88 results about "Fungal agent" patented technology

Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.

Aspects of the invention disclosed herein relate to devices that provide heat and / or ultraviolet light to fingernails or toenails that are afflicted by onychomycosis, as well as methods for treating onychomycosis by application of heat and / or ultraviolet light. The devices of the present invention may be used in connection with systemic and / or topical anti-fungal agents to treat onychomycosis.

The invention relates to a special organic and inorganic compound fertilizer for a lawn and a preparation method thereof. The preparation method comprises the following steps of: fermenting and decomposing sludge, edible fungus residues and a microbial fermentation fungal agent and then adding an inorganic fertilizer to produce the special organic and inorganic compound fertilizer, the nutrient content of which meets the nutrient requirement of the lawn. The special organic and inorganic compound fertilizer has long fertilizer efficiency, uniform nutrient supply and organic and inorganic combination, ensures the lawn quality and improves the soil fertility.

The invention relates to a Metarhiziumanisopliaevar. anisopliae strain CQMa421 of which the CGMCC (China General Microbiological Culture Collection Center) NO is 4609 and an application thereof in the control of rice leaf roller. The production traits of the strain are good and can grow fast and have high spore-producing capability; and the sporulation rate is up to 6.8%, and the strain has high toxicity. The pesticidal fungal agent produced by using the strain can be used to effectively control the number of the rice leaf rollers.

This invention relates to copper complexes that significantly reduce the decay of wood, cellulose, hemicellulose, and lignin caused by fungi. A process for treating such materials with these copper-containing anti-fungal agents is also disclosed.

The present invention pertains to substances of the formula (I) wherein X is O or S; and R1-R4 are defined in the claims as inhibitors of glyoxalase I and / or II, pharmaceutical compositions comprising one or more compounds according to formula (I) and the use of one or more compounds according to formula (I) for the treatment of diseases associated with increased glycolytic metabolism. In one embodiment, the disease is a fungal infection.

The invention relates to a normal-temperature fungus NJGZ-2 capable of degrading agricultural waste straw, belonging to the agricultural waste resource utilization technology. The class of the strain NJGZ-2 is named penicillium oxalicum, and the culture is collected in the China General Microbiological Culture Collection Center (CGMCC), with collection number CGMCC No.7527. Tests indicate that after the rice straw is inoculated with a spore suspension (1% 10<7> spores / mL), the weight loss ratio of the rice straw is 59.7% after 7 days of 170r / min liquid fermentation culture at 30 DEG C. In the fermentation crude enzyme extraction liquid, the activities of incision enzyme, beta-glucosidase, xylanase, beta-xylosidase and total cellulose are 113.3U / gds, 11.6U / gds, 1,439.7U / gds, 2.0U / gds and 13.8U / gds respectively. The crude enzyme liquid can hydrolyze low-concentration alkali-treated corncob to generate high-concentration reducing sugar (962.2mg of reducing sugar / gram of substrate). According to the invention, the agricultural waste straw is degraded by the microbial fermentation technology and is converted into organic fertilizer, therefore, the waste can be turned into wealth to protect the environment, and application prospects are broad.

Belonging to the technical field of biological prevention and control of soil borne diseases of melons, the invention discloses a fungal agent for prevention and control of watermelon fusarium wilt and a preparation method thereof. The method includes: preparation of mediums of different levels and preparation of an adsorption carrier; slant strain culture; shake flask strain propagation; production fermentation tank culture; solid agent preparation and other steps. In the invention, a Hypocrea atroviridis strain 2-22CGMCCNo.7128 is taken as the strain, which is prepared into a liquid and / or solid agent by fermentation, so that the attack time of watermelon fusarium wilt can be delayed, and the incidence can be reduced by over 40%. After watermelons undergo a continuous second crop, a good disease prevention effect can still be maintained. The agent provided in the invention has the advantages of rich raw materials, simple process, low cost, and a shelf life of more than half a year, and can be popularized and applied in watermelon planting areas.

Physically stable pharmaceutical / cosmetic compositions contain at least one hydrophilic phase, at least one lipophilic phase and at least one active principle, e.g., at least one steroidal anti-inflammatory agent, anti-fungal agent, anti-parasitic agent, nuclear receptor modulator and / or sex steroid, said at least one active principle being present in dissolved state in each of these phases; these are formulated via characteristic multi-step methodology.

The present invention relates to a method for identification of anti-fungal agents and their mode of actions. In particular, it relates to cell wall disturbing anti-fungal agents and to an assay to identify them. More particularly, it relates to a screening method for the identification of an anti-fungal compound, which method comprises (i) contacting a potential anti-fungal compound with a polypeptide which is involved in cell wall synthesis; and then (ii) identifying the effect which the potential anti-fungal compound has on the activity of the polypeptide, whereby reduced polypeptide activity is indicative for anti-fungal activity of the potential anti-fungal compound. It also relates to an overexpressing host cell and to a kit for performing the assay.

The present invention is directed to recovery of gold from refractory and double refractory ores using a fungal agent and / or culture media.

Method of identifying an anti-fungal agent which targets as an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 50, 53, 56, 59, 61 or 63, or (ii) a protein which has 60% identity with (i), or (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, or (iv) a polynucleotide that comprises a sequence which encodes (i), (ii) or (iii), or (v) a polynucleotide comprising a sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent.

A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum anti-fungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting.

The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomycosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof; a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent; a lower alcohol; and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.

The invention belongs to the field of heavy metal pollution repairing of land and particularly relates to a method for the enhanced repairing of heavy metal composite polluted soil. The method comprises the steps of carrying out expanding propagation and cultivation on arbuscular mycorrhizal fungi (AMF) by utilizing a host plant to obtain an arbuscular mycorrhizal fungal agent; applying a base fertilizer to the heavy metal composite polluted soil and replenishing water till the water content accounts for 50-70% of water-holding capacity of the soil in the field at the same time; applying microelement selenium to the soil in which the base fertilizer is applied and the water is replenished and balancing for 14-30 days; and finally, inoculating the arbuscular mycorrhizal fungal agent into the balanced heavy metal composite polluted soil and repairing and improving for 60-90 days. The method for the enhanced repairing of the heavy metal composite polluted soil, provided by the invention,has the advantages and effects that while sodium selenite is added, the mycorrhizal fungal agent is added, so that the effectiveness of heavy metal in the soil is reduced by utilizing the solidification effect of the AMF on the heavy metal; and moreover, the inhibition effect of high-concentration selenium ions on crop growth can be attenuated or eliminated by utilizing arbuscular mycorrhiza.

The invention discloses an application of a microbial agent in seedling raising of Angelica sinensis, and a prevention and treatment method for soil-borne diseases. The microbial agent provided by the invention comprises three self-prepared microbial agents and a commercial microbial agent which are respectively used for seed dressing of Angelica sinensis and seedling raising in an uncultivated land; and through counting of the weight of an Angelica sinensis seedling, the number of Angelica sinensis plants and the level of Angelica sinensis seedlings in a test plot of Angelica sinensis seedlings, feasibility of the application the microbial agent in seedling raising of Angelica sinensis and prevention and treatment effects on the soil-borne diseases are researched. A composite fungal agent (Pythium oligandrum and Beauveria bassiana, PO+BB) provided by the invention has best effects on seedling raising of Angelica sinensis and the prevention and treatment of the soil-borne diseases, and is superior to the commercial fungal agent Polyversum Pythium oligandrum oospores; and the composite fungal agent has good application prospects in agriculture and production of traditional Chinese medicinal materials.

The invention discloses a microbial soil layer dispersion mixed inoculation method. The method comprises the steps of pretreating soil and inoculating inoculants in the soil. A bacterial agent and a fungal agent are sequentially applied, so that the removal of heavy metals in the soil is facilitated. The invention further discloses a remediation method of heavy metal contaminated soil. According to the method, after the soil is subjected to dispersion mixing and inoculation of microorganisms, remediation plants are planted, in-situ remediation of the soil is facilitated, cost is low, and applicability is high.

The invention provides an AM fungal agent and an application method thereof, and relates to the technical field of mine repair. The AM fungal agent comprises an AM fungal culture medium and a host plant root system, wherein the AM fungal culture medium comprises a strain culture medium and AM fungi, and the strain culture medium comprises, by weight, 20-50 parts of zeolite, 5-30 parts of vermiculite, 5-30 parts of river sand and 2-5 parts of a water retaining agent. The application method of the AM fungal agent comprises the following steps: S1, sequentially adding a mine matrix modifier, minesoil and the AM fungal agent into a planting pit; S2, transplanting a nursery stock into the planting pit, adding mine soil again, and carrying out AM fungus infection planting. The AM fungal agent and application method thereof can ensure the adaptability of the propagation strain in a semi-arid mining area and effectively improve the activity and spore yield of the strain after the fungal agentis used; meanwhile, the method can obviously improve the nutrient and water conditions of the land in the mining area, improve the biomass of the vegetation, and accelerate the recovery rate and quality of the vegetation in the mining area.

The invention discloses a planting method for pakchoi under high temperature in summer. The planting method comprises following steps: (1) selecting sandy land and disinfecting the land by means of lime and fungal agents; (2) preparing soil subjected to disinfection treatment and covering an insect-proof net; (3) selecting pakchoi varieties with heat-resisting performance, disease-resistant performance and fine commercial characteristics for performing seed treatment; (4) sowing pakchoi seeds subjected to the above operation to a land prepared by the step (2); (5) establishing seedings when the above sowed pakchoi have four to five true leaves with row spacing ranging from three to five centimeters; (6) carrying out field management to pakchoi with established seedlings. By adoption of the mode, the planting method for pakchoi under high temperature in summer is easily operated and helps to satisfy the need of a summer market to vegetables.

The invention belongs to a waste resource utilization technology, and discloses a rice straw degrading fungi trichoderma koningiopsis ZJC-1 and a fungicide thereof. The strain ZJC-1 belongs to Trichoderma koningiopsis, and is collected in China General Microbiological Culture Collection Center (CGMCC) in March, 24th, 2014, and with the collection number of CGMCC NO.8948; the strain ZJC-1 can produce hydrolysis circles on a CMC-congo red culture medium, and can grow on a unique carbon source culture medium of agricultural waste rice straws. The invention further discloses a fungicide comprising the rice straw degrading fungi trichoderma koningiopsis ZJC-1, and a preparation method thereof. The rice straws are degraded by utilizing a microbial fermentation method so as to be converted into an organic fertilizer, thus being capable of changing wastes into valuables, protecting the environment, and having wide application prospects.

The invention discloses a method for making a fertilizer by using dung. The method comprises the following steps: 1, uniformly mixing dung, weathered coal, stalks, rice chaff, a domestic fungus waste base material and a bio-fungal agent, and stacking the obtained mixture for 18-36h; 2, carrying out overturning stirring and aeration on the mixture obtained in step 1 to ferment the mixture and make the temperature rise to 50-65DEG C; 3, continuously fermenting the mixture, regularly carrying out overturning stirring and detecting the temperature of the mixture to make the temperature be not higher than 70DEG C; 4, stacking the mixture for 15-30d when the temperature of the mixture does not continuously rise; 6, obtaining a decomposed compost; and 7, detecting and sub-packaging the decomposed compost to obtain the organic fertilizer. The method for making the fertilizer by using dung has the advantages of full utilization of dung resources, reduction of environment pollution and resource wastes, production cost reduction, and high fertilizer efficiency.

The present invention relates to a compound, which can be used as an anti-bacterial and / or an anti-fungal agent as well as a zinc sensor. Moreover, the present invention relates to a pharmaceutical composition comprising said compound and methods for treating bacterial or fungal infections in mammals.

The invention relates to a device and method for extracting exudates, in particular to a device and method for extracting in situ root exudates of arbuscular mycorrhizal plants. Due to the differences between natural growth conditions and test conditions of plant roots, it is difficult to ensure the integrity of the roots during the extraction of root exudates of arbuscular mycorrhizal plants, and great differences occur between the test results and the results of normal exudates of plant roots. A container for media is arranged in an external culture container in the device, an annular cavity is formed between the external culture container and the container for media, a nutrient solution is arranged in the annular cavity, the top end of the container for media is provided with a seed inlet, and a medium and a bacterial liquid are arranged in the container for media; the method comprises the steps of I, adding seeds; II, inoculating an arbuscular mycorrhiza fungal agent to the container for media; III, performing mycorrhization; IV, extracting root exudates in the annular cavity. The device and method are applicable to the test process of extracting root exudates of arbuscular mycorrhizal plants.

The claimed invention is directed to the use of a composition for use as an antimicrobial comprising an antimicrobial agent. In certain embodiments, the composition is used for treating or ameliorating inflammation in a subject and comprises an anti-inflammatory agent. The anti-inflammatory agent may include an NSAID, such as ibuprofen or diclofenac. The composition may further include solvents, anti-bacterial agents, anti-fungal agents, anti-parasitic agents, anti-viral agents, and buffers. The composition may include particles that have been processed via jet milling to reduce a diameter of the particles and to improve a flowability of the particles.

The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.