2701 results about "OPHTHALMOLOGICALS" patented technology

The invention relates to the technical field of ophthalmology medical diagnosis, and discloses a three-dimensional reconstruction-based fundus focus intelligent labeling method and diagnosis system. The method comprises the following steps: receiving multi-modal image data streams such as fundus color photos, OCT images and FFA images of an ophthalmological patient; performing spatial registration and feature fusion by using a pre-trained lesion feature fusion model to generate a three-dimensional lesion probability distribution diagram and a lesion category confidence matrix; constructing an adaptive annotation threshold model to generate a multi-modal annotation instruction set; based on the focus development chain model, focus development is simulated, and instruction set parameters are optimized and labeled; and iteratively optimizing through a distributed reinforcement learning framework, and outputting the focus labeling action sequence to an ophthalmology diagnosis platform. According to the method, multi-modal image information can be integrated, the diagnosis accuracy and efficiency are improved, personalized diagnosis is realized, resources are reasonably utilized, and powerful support is provided for ophthalmic disease diagnosis.

Provided are multi-wavelength phototherapy devices, systems and methods for the treatment of a disorder or disease, including multi-wavelength low level light therapy (“PBM”), in particular to multi-wavelength PBM and other phototherapy systems and methods for improving functionality in and / or restoring functionality to a cell and / or tissue through the coordinated and targeted delivery to the cell or tissue of two or more doses of light having distinct wavelengths, wherein the two or more doses of light, when delivered in a coordinated fashion, can stimulate the activity of two or more light sensitive factors that, when activated, provide and / or enhance a desired target cell functionality. Ophthalmic phototherapy devices, systems, and treatment methods to expose an eye to selected multi-wavelengths of light to promote the healing of damaged or diseased eye tissue. The devices include a housing having an interior; an eyepiece disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyepiece; a first light source producing a first light beam having a first therapeutic wavelength and disposed within the housing; a second light source producing a second light beam having a second therapeutic wavelength and disposed within the housing, where the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm.

The invention provides a dynamic myopia management lens prescription customization method and system, and relates to the technical field of lens design and customization. According to the dynamic myopia management lens prescription customization technology provided by the invention, ophthalmic basic data of a patient is acquired; then periodically follow-up the patient to obtain ophthalmology measurement follow-up data of the patient; the joint evaluation model dynamically updates a myopia risk evaluation grade of the patient based on ophthalmology basic data and ophthalmology measurement follow-up visit data; and finally, dynamically updating the lens prescription based on the myopia risk assessment level of each time by the joint assessment model. According to the technical scheme, the combined evaluation model can perform dynamic lens prescription adjustment according to follow-up visit ocular axis progress and choroid change conditions, dynamic myopia management lens prescription customization, whole-course tracking of a myopia cycle and individualized prevention and control management are realized, and thus the effectiveness and continuity of myopia prevention and control are improved.

The invention relates to the technical field of medical image processing and artificial intelligence, and discloses an artificial intelligence-based retinochoroid disease course structure change monitoring system, which comprises an image acquisition unit, a feature extraction unit, a lesion segmentation unit and the like. The image acquisition unit acquires retina optical coherence tomography sequence image data and fundus color image data; the feature extraction unit extracts a retina choroidal structure feature tensor through a three-dimensional convolutional neural network; the lesion segmentation unit outputs a lesion area probability distribution diagram by using a U-Net segmentation network; the time sequence alignment unit is used for registering the multi-time-point images to generate a displacement change matrix; the dynamic analysis unit extracts related indexes; an abnormal scoring unit constructs a disease course progress score; the decision grading unit outputs disease course stage classification labels; the multi-modal fusion unit fuses the multi-modal features; the report generation unit generates a structured disease course monitoring report. And favorable support is provided for diagnosis and treatment of ophthalmic diseases and illness state tracking.

Disclosed herein are methods and devices for generating a trained generative foundation model for medical diagnosis, as well as using the trained generative foundation model for the detection of diseases and disorders including ophthalmic and systemic diseases. System and non-transitory computer-readable storage medium configured for performing the methods are also disclosed.

The present disclosure is directed to methods for manufacturing ophthalmic lenses utilizing a freeform process, the method comprising: machining a lens blank, semi-finished lens blank and / or an intermediate ophthalmic lens precursor to form a surface of the spectacle lens with at least a portion of the surface comprising a curvature for the correction of the myopic prescription of the wearer; machining a pattern of a plurality of optical elements and / or spaces therebetween on the surface of the spectacle lens suitable for delivering an effective optical signal to the retinal receptors of a progressive myope to slow, significantly slow, stop and / or shorten / regress the progression of axial eye length growth; and / or polishing the surface of the spectacle lens; wherein, after polishing the spectacle lens, at least one of the plurality of optical elements may have a relative surface elevation change per millimeter interval substantially greater than at least a portion of the prescription surface over a comparable interval. The present disclosure is also directed devices and systems manufactured using the described manufacturing methods.

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

The invention provides an ophthalmologic operation navigation method which comprises the following steps: acquiring operation images and biological parameters of two eyes of a patient, determining a reference image, configuring reference navigation parameters corresponding to the reference image, and constructing an eyeball iris segmentation model; inputting the current frame of operation image and the reference image into an eyeball iris segmentation model, and performing iris fitting on an iris segmentation result; if the current frame of operation image is in an incision stage or an astigmatism axis implantation stage, performing image registration calculation on the current frame of operation image and a reference image according to an iris fitting result to obtain a rotation angle of the current frame of operation image relative to the reference image; calculating a target incision angle or a target astigmatism axis implantation angle based on the rotation angle and the reference navigation parameters; and if the current frame of operation image is in the capsulorhexis stage, calculating the pixel radius of the target capsulorhexis circle based on the iris fitting result and the reference navigation parameters. According to the invention, the accuracy and safety in the operation process are ensured.

A ophthalmic lens for inhibiting progression of myopia includes a central zone and an annular zone. The annular zone includes subsurface optical elements formed via laser-induced changes in refractive index of a material forming the annular zone. The subsurface optical elements are configured to modify distribution of light to the peripheral retina of a user so as to inhibit progression of myopia.

The invention relates to the technical field of medical image processing, and discloses a fundus focus segmentation method, system and device based on an uncertainty OCT image and a medium, and the method comprises the steps: constructing an encoder-decoder network architecture; an uncertainty guiding module is embedded into the tail end of the encoder, an uncertainty graph is generated, and weighted enhancement is carried out on input features; a cross-layer fusion module is embedded in the jump connection of the encoder and the decoder, features of different levels are processed through parallel maximum value fusion and multiplication fusion branches, and fusion features are generated and then transmitted to the decoder; performing independent uncertainty quantization at the tail end of the decoder to generate an uncertainty graph of each lesion category; and combining the target-level uncertainty excitation loss function and the pixel-level uncertainty loss function, and optimizing network parameters through a total loss function. According to the method, the automatic identification and segmentation performance of a complex focus area can be remarkably improved, and accurate quantitative analysis of ophthalmic diseases is facilitated.

An ophthalmic lens configured to correct and / or treat at least one condition of the eye (e.g., presbyopia, myopia, hyperopia, astigmatism, binocular vision disorders, night vision image quality, and / or visual fatigue syndrome) comprising: a base power profile; and at least one pulse selected to modify the base power profile.

The invention relates to the technical field of medical image segmentation, and particularly discloses a pathological myopia analysis method and system based on multi-task learning, and the method comprises the steps: inputting a pathological myopia eye bottom image into a shared feature encoder for feature extraction, and obtaining an image embedding vector; the shared feature encoder is based on a Swin Transform architecture, and the rank value of the LoRA parameter is dynamically adjusted through the information entropy; performing feature enhancement on the image embedding vector through a layered progressive head attention module to obtain an enhanced image embedding vector; and inputting the enhanced image embedding vector into a multi-task solution terminal to obtain an analysis result. According to the method, the diagnosis precision and the calculation efficiency can be remarkably improved, powerful technical support is provided for automatic diagnosis and personalized treatment of ophthalmic diseases, and wide application of the intelligent medical technology in clinical practice is promoted.

The invention provides an application of a cross-linked decellularized bovine amniotic membrane (CAM) and manganese carbon dots (Mn CDs) combined in preparation of an ophthalmic medical material for alkali burn cornea repair. The invention further provides a compound for repairing the alkali burn cornea. Cell and animal experiments show that the compound CDs (at) CAM has good biocompatibility and strong antioxidant and anti-inflammatory effects, can significantly promote corneal epithelium regeneration and inhibit corneal neovascularization and scar generation, and provides a new strategy for treatment of alkali burn cornea and various corneal epithelium injuries and diseases.

A soaking device and methods of using are used to cool and / or to heat a face of a person for a purpose of inducing a desired and / or intended outcome in that person. The cooling and / or the heating of the face may be sufficient to induce the desired and / or the intended outcome in that person. The desired and / or intended outcome may relate to: release of at least one type of neurotransmitter; trigeminal nerve stimulation; (indirect) vagus nerve stimulation; transdermal drug delivery; bypass of the blood-brain-barrier (BBB); aesthetic medicine; cardiovascular; dermatological; ears, nose, and throat (otolaryngological); ophthalmological; neurological; psychological; endocrinological; and / or rheumatological benefits to that person. At least one step of the method may include receiving at least some of the face within an immersion-liquid for at least a minimum amount of time while the immersion-liquid is within a temperature-range and while the immersion-liquid is within the soaking device.

The invention provides a dynamic simulation model construction algorithm for implanting a crystalline lens MPL in the ophthalmology department, and relates to the technical field of dynamic simulation models.The dynamic simulation model construction algorithm comprises the steps that microscopic dynamic data of the crystalline lens in the eye are collected in real time through a nanoscale microsensor array, and the crystalline lens micro-deformation degree (CTMD) and the interaction force (CTIS) of the crystalline lens and an intraocular structure are calculated; the collected microscopic data is transmitted to a central processing unit and is efficiently processed by a high-frequency data processing module; calculating the three-dimensional deformation and focal length change of the crystalline lens in real time based on a multi-physics field coupling algorithm in combination with a physics model; a highly dynamic simulation model is generated through the central processing unit to simulate the performance of the implanted MPL and optimize the surgical planning and design. According to the method, the precision and adaptability of the dynamic simulation model of the implanted crystalline lens MPL in the ophthalmology department can be effectively improved, and more accurate simulation and support are provided for ophthalmology operations.

The invention provides an ophthalmic disease prediction model training method and electronic equipment, and the method comprises the steps: obtaining ophthalmic image data and label data corresponding to the ophthalmic image data; preprocessing the ophthalmology image data to obtain a plurality of image blocks with different scale levels; learning the space offset of each sampling point on each image block through the convolution operation of the stacked adaptive gradient modulation convolution layer, adjusting the original convolution kernel weight of the stacked adaptive gradient modulation convolution layer based on the space offset, and transforming the plurality of image blocks with different scale levels to obtain a morphological enhancement feature map; inputting the morphological enhancement feature map into a mixed attention feature extraction module to obtain a small focus enhancement feature map, and performing dimensionality reduction to obtain a feature vector; and inputting the feature vector and the tag data into a full-connection classifier, outputting a disease category prediction probability, and when a training stop condition is met, completing training of the multi-branch convolutional neural network, forming an ophthalmic disease prediction model, and improving the recognition accuracy of minimal lesions.

An implantable or wearable lens for ophthalmic use, having a front surface and a rear surface, wherein at least one surface of said front surface and rear surface has an aspherical refractive profile with circular or rotational symmetry, or with cylindrical or non-rotational symmetry, with respect to the optical axis, and having a geometric elevation z(r) defined by a series expansion of Forbes polynomials, wherein said refractive profile generates an enhancement of the wavefront W(r) emerging from the lens such as to extend the depth of field thereof progressively and continuously in a power range between −1.0 D and 4.0 D.

The present invention relates to the field of biomedicine, and discloses a fusion-type adeno-associated virus and its application in ear diseases and ophthalmic diseases. The fusion-type adeno-associated virus comprises a fusion peptide segment or a variant thereof formed by fusing peptide segments of serotypes AAV1, 2, 6 and 7, which can efficiently transduce hair cells and / or supporting cells in the cochlea, promote the regeneration of inner hair cells, and help restore hearing. The adeno-associated virus can also efficiently infect the RPE layer and is used for the treatment of ophthalmic diseases. As a safe vector, the fusion-type adeno-associated virus has broad application prospects in the treatment of ear diseases or ophthalmic diseases.

The invention discloses a preparation method of eye drops for treating glaucoma, cataract and vitreous opacification. The eye drops comprise the following components: berberine, N-acetyl carnosine and lycium barbarum polysaccharide. The specific formula comprises the following components: 0.1%-0.5% of berberine, 1%-3% of N-acetyl carnosine and 0.5%-2% of lycium barbarum polysaccharide. The invention belongs to the technical field of ophthalmic pharmaceutical preparations, and solves the problems that in the prior art, glaucoma, cataract and vitreous opacity generally need to be separately taken, the research on compound preparations is less, and the components possibly interact with one another.

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

Disclosed herein are compositions which can be used in methods for treating or preventing ophthalmic and dermatologic conditions in a human subject, including ocular surface conditions such as blepharitis or rosacea. The compositions can be topically administered directly to an eye, eyelid, or eyelashes of the patient for targeted local activity.

A therapeutic laser for use in treating ophthalmological conditions can be modulated by a spatial light modulation device in order to focus the therapeutic laser on a plurality of target locations simultaneously.

The invention provides an optic disk real-time continuous tracking method and device, and relates to the technical field of medical image processing. According to the method, the video sequence of the ophthalmologic operation is acquired and preprocessed, and then the preprocessed video sequence is subjected to multi-scale feature extraction and optic disc target detection, so that an optic disc detection target is obtained; the optic disk detection target is based on Kalman filtering prediction and appearance feature matching, an adaptive gating matching mechanism is introduced to carry out inter-frame target trajectory association, a target trajectory is maintained in combination with an appearance feature cache updating mechanism and ReID cosine similarity retrieval, and a trajectory tracking result is output; wherein the trajectory tracking result comprises a continuous tracking result of the optic disc position, the confidence coefficient, the trajectory identifier and the timestamp. According to the invention, the detection precision of the small-scale optic disc is improved, the shielding recovery and track continuity are enhanced, and high-precision, high-robustness and real-time optic disc continuous tracking is realized in complex operation scenes of strong reflection, low contrast, local shielding and the like.

The invention discloses a focus recognition system and method for a diabetic retinopathy image, and relates to the technical field of medical image processing, and the system comprises a fundus image collection module, an image feature processing module, a focus feature extraction module, a network model training module and a focus model recognition module. By integrating the fundus image collection module, the image feature processing module, the lesion feature extraction module, the network model training module and the lesion model recognition module, full-process automation from original fundus image acquisition to lesion intelligent recognition is realized, and the efficiency of diabetic retinopathy lesion recognition is remarkably improved; in addition, errors possibly caused by manual intervention are reduced, the accuracy and consistency of recognition results are ensured, specifically, the fundus image collection module can automatically obtain images from ophthalmology equipment or a hospital image storage system, format unification and index construction are carried out, and great convenience is provided for follow-up processing.

An ophthalmological device and system is described that allows the simultaneous imaging of an eye using both scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT). Further the device and system is capable of targeting and delivering a treatment laser for treatment of an eye condition.

A visualization system for dynamically visualizing an eye includes a laser module operable for outputting a primary laser beam along a beam axis, a beam splitter positioned in the beam axis and configured to direct a first beam portion along the beam axis and a second beam portion along a detection axis that is orthogonal to the beam axis. A microelectromechanical system (MEMS) scanner is arranged on the beam axis and configured, in response to the first beam portion, to output a scanning laser along a visualization path. An avalanche photodiode (APD) detector receives the second beam portion. A 4F correlator optical system has a spatial filter arranged along the visualization path. An optional optical flat may be disposed between the eye and the 4F correlator optical system to achieve stereo parallax.

A topical ophthalmological composition includes a muscarinic receptor antagonist as an active pharmaceutical ingredient; and medium chain triglycerides (MCTs) or light liquid paraffin oil as liquid vehicle. The topical ophthalmological composition treats an ocular disease.

The invention discloses an eye atomization therapeutic apparatus, and relates to the field of ophthalmology medical instruments, the eye atomization therapeutic apparatus comprises a shell, an opening part of the shell is provided with an upper arc part and a lower fitting part, the shell is internally provided with a waste liquid collection assembly, the waste liquid collection assembly comprises a guide plate fixed with the shell, the guide plate is provided with a diversion trench, and the diversion trench is provided with a lower arc part and a lower fitting part. And the bottom of the shell communicates with a collecting shell. According to the eye atomization therapeutic apparatus, steam can be generated by starting a small steam generator, the steam is conveyed through an input pipe, a mounting shell, an output pipe, a connecting pipe and a heating pipe and finally cooled through a condenser, the steam is changed into a liquid state again and enters a liquid storage box, unatomized liquid medicine in a medicine storage tank can be heated through the heating pipe, and the atomization effect is improved. The problem that the atomization effect of the ultrasonic atomizer is affected due to viscosity increase caused by too low temperature is solved.

An ophthalmic apparatus includes an objective optical system, an illumination optical system, a photographic optical system, a photographing unit, a movement mechanism, and a three-dimensional position identifying unit. The objective optical system is configured to optically relay a measurement position where a pupil of an eye of an examinee can be disposed. The illumination optical system is configured to irradiate illumination light onto the eye through the objective optical system. The photographic optical system is configured to receive returning light of the illumination light from the eye through the objective optical system. The photographing unit includes two or more cameras disposed so as to include a position, that is substantially conjugate optically to the measurement position relayed by the objective optical system, within a field of vision. The movement mechanism is configured to relatively move the objective optical system, the illumination optical system, the photographic optical system, and the photographing unit relative to the eye. The three-dimensional position identifying unit is configured to identify a three-dimensional position of the eye based on two or more photographic images of the eye acquired by the photographing unit.

An incisional instrument and method of use for creating accurate, reproducible surgical incisions. An exemplary embodiment includes an incisional instrument configured for attachment to a patient's eye and for use performing arcuate limbal relaxing incisions (LRIs). The incisional instrument is made up of two coaxial, interconnecting pieces: a docking piece and a cutting piece. The docking piece includes a suction mechanism and is configured for being secured to a patient's eye just outside the corneal limbus. The cutting piece is configured to fit flush within the docking piece and includes cutting blades and one or more handles for rotating the cutting piece relative to the docking piece. When assembled, the cutting blades extend into a patient's eye a desired LRI depth. An embodiment further includes an arcuate guide template with stoppers for providing lateral, arcuate stops for precise cuts in the desired LRI locations. An LRI method includes the steps of utilizing the incisional instrument in an ophthalmologic LRI procedure.