Anti-wrinkle composition and application thereof

Abstract

The invention relates to an anti-wrinkle composition and application thereof. The anti-wrinkle composition comprises a nostoc sphaeroids kutz extract, hydroxydecyl ubiquinone, rutin and raspberry ketone glucoside. The invention creatively finds that the common nostoc extract, the hydroxydecyl ubiquinone, the rutin and the raspberry ketone glucoside are matched for use and have a synergistic effect, so that the composition has good wrinkle-removing and anti-oxidation effects, and can recover skin elasticity, accelerate skin cell viability, reduce skin laxity and recover the health state of the skin.

Description

Technical Field

[0001] The invention belongs to the technical field of daily cosmetics, and particularly relates to an anti-wrinkle composition and application thereof. Background Art

[0002] The formation of skin wrinkles is a complex physiological process involving a variety of internal and external factors, including: 1. Natural aging: Decrease in collagen and elastic fibers: With age, the collagen and elastic fibers in the skin gradually decrease, causing the skin to lose elasticity and firmness, and easily forming wrinkles; 2. Slowed cell renewal: The renewal rate of skin cells slows down, and metabolism slows down, affecting the skin's self-repair ability; 3. Ultraviolet radiation: Long-term exposure to ultraviolet rays can cause skin photoaging, accelerate the degradation of collagen and elastic fibers, and form wrinkles; 4. Air pollution: Pollutants in the air can produce free radicals, damage skin cells, and accelerate skin aging; 5. Lifestyle habits: Such as smoking, harmful substances in tobacco can destroy collagen and elastic fibers, and accelerate skin aging; Unbalanced diet: Lack of necessary vitamins and minerals can affect skin health; Lack of sleep: Long-term lack of sleep can affect the skin's ability to repair and regenerate; Expression habits: Repeated expression movements: Frequent expression movements can cause dynamic wrinkles on certain parts of the skin, which will become static wrinkles over time.

[0003] CN119033664A discloses a firming and anti-wrinkle composition and its application. The firming and anti-wrinkle composition comprises the following components in parts by weight: 3-10 parts of three-factor components, 2-8 parts of enzymatic hydrolysate, 1-4 parts of active peptides, 15-30 parts of polyols, and 50-80 parts of water; wherein the three-factor components are bosaiine, ectoine, and ergothioneine, the enzymatic hydrolysate is an enzymatic hydrolysate of aloe vera and royal jelly complex, and the active peptides are acetyl hexapeptide-8 and palmitoyl tripeptide. The components of the composition synergize to effectively delay skin aging caused by internal factors, and can also effectively fight against skin sagging, wrinkles, and other problems caused by external environmental factors, and has good firming and anti-wrinkle effects.

[0004] CN118873451A discloses a mild anti-wrinkle and anti-aging composition, which uses mild hydroxypinacolone retinoic acid ester, Indian swede sprout extract, ceramide NP, tocopherol (vitamin E), hydrogenated lecithin, caprylic / capric triglyceride, sunflower seed oil, sodium hyaluronate, sodium polyglutamate, and forms a finished product through the preparation process of preparing an oily solution, preparing an aqueous solution, and hot inclusion. Wherein sodium hyaluronate and sodium polyglutamate can better moisturize and lock water, ensure the moisture of the skin, combine hydroxypinacolone retinoic acid ester, Indian swede sprout extract, ceramide NP, tocopherol (vitamin E), hydrogenated lecithin, caprylic / capric triglyceride, sunflower seed oil, can better act on the basal layer of the skin, exert efficacy, and play a mild anti-wrinkle and anti-aging effect.

[0005] At present, although the existing technologies for anti-wrinkle treatment of skin are effective, there may also be some side effects and risks. For example, local redness and swelling of the facial skin may occur when the product is used, affecting normal facial expressions, etc. Therefore, there is an urgent need to provide a safe, non-irritating and more effective product to meet application needs. Summary of the invention

[0006] In view of the deficiencies of the prior art, the present invention aims to provide an anti-wrinkle composition and its application. The anti-wrinkle composition is intended to safely and effectively smooth wrinkles, and has the effects of firming the skin, improving skin elasticity, anti-aging, and anti-oxidation, and has low cost, simple preparation method, and broad application prospects.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides an anti-wrinkle composition, comprising an extract of Pueraria lobata, hydroxydecylubiquinone, rutin and raspberry ketone glucoside.

[0009] The protein content of the kudzu vine extract in the composition of the present invention is as high as 48.61%, and it contains 17 kinds of amino acids in total, including 7 kinds of essential amino acids for humans, with a total content of 44.619%. It has a strong water-locking and moisturizing effect, which is mainly due to its polysaccharide structure, which can effectively maintain the moisture of the skin and keep the skin moisturized for a long time; secondly, the kudzu vine extract can also deeply nourish the skin, enhance the water retention capacity of the skin, effectively relieve dry skin, and make the skin smooth and tender; in addition, the kudzu vine extract is rich in multiple active ingredients, which can promote the metabolism of skin cells, enhance skin immunity, improve skin texture, and increase skin elasticity and vitality; at the same time, it also has an antioxidant effect, which can help the skin resist damage from the external environment and prevent skin aging.

[0010] The hydroxydecyl ubiquinone: Hydroxydecyl ubiquinone, also known as idebenone, is a synthetic ubiquinone compound that is similar in structure to coenzyme Q10 (CoQ10), but has better skin absorption and stability. Hydroxydecyl ubiquinone is popular for its multiple benefits in skin care products, especially as a highly effective antioxidant and skin conditioner. Hydroxydecyl ubiquinone is a powerful antioxidant that can scavenge free radicals and reduce the damage of oxidative stress to skin cells. It has stronger antioxidant capacity than traditional antioxidants such as vitamin C, E and coenzyme Q10; it has anti-inflammatory properties, can reduce skin inflammation, and is particularly beneficial for sensitive and irritated skin. It can reduce pigmentation and has a positive effect on preventing and fading spots.

[0011] Rutin: also known as rutin or vitamin P, is a naturally occurring flavonoid compound, a type of flavonol glycoside. It is mainly derived from plants, especially buckwheat, citrus fruits and some other vegetables. In cosmetics, rutin is mainly used for its antioxidant, anti-inflammatory, anti-ultraviolet and skin barrier enhancement. Rutin can resist the damage of free radicals and reduce the damage of oxidative stress to skin cells, thereby playing an anti-aging effect.

[0012] The raspberry ketone glucoside: raspberry glycoside is a whitening and brightening ingredient derived from raspberry fruit. It can reduce the production of melanin through dual-pathway and multi-target effects, reduce the formation of erythema and pigmentation after ultraviolet radiation, and has particularly good stability and safety.

[0013] The present invention creatively discovered that the combination of the kudzu vine extract, hydroxydecylubiquinone, rutin and raspberry ketone glucoside has a synergistic effect, which can make the composition have good wrinkle removal and antioxidant effects, and can restore skin elasticity, accelerate skin cell activity, reduce skin sagging, and restore the skin to a healthy state.

[0014] Preferably, the mass ratio of the kudzu vine extract, hydroxydecylubiquinone, rutin and raspberry ketone glucoside is (0.1-5):(0.1-20):(0.1-8):(0.1-18).

[0015] Wherein “0.1-5” can be 0.2, 0.5, 0.7, 0.8, 0.9, 1, 1.1, 1.3, 1.5, 1.7, 1.9, 2, 2.1, 2.3, 2.5, 2.7, 2.9, 3, 3.1, 3.3, 3.5, 3.7, 3.9, 4, 4.2, 4.5, 4.7 or 4.9, etc.;

[0016] “0.1-20” can be 0.2, 0.5, 0.8, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 or 19, etc.;

[0017] “0.1-8” can mean 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7 or 7.5, etc.;

[0018] “0.1-18” can be 0.3, 0.5, 0.7, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17, etc.

[0019] Preferably, the mass ratio of the kudzu vine extract, hydroxydecylubiquinone, rutin and raspberry ketone glucoside is (1-4):(1-18):(1-6):(1-15).

[0020] Specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0021] In a second aspect, the present invention provides a use of the anti-wrinkle composition as described in the first aspect in the preparation of cosmetics.

[0022] Preferably, the cosmetics include any one of lotion, essence, emulsion, cream, mask, spray, essence or facial cleanser.

[0023] Preferably, the mass percentage of the composition with skin soothing and repairing effects in the cosmetic is 0.05-10%, for example, it can be 0.08%, 0.1%, 0.3%, 0.5%, 0.7%, 0.9%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% or 9%, etc.

[0024] Specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0025] In a third aspect, the present invention provides an anti-wrinkle essence, the components of which include the anti-wrinkle composition as described in the first aspect, a moisturizer, a thickener and water.

[0026] Preferably, the anti-wrinkle essence comprises, by weight, 0.05-10 parts of the anti-wrinkle composition as described in the first aspect, 1-20 parts of a moisturizer, 0.1-5 parts of a thickener, and 65-99 parts of water.

[0027] The amount of the anti-wrinkle composition added to the essence of the present invention can be 0.08 parts, 0.1 parts, 0.3 parts, 0.5 parts, 0.8 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts, etc.;

[0028] The amount of the moisturizer added can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts or 19 parts, etc.;

[0029] The thickener may be added in an amount of 0.3 parts, 0.5 parts, 0.8 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

[0030] The amount of water added can be 67 parts, 70 parts, 72 parts, 75 parts, 78 parts, 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts or 98 parts, etc.

[0031] Preferably, the moisturizer includes any one of glycerin, butylene glycol, glycerin, caprylyl glycol, sodium hyaluronate, erythritol, polyglycerol-10, 1,3-propylene glycol, β-glucan, hyaluronic acid / sodium hyaluronate, betaine, trehalose or polyethylene glycol-8, or a combination of at least two thereof.

[0032] Preferably, the moisturizing agent is a combination of glycerin, caprylyl glycol, sodium hyaluronate, erythritol and polyglycerol-10.

[0033] Preferably, the thickener includes any one of sodium chloride, PEG-250 distearate, PEG-150 distearate, 1,2-pentanediol, lecithin, carbomer, xanthan gum, hydroxyethyl cellulose, and polyacrylate cross-linked polymer-6, or a combination of at least two thereof.

[0034] Preferably, the anti-wrinkle essence also includes a polysaccharide composition.

[0035] Preferably, the anti-wrinkle essence further comprises 0.1-2 parts of the polysaccharide composition by weight, for example, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts or 1.9 parts, etc.

[0036] Preferably, the polysaccharide composition comprises any one of or a combination of at least two of Euglena polysaccharides, Tremella fuciformis polysaccharides, soluble proteoglycans, Alcaligenes polysaccharides, Pullulan polysaccharides, Aloe vera leaf polysaccharides or Tamarindus indica seed polysaccharides.

[0037] Preferably, the polysaccharide composition is a combination of Alcaligenes polysaccharides and soluble proteoglycans.

[0038] The anti-wrinkle composition and the polysaccharide composition of the present invention also have a synergistic effect in anti-wrinkle effect, and when the polysaccharide composition is a combination of Alcaligenes polysaccharides and soluble proteoglycans, the anti-wrinkle effect of the product after being used in cosmetics is more significant.

[0039] Preferably, the mass ratio of the Alcaligenes polysaccharide to the soluble proteoglycan is 1:(3-6), for example, it can be 1:3.2, 1:3.5, 1:3.8, 1:4, 1:4.2, 1:4.5, 1:4.8, 1:5, 1:5.2, 1:5.5 or 1:5.8, etc.

[0040] Specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0041] In a fourth aspect, the present invention provides a method for preparing the anti-wrinkle essence according to the third aspect, the preparation method comprising:

[0042] The anti-wrinkle essence is obtained by mixing the anti-wrinkle composition of the first aspect, the moisturizer and the thickener in water until homogeneous.

[0043] Preferably, the preparation method comprises:

[0044] (1) heating water, then adding a moisturizer and a polysaccharide composition to obtain a mixed solution;

[0045] (2) adding a thickener to the mixed solution and mixing the mixture, then standing the mixture to cool, and then adding the anti-wrinkle composition to homogenize the mixture to obtain the anti-wrinkle essence.

[0046] Preferably, the temperature in step (1) is raised to 40-60°C, for example, 41°C, 43°C, 45°C, 47°C, 50°C, 52°C, 55°C, 57°C or 59°C.

[0047] Preferably, the mixing in step (2) is carried out under heating in a water bath.

[0048] Preferably, the water bath heating temperature is 65-80°C, for example, 66°C, 68°C, 70°C, 72°C, 74°C, 76°C or 78°C.

[0049] Preferably, the temperature in step (2) is lowered to 20-35°C, for example, 21°C, 23°C, 25°C, 27°C, 29°C, 30°C, 32°C or 34°C.

[0050] Specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0051] Compared with the prior art, the present invention has the following beneficial effects:

[0052] (1) The inventors have creatively discovered that the combination of the kudzu vine extract, hydroxydecylubiquinone, rutin, and raspberry ketone glucoside has a synergistic effect, which can make the composition have good wrinkle removal and antioxidant effects, and can restore skin elasticity, accelerate skin cell activity, reduce skin sagging, and restore the skin to a healthy state.

[0053] (2) The essence provided by the present invention has significant anti-wrinkle, anti-aging and anti-oxidation effects by adding an anti-wrinkle composition, and consumers can make their skin more elastic and more energetic after using it.

[0054] (3) The preparation method of the essence provided by the present invention has simple operation steps, low cost, and is easy to industrialize and mass produce. DETAILED DESCRIPTION

[0055] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0056] The weight percentages involved in the following embodiments and comparative examples are all calculated based on the actual effective ingredients contained in the commercially available raw materials. The commercially available raw materials may also selectively contain any one or a combination of at least two of solvents, fillers, diluents, stabilizers, pH adjusters, antibacterial agents, antioxidants or impurities within the permitted range.

[0057] The following materials and comparative examples are as follows:

[0058] Raw material name Manufacturer Pueraria Extract Ningxia Vanilla Biotechnology Co., Ltd. Hydroxydecylubiquinone Guangzhou Xufan Biotechnology Co., Ltd. Rutin Beijing Naiqu Biochemical Technology Research Institute Raspberry Ketone Glucoside Beijing Belliles Biotechnology Co., Ltd. Alcaligenes polysaccharides Zhixiang Biotech Co., Ltd. Soluble proteoglycan Shanghai Jiufeng Biotechnology Co., Ltd.

[0059] The rest of the raw materials can be used as long as they are purchased from regular dealers.

[0060] Example 1

[0061] This embodiment provides an anti-wrinkle composition, wherein the formula of the anti-wrinkle composition is kudzu vine extract, hydroxydecyl ubiquinone, rutin and raspberry ketone glucoside in a mass ratio of 1:8:5:8.

[0062] Example 2

[0063] This embodiment provides an anti-wrinkle composition, wherein the formula of the anti-wrinkle composition is kudzu vine extract, hydroxydecyl ubiquinone, rutin and raspberry ketone glucoside in a mass ratio of 4:2:1:15.

[0064] Example 3

[0065] This embodiment provides an anti-wrinkle composition, wherein the formula of the anti-wrinkle composition is kudzu vine extract, hydroxydecylubiquinone, rutin and raspberry ketone glucoside in a mass ratio of 1:17:3:1.

[0066] Example 4

[0067] This embodiment provides an anti-wrinkle composition, wherein the formula of the anti-wrinkle composition is kudzu vine extract, hydroxydecyl ubiquinone, rutin and raspberry ketone glucoside in a mass ratio of 6:4.9:10:0.1.

[0068] Example 5

[0069] This embodiment provides an anti-wrinkle composition, wherein the formula of the anti-wrinkle composition is kudzu vine extract, hydroxydecyl ubiquinone, rutin and raspberry ketone glucoside in a mass ratio of 0.1:2.8:0.1:19.

[0070] Comparative Example 1

[0071] This comparative example provides an anti-wrinkle composition, which is different from Example 1 only in that the composition does not include the kudzu vine extract and the mass ratio of hydroxydecylubiquinone, rutin and raspberry ketone glucoside is kept unchanged.

[0072] Comparative Example 2

[0073] This comparative example provides an anti-wrinkle composition, which is different from Example 1 only in that hydroxydecylubiquinone is not included in the components, and the mass ratio of the kudzu vine extract, rutin and raspberry ketone glucoside is kept unchanged.

[0074] Comparative Example 3

[0075] This comparative example provides an anti-wrinkle composition, which is different from Example 1 only in that rutin is not included in the components, and the mass ratio of the kudzu vine extract, hydroxydecylubiquinone and raspberry ketone glucoside is kept unchanged.

[0076] Comparative Example 4

[0077] This comparative example provides an anti-wrinkle composition, which is different from Example 1 only in that raspberry ketone glucoside is not included in the composition, and the mass ratio of kudzu vine extract, hydroxydecylubiquinone and rutin is kept unchanged.

[0078] Comparative Example 5

[0079] This comparative example provides an anti-wrinkle composition, which is different from Example 1 only in that raspberry ketone glucoside and rutin are not included in the composition, and the mass ratio of kudzu vine extract and hydroxydecylubiquinone is kept unchanged.

[0080] Comparative Example 6

[0081] This comparative example provides an anti-wrinkle composition, which is different from Example 1 only in that the composition does not include the kudzu vine extract and hydroxydecylubiquinone, and the mass ratio of raspberry ketone glucoside and rutin is kept unchanged.

[0082] Application Examples 1-3

[0083] This application example provides three anti-wrinkle essences, and their formulas (contents are in parts) are as follows:

[0084]

[0085]

[0086] Its preparation method is:

[0087] Heat water to 50°C, then add moisturizer and polysaccharide composition and stir evenly; continue to add thickener, stir evenly and then cool to 25°C, then add anti-wrinkle composition, stir evenly and serve, to obtain anti-wrinkle essence.

[0088] Application Example 4-5

[0089] This application example provides two essences, the formula of which differs from that of application example 1 only in that the composition of example 1 is replaced with equal amounts of the compositions of examples 4-5, respectively, and other ingredients and contents remain unchanged. The preparation method refers to that of application example 1.

[0090] Application Example 6

[0091] This application example provides an essence, the formula of which differs from that of application example 1 only in that it does not include a polysaccharide composition, the reduced amount of which is supplemented by deionized water, and the other ingredients and contents remain unchanged. The preparation method refers to that of application example 1.

[0092] Application Example 7

[0093] This application example provides an essence, the formula of which differs from that of application example 1 only in that the polysaccharide composition does not include Alcaligenes polysaccharides, and the reduced amount is supplemented by soluble proteoglycans, while other components and contents remain unchanged. The preparation method refers to that of application example 1.

[0094] Application Example 8

[0095] This application example provides an essence, the formula of which differs from that of application example 1 only in that the polysaccharide composition does not include soluble proteoglycan, and the reduced amount is supplemented by alcaligenes polysaccharides, while other components and contents remain unchanged. The preparation method refers to application example 1.

[0096] Comparative Application Examples 1-6

[0097] This comparative application example provides four kinds of essences, the formula of which is different from that of application example 1 only in that the composition of example 1 is replaced by the composition of comparative examples 1-6 in equal amounts, and the other ingredients and contents remain unchanged. The preparation method is the same as that of application example 1.

[0098] Comparative Application Example 7

[0099] This comparative application example provides an essence, the formula of which differs from that of application example 1 only in that the composition of embodiment 1 is not included, the reduced amount of which is supplemented by water, and the other components and contents remain unchanged. The preparation method is similar to that of application example 1.

[0100] Test Example 1 Antioxidant Test

[0101] The DPPH free radical scavenging rate reflects its antioxidant capacity to a certain extent. The higher the scavenging rate, the better the antioxidant degree and the better the anti-aging effect. Therefore, the anti-aging effect of the composition can be judged by studying its ability to scavenge DPPH free radicals.

[0102] Test method: add 2 mL of DPPH test solution with a mass concentration of 0.02 mg / L and 2 mL of the anti-wrinkle composition skin care product prepared in Application Example 1-8 and the anti-wrinkle composition skin care product prepared in Comparative Example Application 1-7 to a test tube, add anhydrous ethanol to the total volume to 5 mL, shake well, react in the dark for a period of time, and measure the absorbance at a wavelength of 517 nm with a 1 cm cuvette, recorded as As; add 2 mL of DPPH test solution and 3 mL of anhydrous ethanol to the test tube, and the measured absorbance is recorded as A0; add 2 mL of anhydrous ethanol and the corresponding volume of the traditional Chinese medicine composition to the test tube, add anhydrous ethanol to the total volume to 5 mL, and the measured absorbance is recorded as sample A.

[0103] The calculation formula of DPPH free radical scavenging rate (Y) is: Y (%) = 1 - (As - A sample) / A0 × 100%, the results are shown in Table 1 (each group of samples was measured 5 times in parallel, and the data are presented as average values).

[0104] Table 1

[0105] project DPPH free radical scavenging rate (%) Application Example 1 89.10％ Application Example 2 87.20％ Application Example 3 88.10％ Application Example 4 76.3％ Application Example 5 75.5％ Application Example 6 61.6％ Application Example 7 71.1％ Application Example 8 70.2％ Comparative application example 1 69.40％ Comparative Application Example 2 70.50％ Comparative Application Example 3 72.30％ Comparative Application Example 4 71.20％ Comparative Application Example 5 54.30％ Comparative Application Example 6 55.60％ Comparative Application Example 7 41.1％

[0106] It can be seen from the test data in Table 1 that, compared with the comparative application example 5, the DPPH free radical scavenging rate of the essence described in the application examples 1-3 of the present invention can reach more than 87%, which is significantly improved, indicating that the composition with skin soothing and repairing effects has very good antioxidant activity, can effectively remove skin free radicals, and reduce oxidative stress-related inflammatory reactions; the DPPH free radical scavenging rate in application example 6 has decreased, and the polysaccharide composition is added to the essence, which can be used in combination with the anti-wrinkle composition to significantly improve the antioxidant properties of the essence, and it can be seen from application examples 7-8 that the component selection of the polysaccharide composition also has an effect on the antioxidant property. It can be seen from comparative application examples 1-4 that the kudzu extract, hydroxydecyl ubiquinone, rutin and raspberry ketone glucoside in the composition with skin soothing and repairing effects of the present invention have a synergistic effect, and the lack of one of the four will reduce the antioxidant capacity of the essence to a certain extent.

[0107] Test Example 2

[0108] The wrinkle-removing and skin elasticity effects of the essences prepared using Examples 1-8 and Comparative Examples 1-7 were evaluated:

[0109] 90 trial subjects aged 20-45 were randomly selected and divided into 15 groups, with 6 subjects in each group. The 15 groups of trial subjects used the essence prepared in Application Examples 1-8 and Comparative Application Examples 1-7 (once in the morning and once in the evening) for 14 days. During the trial period, the subjects were not allowed to use other items to maintain skin elasticity and cosmetics that affect the results, and did not change their original eating habits during the trial period.

[0110] Cutometer MPA580 was used to test the skin condition on the 0th and 14th days. The test site was the zygomatic region. The probe was measured three times in the same test area and the average value was taken. The test parameter is R2 (the ratio of the skin rebound amount Ua without negative pressure to the maximum stretch amount Uf with negative pressure). The closer R2 is to 1, the better the skin elasticity. The average change value of R2 = R2 value on the 14th day - R2 value on the 0th day, and the average change rate of R2 = R2 average change value / R2 value on the 0th day. The specific test results of skin elasticity are shown in Table 2.

[0111] Table 2

[0112]

[0113]

[0114] It can be seen from the data in Table 2 that the essence involved in the present invention has a good skin tightening effect, among which the four components of Pueraria lobata extract, hydroxydecylubiquinone, rutin, and raspberry ketone glucose promote each other in this effect, have an unexpected synergistic effect, and have the best wrinkle removal and elasticity effect.

[0115] Test Example 3: Stability Test

[0116] 1. Heat resistance test: The constant temperature incubator was adjusted to 40°C. The application examples 1-8 prepared above were divided into 8 samples. The samples were placed in transparent glass bottles with a sample volume of 20 ml / bottle. After sealing, they were placed in a constant temperature incubator. After three months, they were taken out and returned to room temperature to observe the changes in appearance.

[0117] 2. Cold resistance test: The constant temperature incubator was adjusted to -10℃. The 8 groups of samples were placed in transparent glass bottles with a sample volume of 20ml / bottle. After sealing, they were placed in a constant temperature incubator. After three months, they were taken out and returned to room temperature to observe the changes in appearance.

[0118] 3. Room temperature test: Put the above 8 samples into transparent glass bottles with a sample volume of 20 ml / bottle. After sealing, place them at room temperature for 6 months, and observe the changes in the appearance of the emulsion.

[0119] Test results: No delamination, precipitation, discoloration, etc. were observed in the heat resistance test, cold resistance test, and room temperature test of the samples of Application Examples 1-8, and the original appearance was maintained, indicating that the products of the present invention have excellent high and low temperature stability.

[0120] Test Example 5: Safety Experiment

[0121] Safety tests were conducted on the essences of Examples 1-8, and 40 volunteers were selected for the tests. The specific test process is as follows: the test substance is placed in a patch tester, with a dosage of about 0.020-0.025g, and the patch tester with the test substance is applied to the back or flexor side of the forearm of the subject with a non-irritating tape, and the palm of the hand is gently pressed to evenly apply it to the skin for 24 hours. After removing the test patch tester for 30 minutes, observe the skin reaction after the indentation disappears. If the result is negative, observe again at 24 hours and 48 hours after the patch test.

[0122] The grading standards for adverse skin reactions are shown in Table 3:

[0123] Table 3

[0124]

[0125] The results are shown in Table 4:

[0126] Table 4

[0127]

[0128]

[0129] From the sample irritation results in Table 4, it can be seen that the irritation classification of the essence prepared by the present invention is non-irritating, which shows that the ingredients used in the essence of the present invention are mild and non-irritating.

[0130] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate an anti-wrinkle composition and its application, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0131] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0132] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. An anti-wrinkle composition, characterized in that: The anti-wrinkle composition comprises kudzu vine extract, hydroxydecylubiquinone, rutin and raspberry ketone glucoside.

2. The anti-wrinkle composition according to claim 1, characterized in that The mass ratio of the kudzu vine extract, hydroxydecylubiquinone, rutin and raspberry ketone glucoside is (0.1-5):(0.1-20):(0.1-8):(0.1-18); Preferably, the mass ratio of the kudzu vine extract, hydroxydecylubiquinone, rutin and raspberry ketone glucoside is (1-4):(1-18):(1-6):(1-15).

3. Use of the anti-wrinkle composition according to claim 1 or 2 in the preparation of cosmetics.

4. The use according to claim 3, characterized in that The cosmetics include any one of lotion, essence, lotion, cream, mask, spray, essence or facial cleanser; Preferably, the composition having the effect of soothing and repairing skin has a mass percentage of 0.05-10% in the cosmetic.

5. An anti-wrinkle essence, characterized in that: The components of the anti-wrinkle essence include the anti-wrinkle composition according to claim 1 or 2, a moisturizer, a thickener and water.

6. The anti-wrinkle essence according to claim 5, characterized in that: The components of the anti-wrinkle essence include 0.05-10 parts of the anti-wrinkle composition according to claim 1 or 2, 1-20 parts of a moisturizer, 0.1-5 parts of a thickener and 65-99 parts of water in parts by weight.

7. The anti-wrinkle essence according to claim 5 or 6, characterized in that: The moisturizer includes any one or a combination of at least two of glycerin, butylene glycol, glycerin, caprylyl glycol, sodium hyaluronate, erythritol, polyglycerol-10, 1,3-propylene glycol, β-glucan, hyaluronic acid / sodium hyaluronate, betaine, trehalose or polyethylene glycol-8; Preferably, the moisturizer is a combination of glycerin, caprylyl glycol, sodium hyaluronate, erythritol and polyglycerol-10; Preferably, the thickener includes any one of sodium chloride, PEG-250 distearate, PEG-150 distearate, 1,2-pentanediol, lecithin, carbomer, xanthan gum, hydroxyethyl cellulose, and polyacrylate cross-linked polymer-6, or a combination of at least two thereof.

8. The anti-wrinkle essence according to any one of claims 5 to 7, characterized in that: The anti-wrinkle essence also includes a polysaccharide composition; Preferably, the anti-wrinkle essence further comprises 0.1-2 parts of a polysaccharide composition by weight; Preferably, the polysaccharide composition comprises any one or a combination of at least two of Euglena polysaccharides, Tremella fuciformis polysaccharides, soluble proteoglycans, Alcaligenes polysaccharides, Pullulan polysaccharides, Aloe vera leaf polysaccharides or Tamarindus indica seed polysaccharides; Preferably, the polysaccharide composition is a combination of Alcaligenes polysaccharides and soluble proteoglycans; Preferably, the mass ratio of the Alcaligenes polysaccharide to the soluble proteoglycan is 1:(3-6).

9. A method for preparing the anti-wrinkle essence according to any one of claims 5 to 8, characterized in that: The preparation method comprises: The anti-wrinkle essence is obtained by mixing the anti-wrinkle composition as claimed in claim 1 or 2, a moisturizer and a thickener in water and homogenizing.

10. The preparation method according to claim 9, characterized in that: The preparation method comprises: (1) heating water, then adding a moisturizer and a polysaccharide composition to obtain a mixed solution; (2) adding a thickener to the mixed solution and mixing the mixture, then standing the mixture to cool, and then adding the anti-wrinkle composition to homogenize the mixture to obtain the anti-wrinkle essence; Preferably, the temperature in step (1) is raised to 40-60°C; Preferably, the mixing in step (2) is carried out under heating in a water bath; Preferably, the water bath heating temperature is 65-80°C; Preferably, the temperature in step (2) is lowered to 20-35°C.

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