, crushing, and sieving with a 100-mesh sieve to obtain the product. Ternary synergistic compounding is formed through the fucoidin-modified polysorbate 20-chitosan-CPP compound, a multi-dimensional molecular interaction network is constructed, and the effect of remarkably improving the water solubility and dispersion stability of ellagic acid is achieved; wherein xylooligosaccharide branched chains of the modified polysorbate 20, hydroxyl groups of the fucoidin and phosphate groups of the chitosan-CPP compound form a multi-point hydrogen bond cross-linked structure through hydrogen bonds, and the hydrophobic association effect and lattice stacking among ellagic acid molecules are broken through the steric hindrance effect.