3511 results about "OPHTHALMOLOGICALS" patented technology

The invention provides a pharmaceutical composition for use in the prevention or therapy of glaucoma, increased intraocular pressure, ocular hypertension and / or a symptom associated therewith, wherein the composition comprises tafluprost and a semifluorinated alkane.

The invention relates to the technical field of ophthalmology medical diagnosis, and discloses a three-dimensional reconstruction-based fundus focus intelligent labeling method and diagnosis system. The method comprises the following steps: receiving multi-modal image data streams such as fundus color photos, OCT images and FFA images of an ophthalmological patient; performing spatial registration and feature fusion by using a pre-trained lesion feature fusion model to generate a three-dimensional lesion probability distribution diagram and a lesion category confidence matrix; constructing an adaptive annotation threshold model to generate a multi-modal annotation instruction set; based on the focus development chain model, focus development is simulated, and instruction set parameters are optimized and labeled; and iteratively optimizing through a distributed reinforcement learning framework, and outputting the focus labeling action sequence to an ophthalmology diagnosis platform. According to the method, multi-modal image information can be integrated, the diagnosis accuracy and efficiency are improved, personalized diagnosis is realized, resources are reasonably utilized, and powerful support is provided for ophthalmic disease diagnosis.

Provided are multi-wavelength phototherapy devices, systems and methods for the treatment of a disorder or disease, including multi-wavelength low level light therapy (“PBM”), in particular to multi-wavelength PBM and other phototherapy systems and methods for improving functionality in and / or restoring functionality to a cell and / or tissue through the coordinated and targeted delivery to the cell or tissue of two or more doses of light having distinct wavelengths, wherein the two or more doses of light, when delivered in a coordinated fashion, can stimulate the activity of two or more light sensitive factors that, when activated, provide and / or enhance a desired target cell functionality. Ophthalmic phototherapy devices, systems, and treatment methods to expose an eye to selected multi-wavelengths of light to promote the healing of damaged or diseased eye tissue. The devices include a housing having an interior; an eyepiece disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyepiece; a first light source producing a first light beam having a first therapeutic wavelength and disposed within the housing; a second light source producing a second light beam having a second therapeutic wavelength and disposed within the housing, where the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm.

The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.

The invention provides a dynamic myopia management lens prescription customization method and system, and relates to the technical field of lens design and customization. According to the dynamic myopia management lens prescription customization technology provided by the invention, ophthalmic basic data of a patient is acquired; then periodically follow-up the patient to obtain ophthalmology measurement follow-up data of the patient; the joint evaluation model dynamically updates a myopia risk evaluation grade of the patient based on ophthalmology basic data and ophthalmology measurement follow-up visit data; and finally, dynamically updating the lens prescription based on the myopia risk assessment level of each time by the joint assessment model. According to the technical scheme, the combined evaluation model can perform dynamic lens prescription adjustment according to follow-up visit ocular axis progress and choroid change conditions, dynamic myopia management lens prescription customization, whole-course tracking of a myopia cycle and individualized prevention and control management are realized, and thus the effectiveness and continuity of myopia prevention and control are improved.

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention relates to the technical field of medical image processing and artificial intelligence, and discloses an artificial intelligence-based retinochoroid disease course structure change monitoring system, which comprises an image acquisition unit, a feature extraction unit, a lesion segmentation unit and the like. The image acquisition unit acquires retina optical coherence tomography sequence image data and fundus color image data; the feature extraction unit extracts a retina choroidal structure feature tensor through a three-dimensional convolutional neural network; the lesion segmentation unit outputs a lesion area probability distribution diagram by using a U-Net segmentation network; the time sequence alignment unit is used for registering the multi-time-point images to generate a displacement change matrix; the dynamic analysis unit extracts related indexes; an abnormal scoring unit constructs a disease course progress score; the decision grading unit outputs disease course stage classification labels; the multi-modal fusion unit fuses the multi-modal features; the report generation unit generates a structured disease course monitoring report. And favorable support is provided for diagnosis and treatment of ophthalmic diseases and illness state tracking.

The devices and methods of the present invention provide a means to depress the sclera in such a fashion as to provide single point, multiple point, semicircular or 360° circumferential scleral tissue depression and light without the need for manual manipulation of the scleral depressor. The device comprises a shaped depressor for insertion between the sclera and the orbit of the eye and a holding means for positioning the depressor. In some embodiments the device can be integrated with a speculum. Use of the device eliminates the need to have a second person manipulate the depressor during the procedure and directly enables bimanual surgery.

Disclosed herein are methods and devices for generating a trained generative foundation model for medical diagnosis, as well as using the trained generative foundation model for the detection of diseases and disorders including ophthalmic and systemic diseases. System and non-transitory computer-readable storage medium configured for performing the methods are also disclosed.

The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.

The present disclosure is directed to methods for manufacturing ophthalmic lenses utilizing a freeform process, the method comprising: machining a lens blank, semi-finished lens blank and / or an intermediate ophthalmic lens precursor to form a surface of the spectacle lens with at least a portion of the surface comprising a curvature for the correction of the myopic prescription of the wearer; machining a pattern of a plurality of optical elements and / or spaces therebetween on the surface of the spectacle lens suitable for delivering an effective optical signal to the retinal receptors of a progressive myope to slow, significantly slow, stop and / or shorten / regress the progression of axial eye length growth; and / or polishing the surface of the spectacle lens; wherein, after polishing the spectacle lens, at least one of the plurality of optical elements may have a relative surface elevation change per millimeter interval substantially greater than at least a portion of the prescription surface over a comparable interval. The present disclosure is also directed devices and systems manufactured using the described manufacturing methods.

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed.

The invention relates to the technical field of ophthalmic disease diagnosis, and discloses an ophthalmic disease intelligent diagnosis and treatment management method and system based on a large model, and the method comprises the steps: obtaining a fundus image of a to-be-diagnosed patient; inputting an eye fundus image of a patient to be diagnosed into the eye fundus disease classification segmentation model to obtain an eye disease category and a disease marker segmentation result corresponding to the eye fundus image to be diagnosed; inputting the ophthalmic disease category, the disease marker segmentation result and the clinical record of the to-be-diagnosed patient into a large language model to obtain a fundus disease treatment management scheme of the to-be-diagnosed patient; the large language model is based on an LLaMA model, and an LoRA layer is added on each multi-head attention layer of the LLaMA model; an Adapter layer is added between each feed-forward layer and a normalization layer of the LLaMA model. According to the invention, quick diagnosis and treatment of ophthalmic diseases can be realized, the diagnosis efficiency is improved, and the doctor seeing burden of patients is relieved.

The present invention relates to the fields of therapy and drug delivery. More specifically, disclosed herein are therapeutic methods and pharmaceutical compositions for treating disorders of blood-tissue barrier-shielded organs that harbour substantive populations of post-mitotic neurons, such as the organs derived from neural tube that include the central nervous system and the eye. The disclosed methods and compositions involve localised administration into such organs of an effector component that targets an intracellular biological target, in combination with a saponin component that enhances effective uptake of the effector component into the cells and / or that enhances effective routing of the effector component inside the cells where the biological target is present. For example, the effector component can be an oligonucleotide therapeutic that is targeting a gene product associated with the disorder of the CNS and / or of the eye. Due to cellular uptake-stimulating and / or endosomal escape enhancing effects of the saponin component, the presented herein neuropharmaceutical and ophthalmic compositions for the localised administration into the CNS and / or into the eye, respectively, can be formulated with lower concentrations of the effector component and / or at lower volumes, which confers safety-benefits to the neurons and to the comfort of the patient.

The invention provides an ophthalmologic operation navigation method which comprises the following steps: acquiring operation images and biological parameters of two eyes of a patient, determining a reference image, configuring reference navigation parameters corresponding to the reference image, and constructing an eyeball iris segmentation model; inputting the current frame of operation image and the reference image into an eyeball iris segmentation model, and performing iris fitting on an iris segmentation result; if the current frame of operation image is in an incision stage or an astigmatism axis implantation stage, performing image registration calculation on the current frame of operation image and a reference image according to an iris fitting result to obtain a rotation angle of the current frame of operation image relative to the reference image; calculating a target incision angle or a target astigmatism axis implantation angle based on the rotation angle and the reference navigation parameters; and if the current frame of operation image is in the capsulorhexis stage, calculating the pixel radius of the target capsulorhexis circle based on the iris fitting result and the reference navigation parameters. According to the invention, the accuracy and safety in the operation process are ensured.

The invention discloses a multi-modal dual-path fusion network structure based on data level fusion, and relates to the technical field of dual-path fusion network structures, comprising the steps of data set construction and preprocessing, selection and processing of a plurality of data sets, and image enhancement and normalization; constructing a network structure, constructing a dual-path network, pre-training on different data sets by using a mainstream backbone network, optimizing training, splicing feature layers, and performing classified training; and performing data fusion and classification, performing horizontal fusion on the double-path features, determining the weight by adopting a weighting strategy, and inputting the fused features into a full connection layer for classification according to a softmax function. According to the method, the ophthalmic disease diagnosis accuracy and model robustness are improved, the generalization ability is improved, network training is optimized, and medical intelligent diagnosis development is promoted.

Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed.

A ophthalmic lens for inhibiting progression of myopia includes a central zone and an annular zone. The annular zone includes subsurface optical elements formed via laser-induced changes in refractive index of a material forming the annular zone. The subsurface optical elements are configured to modify distribution of light to the peripheral retina of a user so as to inhibit progression of myopia.

The invention relates to the technical field of medical image processing, and discloses a fundus focus segmentation method, system and device based on an uncertainty OCT image and a medium, and the method comprises the steps: constructing an encoder-decoder network architecture; an uncertainty guiding module is embedded into the tail end of the encoder, an uncertainty graph is generated, and weighted enhancement is carried out on input features; a cross-layer fusion module is embedded in the jump connection of the encoder and the decoder, features of different levels are processed through parallel maximum value fusion and multiplication fusion branches, and fusion features are generated and then transmitted to the decoder; performing independent uncertainty quantization at the tail end of the decoder to generate an uncertainty graph of each lesion category; and combining the target-level uncertainty excitation loss function and the pixel-level uncertainty loss function, and optimizing network parameters through a total loss function. According to the method, the automatic identification and segmentation performance of a complex focus area can be remarkably improved, and accurate quantitative analysis of ophthalmic diseases is facilitated.

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for reducing dysphotopsia effects, such as straylight, haloes and glare, in diffractive lenses. Exemplary ophthalmic lenses can include a diffractive profile that distributes light among a near focal length, a far focal length, and one or more intermediate focal length. The diffractive profile provides for minimized or zero step heights between one or more pairs of diffractive zones for reducing visual artifacts.

An ophthalmic lens configured to correct and / or treat at least one condition of the eye (e.g., presbyopia, myopia, hyperopia, astigmatism, binocular vision disorders, night vision image quality, and / or visual fatigue syndrome) comprising: a base power profile; and at least one pulse selected to modify the base power profile.

The invention relates to the technical field of medical image segmentation, and particularly discloses a pathological myopia analysis method and system based on multi-task learning, and the method comprises the steps: inputting a pathological myopia eye bottom image into a shared feature encoder for feature extraction, and obtaining an image embedding vector; the shared feature encoder is based on a Swin Transform architecture, and the rank value of the LoRA parameter is dynamically adjusted through the information entropy; performing feature enhancement on the image embedding vector through a layered progressive head attention module to obtain an enhanced image embedding vector; and inputting the enhanced image embedding vector into a multi-task solution terminal to obtain an analysis result. According to the method, the diagnosis precision and the calculation efficiency can be remarkably improved, powerful technical support is provided for automatic diagnosis and personalized treatment of ophthalmic diseases, and wide application of the intelligent medical technology in clinical practice is promoted.

The invention provides an application of a cross-linked decellularized bovine amniotic membrane (CAM) and manganese carbon dots (Mn CDs) combined in preparation of an ophthalmic medical material for alkali burn cornea repair. The invention further provides a compound for repairing the alkali burn cornea. Cell and animal experiments show that the compound CDs (at) CAM has good biocompatibility and strong antioxidant and anti-inflammatory effects, can significantly promote corneal epithelium regeneration and inhibit corneal neovascularization and scar generation, and provides a new strategy for treatment of alkali burn cornea and various corneal epithelium injuries and diseases.

A soaking device and methods of using are used to cool and / or to heat a face of a person for a purpose of inducing a desired and / or intended outcome in that person. The cooling and / or the heating of the face may be sufficient to induce the desired and / or the intended outcome in that person. The desired and / or intended outcome may relate to: release of at least one type of neurotransmitter; trigeminal nerve stimulation; (indirect) vagus nerve stimulation; transdermal drug delivery; bypass of the blood-brain-barrier (BBB); aesthetic medicine; cardiovascular; dermatological; ears, nose, and throat (otolaryngological); ophthalmological; neurological; psychological; endocrinological; and / or rheumatological benefits to that person. At least one step of the method may include receiving at least some of the face within an immersion-liquid for at least a minimum amount of time while the immersion-liquid is within a temperature-range and while the immersion-liquid is within the soaking device.

The invention provides a dynamic simulation model construction algorithm for implanting a crystalline lens MPL in the ophthalmology department, and relates to the technical field of dynamic simulation models.The dynamic simulation model construction algorithm comprises the steps that microscopic dynamic data of the crystalline lens in the eye are collected in real time through a nanoscale microsensor array, and the crystalline lens micro-deformation degree (CTMD) and the interaction force (CTIS) of the crystalline lens and an intraocular structure are calculated; the collected microscopic data is transmitted to a central processing unit and is efficiently processed by a high-frequency data processing module; calculating the three-dimensional deformation and focal length change of the crystalline lens in real time based on a multi-physics field coupling algorithm in combination with a physics model; a highly dynamic simulation model is generated through the central processing unit to simulate the performance of the implanted MPL and optimize the surgical planning and design. According to the method, the precision and adaptability of the dynamic simulation model of the implanted crystalline lens MPL in the ophthalmology department can be effectively improved, and more accurate simulation and support are provided for ophthalmology operations.

A glaucoma aqueous humor drainage tube implantation and injection device, which relates to the field of ophthalmology. The glaucoma aqueous humor drainage tube implantation and injection device comprises a protective housing (1), wherein an adjustable lower housing (8) is slidably connected to an inner wall of the protective housing (1), a fixing post (3) is fixedly connected to a surface of the protective housing (1), a left opening and clamping plate (4) and a right opening and clamping plate (5) are each rotationally connected to a surface of the fixing post (3), contact plates (6) are fixedly connected to both the bottom ends of the left opening and clamping plate (4) and the right opening and clamping plate (5), adhesive stickers (7) are fixedly connected to both the lower surfaces of the pair of contact plates (6), an adjustable rotating cylinder (2) is rotationally connected to the inner wall of the protective housing (1), and an adjustable pressure-reducing mechanism (9) is in threaded connection with an inner wall of the adjustable rotating cylinder (2). The adhesive stickers (7) are provided to adhere to the skin of a human body to provide support, so as to prevent eyelids of a patient from resetting due to fatigue during surgery; by means of providing the left opening and clamping plate (4) and the right opening and clamping plate (5), balanced support is maintained; by providing the protective housing (1), the movement of the adjustable lower housing (8) is guided and positioned; the adjustable pressure-reducing mechanism (9) is provided such that the eyelids of the patient are supported and tensioned during surgery and remain stable; and the functions of needling and of aqueous humor flow guiding are integrated, so as to avoid frequent replacement of a device during surgery.

The invention relates to a method for producing an ophthalmological device (1), having the steps of: providing a container (30) which is transparent to electromagnetic radiation (35), providing at least one first part (10) of the ophthalmological device (1), securing the at least one first part (10) in the container (30) using at least one holding device (31), and for at least one second part (12) of the ophthalmological device (1): providing a liquid (33), which can be cured using electromagnetic radiation (35), in the container (30); generating and / or providing a data set (36) of images (37) of the second part (12) of the ophthalmological device (1), said images (37) containing projections of the second part (12) from different directions; and - tomographically printing the curable liquid (33) using electromagnetic radiation (35) on the basis of the generated and / or provided data set (36) in order to produce the second part (12). The step of generating and / or providing the data set (36) and / or tomographically printing the curable liquid is carried out such that at least one second part (12) is arranged on the at least one first part (10) and / or at least partly surrounds same. The invention additionally relates to an assembly (20).

An apparatus and method for aiding in the detection of dementia, concussion, other neurologic conditions, retinal, and optic nerve conditions. The apparatus enables the diffusion coefficient of the tissue to be ascertained and studied by directing the light from a laser or other coherent light source at the patient's retina, optic nerve or choroid and measuring the fluctuations in the intensity of the back-scattered light caused by the movement of light scatterers in the tissue. By comparing the measurements to a normal database, or to the subject's previous measurement, in combination with an eye examination and OCT image / measurement the changes caused by the disease and the effectiveness of therapy can be ascertained. The disclosed apparatus allows the incident and detection optics to be attached to ophthalmic devices typically used in ophthalmologic care. Also, where both the incident laser fiber optic and the detection fiber optic are directly connected to goggles, one or more or all of the above-described mirrors may not be necessary, as both fiber optics are preferably directly directed into the eye.

The invention provides an ophthalmic disease prediction model training method and electronic equipment, and the method comprises the steps: obtaining ophthalmic image data and label data corresponding to the ophthalmic image data; preprocessing the ophthalmology image data to obtain a plurality of image blocks with different scale levels; learning the space offset of each sampling point on each image block through the convolution operation of the stacked adaptive gradient modulation convolution layer, adjusting the original convolution kernel weight of the stacked adaptive gradient modulation convolution layer based on the space offset, and transforming the plurality of image blocks with different scale levels to obtain a morphological enhancement feature map; inputting the morphological enhancement feature map into a mixed attention feature extraction module to obtain a small focus enhancement feature map, and performing dimensionality reduction to obtain a feature vector; and inputting the feature vector and the tag data into a full-connection classifier, outputting a disease category prediction probability, and when a training stop condition is met, completing training of the multi-branch convolutional neural network, forming an ophthalmic disease prediction model, and improving the recognition accuracy of minimal lesions.