46 results about "Raspberry ketone" patented technology

The invention provides a composition and application thereof in preparation of a fat-reducing product. The composition comprises ginger and green tea composite micro-capsule powder, raspberry ketone, mango concentrated powder, citrus fruit powder and seaweed powder. The composition comprises the following components in parts by weight: 15-22 parts of fresh ginger and green tea composite microcapsule powder, 4-8 parts of mango concentrated powder, 1-5 parts of raspberry ketone, 1-5 parts of citrus fruit powder and 1-5 parts of seaweed powder. The method can solve the problem of large side effects of fat-reducing products in the prior art, and is suitable for the field of functional foods.

The invention discloses a preparation method of silk fibroin-based hemostatic gel. The preparation method comprises the following steps: (1) hydrolyzing regenerated silk fibroin, and dialyzing to obtain micromolecular silk fibroin; (2) modifying the micromolecular silk fibroin by using a modifier to obtain micromolecular modified silk fibroin; and (3) mixing the small-molecule modified silk fibroin with an auxiliary agent, a photoinitiator, modified gelatin and raspberry ketone glucoside in proportion, and stirring and reacting in a dark place to obtain the silk fibroin-based hemostatic gel. The silk fibroin-based hemostatic gel prepared by the invention has the advantages of rapid hemostasis, good application property and the like, and can be widely applied to the fields of trauma hemostasis and the like.

The invention discloses an alkylation catalyst and application thereof in raspberry ketone synthesis, and the preparation method of the catalyst comprises the following steps: (1) pretreatment: washing ion exchange resin with an alcohol solvent to remove impurities, and drying to obtain pretreated resin; (2) hydrophobization treatment: carrying out hydrophobization treatment on the resin pretreated in the step (1) and silane, and then washing and drying to obtain hydrophobized modified resin; and (3) metal ion doping: dipping the hydrophobic modified resin in a metal ion solution for doping, and then filtering, washing and drying to obtain the modified acidic cation exchange resin catalyst. When the catalyst is applied to raspberry ketone synthesis, the catalytic activity, the selectivity and the stability of the catalyst are superior to those of a traditional method and an unmodified catalyst, and the catalyst has remarkable industrial application value.

The application of raspberry ketone in the immunotherapy of pancreatic cancer belongs to the technical field of biological medicine, and provides the application of raspberry ketone in the immunotherapy of pancreatic cancer. The application discloses that raspberry ketone can specifically and widely up-regulate the expression of MHC-I molecules on the surface of pancreatic cancer cells, and significantly enhances the infiltration and function of anti-tumor effector T cells in the tumor immune microenvironment. In-vivo and in-vitro experiments prove that raspberry ketone can reverse tumor immune escape by up-regulating MHC-I, and after being combined with a PD-1 immune checkpoint inhibitor, the raspberry ketone can produce a significant synergistic anti-tumor effect, significantly inhibit the growth of pancreatic cancer and prolong the survival period of tumor-bearing mice. The application provides a new strategy of combining a natural small molecule immunomodulator with an existing immunotherapy, and provides an innovative solution and a drug candidate for overcoming the difficulty of pancreatic cancer tolerance to immunotherapy.

The invention relates to the technical field of enzyme engineering and biology, and discloses an olefin reductase mutant as well as a coding gene, a recombinant vector, a recombinant strain, an enzyme preparation and application thereof. The olefin reductase mutant provided by the invention is obtained by mutating at least one of F297V, F297V / F124N and F297V / F124N / M40F on an enzyme with an amino acid sequence as shown in SEQ ID NO.1. Compared with a wild enzyme, the olefin reductase mutant has the advantages that the efficiency of catalyzing p-hydroxybenzylideneacetone to generate raspberry ketone is obviously improved, complicated reaction environment control equipment is not needed, the cost is low, and the production cost is low. And an efficient and feasible enzyme catalyst scheme is provided for industrial green production of raspberry ketone.

The invention belongs to the technical field of cosmetics, and discloses a plant source antimicrobial composition as well as a preparation method and application thereof. The botanical antimicrobial composition disclosed by the invention is prepared from the following components in parts by weight: 0.05 to 5 parts of cacumen biotae extract, 10 to 30 parts of raspberry ketone and 0.05 to 5 parts of hinokiol. According to the plant source antimicrobial composition disclosed by the invention, a multi-target and all-around antibacterial and antiseptic system is constructed through a synergistic effect of natural plant components, rapid and broad-spectrum inhibition on bacteria, fungi and propionibacterium acnes is realized, and excellent physical and chemical stability can be kept in an extreme environment; the preservative effect is not affected by a complex formula system, and the function of instantly killing acne pathogenic bacteria is achieved. Meanwhile, the plant-derived antimicrobial composition can also be perfectly compatible with active ingredients of various cosmetics, can be flexibly applied to various product types, and provides a natural, efficient, reliable and low-irritation preservative solution for users.

The invention discloses a preservative composition based on raspberry ketone as well as a preparation method and application thereof, and relates to the technical field of preservatives. The preservative composition based on raspberry ketone comprises raspberry ketone, propylene glycol, caprylyl glycol and chlorphenesin. According to the technical scheme, through the synergistic compounding effect of the raspberry ketone, the propylene glycol, the caprylyl glycol and the chlorphenesin, the excellent sterilization and degerming effects are achieved. According to the preservative composition based on raspberry ketone, the bacteriostatic and preservative effects of all the raw materials are fully exerted and utilized, breeding of bacteria and molds in daily necessities can be remarkably inhibited, the remarkable preservative, sterilizing and degerming effects are achieved, and the shelf life of the product is prolonged. The raspberry ketone-based preservative composition provided by the invention is small in irritation, can achieve efficient sterilization and degerming effects only by adding a small amount of the raspberry ketone-based preservative composition, and realizes double breakthrough of improving the preservative efficiency and reducing the irritation.

The invention provides a collagen composition with tightening and anti-wrinkle effects and application thereof. The collagen composition comprises a centella asiatica extract, a collagen extract, collagen amino acids, polyhydric alcohols, raspberry ketone, soluble collagen and recombinant collagen. The centella asiatica extract, the collagen extract, the soluble collagen, the collagen amino acids and the recombinant collagen are matched for use, so that the problem of effect disruption caused by barrier damage when the collagen is independently used is solved, and the defect of insufficient anti-aging (collagen regeneration) strength when the centella asiatica is independently used is overcome; and the double effects of repairing and bottoming, resisting aging and improving efficiency are achieved.

The invention relates to a preparation method and application of acetylated raspberry ketone, and the preparation method is characterized in that acetic anhydride is used as an acetylation reagent to realize hydroxyl acetylation of raspberry ketone in the presence of a proper catalyst and a proper solvent so as to obtain high-purity acetylated raspberry ketone. The reaction conditions are mild, and high temperature and high pressure are not needed; the product purity is high; the method is simple to operate and suitable for industrial production. Moreover, when the acetylated raspberry ketone is used for preparing an antimicrobial composition, the effect is remarkable, and microorganisms comprise Listeria bacteria or salmonella typhimurium.

The application discloses a method for improving the conversion rate of raspberryin in sidestream smoke, which comprises the following steps: mixing raspberryin and a certain amount of intumescent flame retardant, and adding the mixture to the burning position of a cigarette. The method can obviously improve the conversion rate of raspberryin converted into raspberry ketone in sidestream smoke.

The invention discloses a skin care composition with effects of shrinking pores, tendering skin and resisting wrinkles as well as a preparation method and application of the skin care composition, and particularly belongs to the technical field of daily cosmetics. The composition is prepared from the following components in parts by mass: 5 to 8 parts of astragalus membranaceus root extract, 0.15 to 0.2 part of raspberry ketone glucoside, 3 to 5 parts of gloiopeltis furcata extract, 0.8 to 1 part of pyracantha fortuneana fruit extract and 20 to 30 parts of bifidus yeast fermentation product filtrate, and the components are extracted by a specific process. The composition provided by the invention has the effects of shrinking pores, resisting wrinkles, tightening skin, controlling oil and the like, and can be used for preparing various skin care products such as essence, emulsion and the like.

Disclosed herein is a frambinone methacrylate (FMA) or raspberry ketone methacrylate (RKMA) monomer having the following structure:anda zingerone methacrylate (ZMA) having the following structureAlso disclosed are homopolymers and co-polymers utilizing same monomer. Also disclosed is a class of methacrylate monomers comprising a bio-based moiety and a reactive ketone moiety. Also disclosed are paint compositions made with a copolymer including FMA and / or ZMA.

The invention relates to the technical field of biological medicine, in particular to application of raspberry ketone glucoside in preparation of a preparation for preventing and treating monocolonic insect. Experiments and tests show that the raspberry ketone glucoside shows remarkable killing activity on fish monozoiasis, and meanwhile, the raspberry ketone glucoside also keeps good safety on fishes. After short-time immersion bath administration, the raspberry ketone glucoside can weaken the movement of the monoagonism and influence the generation of ATP (adenosine triphosphate) of the monoagonism. The raspberry ketone glucoside disclosed by the invention has a relatively good prevention and control effect on fish mononimus, and more solutions can be provided for disease prevention and control of aquaculture by developing a preparation based on the raspberry ketone glucoside.

The present application discloses a skin care composition and its use, the skin care composition comprises ectoine and raspberry ketone, the mass ratio of the ectoine and raspberry ketone is 10:1~1:15, the skin care composition has a positive effect on promoting skin barrier repair.

A cosmetic sunscreen composition comprises avobenzone and one or more of Raspberry Ketone, γ-Oryzanol and Ethyl Ferulate to stabilize the avobenzone.

The invention relates to liquid watermelon essence as well as a preparation method and application thereof. The liquid watermelon essence comprises the following raw materials in percentage by mass: 10-15% of melonal propylene glycol acetal; 60 to 70 percent of propylene glycol; 10-15% of an alcohol raw material; 1-5% of an aldehyde raw material; 1-5% of a ketone raw material; 0.5-3% of an ester raw material; 0.5-1% of maltol or a derivative thereof; wherein the alcohol raw material is a mixture of leaf alcohol, cis-6-nonenol and nonanol; the aldehyde raw material is a mixture of vanillin, melonal and cyclamen aldehyde; the ketone raw material is a mixture of raspberry ketone, beta-ionone and dihydrojasmonone; the ester raw material is a mixture of ethyl hexanoate, leaf alcohol acetate, diethyl sebacate, ethyl acetoacetate, methyl octyne carboxylate and benzyl cinnamate; the maltol or the derivative thereof is at least one of ethyl maltol and maltol. The essence is resistant to high temperature, and can maintain a strong watermelon fragrance in a high-temperature food processing process.

The application discloses a skin care composition with pore-shrinking, skin tenderizing and wrinkle-resisting effects and a preparation method and application thereof, and particularly belongs to the technical field of daily-use cosmetics. The composition contains the following components in mass fractions: 5-8 parts of Astragalus membranaceus (Fisch.) Bunge root extract, 0.15-0.2 parts of raspberry ketone glucoside, 3-5 parts of sea algae extract, 0.8-1 part of fire jujube fruit extract and 20-30 parts of Saccharomyces bitymus fermentation product filtrate, and each component is prepared through specific process extraction; the composition provided by the application has pore-shrinking, wrinkle-resisting, skin tightening, oil-controlling and other effects, and can be used for preparing various skin care products such as essence and emulsion.

The present application belongs to the technical field of cosmetic compositions, and particularly relates to a composition with nourishing effect on damaged hair and application thereof. The composition comprises Ulva compressa extract, raspberry ketone glucoside, Sudan cola seed extract and Camellia nitidissima flower extract, wherein the weight ratio of the Ulva compressa extract, the raspberry ketone glucoside, the Sudan cola seed extract and the Camellia nitidissima flower extract is (1-20):(1-10):(1-10):(5-50). The components of the present application produce a synergistic effect, can significantly improve the combing property of damaged hair, improve the gloss of hair, and show excellent effects in moisturizing, smoothing, nourishing and repairing, and the consumer's use feeling is obvious.

The invention provides a method of promoting weight management in a mammal comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondrial enhancer. The weight loss agent can be selected from the group consisting of psyllium, guar gum, capsaicin, chitosan, caffeine, gamboge, mume, capsaicin, yohimbine, butterfly pea, glucomannan, African mango, guarana, pyruvate, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney bean, kola nut, chromium, ginseng, psyllium, St. John's wort, dandelion, hydroxycitric acid, conjugated linoleic acid, green tea, black tea, coffee bean extract, forskolin, and bitter orange. The mitochondrial enhancer can be selected from the group consisting of beetroot extract, nitrate, idebenone, nicotinamide riboside, elamipretide, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvate, coenzyme Q10, NADH, niacin, L-carnitine, dichloroacetate, curcumin, schisandrin, and resveratrol. Compositions for weight management are also provided.

The application discloses an alcohol dehydrogenase mutant and a method for synthesizing raspberry ketone by using the same. The mutant is obtained by mutating any one or more of positions 144, 145, 190, 40, 17, 64 and 94 of an alcohol dehydrogenase LbADH from Lactobacillus brevis shown in the sequence of SEQ ID NO:1. The application first mutates and screens a substrate binding pocket of LbADH, successfully obtains a mutant with improved catalytic activity for R-dulcitol and S-dulcitol, and realizes efficient catalysis of a single enzyme on two enantiomers. The application also mutates amino acids around an NADP+ binding site of LbADH, enhances the catalytic oxidation activity of the LbADH under high pH conditions, and successfully obtains a combined mutant with high catalytic efficiency under a high pH environment. The application provides a new technical means and solution for the oxidative conversion of 'natural' raspberry ketone.

The invention discloses a retinoic acid derivative as well as a preparation method and application thereof, and belongs to the technical field of cosmetic raw materials. The derivative is raspberry ketone retinoate, and the structural formula of the derivative is shown in the specification.

The invention provides matrix nutrient soil as well as preparation and application thereof. The matrix nutrient soil is prepared from 10 to 35 parts of sugarcane leaf powder, 30 to 55 parts of vermiculite, 0.01 to 0.06 part of compound microbial agent, 3 to 15 parts of yeast metabolite, 10 to 30 parts of yeast residue, 1 to 10 parts of sugar residue and 0.04 to 0.09 part of raspberry ketone. The matrix nutrient soil provided by the invention is soft, small in density, strong in permeability, high in organic matter content and lasting in fertilizer efficiency, can be beneficial to improving the seed germination rate and promoting crop growth, is wide in raw material source and environment-friendly, and can be beneficial to realizing low-carbon circulation and pollution-free.

The invention provides a compound preservative containing raspberry ketone as well as a preparation method and application thereof, and belongs to the technical field of production and preparation of preservatives. Every 100 parts of the compound preservative containing raspberry ketone comprises the following components in parts by weight: 5-15 parts of raspberry ketone; 45 to 55 parts of caprylyl glycol; and 30 to 60 parts of butanediol. The preservative provided by the invention is simple in components, good in antibacterial effect, broad-spectrum and efficient in corrosion resistance, green, safe and good in stability.

The invention belongs to the technical field of cosmetics, and particularly relates to a raspberry ketone enhanced anti-aging cosmetic formula and a preparation process, the raspberry ketone enhanced anti-aging cosmetic formula comprises raspberry ketone and a phospholipid complex (lecithin and diglyceride in a ratio of 3: 1) in a mass ratio of 1: (2-5), 0.5%-2% of sodium hyaluronate and 1%-3% of vitamin E acetate are added, and the pH value of a system is 5.5-6.5. The preparation process comprises the following steps: dissolving raspberry ketone in absolute ethyl alcohol, adding the phospholipid complex, carrying out ultrasonic treatment, carrying out high-pressure homogenization to form a nano-emulsion, and finally adding sodium hyaluronate and vitamin E acetate to adjust the pH value. The stability and permeability of raspberry ketone are improved, the antioxidant capacity is remarkably improved and wrinkles and elasticity are improved by cooperating with multiple active ingredients, and the raspberry ketone composition is suitable for product forms such as face cream and essence, has the characteristics of high stability, excellent permeability and multiple synergistic interaction, and is suitable for large-scale production.

The application belongs to the field of organic synthesis, and discloses a raspberry ketone synthesis method and a catalyst thereof, which comprises the following steps: butanone alcohol, phenol and a solvent are subjected to a Friedel-Crafts alkylation reaction to obtain raspberry ketone under the catalysis of a composite catalyst; the composite catalyst comprises an active component, a carrier and an additive; the active component is a transition metal salt; the carrier is a molecular sieve; and the additive is a crown ether. The application replaces an organic acid catalyst with a new composite catalyst, reduces the use of the additive crown ether, has high reaction selectivity and yield, reduces the feeding amount of phenol, saves raw material recovery energy consumption, and is beneficial to the industrialized mass production of raspberry ketone.

The invention relates to the technical field of cigarette perfuming, in particular to a core-sheath structure perfumed thread, a preparation method thereof and a cigarette filter stick. The preparation method comprises the following steps: by taking beta-cyclodextrin as a wall material and essence as a core material, preparing beta-cyclodextrin / essence microcapsules by adopting an inclusion method; dissolving the beta-cyclodextrin / essence microcapsule and polylactic acid in a solvent to obtain a core layer spinning solution; polylactic acid is dissolved in a solvent, and a sheath spinning solution is obtained; wet spinning is adopted for coaxial spinning, the center shaft spinning solution is the core layer spinning solution, the outer shaft spinning solution is the sheath layer spinning solution, and the core-sheath structure fragrant thread is obtained. Spinning is carried out by combining microcapsule embedding with a wet spinning integrated technology, the prepared incense thread has the stable essence adding and releasing capacity, when high-temperature smoke passes through the incense thread, raspberry ketone can be released from microgaps in the wall of the microcapsule, and therefore the durability of cigarette fragrance is guaranteed.

The invention discloses a mosquito-repelling, bacterium-inhibiting and itching-relieving composition containing a sweet-scented osmanthus extract and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The mosquito-repelling, bacterium-inhibiting and itching-relieving composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of sweet-scented osmanthus extract, 15 to 25 parts of lepidium sativum bud extracting solution, 10 to 18 parts of mistletoe extract, 7 to 12 parts of garden burnet root extract, 5 to 12 parts of wormwood, 5 to 10 parts of mint, 4 to 10 parts of honeysuckle flower, 3 to 8 parts of raspberry ketone glucoside, 2 to 6 parts of glycyrrhetinic acid and 100 to 300 parts of water. The raw materials of the mosquito-repelling, bacterium-inhibiting and itching-relieving composition are all from plant components, so that the mosquito-repelling, bacterium-inhibiting and itching-relieving composition is safe to use, free of side effects, capable of rapidly achieving mosquito-repelling and itching-relieving effects and good in bacterium-inhibiting effect.

The invention discloses a method for synthesizing raspberry ketone through chemical enzyme stage combination and application, and belongs to the technical field of organic synthesis and biological engineering. The raspberry ketone is obtained through whole-cell catalysis by taking recombinant engineering bacteria of co-expressed olefine aldehyde reductase and formate dehydrogenase genes as a biocatalyst. When the adding amount of a genetic engineering bacterium E.coli BL21 (DE3) pRSF-AtQOR (I56S / A69H / A118N)-LbFDH is 20 g / L, the substrate HBA is 100 g / L, the sodium formate is 125 g / L, the NADP < + > is 0.5 mM, the reaction temperature is 37 DEG C, the pH is 7.5, the reaction time is 12 h, and the rotating speed is 220 rpm, the raspberry ketone concentration can reach 82.23 g / L. The problems of serious environmental pollution of a chemical method and low yield of a biological method are solved.

The present application provides a kind of infantile additive-free wet wipes, belong to nursing wet wipes technical field, including formula liquid and base cloth, the formula liquid contains raspberry ketone, characterized in that, the formula liquid is further compounded with octanol and ethyl hexyl glycerin, the ratio of octanol and ethyl hexyl glycerin is as follows: octanol: 0.03%~0.06%;Ethyl hexyl glycerin: 0.02%~0.06%, the viscosity of the residue of the present application is not only low, and bactericidal effect is good, will not stimulate skin.

This utility model relates to the field of raspberry ketone extraction technology, specifically to an extraction device for natural raspberry ketone, including a tank, a top cover, a crushing roller, a filter barrel, and an external toothed ring. The top cover is located on the top of the tank, with a feed pipe in the middle and a receiving hopper at the top of the feed pipe. Two crushing rollers are provided and rotatably connected inside the feed pipe. The filter barrel is rotatably connected to the bottom of the top cover, and the external toothed ring is rotatably connected to the bottom of the top cover and located inside the filter barrel. A stirring rod is rotatably connected to one end of the inner wall of the external toothed ring, and stirring blades are fixedly connected to both ends of the stirring rod. This utility model uses a second motor to drive a fourth gear to rotate, thereby driving the second internal toothed ring and the filter barrel to rotate. The centrifugal force generated when the filter barrel rotates allows the extract in the filter barrel to be quickly thrown out, thereby accelerating the discharge speed.