28 results about "Vitamin injection" patented technology

The invention discloses a stable vitamin B6 composition and a preparation method thereof. The pH value of the vitamin B6 injection is controlled to be 2.5-2.8, and the impurity content in the product is remarkably reduced by controlling the heating and cooling rate in the terminal sterilization process, so that the product stability and the clinical use safety are improved.

The invention provides a vitamin B6 injection and a preparation method thereof, and particularly relates to the field of medicines. Comprising 10 g of vitamin B6, a proper amount of a pH regulator, a proper amount of nitrogen and the balance of water for injection, the volume is fixed to 100 ML, and the pH is 2.0-3.0. The method comprises the following steps: S1, adding 70% of injection water into a liquid preparation tank, controlling the water temperature to be less than 40 DEG C, and filling nitrogen into the liquid preparation tank and a pipeline; s2, weighing the vitamin B6 according to the prescription dosage, putting the vitamin B6 into a liquid preparation tank, and stirring for 30-60 minutes at the temperature of 10-40 DEG C to dissolve the vitamin B6; s3, adding a pH (Potential of Hydrogen) regulator with the concentration of 0.01 mol / L to 1 mol / L into the solution obtained in the S2; adjusting the pH (Potential of Hydrogen) to 2.0 to 2.8; s4, fixing the volume of the solution obtained in S3 to 100% of the total volume, and stirring for 15-30 minutes after fixing the volume; s5, sterilizing and filtering the stirred solution, and filling nitrogen; and S6, sterilizing the filled and sealed sample at 121 DEG C for 12 minutes to finally obtain the vitamin B6 injection product. Degradation of related substances of liquid medicine is reduced by controlling a liquid medicine production process, and the more stable vitamin B6 injection is obtained.

This invention provides an injectable cefminox sodium preparation and its preparation method, belonging to the field of pharmaceutical preparation technology. The preparation, by weight, comprises: 1 part of refined cefminox sodium, 0.5 parts of sodium lactate Ringer's solution, 0.2 parts of vitamin B12 injection, 0.1-0.3 parts of a modified composite antioxidant, and 3 parts of physiological saline. The preparation method of the modified composite antioxidant is as follows: S1, add 1 part by weight of poloxamer to 20 parts by weight of distilled water and stir for 6-8 minutes to obtain a solution; S2, after passing 1 part by weight of natural vitamin C through a 100-mesh sieve, mix it into the solution obtained in S1, and sonicate for 10-15 minutes to obtain a vitamin C solution; S3, mix 0.5 parts by weight of vitamin D into the vitamin C solution obtained in S2, and sonicate for 15-20 minutes to obtain the modified composite antioxidant. The formulation of this invention exhibits excellent stability and stable content of cefminox sodium when exposed to environments of 35℃±2℃, 65%±5%RH and natural light, ensuring the safety and reliability of medication.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a vitamin B2 injection composition and a preparation method thereof. The invention provides a preparation method of a vitamin B2 injection composition, which comprises the following steps: mixing malic acid, citric acid and propylene glycol, heating to 80-90 DEG C, and continuously stirring until transparent liquid is formed; adding zein and riboflavin sodium phosphate into the transparent liquid under a dark condition, and carrying out heat preservation reaction at 25-30 DEG C for at least 30 seconds to obtain a stock solution; and mixing the stock solution, an auxiliary agent and water to prepare the vitamin B2 injection composition with the pH value of 4.5-6.5. The deep eutectic solvent is prepared from malic acid, citric acid and propylene glycol, the zein and the riboflavin sodium phosphate are uniformly mixed, and the prepared vitamin B2 injection composition has good light stability.

The application provides a kind of medicine composition for treating muscle and bone disease and its application, belong to medical technology field.The medicine composition includes the following weight parts components: compound angelica injection 5-10 parts, kadsura injection 5-10 parts, wild medlar injection 5-10 parts, methylcobalamin injection 5-10 parts;It can also be selectively added vitamin B1 injection, vitamin B12 injection, yellow Chinese wax injection or bone peptide injection.The composition of the application is administered by acupoint injection or intramuscular injection, utilizes the synergistic effect of multiple traditional Chinese medicine injection and western medicine injection, reaches the comprehensive treatment effect of promoting blood circulation to remove blood stasis, dispelling wind to stop pain, nerve nutrition.Clinical experiments show that the application has significant effect on lumbar disc herniation, cervical spondylosis, shoulder periarthritis, knee osteoarthritis, femoral head necrosis, osteoporosis and the like, and the total effective rate is more than 95%, with fast effect, low recurrence rate, and no hormone-related side effects, suitable for patients of all ages.

The invention relates to the technical field of veterinary medicines, in particular to a vitamin ADE injection for cattle and a preparation method thereof. Every 10 L of the vitamin ADE injection for the cattle is prepared from the following components: 500 to 600 g of vitamin A palmitate, 2 to 3 g of vitamin D3, 2800 to 3200 g of vitamin E acetate, 10 to 20 g of butylated hydroxytoluene, 1800 to 2200 g of absolute ethyl alcohol, 180 to 220 g of analgesic, 250 to 350 g of solubilizer, 150 to 250 g of stable synergist and the balance of isopropyl myristate. According to the invention, hydrogenated palm oil glyceride, ethylene oxide, succinic anhydride, ascorbyl palmitate and the like are used as raw materials, and the stable synergist with the following effects is prepared through related chemical reactions, and the prepared stable synergist integrates the functions of solubilization, oxidation resistance and stimulation reduction; as a raw material of the injection, the oxidation resistance and the stability of the injection are effectively improved; the injection prepared by the invention is clear and transparent, has excellent stability, can effectively relieve injection pain and tissue stimulation, and remarkably improves the safety, stability and clinical applicability of the injection.

To provide a preparation for vitamin C injection having high stability, free of sodium, and not inducing vascular pain.SOLUTION: A preparation for vitamin C injection comprising a freeze-dried powder of an aqueous solution containing 5 mass% or more and 22 mass% or less of L-arginine ascorbate neutral salt.SELECTED DRAWING: None

The utility model relates to a dilution tank for vitamin B12 injection production, which comprises a tank body, a sealing cover installed on the top of the tank body, a liquid inlet arranged on one side of the top of the tank body, a water inlet arranged on the other side of the top of the tank body, a liquid outlet arranged at the bottom of the tank body, a first filter element installed in the liquid inlet and extending into the tank body, a second filter element installed in the liquid outlet, an L-shaped liquid discharge pipe installed at the bottom of the liquid outlet, a corrugated flexible pipe arranged on the vertical section of the liquid discharge pipe, the second filter element arranged in the corrugated flexible pipe, a hanger connected with the liquid discharge pipe arranged at the bottom of the tank body, a safety valve and an ultrasonic liquid level sensor installed on the top of the sealing cover, a temperature sensor arranged on the inner wall of the tank body, a pressure sensor arranged on the bottom of the inner wall, a plurality of sampling valves arranged on one side of the tank body from top to bottom, and magnetic stirrers arranged on both sides of the bottom of the tank body and symmetrical to the liquid outlet. The utility model adds a filtering function, thereby improving the purity and production safety of the liquid medicine.

The present invention relates to the use of 25-hydroxy-vitamin D3 in animal breeding. More particularly, the invention relates to an injectable composition of 25-hydroxy- vitamin D3 and its use of 25-hydroxy-vitamin D3 raising plasma25-hydroxy-vitamin D3 levels of piglets in pig breeding.

A vitamin shot having essential vitamins, minerals and a plant extract.

The invention discloses a vitamin C injection with low impurity content and a preparation method thereof, and belongs to the technical field of pharmaceutical preparation preparation. According to the vitamin C injection disclosed by the invention, D-calcium gluconate, L-cysteine and polyethylene glycol-6000 are adopted to prepare a stabilizer, and the three components have a synergistic effect, so that the stability of an injection system is remarkably improved, the oxidation chain reaction of vitamin C is effectively blocked, and the generation of impurities is reduced. In addition, a buffer system is optimized, compared with a traditional sodium bicarbonate buffer system, pH fluctuation caused by CO2 release is avoided, the content of active oxygen in the injection can be reduced through the ultra-pure deoxidation process, operation is conducted in the environment with the temperature smaller than or equal to 25 DEG C in the whole process, and light degradation is reduced by adopting an amber neutral glass ampoule. The long-acting stability of the injection is improved, and the impurity content is reduced.

The present application relates to the technical field of pharmaceutical preparation, and discloses a fat-soluble vitamin injection and a preparation method thereof.In the present application, soybean oil, vitamin E and lecithin are mixed uniformly, and then other fat-soluble vitamins are added and mixed uniformly under the protection of inert gas; by controlling the dissolved oxygen in water for injection and the residual oxygen level in ampoule headspace, a method for preparing fat-soluble vitamin injection through one-time emulsification and conventional sterilization process is provided.The fat-soluble vitamin injection prepared by the above method has significantly improved stability, can be stored stably at 25 DEG C, and has practical significance and important social value.

The invention discloses an anti-inflammatory and analgesic medicament and a preparation process thereof, and relates to the technical field of medicaments. The defects in the prior art are overcome. The medicine for diminishing inflammation and relieving pain is prepared from the following components in parts by weight: 80 to 200g of gypsum, 80 to 200g of mirabilite, 80 to 200ml of water and 1 to 2ml of vitamin B12 injection. The preparation process of the anti-inflammatory and analgesic medicine comprises the following steps: taking the components according to the weight for later use; adding water into a boiler, boiling until boiling, sequentially adding mirabilite and gypsum powder, and slowly and uniformly stirring to obtain liquid medicine; and airing the liquid medicine to normal temperature, adding the vitamin B12 injection, and uniformly mixing with the liquid medicine. The traditional Chinese medicine preparation is safe, effective, free of toxic and side effects, free of stimulation, good in antibacterial, anti-inflammatory and repairing effects and easy to obtain raw materials, does not generate dependence after being used for a long time, has high popularization value, is short in use course of treatment and can keep negative after curing HPV for a long time, and relapse is not prone to occurring.

The invention discloses a method for determining an aluminum element in a vitamin injection by atomic absorption spectrometry, which is suitable for detecting the aluminum element in water-soluble vitamin and fat-soluble vitamin injections, and the technical scheme of the invention comprises a graphite tube treatment method capable of obviously prolonging the service life and a graphite furnace heating procedure matched with the graphite tube treatment method. The blank of the method for detecting the aluminum element in the vitamin injection in the prior art is filled, and the method has important significance in the aspect of improving the product quality.

The invention provides a method for detecting related substances of a vitamin K1 injection, and relates to the technical field of drug detection and analysis. According to the method, high performance liquid chromatography is adopted for determination, and the chromatographic conditions are as follows: an octadecyl silane bonded silica gel chromatographic column is adopted, a potassium chloride solution-absolute ethyl alcohol is taken as a mobile phase A, absolute ethyl alcohol is taken as a mobile phase B for gradient elution, the concentration of the mobile phase A is adjusted within the range of 15% v / v-40% v / v, the concentration of the mobile phase B is adjusted within the range of 60% v / v-85% v / v, and the elution time is 60-70 min. According to the detection method, the vitamin K1 can be effectively separated from the impurity B, the vitamin K1 epoxide and other impurities, the specificity of the method is high, the sensitivity is high, the reproducibility is good, and the drug quality of the vitamin K1 injection can be more effectively controlled by detecting related substances.

The invention discloses a composition and a preparation method of a vitamin C injection, the formula of the vitamin C injection comprises vitamin C, sodium bicarbonate, hydrochloric acid, thioglycerol and water for injection, and the dosage of the thioglycerol is 20mg / ml. The vitamin C injection disclosed by the invention is simple in composition, stable in quality, simple, convenient and efficient in preparation process, low in finished product impurity level and good in safety.

The invention relates to the technical field of biological medicine, in particular to application of vitamin B1 in preparation of a medicine for inhibiting liver cancer. Researches find that the vitamin B1 can significantly inhibit proliferation of hepatoma carcinoma cells and induce death of hepatoma carcinoma cells within a certain dosage range, and presents time and dosage dependence. Furthermore, a liver cancer tumor-bearing animal model verifies that the injection administration of the vitamin B1 can obviously inhibit the increase of the tumor volume and the tumor weight, and the tumor growth tends to be stable under the condition of high dosage. Meanwhile, the vitamin B1 can obviously improve the microcirculation perfusion level of the tumor tissue and improve the blood perfusion amount and the blood cell perfusion speed along with the reduction of the number of tumor tissue capillaries. Animal experiment results show that no obvious toxic or side effect is observed in the administration process of the vitamin B1. The new application of the vitamin B1 in inhibiting the liver cancer is disclosed for the first time, and a new choice with high safety and good potential application value is provided for treatment of the liver cancer.

The invention discloses three impurities in B12 injection as well as a preparation method and application thereof. The structures of three impurities in the vitamin B12 injection are respectively shown as an impurity 1, an impurity 2 and an impurity 3. According to the specific embodiment of the invention, the contents of three impurities in the vitamin B12 injection can be gradually increased in the storage period of the vitamin B12 injection, so that the contents exceed the limit of the impurities in the vitamin B12 injection, and the quality of the vitamin B12 injection is possibly influenced. Therefore, the inventor researches and characterizes the impurities, so as to monitor the impurities in the vitamin B12 injection.

The invention discloses a preparation method of eyedrops for preventing eye injury, and belongs to the technical field of eyedrops, the eyedrops are prepared by taking rhizoma polygonati, herba houttuyniae, sodium chloride, ethylparaben, distilled water and hypertonic liquid as raw materials, and the hypertonic liquid prepared by mixing glucose injection and vitamin C injection in the eyedrops has a dehydration effect in the application process, so that the eye injury can be prevented. The corneal edema can be quickly eliminated, the dehydration of corneal tissues is promoted, and the normal thickness is recovered, so that the vision is quickly recovered, the damage of corneal endothelium is furthest reduced, the corneal edema in the treatment process is effectively reduced, and the probability of cataract is further reduced; according to the traditional Chinese medicine eye drop, the components of rhizoma polygonati and herba houttuyniae are added, so that the eye drop has antibacterial and antiviral effects, rhizoma polygonati polysaccharide contained in rhizoma polygonati has the effects of increasing tear secretion and promoting ocular surface healing, dry eyes, foreign body sensation and burning sensation are improved, and the eye drop has no obvious irritation to cornea and iris and is suitable for different people.

The application belongs to the technical field of pharmaceutical preparation, and particularly relates to a vitamin K1 injection and a preparation method thereof. The vitamin K1 injection provided by the application is prepared from an active ingredient vitamin K1, excipients and water for injection; wherein the excipients include a solubilizer, bile acid and phospholipid, a cosolvent, an alkaline reagent, and a pH regulator; wherein the mass ratio of the bile acid to the phospholipid is 0.5-0.8:1. The vitamin K1 injection does not contain a surfactant, and does not need to use an organic solvent in the preparation process. On the premise of not increasing high equipment cost investment, the product with the required quality is obtained, the clarity, color, particle size distribution, pH value, main ingredient content, related substance content and stability of the product are consistent with those of the original preparation, the safety of clinical use is significantly improved, and the product has a great commercial application prospect.

The utility model provides a precise automatic titrator for vitamin B6 injection, which relates to the technical field of medicine research equipment and comprises a main control computer and a sample container, a reagent bottle is arranged on the side face of the main control computer, a titration module is arranged on the top face of the main control computer, and a PH sensor, a titration head and a stirring piece are respectively arranged on the top of the sample container. A mounting column is fixed on the top surface of the main control computer, the surface of the mounting column is sleeved with a sleeve plate, a connecting rod is fixed in a connecting port in one end of the sleeve plate, the tail end of the connecting rod is in screw connection with a connecting disc, and the PH sensor and the titrating head are both located in through holes in the top surface of the connecting disc; the HP sensor, the stirring piece and the titrating head can vertically lift and move along with the sleeve plate, the height can be automatically adjusted according to the depth of the sample container, the titrating head, the pH electrode sensor and the stirrer are ensured to work at the optimal position, the device is flexibly suitable for different containers, and the adaptability of the device is improved.

This invention discloses a method for studying the procoagulant mechanism of vitamin K1 based on nuclear magnetic resonance metabolomics. The method includes: inducing a rat bleeding model by gavage administration of warfarin, followed by intravenous injection of vitamin K1 via the tail vein; analyzing rat serum using 1H NMR to obtain the 1H NMR spectra of metabolites; screening the 1H NMR spectra of metabolites using an orthogonal partial least squares discriminant analysis model to identify potential biomarkers; performing metabolic pathway enrichment analysis on the potential biomarkers to identify relevant important metabolic pathways; and connecting the potential biomarkers within the important metabolic pathways to obtain a comprehensive metabolic network. This method provides a more comprehensive and unbiased explanation of the procoagulant mechanism of vitamin K1 at a holistic level, offering new insights for future research on the procoagulant mechanism of vitamin K1.

The invention provides a vitamin D2 injection composition with an improved formula. The composition comprises 22.5-15% w / v of vitamin D2, 6-12% w / v of a cosolvent, 3-5% w / v of an isotonic agent, 0-2% w / v of a pH regulator and the balance of water for injection, wherein the cosolvent is at least one of medium chain triglyceride, Tween 20, Tween 40 and Tween 80. The composition is reasonable in formula, simple in process and good in stability, can be used for preparing a vitamin D2 water-soluble injection, and has remarkable advantages compared with an oily vitamin D2 preparation which is high in irritation and prone to allergy.

A preparation method for a vitamin K1 injection package, and a vitamin K1 injection package. The preparation method comprises filling, nitrogen flushing, stoppering and rod screwing; in the nitrogen flushing step, sterile nitrogen is introduced into a glass cartridge (1) to reduce oxygen content inside the glass cartridge (1) to 2.0% or less; in the stoppering step, the glass cartridge (1) is evacuated, thereby drawing a plunger (2) into the glass cartridge (1), and the headspace volume is controlled to 0.1-0.2 ml.

The invention provides a vitamin K1 injection package preparation method and a vitamin K1 injection package, the vitamin K1 injection package preparation method comprises the steps of filling, nitrogen filling, plug adding and rod screwing, in the nitrogen filling step, sterile nitrogen is filled into a glass needle tube, oxygen in the glass needle tube is removed to be 2.0% or below, in the plug adding step, the glass needle tube is vacuumized, so that a piston is sucked into the glass needle tube, and the rod screwing is performed. The headspace volume is controlled to be 0.1 to 0.2 ml. According to the present invention, the total impurity amount and the maximum single impurity content of the vitamin K1 preparation in the glass needle tube can be maintained at the low level after the long-term placement, and the potential secondary pollution risk is avoided by using the glass needle tube packaging form.

The invention discloses a method for detecting related substances of vitamin B12, belongs to the field of chemical drug analysis and detection, solves the defects in the prior art, can realize effective separation of vitamin B12 from an impurity A-impurity I, and particularly can realize separation and control of the impurity I. The method is simple and convenient to operate, has good specificity, linearity and precision, and is suitable for industrial production. The method has the advantages of high sensitivity, high accuracy and good durability, can be used for quality control of vitamin B12 bulk drugs, and meets the quality control requirements of vitamin B12 injections at the same time.

The present application provides a vitamin D3 liquid composition, which comprises vitamin D3 and polyethylene glycol-15-hydroxystearate. The pH value of the vitamin D3 liquid composition is 7.1-7.6. The vitamin D3 liquid composition does not comprise ethanol, propylene glycol, polyethylene glycol, poloxamer, or polyvinylpyrrolidone. The aqueous solution composition of the present invention is stable and uniform, is more suitable for injection than oil solutions, and can be used for preventing and treating vitamin D deficiency.

The utility model relates to the field of vitamin C injection cold storage tanks, and particularly discloses a vitamin C injection cold storage tank which comprises a tank body mechanism used for bearing vitamin C injection. When the vitamin C injection storage tank is used, an operator puts the vitamin C injection into the groove in the tank body mechanism, and the condensation system is used for refrigeration, so that the vitamin C injection can be refrigerated and protected conveniently; and the rotating mechanism is used for rotating the groove for bearing the vitamin C injection to the position of the small door, so that an operator can open the door to take the vitamin C injection conveniently, the vitamin C injection which is not taken is protected from deterioration caused by illumination influence, and the applicability of the refrigeration tank is further improved.