67 results about "Raspberry ketone" patented technology

The invention discloses an oil-control composition for whitening and removing acnes. The oil-control composition comprises a raspberry extract, a mangnolia officinalis extract and a natural active matter, the weight ratio of the raspberry extract to the mangnolia officinalis extract to the natural active matter is (0.1-1): (1-5): 1. According to the invention, the raspberry ketone, the magnolia bark extract and the natural active matters are combined, so that the exuberant grease secretion of skin can be fundamentally improved, and inflammation and acne of the skin can be inhibited. Under the optimal weight ratio, the oil can be controlled for a long time, the oil secretion is effectively regulated, the pores are refined, the acne breeding is prevented, and the skin is smoother and finer. The problems that part of current oil control raw materials treat the symptoms but not the root causes, the oil control effect is not lasting, and part of raw materials cause skin thinning and drying and have large irritation to the skin can be solved.

The invention provides a composition and application thereof in preparation of a fat-reducing product. The composition comprises ginger and green tea composite micro-capsule powder, raspberry ketone, mango concentrated powder, citrus fruit powder and seaweed powder. The composition comprises the following components in parts by weight: 15-22 parts of fresh ginger and green tea composite microcapsule powder, 4-8 parts of mango concentrated powder, 1-5 parts of raspberry ketone, 1-5 parts of citrus fruit powder and 1-5 parts of seaweed powder. The method can solve the problem of large side effects of fat-reducing products in the prior art, and is suitable for the field of functional foods.

According to the herbal amino acid face cleaning mousse disclosed by the invention, performance comparison is carried out on high and low addition amounts of various surfactants, a data basis is provided for compounded surfactants, and then a face cleaning mousse system is constructed by utilizing a compounded optimal surfactant group; the cleansing mousse is good in stability, rich and fine in foam, good in washing smoothness, easy to wash cleanly and low in water loss rate, skin dryness after use is reduced, and diversified requirements of consumers are met. By optimizing the dosage of glycerol and 1, 3-butanediol, the foam texture is better, and the foam is more elastic. By adding the jojoba oil, the irritation to the skin and eyes is minimized while the facial greasy dirt is mildly washed off, and obvious moistening and moisturizing effects are brought. By adding raspberry ketone and raspberry ketone glucoside, a preservative-free system is constructed, and the anti-oxidation effect is achieved; by means of the herbal extracts, product irritation is reduced, damage of free radicals is prevented, the resistance of skin is improved, and the product can be applied to various skin types better.

The present invention is in the field of genetically modified enzyme and microorganism comprising such a modified enzyme for the production of raspberry ketone or zingerone. The modified enzyme is a polyketide synthase (PKS) issued or derived from a wild type PKS. The modified PKS has the capability to produce vanillylidene acetone from feruloyl-CoA and / or 4-hydroxybenzalacetone from 4-coumaroyl-CoA in a more effective way as compared to wild type BAS or wild type PmPKS, in particular in recombinant bacteria strains.

The invention discloses a whitening and freckle-removing essence which comprises the following components: a calendula extract, pure water, 1, 2-pentanediol, methylpropanediol, carbomer, arginine, nicotinamide, a freckle-removing essence, a natural plant penetration enhancer, hydroxyethyl piperazine ethanesulfonic acid, small-molecule ellagic acid, dipropylene glycol, 1, 2-propylene glycol, ethanol and water. The composition is prepared from 1, 2-hexanediol, caprylyl glycol, ethylhexylglycerin, raspberry ketone glucoside and a PEG / PPG-17 / 6 copolymer. The invention further discloses a production process of the whitening and freckle-removing essence water. The invention has the following advantages: with pure natural plants as a main product, the skin has obvious change after being used for a week, specifically, pregnancy spots, sunburn, chloasma, pigmentation after inflammation and other color spots on the face can be reduced and faded, the face skin can be whitened, the face is mild and non-irritating, and the effects of improving uneven skin color, brightening skin color and the like can be achieved.

The invention provides a method for extracting raspberry ketone through raspberry enzymolysis and ultrasonic wave, and belongs to the technical field of natural product extraction. The method comprises the following steps: selecting cyan raspberry fruits which are about to be ripe and free from diseases and insect pests, washing, freeze-drying and crushing to 30 meshes; then, carrying out composite enzymolysis, and carrying out enzymolysis on cellulase, pectinase and hemicellulase at the mass ratio of 0.8%-1.2% to 3: 1: 2 for 2-4 hours under the conditions that the temperature is 50 DEG C and the pH is 5.0; and extracting for 20-60 minutes by using a 80% ethanol solution under the assistance of the ultrasonic power of 220W and the frequency of 30kHz. And finally, carrying out vacuum concentration and silica gel column chromatography separation to obtain a high-purity product. The method obviously improves the extraction rate, has the advantages of environmental protection and economy, and meets the requirements of industrial production on raspberry ketone extraction.

The invention provides gel containing SOD (superoxide dismutase) and a preparation method, and relates to the field of gel preparation. The preparation method of the gel containing the SOD superoxide dismutase comprises the following steps: S1, adding water and glycerol into a stirring pot, and stirring; s2, uniformly stirring, adding carbomer, and homogenizing for a proper time; s3, stirring while heating after mixing, and adding raspberry ketone and 1, 2-hexanediol during the period; s4, continuously raising the temperature, keeping the temperature for a proper time after the designed temperature is reached, and cooling after the temperature is kept; s5, adding SOD (superoxide dismutase) and continuously stirring; s6, stirring until dissolving, adding triethanolamine or sodium hydroxide, and stirring; and S7, uniformly stirring, and cooling to room temperature to obtain the gel containing SOD. In the invention, the gel containing superoxide dismutase not only resists oxidation, but also contributes to promoting skin repair and relieving inflammation, and especially under the condition of sensitivity or susceptibility to stimulation, the gel containing superoxide dismutase possibly contributes to accelerating repair, relieving discomfort and improving comfort.

The invention discloses a preparation method of silk fibroin-based hemostatic gel. The preparation method comprises the following steps: (1) hydrolyzing regenerated silk fibroin, and dialyzing to obtain micromolecular silk fibroin; (2) modifying the micromolecular silk fibroin by using a modifier to obtain micromolecular modified silk fibroin; and (3) mixing the small-molecule modified silk fibroin with an auxiliary agent, a photoinitiator, modified gelatin and raspberry ketone glucoside in proportion, and stirring and reacting in a dark place to obtain the silk fibroin-based hemostatic gel. The silk fibroin-based hemostatic gel prepared by the invention has the advantages of rapid hemostasis, good application property and the like, and can be widely applied to the fields of trauma hemostasis and the like.

The invention discloses an alkylation catalyst and application thereof in raspberry ketone synthesis, and the preparation method of the catalyst comprises the following steps: (1) pretreatment: washing ion exchange resin with an alcohol solvent to remove impurities, and drying to obtain pretreated resin; (2) hydrophobization treatment: carrying out hydrophobization treatment on the resin pretreated in the step (1) and silane, and then washing and drying to obtain hydrophobized modified resin; and (3) metal ion doping: dipping the hydrophobic modified resin in a metal ion solution for doping, and then filtering, washing and drying to obtain the modified acidic cation exchange resin catalyst. When the catalyst is applied to raspberry ketone synthesis, the catalytic activity, the selectivity and the stability of the catalyst are superior to those of a traditional method and an unmodified catalyst, and the catalyst has remarkable industrial application value.

The application of raspberry ketone in the immunotherapy of pancreatic cancer belongs to the technical field of biological medicine, and provides the application of raspberry ketone in the immunotherapy of pancreatic cancer. The application discloses that raspberry ketone can specifically and widely up-regulate the expression of MHC-I molecules on the surface of pancreatic cancer cells, and significantly enhances the infiltration and function of anti-tumor effector T cells in the tumor immune microenvironment. In-vivo and in-vitro experiments prove that raspberry ketone can reverse tumor immune escape by up-regulating MHC-I, and after being combined with a PD-1 immune checkpoint inhibitor, the raspberry ketone can produce a significant synergistic anti-tumor effect, significantly inhibit the growth of pancreatic cancer and prolong the survival period of tumor-bearing mice. The application provides a new strategy of combining a natural small molecule immunomodulator with an existing immunotherapy, and provides an innovative solution and a drug candidate for overcoming the difficulty of pancreatic cancer tolerance to immunotherapy.

The invention relates to the technical field of enzyme engineering and biology, and discloses an olefin reductase mutant as well as a coding gene, a recombinant vector, a recombinant strain, an enzyme preparation and application thereof. The olefin reductase mutant provided by the invention is obtained by mutating at least one of F297V, F297V / F124N and F297V / F124N / M40F on an enzyme with an amino acid sequence as shown in SEQ ID NO.1. Compared with a wild enzyme, the olefin reductase mutant has the advantages that the efficiency of catalyzing p-hydroxybenzylideneacetone to generate raspberry ketone is obviously improved, complicated reaction environment control equipment is not needed, the cost is low, and the production cost is low. And an efficient and feasible enzyme catalyst scheme is provided for industrial green production of raspberry ketone.

The invention belongs to the technical field of cosmetics, and discloses a plant source antimicrobial composition as well as a preparation method and application thereof. The botanical antimicrobial composition disclosed by the invention is prepared from the following components in parts by weight: 0.05 to 5 parts of cacumen biotae extract, 10 to 30 parts of raspberry ketone and 0.05 to 5 parts of hinokiol. According to the plant source antimicrobial composition disclosed by the invention, a multi-target and all-around antibacterial and antiseptic system is constructed through a synergistic effect of natural plant components, rapid and broad-spectrum inhibition on bacteria, fungi and propionibacterium acnes is realized, and excellent physical and chemical stability can be kept in an extreme environment; the preservative effect is not affected by a complex formula system, and the function of instantly killing acne pathogenic bacteria is achieved. Meanwhile, the plant-derived antimicrobial composition can also be perfectly compatible with active ingredients of various cosmetics, can be flexibly applied to various product types, and provides a natural, efficient, reliable and low-irritation preservative solution for users.

The invention discloses a preservative composition based on raspberry ketone as well as a preparation method and application thereof, and relates to the technical field of preservatives. The preservative composition based on raspberry ketone comprises raspberry ketone, propylene glycol, caprylyl glycol and chlorphenesin. According to the technical scheme, through the synergistic compounding effect of the raspberry ketone, the propylene glycol, the caprylyl glycol and the chlorphenesin, the excellent sterilization and degerming effects are achieved. According to the preservative composition based on raspberry ketone, the bacteriostatic and preservative effects of all the raw materials are fully exerted and utilized, breeding of bacteria and molds in daily necessities can be remarkably inhibited, the remarkable preservative, sterilizing and degerming effects are achieved, and the shelf life of the product is prolonged. The raspberry ketone-based preservative composition provided by the invention is small in irritation, can achieve efficient sterilization and degerming effects only by adding a small amount of the raspberry ketone-based preservative composition, and realizes double breakthrough of improving the preservative efficiency and reducing the irritation.

The present invention provides a method for producing raspberry ketone by microbial fermentation. Using agricultural production waste as the raw material for the fermentation medium, it adopts a one-step fermentation method with natural yeast from raspberry fruits to produce raspberry ketone, solving problems such as complex operation, long fermentation cycle, and high raw material prices. The operation steps include: S1: activation of the fermentation strain; S2: preparation of the fermentation seed liquid; S3: preparation of the sterilized raspberry leaf extract; S4: preparation of the sterilized bamboo shoot skin extract; S5: preparation of the fermentation medium; S6: production inoculation and fermentation of raspberry ketone; S7: obtaining the raspberry ketone product. The present invention effectively utilizes resources, reduces environmental pollution caused by discarded agricultural waste; the fermentation medium is green, environmentally friendly, and low-cost, and the produced raspberry ketone has high economic value, turning waste into treasure; the fermentation conditions are mild, with a short time, high efficiency, and high yield. The equipment required for industrial production is conventional fermentation equipment, with simple operation and strong feasibility.

The invention provides a collagen composition with tightening and anti-wrinkle effects and application thereof. The collagen composition comprises a centella asiatica extract, a collagen extract, collagen amino acids, polyhydric alcohols, raspberry ketone, soluble collagen and recombinant collagen. The centella asiatica extract, the collagen extract, the soluble collagen, the collagen amino acids and the recombinant collagen are matched for use, so that the problem of effect disruption caused by barrier damage when the collagen is independently used is solved, and the defect of insufficient anti-aging (collagen regeneration) strength when the centella asiatica is independently used is overcome; and the double effects of repairing and bottoming, resisting aging and improving efficiency are achieved.

The invention relates to a preparation method and application of acetylated raspberry ketone, and the preparation method is characterized in that acetic anhydride is used as an acetylation reagent to realize hydroxyl acetylation of raspberry ketone in the presence of a proper catalyst and a proper solvent so as to obtain high-purity acetylated raspberry ketone. The reaction conditions are mild, and high temperature and high pressure are not needed; the product purity is high; the method is simple to operate and suitable for industrial production. Moreover, when the acetylated raspberry ketone is used for preparing an antimicrobial composition, the effect is remarkable, and microorganisms comprise Listeria bacteria or salmonella typhimurium.

The application discloses a method for improving the conversion rate of raspberryin in sidestream smoke, which comprises the following steps: mixing raspberryin and a certain amount of intumescent flame retardant, and adding the mixture to the burning position of a cigarette. The method can obviously improve the conversion rate of raspberryin converted into raspberry ketone in sidestream smoke.

The invention discloses a skin care composition with effects of shrinking pores, tendering skin and resisting wrinkles as well as a preparation method and application of the skin care composition, and particularly belongs to the technical field of daily cosmetics. The composition is prepared from the following components in parts by mass: 5 to 8 parts of astragalus membranaceus root extract, 0.15 to 0.2 part of raspberry ketone glucoside, 3 to 5 parts of gloiopeltis furcata extract, 0.8 to 1 part of pyracantha fortuneana fruit extract and 20 to 30 parts of bifidus yeast fermentation product filtrate, and the components are extracted by a specific process. The composition provided by the invention has the effects of shrinking pores, resisting wrinkles, tightening skin, controlling oil and the like, and can be used for preparing various skin care products such as essence, emulsion and the like.

Disclosed herein is a frambinone methacrylate (FMA) or raspberry ketone methacrylate (RKMA) monomer having the following structure:anda zingerone methacrylate (ZMA) having the following structureAlso disclosed are homopolymers and co-polymers utilizing same monomer. Also disclosed is a class of methacrylate monomers comprising a bio-based moiety and a reactive ketone moiety. Also disclosed are paint compositions made with a copolymer including FMA and / or ZMA.

The invention relates to the technical field of biological medicine, in particular to application of raspberry ketone glucoside in preparation of a preparation for preventing and treating monocolonic insect. Experiments and tests show that the raspberry ketone glucoside shows remarkable killing activity on fish monozoiasis, and meanwhile, the raspberry ketone glucoside also keeps good safety on fishes. After short-time immersion bath administration, the raspberry ketone glucoside can weaken the movement of the monoagonism and influence the generation of ATP (adenosine triphosphate) of the monoagonism. The raspberry ketone glucoside disclosed by the invention has a relatively good prevention and control effect on fish mononimus, and more solutions can be provided for disease prevention and control of aquaculture by developing a preparation based on the raspberry ketone glucoside.

The present invention is in the field of genetically modified enzyme and microorganism comprising such a modified enzyme for the production of raspberry ketone or zingerone. The modified enzyme is a polyketide synthase (PKS) issued or derived from a wild type PKS. The modified PKS has the capability to produce vanillylidene acetone from feruloyl-CoA and / or 4-hydroxybenzalacetone from 4-coumaroyl-CoA in a more effective way as compared to wild type BAS or wild type PmPKS, in particular in recombinant bacteria strains.

The present application discloses a skin care composition and its use, the skin care composition comprises ectoine and raspberry ketone, the mass ratio of the ectoine and raspberry ketone is 10:1~1:15, the skin care composition has a positive effect on promoting skin barrier repair.

A cosmetic sunscreen composition comprises avobenzone and one or more of Raspberry Ketone, γ-Oryzanol and Ethyl Ferulate to stabilize the avobenzone.

The invention relates to an anti-wrinkle composition and application thereof. The anti-wrinkle composition comprises a nostoc sphaeroids kutz extract, hydroxydecyl ubiquinone, rutin and raspberry ketone glucoside. The invention creatively finds that the common nostoc extract, the hydroxydecyl ubiquinone, the rutin and the raspberry ketone glucoside are matched for use and have a synergistic effect, so that the composition has good wrinkle-removing and anti-oxidation effects, and can recover skin elasticity, accelerate skin cell viability, reduce skin laxity and recover the health state of the skin.

The invention relates to liquid watermelon essence as well as a preparation method and application thereof. The liquid watermelon essence comprises the following raw materials in percentage by mass: 10-15% of melonal propylene glycol acetal; 60 to 70 percent of propylene glycol; 10-15% of an alcohol raw material; 1-5% of an aldehyde raw material; 1-5% of a ketone raw material; 0.5-3% of an ester raw material; 0.5-1% of maltol or a derivative thereof; wherein the alcohol raw material is a mixture of leaf alcohol, cis-6-nonenol and nonanol; the aldehyde raw material is a mixture of vanillin, melonal and cyclamen aldehyde; the ketone raw material is a mixture of raspberry ketone, beta-ionone and dihydrojasmonone; the ester raw material is a mixture of ethyl hexanoate, leaf alcohol acetate, diethyl sebacate, ethyl acetoacetate, methyl octyne carboxylate and benzyl cinnamate; the maltol or the derivative thereof is at least one of ethyl maltol and maltol. The essence is resistant to high temperature, and can maintain a strong watermelon fragrance in a high-temperature food processing process.

The application discloses a skin care composition with pore-shrinking, skin tenderizing and wrinkle-resisting effects and a preparation method and application thereof, and particularly belongs to the technical field of daily-use cosmetics. The composition contains the following components in mass fractions: 5-8 parts of Astragalus membranaceus (Fisch.) Bunge root extract, 0.15-0.2 parts of raspberry ketone glucoside, 3-5 parts of sea algae extract, 0.8-1 part of fire jujube fruit extract and 20-30 parts of Saccharomyces bitymus fermentation product filtrate, and each component is prepared through specific process extraction; the composition provided by the application has pore-shrinking, wrinkle-resisting, skin tightening, oil-controlling and other effects, and can be used for preparing various skin care products such as essence and emulsion.

The present application belongs to the technical field of cosmetic compositions, and particularly relates to a composition with nourishing effect on damaged hair and application thereof. The composition comprises Ulva compressa extract, raspberry ketone glucoside, Sudan cola seed extract and Camellia nitidissima flower extract, wherein the weight ratio of the Ulva compressa extract, the raspberry ketone glucoside, the Sudan cola seed extract and the Camellia nitidissima flower extract is (1-20):(1-10):(1-10):(5-50). The components of the present application produce a synergistic effect, can significantly improve the combing property of damaged hair, improve the gloss of hair, and show excellent effects in moisturizing, smoothing, nourishing and repairing, and the consumer's use feeling is obvious.

The invention provides a method of promoting weight management in a mammal comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondrial enhancer. The weight loss agent can be selected from the group consisting of psyllium, guar gum, capsaicin, chitosan, caffeine, gamboge, mume, capsaicin, yohimbine, butterfly pea, glucomannan, African mango, guarana, pyruvate, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney bean, kola nut, chromium, ginseng, psyllium, St. John's wort, dandelion, hydroxycitric acid, conjugated linoleic acid, green tea, black tea, coffee bean extract, forskolin, and bitter orange. The mitochondrial enhancer can be selected from the group consisting of beetroot extract, nitrate, idebenone, nicotinamide riboside, elamipretide, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvate, coenzyme Q10, NADH, niacin, L-carnitine, dichloroacetate, curcumin, schisandrin, and resveratrol. Compositions for weight management are also provided.

The application discloses an alcohol dehydrogenase mutant and a method for synthesizing raspberry ketone by using the same. The mutant is obtained by mutating any one or more of positions 144, 145, 190, 40, 17, 64 and 94 of an alcohol dehydrogenase LbADH from Lactobacillus brevis shown in the sequence of SEQ ID NO:1. The application first mutates and screens a substrate binding pocket of LbADH, successfully obtains a mutant with improved catalytic activity for R-dulcitol and S-dulcitol, and realizes efficient catalysis of a single enzyme on two enantiomers. The application also mutates amino acids around an NADP+ binding site of LbADH, enhances the catalytic oxidation activity of the LbADH under high pH conditions, and successfully obtains a combined mutant with high catalytic efficiency under a high pH environment. The application provides a new technical means and solution for the oxidative conversion of 'natural' raspberry ketone.

The present invention relates to a raspberry ketone derivative formed by esterification of a raspberry ketone of chemical formula 1 and an amino acid or an amino acid substituted with an amine-protecting group, or a cosmetically or food-acceptable salt thereof, a preparation method therefor, and a cosmetic composition and a food composition comprising same. The raspberry ketone derivative exhibits excellent effects in anti-inflammation, skin whitening, skin elasticity enhancement, and wrinkle reduction, and thus can be effectively used for cosmetics and food.