8177results about How to "Reduce morbidity" patented technology

Surgical method and apparatus for resectioning tissue, preferably lumenal tissue, with a remaining portion of an organ being anastomized with staples or other fastening devices, preferably endolumenally. The apparatus may be inserted via a naturally occurring body orifice or a surgical incision and then advanced using either endoscopic or radiological imaging guidance to an area where surgery is to be performed. Under endoscopic or diagnostic imaging guidance the apparatus is positioned so tissue to be resected is manipulated into an inner cavity of the apparatus. The apparatus then cuts the diseased tissue after stapling and retains the diseased tissue within the apparatus. The rent resulting in a border of healthy tissue is anastomosed with surgical staples.

The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and / or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and / or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and / or sampling device, and monitoring systems employing the methods described herein.

A method of implanting a universal heart valve prosthetic anchor device for receipt of a mating occluder. The anchor device includes a pair of rings axially shiftable from a retracted to a deployed position. The anchor device further formed with a plurality of flexible retaining elements received within the anchor rings and which are capable of laterally downwardly outward movement upon deployment of the rings. The deployment tool includes an elongated tubular housing mounted at its distal end with radially outwardly diverging tines for reversible engagement with the anchoring rings. A wire is telescoped through the tines for actuation of the fork thereby causing deployment of the anchoring rings. Once placed at the desired location within the heart muscle, the deployment tool is actuated causing the anchor device to shift axially thereby causing the retainers to deploy outwardly and upwardly to secure the valve anchor in place at the heart valve annulus shelf.

In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of a pharmaceutically active agent, wherein the agent is associated with a polymeric biocompatible material.

A method of ameliorating the adverse effects of a defect in the annulus fibrosus by applying a curable bio-compatible material to the defect, and curing that material, in situ, into a cross linked visco-elastic solid polymer adhering to remaining annulus fibrosus and thereby closing said defect. Alternatively, the bio-compatible material may be cross linked immediately before insertion into the annulus fibrosus.

The invention provides an artificial antigen presenting cell (AAPC) comprising a eukaryotic cell expressing an antigen presenting complex comprising a human leukocyte antigen (HLA) molecule of a single type, at least one exogenous accessory molecule and at least one exogenous T cell-specific epitope. Methods of use for activation of T lymphocytes are also provided.

A heart valve implant has a body sized and configured to rest near or within a heart valve annulus. A plurality of spaced-apart retainers extend outwardly from the body to contact tissue near or within the heart valve annulus. The retainers are sized and configured to secure the body to the heart valve annulus. The implant can be secured, e.g., without the use of sutures.

Conformal nanolaminate dielectric deposition and etch back processes that can fill high aspect ratio (typically at least 5:1, for example 6:1), narrow width (typically sub 0.13 micron, for example 0.1 micron or less) gaps with significantly reduced incidence of voids or weak spots involve the use of any suitable confirmal dielectric deposition technique and a dry etch back. The etch back part of the process involves a single step or an integrated multi-step (for example, two-step) procedure including an anisotropic dry etch followed by an isotropic dry etch. The all dry deposition and etch back process in a single tool increases throughput and reduces handling of wafers resulting in more efficient and higher quality nanolaminate dielectric gap fill operations.

A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.

The present invention is directed to an expandable spinal fusion intervertebral implant that provides for maintaining and creating lordosis in the human spine that can be filled with biologics while in situ to encourage spinal fusion. A threaded rod that traverses an insertion / injection handle can be rotated to operate a screw within the interbody cage that displaces opposing vertical tapped sliding wedges, causing them to converge towards each other. Such contact causes the operation of a horizontal wedge that acts as a lift to expand the interbody cage to one of various dimensions in a preferred range. At its desired expansion, the spinal fusion implant of the present invention is sized to fit within the disc space between two vertebral bodies and fill all voids left while the vertical and horizontal wedges operate within, due to the biologics being contained within the interbody cage.

The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and / or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and / or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and / or sampling device, and monitoring systems employing the methods described herein.

Devices and methods are provided for the treatment of glaucoma. An ocular implant is adapted such that aqueous humor flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. The implant may utilize one or more bioactive agents effective in treating glaucoma or other pathology.

The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.

The disclosure generally relates to providing a network of security volunteers who can opt-in to provide security services and / or a physical presence to deter, distract, delay, or prevent a potentially threatening situation. Security volunteers can receive alerts from a central monitoring center regarding nearby distress signals sent from a victim's device, and can then proceed to the location of the victim. Security volunteers can view their location and the location of the victim on a map on their mobile devices, as well as communicate with a victim's device, the central monitoring center, and other security volunteers who are responding to the scene.

A patient interface system having a patient interface and chin support system for supporting the patient interface on the patient and for supplying a flow of gas from a patient circuit to the patient interface. In one embodiment, the chin support is formed from flexible hollow chambered support and extends from either side of the patient interface curving downwardly in front of the patient's cheeks, around the outside of the patient's mouth, to a position beneath the patient's mandible. In another embodiment, the chin support is coupled to a conduit that is coupled to the patient interface. The chin support includes at least a portion that is disposed under the patient's mandible.

Methods and systems for capacitive proximity and contact sensing employ one or more simple sensors (which may be a conductive fiber or pattern of conductive ink) in communication with a microcontroller. Digital signal processing executed by the microcontroller enables resolution enhancement, automatic and continuous calibration, noise reduction, pattern recognition and the configuration of virtual sensors capable of detecting how an object incorporating the sensors is being manipulated.

Methods and systems for capacitive proximity and contact sensing employ one or more simple sensors (which may be a conductive fiber or pattern of conductive ink) in communication with a microcontroller. Digital signal processing executed by the microcontroller enables resolution enhancement, automatic and continuous calibration, noise reduction, pattern recognition and the configuration of virtual sensors capable of detecting how an object incorporating the sensors is being manipulated.

Method for transmitting data from infrastructure to vehicles includes arranging a transmitter apart from the vehicles, providing information relating to operation of at least one vehicle or of an occupant of a vehicle to the transmitter, transmitting the information from the transmitter to the at least one vehicle, and receiving the transmitted information at the at least one vehicle. Transmitters may be arranged on a roadway on which the vehicles travel, at a gas station or other vehicle-accessible commercial or public location such as a mall, at the vehicle operator's home and on a road sign, basically anywhere in range of a traveling vehicle. The information to be transmitted to the vehicle may be prioritized and transmitted via the transmitter based on the prioritization.

Surgical methods and related medical devices for treating glaucoma are shown. The method includes trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a seton implant. The seton implant is used to prevent a healing process known as filling in, which has a tendency to close surgically created openings in the trabecular meshwork. The surgical method and novel implant are addressed to the trabecular meshwork, which is a major site of resistance to outflow in glaucoma. In addition to bypassing the diseased trabecular meshwork at the level of the trabecular meshwork, existing outflow pathways are also used or restored. The seton implant is positioned through the trabecular meshwork so that an inlet end of the seton implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.

A trabecular shunt and methods for treating glaucoma are disclosed. One of the methods comprises transporting fluid from the anterior chamber of an eye to Schlemm's canal through an implant, the implant extending between the anterior chamber and Schlemm's canal; sensing an intraocular pressure using a sensor incorporated into the implant; and transmitting a signal indicative of the sensed pressure to an external receiver.

An endoscopic staple and related stapling device that can be used in conjunction with flexible or rigid endoscopy. The staple can also be used for other surgical procedures. The invention relates to performing a stapling operation on internal body tissues as part of a surgical procedure, diagnostic procedure or therapeutic procedure. This invention includes a surgical staple, an associated staple holder, and an associated staple delivery and deployment device. The staple holder and delivery system have a design iteration whereby the holder can be reloaded with additional staples to be used on the same patient. There is another design iteration whereby the staple holder and stapler are reusable after appropriate cleaning and sterilization.

Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.

A patient interface system having a patient interface and chin support system for supporting the patient interface on the patient and for supplying a flow of gas from a patient circuit to the patient interface. In one embodiment, the chin support is formed from flexible hollow chambered support and extends from either side of the patient interface curving downwardly in front of the patient's cheeks, around the outside of the patient's mouth, to a position beneath the patient's mandible. In another embodiment, the chin support is coupled to a conduit that is coupled to the patient interface. The chin support includes at least a portion that is disposed under the patient's mandible.

A device (10) for treatment of obesity of a patient comprises an annular element (12) having a relatively large outer boundary and a relatively small inner boundary, and an elongated flexible tube (14) extending from the relatively small inner boundary of the annular element to a distal end. The relatively large outer boundary is adapted to be attached to an inner wall of a stomach (100) of a patient, such that the annular element divides the stomach (100) into two chambers, an esophagus-end chamber close to an esophagus of the patient, and a pylorus-end chamber close to a pylorus of the patient. The invention also provides a method for treatment of obesity of a patient which includes inserting an annular element having a relatively large outer boundary and a relatively small inner boundary into a stomach of the patient, and attaching the relatively large outer boundary of the annular element to an inner circumference of the stomach of the patient.

An implantable prosthesis and device and method for loading and delivering the implantable prosthesis to a trocar cannula. The implantable prosthesis includes a body portion sufficient to extend across and occlude a defect opening and a semi-rigid ring for supporting the body portion. The implantable prosthesis may be provided with a sufficient hoop strength to prevent the body portion from collapsing into the defect opening. A loading and delivery tool includes a main body with a lumen sized to collapse the implantable prosthesis. An elongated shaft is rotatable to wind the implant into a slender configuration and axially moveable to advance the rolled-up implant into the trocar cannula. A cartridge extends from the main body and holds the implant in a normal expanded configuration.

A computer-implemented method, including receiving information regarding a transaction involving an account, wherein the information regarding the transaction is received by a receiver prior to a processing, a completion, a consummation, or a cancellation, of the transaction, processing the information regarding the transaction with a processing device using information regarding the account, generating a report or a message in response to the processing of the information regarding the transaction, wherein the report or the message contains information regarding a charge-back regarding a previous transaction involving the account, and transmitting the information report to a communication device associated with a merchant, vendor, or provider, of a good, product, or service.