1673 results about "OPHTHALMOLOGICALS" patented technology

The invention provides a dynamic myopia management lens prescription customization method and system, and relates to the technical field of lens design and customization. According to the dynamic myopia management lens prescription customization technology provided by the invention, ophthalmic basic data of a patient is acquired; then periodically follow-up the patient to obtain ophthalmology measurement follow-up data of the patient; the joint evaluation model dynamically updates a myopia risk evaluation grade of the patient based on ophthalmology basic data and ophthalmology measurement follow-up visit data; and finally, dynamically updating the lens prescription based on the myopia risk assessment level of each time by the joint assessment model. According to the technical scheme, the combined evaluation model can perform dynamic lens prescription adjustment according to follow-up visit ocular axis progress and choroid change conditions, dynamic myopia management lens prescription customization, whole-course tracking of a myopia cycle and individualized prevention and control management are realized, and thus the effectiveness and continuity of myopia prevention and control are improved.

Disclosed herein are methods and devices for generating a trained generative foundation model for medical diagnosis, as well as using the trained generative foundation model for the detection of diseases and disorders including ophthalmic and systemic diseases. System and non-transitory computer-readable storage medium configured for performing the methods are also disclosed.

The present disclosure is directed to methods for manufacturing ophthalmic lenses utilizing a freeform process, the method comprising: machining a lens blank, semi-finished lens blank and / or an intermediate ophthalmic lens precursor to form a surface of the spectacle lens with at least a portion of the surface comprising a curvature for the correction of the myopic prescription of the wearer; machining a pattern of a plurality of optical elements and / or spaces therebetween on the surface of the spectacle lens suitable for delivering an effective optical signal to the retinal receptors of a progressive myope to slow, significantly slow, stop and / or shorten / regress the progression of axial eye length growth; and / or polishing the surface of the spectacle lens; wherein, after polishing the spectacle lens, at least one of the plurality of optical elements may have a relative surface elevation change per millimeter interval substantially greater than at least a portion of the prescription surface over a comparable interval. The present disclosure is also directed devices and systems manufactured using the described manufacturing methods.

An ophthalmic lens configured to correct and / or treat at least one condition of the eye (e.g., presbyopia, myopia, hyperopia, astigmatism, binocular vision disorders, night vision image quality, and / or visual fatigue syndrome) comprising: a base power profile; and at least one pulse selected to modify the base power profile.

The invention relates to the technical field of medical image segmentation, and particularly discloses a pathological myopia analysis method and system based on multi-task learning, and the method comprises the steps: inputting a pathological myopia eye bottom image into a shared feature encoder for feature extraction, and obtaining an image embedding vector; the shared feature encoder is based on a Swin Transform architecture, and the rank value of the LoRA parameter is dynamically adjusted through the information entropy; performing feature enhancement on the image embedding vector through a layered progressive head attention module to obtain an enhanced image embedding vector; and inputting the enhanced image embedding vector into a multi-task solution terminal to obtain an analysis result. According to the method, the diagnosis precision and the calculation efficiency can be remarkably improved, powerful technical support is provided for automatic diagnosis and personalized treatment of ophthalmic diseases, and wide application of the intelligent medical technology in clinical practice is promoted.

A soaking device and methods of using are used to cool and / or to heat a face of a person for a purpose of inducing a desired and / or intended outcome in that person. The cooling and / or the heating of the face may be sufficient to induce the desired and / or the intended outcome in that person. The desired and / or intended outcome may relate to: release of at least one type of neurotransmitter; trigeminal nerve stimulation; (indirect) vagus nerve stimulation; transdermal drug delivery; bypass of the blood-brain-barrier (BBB); aesthetic medicine; cardiovascular; dermatological; ears, nose, and throat (otolaryngological); ophthalmological; neurological; psychological; endocrinological; and / or rheumatological benefits to that person. At least one step of the method may include receiving at least some of the face within an immersion-liquid for at least a minimum amount of time while the immersion-liquid is within a temperature-range and while the immersion-liquid is within the soaking device.

The invention provides an optic disk real-time continuous tracking method and device, and relates to the technical field of medical image processing. According to the method, the video sequence of the ophthalmologic operation is acquired and preprocessed, and then the preprocessed video sequence is subjected to multi-scale feature extraction and optic disc target detection, so that an optic disc detection target is obtained; the optic disk detection target is based on Kalman filtering prediction and appearance feature matching, an adaptive gating matching mechanism is introduced to carry out inter-frame target trajectory association, a target trajectory is maintained in combination with an appearance feature cache updating mechanism and ReID cosine similarity retrieval, and a trajectory tracking result is output; wherein the trajectory tracking result comprises a continuous tracking result of the optic disc position, the confidence coefficient, the trajectory identifier and the timestamp. According to the invention, the detection precision of the small-scale optic disc is improved, the shielding recovery and track continuity are enhanced, and high-precision, high-robustness and real-time optic disc continuous tracking is realized in complex operation scenes of strong reflection, low contrast, local shielding and the like.

A visualization system for dynamically visualizing an eye includes a laser module operable for outputting a primary laser beam along a beam axis, a beam splitter positioned in the beam axis and configured to direct a first beam portion along the beam axis and a second beam portion along a detection axis that is orthogonal to the beam axis. A microelectromechanical system (MEMS) scanner is arranged on the beam axis and configured, in response to the first beam portion, to output a scanning laser along a visualization path. An avalanche photodiode (APD) detector receives the second beam portion. A 4F correlator optical system has a spatial filter arranged along the visualization path. An optional optical flat may be disposed between the eye and the 4F correlator optical system to achieve stereo parallax.

A topical ophthalmological composition includes a muscarinic receptor antagonist as an active pharmaceutical ingredient; and medium chain triglycerides (MCTs) or light liquid paraffin oil as liquid vehicle. The topical ophthalmological composition treats an ocular disease.

The invention relates to the technical field of multi-modal ophthalmology image analysis, and particularly discloses a multi-modal ophthalmology image analysis method, model and system based on optimal transmission image diffusion and a medium thereof.The method at least comprises the steps that S100, the distance between fundus color photo and OCT image modals is explicitly calculated through an optimal transmission algorithm, and the distance between fundus color photo and OCT image modals is calculated; carrying out collaborative evolution on the features in a continuous time domain in combination with a graph neural network and a Sheng differential equation model; and step S200, applying self-attention and cross attention in parallel, reserving modal specificity with low-layer fine granularity, and progressively fusing the color photo texture and the OCT depth structure in a high layer to realize cross-layer long-range dependent depth semantic fusion. The method not only promotes the leading-edge development of multi-modal medical image analysis, but also provides important scientific basis and technical support for constructing a high-precision and high-robustness intelligent ophthalmology diagnosis system.

In some embodiments provided herein is a generative foundation model trained over millions of health system-scale electronic health records along with web-scale medical text corpora to acquire knowledge of both medical practices and theories, and use of the generative model for rare disease diagnosis (including rare ophthalmic, diseases and rare systemic diseases), emergency condition identification (including ophthalmic emergencies and systemic emergencies), complex disease solving ("diagnostic puzzles"), or generating multimodal medical imaging reports (including ophthalmic images and radiology images such as X-rays and CT scans). In some embodiments, the generative model involves the use of language data, for pre-training, language data for supervised finetuning using a instruction tuning approach (e.g., QA pairs), and a human-machine hybrid evaluation strategy. In some embodiments, both the pre-training and supervised finetuning phases involve the use of a particular method of scaling to extend the context window. In some embodiments, the human-machine hybrid evaluation strategy involves language data for automated evaluations, as well as evaluations by generalists and by different specialists (e.g., ophthalmologists and radiologists) of varying levels of experience. In some embodiments, the generative foundation model, MetaGP, is used for unmet clinical needs through integration of medical and multimodal imaging data.

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention provides gelatin derivative microspheres coated with stem cell exosomes, a preparation method of the gelatin derivative microspheres and application of the gelatin derivative microspheres in preparation of external ophthalmic preparations, and relates to the technical field of medicines. The gelatin derivative microsphere mainly comprises a microsphere core and a shell, wherein the microsphere core is a stem cell exosome coated with a gelatin derivative; the shell is obtained by crosslinking a gelatin derivative and sodium hyaluronate. The gelatin derivative used in the invention not only has good compatibility with the stem cell exosome, but also has good dispersibility in tears or periorbital secretion after being prepared by crosslinking the gelatin derivative and sodium hyaluronate, so that the elimination of an eye protection mechanism to the microspheres can be reduced, and the slow release effect of the exosome can be improved; besides, the shell formed by the hyaluronic acid has a very good tackifying effect, so that the retention time of the gelatin derivative hyaluronic acid microspheres in eyes is prolonged, and the problem of burst release of the medicine is also avoided by virtue of the double-layer coated microsphere structure.

The invention relates to a method for providing control data for an ophthalmic laser (12) of a treatment device (10).The procedure comprises the following steps: determining a preoperative corneal thickness profile (24) of a cornea (16) of a human or animal eye from predetermined examination data; determining a target corneal thickness profile (26) of the cornea (16), wherein at least one corneal thickness of the target corneal thickness profile (26) is set to a predetermined corneal thickness value (28) present at at least one predetermined position of the preoperative corneal thickness profile (24); determining tissue removal data to generate the target corneal thickness profile (26), wherein in the tissue removal data only tissue (14) at positions between the preoperative corneal thickness profile (24) and the target corneal thickness profile (26) is defined as tissue (14) to be removed; and providing control data for controlling the ophthalmic laser (12), which includes the tissue removal data.

Certain aspects of the present disclosure provide a system for processing image data from an intraoperative diagnostic device in real-time during an ophthalmic procedure. The system comprises an image capture element that captures a grayscale image of a first size and an image processing element that scales the grayscale image from the first size to a second size. The system also comprises a two-stage classification model comprising: a feature extraction stage to process the scaled grayscale image and generate a feature vector based on the scaled grayscale image and a classification stage to process the feature vector and generate an output vector. The image processing element is further configured to determine an image quality of the obtained grayscale image based on the output vector for display to an operator and the image quality of the obtained grayscale image indicates a probability that the obtained grayscale image includes an artifact.

The invention discloses an eye examination device with a postoperative care eyelid supporting function, and belongs to the technical field of eye examination.The eye examination device comprises an eyeshade type frame, a tightening belt, a shell, an examination base, an examination module, an eyelid dilator and the like, stable wearing can be achieved through the tightening belt, the position of the examination module is adjusted through a micro electric push rod, and the eyelid dilator is arranged on the shell; an upper eyelid supporting piece and a lower eyelid supporting piece of the eyelid dilator achieve accurate dilation by means of the SMA driving dilator, a contact air bag on an arc-shaped silica gel supporting pad can adjust contact pressure through a pneumatic adjuster, a piezoelectric ceramic vibrator can assist in tear adjustment and muscle relieving, a liquid absorber can treat redundant tears, and the device integrates a control module and various detection modules and is convenient to use. The eye protection device can monitor the eye state in real time and trigger a protection mechanism, provides safe and comfortable support and nursing for postoperative patients while completing eye examination, and is suitable for ophthalmologic postoperative examination and rehabilitation assistance.

The invention provides a quantitative detection method and system based on an ophthalmic retina OCT image. The method comprises the steps that a quantitative parameter matrix of a three-dimensional structure is constructed according to a reflection intensity distribution curve corresponding to a target OCT image, the reflection intensity distribution curve and blood vessel density data of an OCTA image, and each voxel in the quantitative parameter matrix comprises space coordinates and parameter dimensions; inputting the quantitative parameter matrix into a pre-trained joint model to detect a retina leakage bounding box through a YOLOv7 network in the joint model, and segmenting the retina leakage area through a U-Net network in the joint model to obtain bounding box coordinates and a segmentation mask of the retina leakage area; and determining quantitative information of the retina lesion area according to the bounding box coordinates and the segmentation mask of the retina permeation area and a mapping relation between a preset permeation area and the lesion area. According to the technical scheme provided by the invention, the YOLOv7 network and the U-Net network are combined to accurately detect and segment the retinopathy area, and quantitative analysis is realized.

To provide an ophthalmic product in which an ophthalmic composition is filled in a container in which a pressing deformation part is formed by using an elastic material, and although the ophthalmic composition contains chlorpheniramine, diphenhydramine or a salt thereof, adsorption of these components is suppressed.SOLUTION: An ophthalmic product comprising an ophthalmic composition and a container filled with the ophthalmic composition, wherein the container comprises a container body having a discharge port and a press-deforming part, and a cap, and the press-deforming part is formed using an elastic material, (A) one or more selected from the group consisting of chlorpheniramine, diphenhydramine, and pharmaceutically acceptable salts thereof, and (B) one or more selected from the group consisting of an amino acid and a salt thereof, glycyrrhizic acid and a salt thereof, a mucopolysaccharide and a salt thereof, trometamol and a salt thereof, ethylenediaminetetraacetic acid and a salt thereof, and a vitamin and a derivative thereof.SELECTED DRAWING: Figure 1

The invention provides pharmaceutical compositions comprising about 0.05 to 0.1% (w / v) cyclosporine dissolved in 1-perfluorobutyl-pentane for use in the topical treatment of dry eye disease and provides for dosing and treatment methods thereof. The invention further provides kits comprising such compositions.

In certain embodiments, an ophthalmic system is provided. The ophthalmic system includes a low power laser source configured to generate a low power laser beam, wherein the low power laser source has a power of between 5 milliwatts (mW) and 20 mW, and a first illumination device configured to transmit the low power laser beam into a vitreous cavity of an eye. The ophthalmic system further includes a red-green-blue (RGB) light-emitting diode (LED) light source configured to generate a RGB light, and a second illumination device configured to transmit the RGB light into the vitreous cavity of the eye.

Compositions for treating ocular disease are disclosed herein. In some embodiments, the composition comprises a dynamic hydrogel comprising a polymer and a plurality of nanoparticles, wherein the polymer is non-covalently crosslinked with the plurality of nanoparticles. The dynamic hydrogel can also comprise an ocular therapeutic encapsulated by the dynamic hydrogel.

The present application relates to an ophthalmic lens and frame eyeglasses comprising the lens. The ophthalmic lens includes a central portion, multiple first refractive regions, and multiple second refractive regions. The multiple first refractive regions are arranged in a first zone surrounding the central portion, while the multiple second refractive regions are arranged in a second zone farther away from the central portion compared to the first zone. The central portion has a prescription power based on the human eye, and the first and second refractive regions have different powers than the prescription power. Furthermore, the total area ratio of the multiple first refractive regions to the area of the first zone is greater than the total area ratio of the multiple second refractive regions to the area of the second zone. As a result, the present application allows for more effective management and control of myopia progression.

Ophthalmic medical image segmentation method includes dividing the medical image data into a training set and a test set according to an autonomously set proportion; constructing a convolutional neural network model adopting a U-shaped encoding and decoding structure based on an attention mechanism and a weighted loss function, and performing training; transmitting a to-be-segmented medical image to obtain a segmentation result, wherein the attention mechanism is introduced into the U-shaped encoding and decoding structure: a superficial layer feature map ILE of an encoder is subjected to convolution to obtain ILE-1, and a deep layer feature map IHD of a decoder is subjected to up-sampling and convolution to obtain IHD-1; the ILE-1 and the IHD-1 are multiplied to obtain IMul; the IMul and the IHD-1 are summed, and ISum is then output through an activation function; and the IMul and the ISum are spliced, and then output to a target layer.

The present disclosure generally relates to microsurgical instruments for ophthalmic surgical procedures, and more particularly, methods and microsurgical instruments for vitreoretinal procedures. In certain embodiments described herein, a vitreoretinal procedure is performed utilizing two surgical instruments: 1) a treatment instrument configured to a) treat a target ophthalmic tissue (e.g., sever and remove the vitreous body), and b) infuse fluid into the intraocular space to maintain intraocular pressure (IOP); and 2) an illumination probe for providing illumination within the intraocular space. The combined treatment and infusion functionalities of the treatment instrument eliminate the need for a separate infusion cannula, thus enabling the vitreoretinal procedure to be performed with only two instruments and reducing the number of incisions made in the eye. Additionally, utilization of two instruments facilitates easier manipulation of the eye by a surgeon, as one of the two instruments can be used to “steer” the eye during the procedure.

The invention provides an image-based eye lesion grading analysis method and device, a medium, a program product and a terminal, and the method comprises the steps: obtaining one or more eye lesion images, inputting the one or more eye lesion images to a pre-trained first model, and generating a corresponding eye feature vector; for a single image, calculating the similarity between the feature vector and each eye disease category, and outputting a prediction category with the highest similarity; and for a plurality of images, respectively calculating the similarity between the feature vectors and each category, and realizing adaptive weighted integration by using the second model to obtain a final prediction category. Sub-model subdivision and risk level layering are carried out according to prediction categories, and a structured risk layering report is output. The problem that in the prior art, the diagnostic value of multi-image information in complex cases is difficult to effectively evaluate is solved, the accuracy of ultrasound in serious vitreous lesion and intraocular tumor recognition is remarkably improved through a self-adaptive weighted integration mechanism, high-risk patient screening and clinical decision making are supported, and the application scene of ultrasound in ophthalmic diagnosis is expanded.

To provide an ocular device for placement under an eyelid.SOLUTION: The ocular device includes a plate with a back surface having at least one protrusion, where the at least one protrusion has a convex contact surface to contact the sclera of the eye and to provide an offset space. The plate can be connected to an elongated support member. The ocular device can deliver, to an eye of a user, a material including, e.g., a pharmaceutically active agent. A case for holding and dispensing an ocular device includes a well configured to retain fluid, a stabilizer, and a lid. The lid is connected to the well and rotatable between a position covering the well and a position with the well uncovered. The lid can have a port for adding fluid to the well, and a receiver, which can hold an ocular device, can project from the lid.SELECTED DRAWING: Figure 7H

The invention provides an ophthalmology auxiliary diagnosis report generation method based on a multi-modal ophthalmology knowledge graph. The method comprises the following steps: acquiring the multi-modal ophthalmology knowledge graph and a fundus image of a detection object; generating a corresponding auxiliary diagnosis report according to the eye fundus image by using a trained report generation model, wherein the method comprises the following steps: extracting image features from the eye fundus image of the detected object; generating enhanced visual features after knowledge enhancement; key knowledge features are extracted from key entity nodes recalled from the multi-modal ophthalmologic knowledge graph according to the fundus image of the detection object by using a graph encoder; the big language model is guided by the prompt template to generate an auxiliary diagnosis report according to the image features, the enhanced visual features and the key knowledge features of the eye fundus image of the detected object; the key knowledge features extracted from the key entity nodes recalled from the multi-modal ophthalmic knowledge graph by the fundus image are utilized to help the large language model to generate the auxiliary diagnosis report, and the professional, generalization ability and clinical availability of the model to generate the auxiliary diagnosis report are improved.

Described is an ophthalmic device that contains visible light filters. The ophthalmic device is a free radical reaction product of a reactive mixture comprising: one or more monomers suitable for making the ophthalmic device; a first visible light filtering compound, the first visible light filtering compound having a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 150 nanometers, wherein the compound is photostable, and wherein the compound has a molar extinction coefficient of at least 7740 L·mol−1·cm−1; and a second visible light filtering compound. The devices may provide one or more benefits to wearers, including enhanced macular pigment optical density (MPOD), as well as improved color perception and color enhancement.

The present disclosure relates to ophthalmic compositions containing solid complexes of active pharmaceutical ingredient and cyclodextrin, to their method of preparation and their uses. The compositions can include an active agent drug / cyclodextrin complex substantially dissolved in an aqueous eye drop vehicle. The ophthalmic composition is generally in the form of a microsuspension including an active agent complex having a diameter of less than about 100 μm.