812 results about "Pentane" patented technology

The invention discloses a preparation method of antistatic modified chinlon filaments, and relates to the field of chinlon filaments. When the antistatic modified chinlon filament is prepared, (formylmethyl) diethyl phosphate and 1-aminopyrrole react to prepare pyrrole diethyl phosphate; reacting the hydroxylated multi-walled carbon nanotube with pyrrole diethyl phosphate to obtain a modified multi-walled carbon nanotube; the preparation method comprises the following steps: reacting 2, 2 '-bipyridine-5, 5'-dicarboxylic acid with 2-amino-5-nitrophenol, and then reducing to obtain a benzoxazole diamine monomer; then, adipic acid, 1, 5-diaminopentane and a benzoxazole diamine monomer are subjected to a reaction, and modified polyamide is prepared; uniformly mixing the modified polyamide, the modified multi-walled carbon nanotubes, pyrrole, ferric trichloride and copper chloride, and performing melt spinning to obtain the antistatic modified polyamide filament. The antistatic modified chinlon filament prepared by the invention has excellent antistatic, flame-retardant, anti-aging and mechanical properties.

The invention relates to the technical field of radiopharmaceuticals, and in particular relates to a bicyclo [1.1. 1] pentane compound for targeting and combining fibrocyte activating protein and application of the bicyclo [1.1. 1] pentane compound. The structure of the compound as shown in the formula (I) is # imgabs0 # (I); according to the invention, the structure of the FAP combined compound is modified, so that the compound with longer residence time in in-vivo tumors is obtained.

The invention relates to the field of materials, in particular to a silicon dioxide aerogel composite thermal insulation material and a preparation method thereof. The silicon dioxide aerogel composite thermal insulation material is prepared by taking silicon dioxide aerogel, phenolic resin, a nano zirconium oxide graft and a locust bean gum graft as main raw materials and taking n-pentane, UV-327, hexamethylenetetramine and an antioxidant 1010 as auxiliary materials. The nano zirconium oxide graft and the locust bean gum graft are added into the silicon dioxide aerogel material, so that the prepared silicon dioxide aerogel composite material has excellent heat-insulating property, flame-retardant property and toughening effect, and the comprehensive requirements of the use scene of the silicon dioxide aerogel composite material on toughness and flame retardance are met; and the application market is expanded.

The invention discloses a polyurethane protective adhesive tape for aviation and a preparation method thereof, and relates to the technical field of adhesives. When the polyurethane protective adhesive tape for aviation is prepared, polyester glycol, an ultraviolet absorption monomer, 3-(4-pyridyl) pentane-1, 5-diol, 1, 4-butanediol and isophorone diisocyanate are polymerized to prepare polyurethane; the preparation method comprises the following steps: carrying out a reaction on polyurethane and 2-bromoethyl acrylate to prepare modified polyurethane; enabling the pretreated magnesium hydroxide to react with 3-epoxypropoxy-1, 1, 3, 3-tetramethyldisiloxane and ammonia water in sequence, so as to obtain modified magnesium hydroxide; the modified polyurethane and the modified magnesium hydroxide are mixed and then subjected to compression molding to prepare a polyurethane film; and coating a polyurethane film with the polyacrylate glue solution, and drying to obtain the polyurethane protective adhesive tape for aviation. The polyurethane protective adhesive tape for aviation prepared by the invention has excellent flame-retardant, anti-aging, antibacterial and self-repairing properties.

The invention belongs to the field of fluorine-containing fine organic chemical synthesis, and particularly relates to a method for continuously and cleanly producing perfluoroolefin epoxide by using hydrogen peroxide. The invention relates to a method for continuously and cleanly producing perfluoroolefin epoxide by using hydrogen peroxide, which comprises the following steps of: reacting perfluoro-2-methyl-2-pentene serving as a raw material in the presence of a polar solvent and hydrogen peroxide serving as an oxidant under the action of a catalyst to obtain perfluoro-2-methyl-2, 3-epoxypentane. The method has the beneficial effects that the micro-reactor is used, and the oxidizing agent, the catalyst, the cocatalyst and the polar solvent are continuously introduced into the pipeline of the micro-reactor, so that the synthesis from the hexafluoropropylene dimer to the epoxy compound is completed in a short time.

The utility model relates to a mineral wool sandwich board PIR edge sealing production system which comprises a white material storage tank, a pentane storage tank, an on-line cutting precision mixer, a transition tank, a black material storage tank and a mixing head. Due to the fact that the using amount of edge sealing materials is small, the mixing effect of polyester and pentane is affected, and edge sealing sandwich boards with high fire resistance cannot be manufactured, the system cuts, extrudes, impacts and disperses white materials and pentane in the mixer by increasing flow feeding, and the mixing effect is improved. Due to the fact that the premixing white material amount consumed by the mixing head is small, discharging of the mixing head cannot be interrupted, and the output of the premixing white material is different from the premixing white material amount consumed by the mixing head, in order to achieve flow balance of the premixing white material and the premixing white material amount consumed by the mixing head, flow balance is achieved by increasing the premixing white material flow + intermittent feeding = small flow of the mixing head + continuous discharging. The middle transfer transition device caches the premixed white material to solve the problem of uninterrupted discharging of the mixing head so as to achieve continuous production, and the major problem that online mixing foaming cannot be achieved due to small flow of polyester and pentane is successfully solved.

The invention discloses a refining device and method for a polymerization product and application. The refining device comprises an aldehyde removal tower, a dehydration tower, a water separation tank, a light component removal tower, a byproduct tower and a product tower. According to the present invention, the reaction product obtained through the ethylene glycol dehydration condensation reaction contains water, acetaldehyde, diethylene glycol, 1, 4-dioxane, 2-methyldioxocyclopentane and other components, and has characteristics of complex components and coexistence of multiple azeotropic pairs, and the invention provides the sequential rectification method by introducing the azeotropic breaking component according to the composition, therefore, a diethylene glycol product with high purity and byproducts of acetaldehyde and 1, 4-dioxane are separated, the process is continuous and easy to operate, and the method has industrial feasibility.

The present disclosure relates to pharmaceutically acceptable salts, cocrystals, and crystalline forms thereof, of a compound which is N—((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2- ((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-TH-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

The invention belongs to the technical field of alkane processing, and particularly relates to a process for preparing isopentene by dehydrogenation of isopentane, a catalyst and a tert-amyl alcohol preparation process. The process for preparing isopentene by dehydrogenation of isopentane comprises an isopentane dehydrogenation device and an isopentene separation device, in the isopentane dehydrogenation device, a dehydrogenation reactor is a fixed bed adiabatic reactor and is filled with a Pt-Sn-K / alumina type alkane dehydrogenation catalyst, the catalyst has hydromethanation performance under the CO2-containing dehydrogenation reaction condition, and the arrangement and operation of a dehydrogenation reactor group comprise a mode A, a mode B or a mode C; the isopentene separation device comprises a cooling separation system, a pressure swing adsorption separation system and an optional rectification system. The tert-amyl alcohol is further prepared from isoamylene under the conditions of a fixed bed hydration reactor, ethylene glycol monobutyl ether and other solvents, and the tert-amyl alcohol product is obtained through separation. The process is superior to the prior art on the whole, and has certain application prospects.

This invention provides an environmentally friendly expandable polystyrene bead and its preparation process, belonging to the field of foaming material technology. The preparation process includes the following steps: S1, injecting 65.28g of deionized water into a reaction vessel, stirring, adding 0.13g of dispersant and 0.16g of composite stabilizer, dispersing for 20min, then adding 31.95g of styrene monomer and 0.3g of composite initiator, followed by the addition of pentane and SiO2 micelle composite to obtain a base solution; wherein the mass ratio of pentane to SiO2 micelle composite is 1:(0.2-0.3); the mass of pentane is 3.1%-3.2% of the mass of the base solution; S2, subjecting the base solution to stepwise heating at 86℃-140℃ with stirring, then stopping heating, continuing stirring, and allowing it to cool naturally to 40℃, then stopping stirring, with a total reaction time of 8.5-9.5h to obtain the reaction product; S3, discharging the material, washing the reaction product with warm water, filtering, and obtaining the environmentally friendly expandable polystyrene beads. This invention improves the average particle size of expandable polystyrene beads while reducing fine powder.

The invention belongs to the field of chemical production, and particularly relates to a method for catalytically synthesizing propiconazole by using ionic liquid. And carrying out condensation reaction on the brominated substance 2-bromomethyl-2-(2, 4-dichlorophenyl)-4-propyl-1, 3-dioxopentane and triazole under the catalysis of the ionic liquid to generate propiconazole. The ionic liquid is one of [Emim] BF4, [Emim] PF6, [BMIM] PF6 and [BMIM] OH. According to the invention, the imidazole cation ionic liquid is used as a catalyst and a solvent to catalyze the N-alkylation reaction of 2-bromomethyl-2-(2, 4-dichlorophenyl)-4-propyl-1, 3-dioxopentane and triazole, and the research finds that the alkaline imidazole cation liquid has good catalytic performance, high yield and good selectivity, and can be used as a catalyst for catalyzing the N-alkylation reaction of 2-bromomethyl-2-(2, 4-dichlorophenyl)-4-propyl-1, 3-dioxopentane and triazole. And the reaction conditions are mild, the operation is simple, the ionic liquid is easy to recover, and the catalytic activity is not obviously reduced after being applied for five times.

The invention discloses a method for extracting a p-phenylenediamine antioxidant in a liquid sample and application of the p-phenylenediamine antioxidant. The p-phenylenediamine antioxidant comprises N-(1, 2, 4-trimethyl-1, 3-pentanediol) the organic solvent is at least one of N, N '-diphenyl-1, 3-dimethyl butyl)-N'-phenyl p-phenylenediamine, N-cyclohexyl-N '-phenyl p-phenylenediamine, N-isopropyl-N'-phenyl-p-phenylenediamine, N, N '-diphenyl-1, 4-phenylenediamine, N, N'-di-2-naphthyl p-phenylenediamine and 2-((4-methylpentane-2-yl) amino)-5-(phenyl amino) cyclohex-2, 5-diene-1, 4-diketone. According to the method, liquid-liquid extraction which is simple and efficient to operate, low in cost and good in repeatability is adopted as a sample pretreatment method, and is combined with an isotope label method and an ultra-high performance liquid chromatography-tandem mass spectrometry technology, so that separation and qualitative and quantitative detection of six p-phenylenediamine antioxidants and quinone derivatives in a sample are realized; meanwhile, the sensitivity is high, the quantity of isotope internal standards is small, the solvent loss is small, and the actual detection requirement is met.

The invention relates to the technical field of analytical chemistry, and particularly discloses an HPLC (High Performance Liquid Chromatography) detection method for related impurities in a vitamin B6 injection. The invention provides an HPLC detection method for related impurities in vitamin B6 injection. The HPLC detection method comprises the following steps: carrying out separation detection on a to-be-detected sample by adopting a chromatographic column taking octadecylsilane chemically bonded silica as a filler and a mobile phase gradient elution method; the mobile phase A is 0.04% sodium pentane sulfonate solution-methanol with the volume ratio of 95: 5, and the pH value of the 0.04% sodium pentane sulfonate solution is adjusted to 3.0 by adopting phosphoric acid; the mobile phase B is methanol. The HPLC detection method provided by the invention can detect 13 impurities in the vitamin B6 injection at the same time, the detection specificity is high, the sensitivity is high, the separation degree is good, and the quality of the vitamin B6 injection can be effectively controlled when the detection method is applied to production of the vitamin B6 injection.

The invention relates to the technical field of organic pollutant degradation, and discloses a mycobacterium and a method for degrading alkane organic pollutants. The Mycobacterium sp. Is named as SLQ-1, the Mycobacterium sp. Is preserved in the China Center for Type Culture Collection on January 15, 2024, and the preservation number is CCTCC No: M 2024107. The Mycobacterium sp. Is named as SLQ-1, and the Mycobacterium sp. Has been preserved in the China Center for Type Culture Collection on January 15, 2024. The mycobacterium can effectively degrade alkane organic pollutants, especially organic pollutants below C8, SLQ-1 can grow and breed with 3-methylpentane as a carbon source and an energy source, 3-methylpentane is efficiently degraded, and the mycobacterium can adapt to a wide temperature range and a wide pH range (the degradation rate of 3-methylpentane can reach 99% or above when the pH is 6-8 and the temperature is 30-40). In addition, the mycobacterium SLQ-1 can also take 2-methylpentane, n-hexane, n-pentane and 2-methylbutane as a carbon source and an energy source, and can efficiently degrade the 2-methylpentane, the n-hexane, the n-pentane and the 2-methylbutane.

The invention belongs to the technical field of drug synthesis, and particularly relates to an adamantane derivative as well as a synthesis method and application thereof. The adamantane derivative comprises an intermediate structural formula I, an intermediate structural formula II and an intermediate structural formula III, and the structural general formula is as follows: Linker is substituted or unsubstituted C6-C10 aroyl, R1 is hydrogen or C1-C6 alkyl, R2 is hydrogen, C1-C6 alkyl or a nitrogen-containing or nitrogen-free structural fragment, or the integral structure of R1R2 is N-substituted heterocyclic pentyl or heterocyclic cyclohexyl. According to the adamantane derivative provided by the invention, an adamantane structure is combined with part of groups of OAB-14, and a parent nucleus structure is changed, so that the drug activity is improved. The invention also provides a synthesis method of the compound, the obtained compound is screened through cell viability research, and the compound has a potential synergistic effect in the aspects of preventing influenza and treating Alzheimer's disease.

The invention relates to a non-aqueous electrolyte and a lithium ion battery. In order to improve the cycle performance and the heat resistance of the lithium ion battery, the non-aqueous electrolyte provided by the invention comprises a lithium salt, an organic solvent and an additive, and the additive comprises 1, 2, 3, 4, 5-penta (2-cyanoethoxy) pentane and 4-methyl ethylene sulfate. According to the non-aqueous electrolyte disclosed by the invention, the cycle performance and the heat resistance of the lithium ion battery are effectively improved by compounding the 1, 2, 3, 4, 5-penta (2-cyanoethoxy) pentane and the 4-methyl ethylene sulfate.

The invention belongs to the technical field of organic synthesis, and provides a preparation method of a cationic lipid compound, which comprises the following steps: (1) reacting 1, 5-dihalopentane, 2-tert-butyl glycolate and alkali to obtain a product G; (2) hydrolyzing the product G under an acidic condition to obtain a product H; (3) carrying out esterification reaction on the product H, the raw material C, 4-dimethylaminopyridine and a condensing agent in dichloromethane to obtain a product J; and (4) carrying out amination reaction on the product J, the raw material L and alkali in acetonitrile to obtain the cationic lipid compound. Compared with the prior art, the method has the relatively remarkable advantages that when the first part of halogenated long-chain alkyl ester H is synthesized by the method, 1, 5-dihalopentane and 2-tert-butyl glycolate are used as raw materials, the halogenated long-chain alkyl ester J is synthesized by a simple method, the product is obtained at a higher yield in synthesis, and the method is suitable for kilogram-level production. The route synthesis only comprises four steps of chemical reactions, and is suitable for industrial production.

The invention provides a cationic conjugated polymer as well as a preparation method and application thereof. The structural formula of the cationic conjugated polymer is shown in the specification. The preparation method comprises the following steps: reacting tris (4-bromophenyl) amine and N, N-dimethyl-4-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolane-2-yl) aniline in an organic solvent under the action of a catalyst and an initiator to obtain a first intermediate; the cationic conjugated polymer is prepared from the first intermediate, the second intermediate and the third intermediate under the action of a catalyst and an initiator. The cationic conjugated polymer shows good photo-thermal and photodynamic performance under the irradiation of near-infrared light with the wavelength of 980 nm, so that the effect of inhibiting the growth of bacteria is realized. # imgabs0 #

The invention provides pharmaceutical compositions comprising about 0.05 to 0.1% (w / v) cyclosporine dissolved in 1-perfluorobutyl-pentane for use in the topical treatment of dry eye disease and provides for dosing and treatment methods thereof. The invention further provides kits comprising such compositions.

The invention relates to the field of sponge materials, and provides a flame-retardant sponge material as well as a preparation method and application thereof. The flame-retardant flame-retardant coating is prepared from the following components: phosphorus-based flame retardant modified oxidized feather-shaped carbon nanotubes, phosphorus-containing diol modified silicon dioxide aerogel, polyurethane, aluminum hydroxide, ammonium tripolyphosphate, toluene diisocyanate, deionized water, cyclopentane, triethanolamine, dibutyltin dilaurate, epoxidized soybean oil, talcum powder, an antioxidant, a light stabilizer, pigment and antimony trioxide. The composite material is prepared from expanded graphite, a silicone oil surfactant, an isothiazolinone antibacterial agent and a phosphorus-based flame retardant modified oxidized feather-shaped carbon nanotube through wet oxidation and dimethyl methylphosphonate modification, and phosphorus-containing diol is prepared from diethyl phosphite, diethanol amine and paraformaldehyde through condensation. The sponge disclosed by the invention has excellent mechanical and flame-retardant properties, and is widely applied to the fields of buildings, home furnishing and transportation.

The invention relates to a production method of a high-end filter aluminum foil for a coating, which comprises the following steps: (1) stirring and mixing polymethylene polyphenyl isocyanate, polyol, a polymerization inhibitor, a catalyst and water, and reacting to obtain a prepolymer; (2) mixing the prepolymer with polysorbate and cyclopentane to obtain a base coating; (3) the surface of the aluminum foil is coated with the base layer paint, and the aluminum foil coated with a base layer coating is obtained; (4) adding a surfactant into water, uniformly mixing, adding silicate, a boron compound and nano silicon dioxide, and uniformly stirring to obtain a hydrophilic coating; and (5) the surface of the base layer coating is coated with hydrophilic paint, and the coating aluminum foil is obtained. The base layer coating is of a porous structure, the roughness of the surface of the aluminum foil is improved, the hydrophilicity of the hydrophilic coating is improved to a certain extent through the roughness of the porous structure in the base layer coating, and the hydrophilic angle of the hydrophilic coating is reduced.

The invention discloses a quaternary ammonium salt composite bactericide capable of efficiently killing fungi and a preparation method of the quaternary ammonium salt composite bactericide. The preparation method comprises the following steps: S1, preparing zinc oxide nanoparticles; s2, adding the prepared zinc oxide nanoparticles into a buffer solution, adding dopamine hydrochloride, and preparing modified zinc oxide after the reaction is finished; s3, adding the modified zinc oxide and 1-vinyl imidazole into N, N-dimethylformamide, and carrying out a reaction for 2 to 2.5 h so as to obtain modified zinc oxide; s4, under the nitrogen atmosphere, adding the modified zinc oxide and 1-bromopentane into cyclohexane, and heating to 50 DEG C to prepare the quaternary ammonium salt composite bactericide; the sterilizing effect of the sterilizing agent is remarkably improved through cooperation of quaternary ammonium salt and zinc oxide nanoparticles, the sterilizing effect of the composite sterilizing agent is remarkably improved through the synergistic sterilizing performance of quaternary ammonium salt and zinc oxide by inoculating imidazole quaternary ammonium salt to the surface of zinc oxide, and the heat stability of the composite sterilizing agent can be remarkably improved through introduced imidazole groups.

The invention discloses a composite molecular sieve catalyst as well as a preparation method and application thereof. The composite molecular sieve catalyst is formed by compounding an ordered mesoporous molecular sieve and a modified USY molecular sieve catalyst in a mass ratio of 1: (1-5), the modified USY molecular sieve catalyst is obtained by treating a USY molecular sieve with an inorganic solution and roasting; the inorganic solution is one of ammonium chloride, ammonium fluoride and hydrofluoric acid. According to the method, the composite molecular sieve of the ordered mesoporous molecular sieve and the inorganic matter modified USY molecular sieve is used as the catalyst for removing the trace olefin in the isopentane oil, so that the trace olefin in the isopentane oil can be deeply removed, and the quality of the isopentane oil is improved; and the composite molecular sieve catalyst has good adsorption performance and small loss of isopentane.

The invention discloses a bletilla striata polysaccharide gel patch for wound repair and a preparation method of the bletilla striata polysaccharide gel patch, and relates to the field of high polymer materials. When the bletilla striata polysaccharide gel patch for wound repair is prepared, graphene oxide sequentially reacts with 3-methylaminopropylamine and 4-(N-maleimidomethyl) cyclohexane-1-carboxylic acid succinimide ester, and modified graphene oxide is prepared; the preparation method comprises the following steps: extracting bletilla striata polysaccharide from bletilla striata, and reacting the bletilla striata polysaccharide with maleic anhydride and N-methyldopamine in sequence to prepare modified bletilla striata polysaccharide; and reacting the modified bletilla striata polysaccharide, the modified graphene oxide and 1, 5-dibromopentane, mixing with deionized water, coating, and preparing a film, so as to obtain the bletilla striata polysaccharide gel patch for wound repair. The bletilla striata polysaccharide gel patch for wound repair, prepared by the invention, has antibacterial, high-adhesion and antioxidant capacities.

Disclosed herein are compositions and formulations of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile (Compound (I)), wherein Compound (I) has the structure (I) and methods of making and using such compositions and formulations.

The present invention relates to a process for the preparation of a compound of formula (I), a stereoisomer, a salt, a hydrate or a solvate thereof, (II) comprising the step of sulfinylation of a compound of formula (IV) to produce compound of formula (II); (IV) wherein: R1 and R2 are as defined in the claims, wherein said sulfinylation step is performed in the presence of a solvent selected from the group comprising benzene, toluene, ethylbenzene, xylene, chlorobenzene, bromobenzene, fluorobenzene, anisole, nitrobenzene, tetralin, dichlorobenzene, trimethylbenzene, ethylacetate, propylacetate, butylacetate, propanol, butanol, 2- methyltetrahydrofuran, diethylether, methyltertbutylether, cyclopentyl methyl ether, dichloromethane, tetrachloromethane, pentane, hexane, heptane, cyclohexane, decaline and mixtures thereof.

The continuous production heat pump assisted integrated extractive distillation device is adopted to realize high-purity separation and recovery of the diethyl ether-methyl formate-n-pentane azeotrope, and separation is realized by utilizing the characteristic that the extraction agent has great influence on the relative volatility of the diethyl ether-methyl formate-n-pentane azeotrope. The purity of the separated diethyl ether, n-pentane and methyl formate reaches 99.9% or above, high-purity recycling of the extraction agent can be achieved, the separation cost is greatly reduced, and the method is low in energy consumption and flexible to operate.

The invention discloses a preparation method of a waterproof thermal-insulation homogeneous plate, the homogeneous plate comprises the following raw materials by weight: 80-100 parts of Portland cement, 40-50 parts of modified polystyrene, 5-8 parts of modified basalt fiber, 1.5-3 parts of an early strength agent and 5-10 parts of silica fume, when the raw materials are blended and pressed at high temperature and high pressure, pentane in the modified polystyrene is evaporated, and the modified polystyrene and the silica fume are mixed to form the homogeneous plate. The modified polystyrene forms a foaming material, the foaming material, an internal cellulose structure and surrounding basalt fibers all contain a large number of pores, heat transfer can be effectively reduced, meanwhile, the basalt fibers are extremely low in heat conductivity coefficient, the prepared homogeneous plate has a very good heat preservation effect, and after high-temperature and high-pressure heat preservation pressing is conducted, treatment liquid is used for treatment, and the heat preservation effect is good. A hydrophobic membrane is formed by surface gap treatment, glutaraldehyde is added, and an aldehyde group on the glutaraldehyde is grafted with an amino group on a side chain of polysiloxane, so that the compactness of the hydrophobic membrane is improved, the waterproofness of the homogeneous plate is further ensured, and the service life is prolonged.

The invention discloses a series of recombinant bacteria for expressing a steroid compound taking a cyclopentane multi-hydrogen phenanthrene structure as a structural mother nucleus, such as recombinant strains for expressing cholesterol, 22-hydroxycholesterol, diosgenin or polyphyllin II, and construction and application of the strains. The invention provides a recombinant bacterium which can efficiently express a steroid compound taking cyclopentane multi-hydrogen phenanthrene as a structural mother nucleus, for example, the yield of diosgenin can be increased to the level of 40 mg / L or above, heterologous synthesis of the polyphyllin II is also realized to obtain a polyphyllin II synthetic strain, the yield of the polyphyllin II in a shake flask reaches 0.13 mg / L, and the yield of the polyphyllin II in the shake flask reaches 0.13 mg / L. The strain is the first strain for heterologous synthesis of the polyphyllin II at present.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a memantine derivative and a synthesis method and application thereof. The memantine derivative comprises an intermediate structural formula I, an intermediate structural formula II, an intermediate structural formula III and a structural general formula, Linker is substituted or unsubstituted C6-C10 aroyl, R1 is hydrogen or C1-C6 alkyl, R2 is hydrogen, C1-C6 alkyl or a nitrogen-containing or nitrogen-free structural fragment, or the integral structure of R1 and R2 is N-substituted heterocyclic pentyl or heterocyclic cyclohexyl. According to the memantine derivative provided by the invention, a memantine group is combined with an OAB-14 partial structure to change a parent nucleus structure, so that the drug activity is improved. The invention also provides a synthesis method of the compound, and the obtained compound is used for treating Alzheimer's disease and Parkinson's disease.