42results about How to "Reduce morbidity" patented technology

The invention discloses a lung disease diagnosis and grading method based on quantitative CT image omics and deep learning. According to the method, through multi-dimensional information integration and model optimization, two core tasks of disease judgment and disease condition grading can be completed at the same time, and comprehensive support is provided for clinical diagnosis and treatment. The model sets feature priorities by referring to clinical diagnosis logic in the training process, the judgment result and the grading standard are completely matched with clinical general specifications, and the model can be directly applied to diagnosis and treatment decision-making without secondary conversion of doctors. After multi-center clinical verification and iterative optimization, the stability and the accuracy of the model are fully guaranteed, subjective errors caused by manual film reading can be effectively reduced, the diagnosis efficiency can be improved, the chronic obstructive pulmonary disease screening capability of primary medical institutions can be remarkably improved, early diagnosis and early treatment of more patients can be helped, and the clinical application prospect is wide. Therefore, the morbidity and disability rate of diseases are reduced, a clinical management path is optimized, and the overall disease burden is relieved.

The application discloses a kind of fermented feed fermented by three strains of probiotics of Bacillus YA ( Bacillus sp ), yeast Y ( Saccharomyces cerevisiae ) and capsular red bacteria R3 ( Rhodobacter capsulatus ), and preparation method and application in aquaculture thereof, and viable count is not less than 1×10 7 CFU / g.The fermented feed is replaced ordinary feed according to certain proportion, and feeding result shows that aquaculture water quality is significantly improved after adding fermented feed, and fish growth performance, digestive enzyme activity, immunity, and muscle quality are also obviously improved.Using the feed in suitable range can shorten growth cycle, reduce cost, improve aquaculture environment, reduce antibiotic use, and improve muscle quality of farmed animals, with good economic and ecological benefits, simple fermentation process, low cost, and suitable for industrial large-scale production.

The invention belongs to the technical field of strawberry biocontrol, and relates to application of chaetomium aureum JSNL-B47 in prevention and treatment of strawberry gray mold. The preservation number of the chaetomium aureum JSNL-B47 is CGMCC (China General Microbiological Culture Collection Center) NO. 40437. According to the present invention, the flat plate confrontation inhibition rate of the bacterial strain on Botrytis cinerea can achieve 67.94%, the extracellular metabolite inhibition rate can achieve 69.58%, strawberry resistance can be induced, and the scab inhibition rate can achieve 82.26%; the invention also provides a biocontrol inoculant containing hyphae, spores or secondary metabolites of the strain and a preparation method of the biocontrol inoculant. The biocontrol bacterium and the preparation thereof provided by the invention can significantly reduce the occurrence of strawberry gray mold, reduce the use of chemical pesticides, and are suitable for green agriculture.

The invention relates to the technical field of industrial robot load identification, in particular to a six-degree-of-freedom robot end load parameter identification method, which comprises the following steps: establishing a six-degree-of-freedom series robot dynamical model, reconstructing a load minimum parameter set, and determining that identification can be completed only by exciting a third joint, a fifth joint and a sixth joint. Designing four groups of symmetric excitation trajectories combined by Fourier series and quintic polynomials, and performing discrete sampling to generate an observation matrix; optimizing a load parameter set and a regression matrix, and reducing the condition number of an observation matrix; a load minimum parameter set is obtained through difference calculation of the no-load identification result and the on-load identification result; and based on the parameter set, solving the mass, the mass center coordinate, the inertia moment and the inertia product of the load. The method solves the ill-conditioned problem of a regression matrix by reconstructing the minimum parameter set, reduces the number of excitation joints, does not need to depend on a robot body kinetic model, and has the advantages of high identification precision, high stability, low experiment complexity and high efficiency.

The invention relates to nutritional compositions with Bifidobacterium breve and non-digestible oligosaccharides for use infants or toddlers for use in improving cognitive or behavioral performance or neuroinflammation.

The present application relates to the field of biotechnology, in particular to the use of Flotillin1 gene and Importinα4 gene, and the use of molecules inhibiting the transcription or translation of Flotillin1 gene and Importinα4 gene in the preparation of a kit. The present application also relates to a method for obtaining a plant capable of resisting pathogen.

The application discloses a kind of low morbidity feed for California bass antibiotic-free breeding and preparation method thereof, belong to aquatic feed field.The feed is composed of 60~80 parts of basic feed component, 10~20 parts of fermented plant protein, 2~6 parts of functional compound additives.Fermented plant protein is prepared by compound fermentation of butyric acid clostridium and bacillus subtilis from soybean meal, bran, rice bran, brown sugar and the like.Functional compound additives include pre-embedded material and microcapsule coated sodium butyrate, and the pre-embedded material is prepared by embedding treatment of astaxanthin, lutein and rosemary extract with β-cyclodextrin and gum arabic.The application significantly reduces the incidence of intestinal inflammation of California bass through the synergistic effect of fermented plant protein, pre-embedded antioxidant combination and microcapsule sodium butyrate, enhances antioxidant capacity, improves body color, improves the stability of active ingredients and feeding rate, and realizes low morbidity under antibiotic-free breeding conditions.

The invention relates to the field of biological medicines, in particular to application of a hepatocyte nuclear factor 1 alpha (HNF1 alpha) in promoting beta cell regeneration and preventing and treating diabetes. Specifically, by regulating and controlling the expression of an HNF1alpha coding gene and the activity of HNF1alpha, pancreas islet alpha cells can be promoted to be transdifferentiated into beta cells to achieve beta cell regeneration, the functions of pancreas islet beta cells are reserved, the occurrence of diabetes mellitus is delayed, and a new medical approach is provided for prevention and treatment of diabetes mellitus.

This invention discloses a method for preparing bio-organic fertilizer that reduces the incidence of tobacco root-knot nematodes. The bio-organic fertilizer consists of a fermentation substrate, microbial inoculant, and earthworm castings in a mass ratio of 10:0.2-0.4:2-3. The invention uses Bacillus subtilis, Trichoderma harzianum, and Bacillus mucilaginosus in a mass ratio of 15-25:8-13:30-40 to prepare the microbial inoculant. The fermentation substrate and microbial inoculant are mixed and fermented. The fermentation substrate includes cow dung, wheat bran, straw, and earthworm castings. The bio-organic fertilizer of this invention can reduce the incidence of tobacco root-knot nematodes and also promotes tobacco root growth and increases tobacco leaf yield.

This invention belongs to the field of potato scab control technology, specifically relating to a fungal-agent composition for controlling potato scab and its application. The fungal-agent composition for controlling potato scab provided by this invention comprises the following raw materials: a chemical control agent for potato scab and a compound fungal agent; the volume ratio of the chemical control agent to the compound fungal agent is 75-150:5000; the compound fungal agent includes *Bacillus belyceta* BEV2 and *Bacillus atrophus* FM2-4. Using the fungal-agent composition of this invention can reduce the dosage of chemical agents by at least half, while providing rapid, long-lasting, and effective control of potato scab, and also taking into account the advantages of environmental friendliness.

A solar dark green glass is provided in the present disclosure. The solar dark green glass includes a glass basic component and a glass tinted component. The solar dark green glass manufactured has a thickness of 1.6mm-2.1mm, and solar direct transmittance less than or equal to 65%, infrared transmittance less than or equal to 45%, and ultraviolet transmittance less than or equal to 35%. According to the present disclosure, the solar direct transmittance, the infrared transmittance, and the ultraviolet transmittance of the glass can be reduced while the thickness of the glass is thinned.

This invention discloses a method for improving soil in potato cultivation, belonging to the field of agricultural soil remediation technology. Addressing the problems of soil acidification, compaction, reduced beneficial microorganisms, and severe soil-borne diseases caused by continuous potato cropping, this invention provides a synergistic improvement method integrating soil pretreatment, coupled application of microbial agents and organic fertilizers as basal fertilizers, dynamic and precise regulation throughout the growth cycle, coordinated water and fertilizer management, and post-harvest remediation. This method involves basal application of a specific ratio of compound microbial agents coupled with organic fertilizers. Based on the physiological needs and disease occurrence patterns of potatoes at different growth stages, and combined with the dynamic and precise regulation of the timing and dosage of microbial agent application through a drip irrigation system, water and fertilizer supply are simultaneously optimized, achieving synergistic effects of biological antagonism, soil ecological restoration, and crop nutrient regulation. This invention effectively improves the soil micro-ecological environment, reduces the incidence of soil-borne diseases, reduces reliance on chemical fertilizers and pesticides, and improves potato yield and quality.

This invention proposes a culture medium and cultivation method for Tremella fuciformis, belonging to the field of Tremella fuciformis cultivation technology. It is prepared from the following raw materials in parts by weight: 0.5-1 parts antibacterial agent, 5-7 parts traditional Chinese medicine residue, 3-5 parts sugarcane bagasse, 2-3 parts fermentation extract, 30-40 parts cottonseed hulls, 7-10 parts wheat bran, 0.5-1 part gypsum, and 50-60 parts sterile water. The Tremella fuciformis culture medium obtained by this invention can significantly inhibit the growth of pathogenic bacteria during cultivation, reduce the pathogenicity rate, and increase the yield of Tremella fuciformis. Simultaneously, it increases the content and efficacy of active substances in Tremella fuciformis, producing selenium-enriched Tremella fuciformis polysaccharide. The active substances exhibit excellent antioxidant, anti-inflammatory, anti-tumor, moisturizing, hypoglycemic, hypolipidemic, and cardiovascular protective effects. Using this invention's culture medium, along with a suitable ratio of Tremella fuciformis and Clematis chinensis symbiotically, provides a new method and material for Tremella fuciformis cultivation, resulting in Tremella fuciformis with better utilization value and broad application prospects.

This invention relates to the field of agricultural biotechnology, and in particular to... Sr10618 Genes and their encoded proteins, their application in regulating resistance to white mold disease in peppers, primer pairs, recombinant viral silencing vectors and methods. Related factors in pepper plant resistance to white mold disease. Sr10618 The nucleotide sequence of the gene is shown in SEQ ID NO.1. Sr10618 The amino acid sequence of the protein encoded by the gene is shown in SEQ ID NO.2. A method for improving the resistance of pepper plants to white mold disease is also provided, including silencing the white mold pathogen effector. Sr10618 The expression of the gene in pepper plants, the Sr10618 The nucleotide sequence of the gene is shown in SEQ ID NO.1. (The above...) Sr10618 The application of genes and their encoded proteins, amplification primer pairs, recombinant silencing vectors, and methods to improve the resistance of pepper plants to white mold disease can regulate the resistance of pepper plants to white mold disease.

The invention discloses a leech breeding device which comprises a water inlet device, a barrel body, an anti-escape device, a vortex cleaning device, a drainage device, a sensor device, an isolation inhabitation device, a feeding frame and a temperature control device, the anti-escape device is arranged at the top end of the barrel body, and the drainage device is arranged at the bottom end of the barrel body; the sensor device and the temperature control device are connected with the barrel body; a detachable isolation inhabitation net is arranged between the barrel body and the drainage device, and a vortex cleaning device is arranged between the isolation inhabitation device and the drainage device; the feeding frame is arranged to be movable; the temperature controller is set to be capable of automatically monitoring, regulating and controlling the temperature in the barrel body; and the water inlet device is used for conveying water into the barrel body. According to the leech breeding device and the leech breeding method, the leech breeding density can be increased to 4-6 jin per square meter, the breeding survival rate can reach 80% or above, the disease incidence rate can reach 10% or below, the accumulation fermentation effect of pollutants can be reduced, and pollution caused by breeding can be effectively reduced.

The utility model discloses a wheat seed soaking and germination accelerating disc, which relates to the technical field of agricultural planting and particularly comprises a seed soaking disc, a tray and a cover, a circle of supporting table used for supporting the tray is integrally formed in the position, close to the top, of the inner side of the seed soaking disc, a water adding groove and a drainage hole are formed in one end of the seed soaking disc, the tray is located on the inner side of the seed soaking disc, a layer of wet gunny bag cloth is laid at the disc bottom of the inner side of the tray, a plurality of water absorption cotton strips are evenly distributed at the bottom of the wet gunny bag cloth, and the cover covers the top of the tray. The whole wheat seed soaking device is in a square plate design, seeds do not need to be moved in the whole wheat seed soaking process from infiltration, moisture preservation and heat preservation to germination acceleration, the seeds are continuously kept stable from the initial spreading state, seed germs can be effectively prevented from being damaged, the germination and emergence rate is ensured, the seeds are infiltrated through the square shallow plate, the spreading thickness of the seeds is easy to control, and the germination rate is high. Medicine adhesion is more uniform in the seed soaking process, the seed sterilization effect can be effectively improved, and the morbidity after seed emergence is reduced.

The invention discloses a cubilose fruit grafting seedling raising method, and belongs to the technical field of fruit tree cultivation. The method comprises six aspects of stock planting field establishment, stock seedling raising, stock water and fertilizer management, grafting, grafted seedling water and fertilizer management and grafted seedling field management. A special cutter tool for cubilose fruit grafting is adopted, an L-shaped section can be formed, the section is smooth and good in integrating degree, and the grafting survival rate and the grafting efficiency can be improved. According to the invention, the seedling raising grids are used for stock seedling raising, so that the seedling raising cost can be saved, and the space utilization rate can be improved. According to the method, the thorn-free huanglong and the argentodoxa cuneata are adopted as the stocks, the root systems are developed, the morbidity of root-knot nematodes can be reduced, the grafting survival rate and the growth vigor are improved, and meanwhile the canker resistance of plants is improved; the quality of the rootstock is guaranteed, the grafting growth vigor is improved, bud germination is promoted, and fruit bearing is carried out in advance by optimizing the length, the period and the number of bud points of the rootstock.

The application discloses a kind of construction methods of rice green production paddy field ecosystem, the method includes: reasonable application organic fertilizer, select suitable local climatic conditions, strong resistance, high yield, rice quality is excellent rice variety as main cultivation variety, set up ecological ditch around paddy field, plant aquatic plant, control the number of pests by releasing natural enemy insects, introduce duck into paddy field during rice growth, promote rice growth.Finally, establish disease and pest monitoring and early warning system, regularly detect paddy field ecological environment, take measures in time to cope with possible problems.The present application aims to integrate the trinity of "ecological benefits + ornamental value + economic benefits" green rice production system.Through the present application, the use of chemical pesticides and fertilizers can be effectively reduced, the yield and quality of rice can be improved, the ecological environment can be protected, and sustainable development can be realized.

This invention relates to the field of pig farming technology, specifically to a pigsty with a function to prevent the backflow of foul air. The pigsty includes a frame, a support plate with multiple slatted floor panels, and side panels on both sides of the frame. A working cavity is located at the bottom of the support plate, and a manure collection cavity is located at the bottom of each slatted floor panel. A main ventilation duct is installed inside the pigsty frame, and a ventilation connection mechanism for controlling the flow of gas into the manure collection cavity is located on one side of the main ventilation duct. This invention uses multiple rotatable adjustable blocks to block the holes in the slatted floor panels in batches, controlling the flow direction of foul air. By creating hollow channels inside the adjustable blocks and installing internal ventilation ducts, ventilation through these hollow channels prevents foul air from rising and spreading into the pig farm. This prevents harmful gases in the foul air from affecting the growth of pigs, thereby reducing the content of harmful gases in the pig farm and lowering the probability of disease in pigs.

This invention belongs to the field of feed technology, specifically relating to a beef cattle feed containing Artemisia annua and its preparation method. Artemisia annua is added to an acetic acid aqueous solution, boiled at a specified temperature for a specified time, filtered, and cooled. The cooled Artemisia annua is then mixed with forage to obtain the beef cattle feed containing Artemisia annua. The preparation method of this application is simple and convenient, greatly improving the palatability of Artemisia annua and effectively increasing its utilization rate. Furthermore, experiments have shown that feeding cattle with the beef cattle feed prepared in this application as roughage does not adversely affect their growth and development; the average weight gain of cattle is the same as that fed with ordinary roughage. Moreover, the beef cattle feed of this application can reduce the incidence of foot-and-mouth disease in cattle, helping them resist the disease.

The invention discloses a bio-organic fertilizer for relieving continuous cropping obstacles of tobaccos as well as a preparation method and application of the bio-organic fertilizer, and belongs to the technical field of bio-organic fertilizers. The bio-organic fertilizer is prepared by taking wood biochar, rice straw biochar, sludge wormcast and cow dung wormcast as organic matrixes, inoculating aspergillus fumigatus JD-33 with a specific function and performing fermentation. The biological organic fertilizer can effectively improve the continuous cropping soil structure, inhibit soil-borne pathogenic bacteria and adjust rhizosphere microflora, so that the incidence rate of tobacco diseases is remarkably reduced, the yield and the output value are increased, and the purposes of relieving tobacco continuous cropping obstacles and promoting agricultural sustainable development are achieved.

The application belongs to the technical field of biological control, and specifically discloses a biological control agent for preventing and treating clubroot, and specifically provides application of L-methyll pyroglutamate in any one of inhibiting clubroot spores, preparing a preparation for inhibiting clubroot spores, preventing and treating plant clubroot, and preparing a biological control agent for preventing and treating plant clubroot. The application is verified by experiments that L-methyll pyroglutamate is effective on both dormant spores and activated spores, solves the problem that existing agents are difficult to kill dormant spores, thereby inhibits clubroot, through potting experiments, the application significantly reduces the incidence and disease index of clubroot, and has good prevention and treatment effects. In addition, L-methyll pyroglutamate is a potential natural product derivative, is easy to biodegrade, is safe to non-target organisms, has no chemical pesticide residue problem, and meets the requirements of green agriculture and sustainable development.

This invention discloses a strain of *Bacillus amyloliquefaciens*, JDF630, and its application in controlling *Fusarium wilt* of *Cotinus coggygria*, belonging to the field of microbial technology. The *Bacillus amyloliquefaciens* strain JDF630 described in this invention was deposited on July 13, 2022, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC NO. 25289. This invention demonstrates that strain JDF630 exhibits broad-spectrum inhibitory activity against various plant pathogens. Treatment with JDF630 significantly reduces the damage caused by *Fusarium wilt* to *Cotinus coggygria*, providing a new microbial strain and control strategy for the prevention and control of plant pathogens, demonstrating excellent biological control effects.

This invention discloses a strain of *Bacillus paralicheniformis* IFST-745 and the application of its volatile substances. *Bacillus paralicheniformis* IFST-745 was deposited on May 4, 2023, at the China General Microbiological Culture Collection Center (CGMCC), located at No. 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing, with accession number CGMCC No. 27245. The volatile substances produced by this strain IFST-745 can inhibit the growth of various plant pathogenic fungi in vitro. It can effectively inhibit *Penicillium fingernail* infection of citrus and *Fusarium verticillatum* infection of corn kernels. It also has good control effects on green mold of citrus fruits and ear rot of corn. This invention provides a reference and more options for biocontrol agents of postharvest fungal diseases, and has significant application value.

This invention relates to the field of livestock breeding technology, and more particularly to an acidic solid environmental conditioner for pig farms, its preparation method, and its application. By mass percentage, its raw materials consist of the following components: 80%-90% natural minerals, 4%-8% natural acidic extracts, 4%-8% natural organic acids, 0.5%-1% photocatalytic nanomaterials, and 1.5%-3.0% natural compound essential oils; and the sum of the mass percentages of each component is 100%. The advantages of this invention are that it contains natural mineral components and natural active extract components, wherein the natural mineral components are mainly calcium-based bentonite and nano-titanium dioxide; the natural active extract components are mainly phenyl lactic acid, citric acid, and plant extracts; it has antibacterial, dehumidifying, and deodorizing effects; it is safe and non-toxic when applied to pig farm environments, does not induce drug resistance, leaves no residue, is low in cost, has stable performance, and is easy to use. It can significantly reduce the number of bacteria in pig houses, reduce ammonia concentration and humidity, and plays an important role in maintaining a good breeding environment and reducing the incidence of disease in pig herds.

The application discloses a feline panleukopenia virus, feline herpes virus and feline calicivirus yolk antibody preparation and a preparation method and application thereof. The feline triple yolk antibody preparation comprises a core material, and the core material comprises feline calicivirus yolk antibody, feline panleukopenia virus yolk antibody, feline herpes virus type 1 yolk antibody and probiotics. The application can produce specific neutralization to feline calicivirus, feline panleukopenia virus and feline herpes virus type 1, significantly reduces the infection rate and the severity of clinical symptoms, is stably released in the gastrointestinal tract after oral administration, the antibody activity retention rate is more than 90%, the probiotics synergistically regulate intestinal microecology, enhance the immune response of the body and improve the overall protection efficiency.

A pharmaceutical combination comprising (a) a B-Raf inhibitor, (b) a EGFR inhibitor and, optionally, (c) a PI3K inhibitor; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

This invention discloses a biocontrol bacterium for bacterial wilt, YL-Ste-01evo (accession number CCTCC NO: M2022939); a biocontrol bacterium for bacterial wilt, YL-Ste-01 (accession number CCTCC NO: M2022324); and a lytic bacteriophage, YL-Ste-01P (accession number CCTCC NO: M2022460). This invention discloses the application of biocontrol bacterium YL-Ste-01evo, or biocontrol bacterium YL-Ste-01, or biocontrol bacterium YL-Ste-01evo in synergy with bacteriophage YL-Ste-01P in the control of soil-borne bacterial wilt in tomato. The biocontrol bacterium YL-Ste-01 can significantly inhibit the growth of Ralstonia solanacearum and reduce the incidence of bacterial wilt in tomato plants. Through phage stress, YL-Ste-01 evolved into a biocontrol bacterium YL-Ste-01evo with stronger phage resistance and better antibacterial effect.

The present application relates to the technical field of microorganism technology and postharvest disease biological control of fruits and vegetables, and particularly relates to a marine source bacillus velezensis SCSX9, a biocontrol composite microbial agent, and a preparation method and application thereof.The marine source bacillus velezensis SCSX9 is obtained by separation and screening, and the strain, fermentation product (bacterial suspension, bacterial fermentation broth) and green biocontrol microbial agent thereof can effectively inhibit various pathogenic bacteria, thereby safely and effectively controlling the occurrence and development of plant diseases.Further, the biocontrol composite microbial agent composed of the bacillus velezensis 12Y can produce various antibacterial substances, through the synergistic effect between the strains, significantly improves the broad-spectrum bacteriostasis, stability and control efficiency, prolongs the fruit preservation period and storage time, improves the quality of strawberries and mangoes, and has high economic significance in agricultural production.