1998results about "Inorganic boron active ingredients" patented technology

The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable conjugate. The targetable conjugate comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable conjugate further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.

The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): in which Z1 and Z2 are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.

The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.

A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

An antimicrobial composition that involves a synergistic mixture in terms of active agents, of a primary antimicrobial agent, such as polyhexamethylene biguanide (PHMB), a secondary antimicrobial agent, and optionally an organic acid against various kinds of microbes is described. Various additional processing aids, such as alcohols and surfactants, may also be incorporated within the mixture. The composition allows one to use a significantly less concentration of individual constituent antimicrobial agents to achieve the same or a better degree of antimicrobial efficacy. The antimicrobial composition can be applied to the surface of almost any kind of substrate material, and can achieve a killing-efficacy of about 3 Log10 reduction in microbes within 30 minutes under ambient conditions.

Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.

A boron nitride composition having its surface treated with a coating layer comprising at least one of a silane, a siloxane, a carboxylic derivative, and mixtures thereof, wherein the coating layer adheres to at least 10% of the surface of the boron nitride. The boron nitride powder surface is first treated by either a calcination process, or by coating with at least an inorganic compound for the surface to have a plurality of reactive sites containing at least a functional group that is reactive to at least one functional group of the final coating layer.

A boron nitride composition having its surface treated with a coating layer comprising a zirconate coupling agent. The boron nitride composition can be used as fillers in polymeric compounds at levels of up to 90 wt. %, giving thermal conductivity of up to 35 W / mK.

This invention relates to a chewable lanthanum formulation comprising a pharmaceutically effective amount of a lanthanum compound; and at least one chewable pharmaceutically acceptable excipient. This invention also relates to a pharmaceutical formulation in a tablet or in a powder comprising a pharmaceutically effective amount of a lanthanum compound produced by a process which comprises the steps of: a) powder blending the lanthanum compound and at least one pharmaceutically acceptable excipient in a mixer to form a mixture; or b) powder blending the lanthanum compound and excipients, compressing the resulting combination into a slug material or roller compacting the resulting combination into a strand material, and milling the prepared material into a free flowing mixture; and c) compressing the resulting mixture into a tablet or filing up the resulting mixture in a appropriate container.

Compositions comprising an asymmetric disiloxane surfactant composition comprising a silicone composition comprising a silicone having the formula: MM′where M or M′ comprises an alkylpolyalkyleneoxide bearing substituent selected from the group consisting of: R13(C2H4O)a(C3H6O)b(C4H8O)cR14 and R12SiR5R6(R13(C2H4O)a(C3H6O)b(C4H8O)cR14) that exhibit resistance to hydrolysis over a wide pH range.

The invention relates to lotion for treating female vagina inflammation, aiming at providing lotion which has obvious clinical curative effect for treating gynecologic inflammation, has small side effect to the body and does not destroy the self defense function of the human body. The invention has the technical scheme that the lotion is external-application lotion prepared from the following raw materials according to parts by weight: 10 to 20 parts of coptis root, 10 to 20 parts of yellow-corktree bark, 10 to 20 parts of baikal skullcap root, 20 to 40 parts of cnidium fruit, 20 to 40 parts of broom cypress fruit, 5 to 15 parts of dried alum, 20 to 40 parts of cordate houttuynia, 20 to 40 parts of kuhseng, 20 to 40 parts of wild chrysanthemum flower, 20 to 40 parts of radix gentianae, 20 to 40 parts of smilax glabra rhizoma, 10 to 20 parts of stemona root, 20 to 40 parts of zanthoxylum, 20 to 40 parts of dandelion, 15 to 25 parts of radix sileris, 20 to 40 parts of borax, 10 to 20 parts of peppermint, 20 to 40 parts of angelica, 20 to 40 parts of radix arnebiae seu lithospermi and 10 to 20 parts of licorice. The invention is suitable for clinically common gynecologic inflammation.

Provided is a method for coloring and, optionally, preserving wood and wood products. The method comprises application of pigment dispersions, and optionally biocide dispersions, to wood such that the wood is impregnated. A composition for coloring and, optionally, preserving wood is disclosed, comprising dispersions of micronized pigment and, optionally, micronized biocide.

The invention discloses an externally applied antibacterial and antiphlogistic medicament and a preparation method thereof, and relates to an antiphlogistic medicament and the preparation method thereof. The antiphlogistic medicament is processed and prepared by the following raw materials: peppermint, fineleaf schizonepeta herb, divaricate saposhnikovia root, rhubarb, amur corktree bark, common andrographis herb, fructus forsythiae, baical skullcap root, Philippine violet herb, radix salviae miltiorrhizae, lightyellow sophora root, dahurian angelica root, tree peony bark, aloe, membranous milkvetch root, indigowoad leaf, sweet wormwood herb, Chinese gentian, sinkiang arnebia root, liquoric root, Chinese gall, golden thread, cassia seed, indigowoad root, honeysuckle flower, chrysanthemum, hawthorn fruit, sessile stemona root, argy wormwood leaf, common cnidium fruit, borneol powder, borax powder, honey, propanetriol, propanediol, Tween-60, OP10, castor oil and turpentine oil. The product has good antibacterial and antiphlogistic effects, bacteria can not generate an antibody and can not generate the resistance to the medicament, the bacteria can be prevented from being mutated to superbacteria, and the antiphlogistic medicament has no toxicity or side effects and is safe to use.

This invention relates to novel beverage compositions and methods to make such beverage compositions that can be used to reduce or prevent adverse physiological effects of physical exercise or environmental exposure by providing a beverage composition for use in rehydration and nutrition before, during, or after athletic exercise. The novel compositions comprise fluids containing water, sugar including carbohydrates, such as fructose and raftilose, and electrolytes, such as zinc, chromium, copper, potassium, magnesium, sodium, and citric acid. Such beverage can act as an energy source for the consumer.

Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.

This invention relates to a leach-resistant borate preservative for lignocellulosic-based products, providing resistance against insect and fungal attack for use in exterior and ground contact applications. The preservative compositions of this invention may be provided as a high strength liquid concentrate, suitable for transportation, storage and easy on-site dilution, or as a ready-to-use treatment solution. These wood preservative compositions include a borate preservative component and a co-biocidal metal fixative such as copper or zinc. The preservative compositions also contain volatile organic acid, free ammonia and ammonium salts to aid dissolution. Methods for the application of these preservative compositions to wood are also provided.

The invention relates to a traditional Chinese medicine preparation for treating cancers and a preparation method thereof. Cancer is one of serious illnesses in human society, numerous people in medical circle carries out research and treatment for years, but the effect is very little and the western medicine can even not effect a permanent cure; commonly, people associate cancer with death which makes the people suffer untold misery. The traditional Chinese preparation comprises 121 types of pure traditional Chinese medicines as follows: musk, bezoar, cordyceps, barbed skullcap herb, centipede, pangolin scales, earthworm, dogwood, lalang grass rhizome, asparagus, puff-ball, twotooth achyranthes root, prepared common monkshood daughter root, cortex cinnamomi, Chinese angelica, figwort root, carapax trionycis, blackberrykiky rhizome, cornucervi pantotrichum, honey and the like. When in preparing, the finished products of pills are prepared by selecting materials, crushing, mixing, preparing pills, drying, inspecting and packing or the finished products of oral liquid are prepared by selecting materials, soaking, decocting, concentrated matching, filtering, filling, pressing caps, sterilizing and packing. By utilizing the pure traditional Chinese medicine preparation to treat cancers, the invention has the advantages of addressing both the symptoms and root causes, having no toxic side effect, eliminating pains of patients and achieving the effect of treating thoroughly.

The present invention includes an aqueous solution, comprising boric acid and non-colloidal silicic acid. This solution can also comprise a water absorbing additive. The solution contains bioavailable non-colloidal silicic acid, and the solution is stable for more than one year. The invention also describes a method for the preparation of a solution in which one or more silicon and boron compounds are hydrolysed in an acidic solution containing one or more solved water absorbing additives.

Metal amino acid chelates for animals are beneficial for facilitating and promoting growth by increasing desired metallic ion uptake. The present invention is directed to a process for providing an animal fed additive by preparing metal amino acid chelates, and the metal amino acid chelate growth facilitator, promoter and enhancer prepared by the process.

Provided herein are pharmaceutically acceptable sodium thiosulfate and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-purgable organic carbon in a sodium thiosulfate-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium thiosulfate. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium thiosulfate.

Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.

Aqueous dispersions comprising microfine metal oxide particles and dispersion auxiliaries, wherein, as dispersion auxiliaries, at least one of the compounds of the general formula (I)in whichM is hydrogen, monovalent or divalent metal cation, ammonium ion, organic amine radical;a is 1, or where M is a divalent metal cation, is ½;X is likewise —OMa or —O—(CpH2pO)q—Rl where R1═H, aliphatic hydrocarbon radical having 1-20 carbon atoms, cycloaliphatic hydrocarbon radical having 5 to 8 carbon atoms, optionally substituted aryl radical having 6 to 14 carbon atoms, p=2 to 4, q=0 to 100, —NHR2 and / or —NR22 where R2═R1 or —CO—NH2;Y is O, NR2;A1 is ethylene radical, propylene radical, isopropylene radical, butylene radical;m is 10 to 30;n is 0 to 50; andk is 10 to 30, where the summ+k is in the range from 20 to 60, is co-used.

The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.

Preservative compositions for wood products is described. The compositions include at least one boron-containing material, such as but not limited to boric anhydride, and at least one silane-containing material, such as but not limited to methyltrichlorosilane. Optionally, at least one solvent, such as tetrahydrofuran, pentane, or water, may also be employed in the compositions. The compositions impart protection to the treated wood products, especially damage caused by exposure to water and insects.

A Chinese medicine in the form of colon-soluble capsule for treating chronic ulcerativ colitis contains the medicine A prepared from one or more of 11 Chinese-medicinal materials including pearl, natural indigo, borneol, etc through pulverizing and the medicine B prepared from one or more of 19 Chinese-medicinal materials including coptis root, liquorice root, rhubarb, etc through extracting.

The invention provides a medical or health-care compound and a preparation method. The compound contains at least one natural anti-bacterial agent which is separated for plants and is the soluble salt or ester formed through the extraction of the non-soluble anti-bacterial substance from plants. Further, the compound of the invention can also contain inflammation-diminishing, detumescence and anti-oxidation ingredients, as well as the preparation type auxiliary substances, Chinese medicine padding agent, etc, which are produced into a series of medicines or health-care medicines which restrain the anaerobic bacteria and effectively prevent the oxidation or aging of the human body cells. The compound of the invention can be produced into various forms, not only confined in the liquid form (for example the orally taken liquid), but also including spraying agent, liquid spraying agent, pills( e.g. buccal tablets), capsules, toothpaste, mouth clearing, etc. Moreover, the invention can be used for the health care for mouth, heart, gastrointestinal tract and joint or the treatment of the related diseases.

The present disclosure relates to surface covering building materials for roofs, sidewalls and other exterior surfaces exposed tb the weather such as, but not limited to, asphaltic and non-asphaltic roofing materials, wherein said surface covering building materials exhibit long-term resistance to microbial growth-induced staining. The surface covering building materials include a component having antimicrobial potential which consists essentially of (a) a copper component or a tin component and (b) a barium metaborate monohydrate component.

Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.