7 results about "Raspberry ketone" patented technology

The application of raspberry ketone in the immunotherapy of pancreatic cancer belongs to the technical field of biological medicine, and provides the application of raspberry ketone in the immunotherapy of pancreatic cancer. The application discloses that raspberry ketone can specifically and widely up-regulate the expression of MHC-I molecules on the surface of pancreatic cancer cells, and significantly enhances the infiltration and function of anti-tumor effector T cells in the tumor immune microenvironment. In-vivo and in-vitro experiments prove that raspberry ketone can reverse tumor immune escape by up-regulating MHC-I, and after being combined with a PD-1 immune checkpoint inhibitor, the raspberry ketone can produce a significant synergistic anti-tumor effect, significantly inhibit the growth of pancreatic cancer and prolong the survival period of tumor-bearing mice. The application provides a new strategy of combining a natural small molecule immunomodulator with an existing immunotherapy, and provides an innovative solution and a drug candidate for overcoming the difficulty of pancreatic cancer tolerance to immunotherapy.

This utility model relates to the field of raspberry ketone extraction technology, specifically to an extraction device for natural raspberry ketone, including a tank, a top cover, a crushing roller, a filter barrel, and an external toothed ring. The top cover is located on the top of the tank, with a feed pipe in the middle and a receiving hopper at the top of the feed pipe. Two crushing rollers are provided and rotatably connected inside the feed pipe. The filter barrel is rotatably connected to the bottom of the top cover, and the external toothed ring is rotatably connected to the bottom of the top cover and located inside the filter barrel. A stirring rod is rotatably connected to one end of the inner wall of the external toothed ring, and stirring blades are fixedly connected to both ends of the stirring rod. This utility model uses a second motor to drive a fourth gear to rotate, thereby driving the second internal toothed ring and the filter barrel to rotate. The centrifugal force generated when the filter barrel rotates allows the extract in the filter barrel to be quickly thrown out, thereby accelerating the discharge speed.

The present application relates to the technical field of fine chemicals synthesis, in particular to a Cu / HZSM-5 molecular sieve, its preparation and application in raspberry ketone synthesis. The copper salt is dissolved and mixed with HZSM-5 molecular sieve, then ammonia is evaporated, and CuO / HZSM-5 molecular sieve is obtained after post-processing; then the CuO / HZSM-5 molecular sieve is subjected to hydrogen reduction treatment to obtain Cu / HZSM-5 molecular sieve. The Cu / HZSM-5 molecular sieve prepared by the present application is used as a catalyst to catalyze H2 and 4-(4-hydroxyphenyl)-3-buten-2-one to generate raspberry ketone, the catalytic efficiency is high, the conversion rate of 4-(4-hydroxyphenyl)-3-buten-2-one can reach 100%, the selectivity of raspberry ketone can reach 99.8% at most, and the present application has the advantages of low cost, high efficiency, good stability, short production cycle and the like.

This invention belongs to the field of cosmetic technology, specifically relating to a composition with anti-ultraviolet protection for hair and its application. It includes extracts of coltsfoot flower, sisal extract, raspberry ketone glucoside, and camellia flower extract, with a weight ratio of (1-3):(1-3):(2-5):(2-6). The composition provided by this invention, through the synergistic effect of its components, can effectively absorb UVA / UVB ultraviolet rays, reducing damage to the hair cuticle and cortex caused by ultraviolet radiation; it also has excellent antioxidant capacity, scavenging free radicals generated by ultraviolet radiation, delaying keratin degradation and lipid peroxidation; and it can stabilize melanin, preventing hair color fading. This composition can significantly reduce problems such as increased hair combing resistance and cuticle lifting caused by ultraviolet radiation.

This invention relates to the field of flavor technology, and particularly to an aerosol matrix composition and atomizing liquid. The aerosol matrix composition comprises lactic acid, leaf alcohol, raspberry ketone, butyric acid, and sucralose. In the technical solution provided by this invention, lactic acid and butyric acid are used as acidulants to stimulate salivary gland secretion; leaf alcohol and raspberry ketone are used as flavoring agents to enhance flavor perception and influence saltiness perception, making the saltiness more natural; sucralose is used as a sweetener to provide sweetness, and simultaneously works with the acidulants so that taste receptors in the oral cavity receive both sweet and sour signals, stimulating the salivary glands to secrete more saliva and amplifying the saltiness. Furthermore, the coexistence of sweetness and saltiness, with an appropriate amount of sweetness highlighting the saltiness, further enhances the saltiness sensation.

The present application provides a kind of whitening, improve skin barrier composition and its preparation method and application, it is related to skin care product technical field.The composition raw material includes: plant extract 30-42 parts, Lotus nut extract 13-17 parts, Beauveria extract 12-14 parts, malt oligosaccharide glucoside 1.2-1.6 parts, raspberry ketone glucoside 2-3 parts, oligopeptide 4-6 parts, sucrose laurate 1-2 parts, humectant 2-4 parts, thickening agent 1-1.8 parts, water 280-340 parts.The present application can inhibit tyrosinase activity by the synergistic effect of specific plant extract, Lotus nut extract, Beauveria extract, malt oligosaccharide glucoside, raspberry ketone glucoside, oligopeptide and other raw materials, achieve good whitening effect, and make each active ingredient transdermal absorption, protect skin keratin layer lipid bilayer structure from being destroyed, maintain the water-retention capacity of skin, avoid water loss, thereby play the role of improving skin barrier.

The invention relates to raspberry ketone compounds III-1III-13, V-1V-15 and VI-1VI-11, a preparation method of the raspberry ketone compounds III-1III-13, V-1V-15 and VI-1VI-11, and an application of the raspberry ketone compounds III-1III-13, V-1V- The invention provides a series of raspberry ketone compounds, develops an efficient synthesis method of the compounds, discovers the plant virus and plant pathogen resisting activity of the compounds, and lays a foundation for synthesis and biological activity research of the compounds. The raspberry ketone compounds III-1III-13, V-1V-15 and VI-1VI-11 disclosed by the invention have the activity of resisting plant viruses, can be used for inhibiting tobacco mosaic viruses, and meanwhile, the compounds show broad-spectrum activity of resisting plant pathogenic bacteria.