72 results about "Vitamin injection" patented technology

The invention discloses a mesenchymal stem cell self-preserving liquid which is prepared from the following raw materials according to volume ratios: 1-6% of self platelet lysate, 95-97% of solution medium and 0-1% of vitamin C injection, wherein the solution medium is a mixed sugar electrolyte injection or physiological saline injection. The mesenchymal stem cell self-preserving liquid has the advantages that: growth factors contained in the mesenchymal stem cell self-preserving liquid can maintain the activity state of cells, the vitamin C can maintain the activity of various peroxidases, at the same time, the mixed sugar electrolyte injection is especially suitable for cell preservation, and osmotic pressure is also favorable for nutrient absorption of the cells so as to carry out metabolism; the activity of the mesenchymal stem cells which are preserved in the mesenchymal stem cell self-preserving liquid within 8 hours is still larger than 90%, the cell activity change is not larger than 7%, and the activity of the mesenchymal stem cells which are preserved in the mesenchymal stem cell self-preserving liquid within 12 hours is still maintained at 85%; and by using the mesenchymal stem cell self-preserving liquid, the requirements for human intravenous back-transfusion safety can be met, and the cell preserving problem of long-time transport is solved, thus more patients have opportunity to undergo mesenchymal stem cell treatment.

The invention is concerned with compound vitamin injecting liquid and its produce method. This injecting liquid relates compound vitamin for adult and children and made of two bottles. The first bottle has vitamin C, vitamin A, vitamin D3, vitamin B1, vitamin B2, vitamin B6, niacinamide, dextrorotation panthenol, vitamin E, vitamin K and proper hydrotropic agent. The second bottle has folic acid, vitamin H and vitamin B12. The injecting liquid has same component in different dosage. The production is water-solubility injection with nice stability and safety. It can be diluted as common vitamin maintain agent. It can be used in vein for some conditions. The conditions relate to surgical, burn with large range, fracture and other trauma, serious infection illness and narcosis. Those conditions change the demand greatly and consume nutrition.

The invention relates to a medicinal composition of a liposoluble vitamin injection (I) and a water-soluble vitamin for injection, in particular to a combined application package. The medicinal composition contains the liposoluble vitamin injection (I) and the water-soluble vitamin for injection. When in use, the medicinal composition is dissolved or diluted by using water for injection or glucose injection firstly, and then is subjected to intravenous drip respectively. In the combined application package, vitamins required by a human body are comprehensively implemented, the defect caused by using a single vitamin is overcome, and the treatment effect is greatly improved.

The invention discloses sodium selenite vitamin injection and a preparation method thereof and belongs to the technology of veterinary medicaments. The vitamin injection is water-soluble injection which is prepared from active ingredients of vitamin A, vitamin D3, vitamin E and sodium selenite through a solubilizer Tween, span, polyoxyethylenated castor oil (35), a preservative 2, and 6-ditertiary butyl paracresol. The sodium selenite vitamin injection has the effects of improving the nutritional conditions of cows, enhancing the cow body physique, accelerating the oestrous period, improving the artificial fertilization and conception rate, preventing hysteritis and retained fetal membranes of the cows, promoting healthy development of calves, and preventing white muscle disease of the calves.

The invention provides a composite vitamin injection pharmaceutical composition containing 13 vitamins and a preparation method thereof. The composition comprises 4 fat-soluble vitamins and 9 water-soluble vitamins, which are respectively placed in two ampoules, wherein the first ampoule contains vitamin A palmitate, vitamin K1, vitamin D3, vitamin E, vitamin C, vitamin B1, riboflavin sodium phosphate, dexpanthenol, vitamin B6, nicotinamide and a cosolvent, an antioxidant, and a pH adjusting agent; the second ampoule contains vitamin B12, folic acid, biotin, a stabilizing agent and a pH adjusting agent. The preparation method comprises that the preparation of the first ampoule comprises steps of oil-phase medicinal liquid preparation, water-phase medicinal liquid preparation, mixing, pH adjustment, filtration, filling, sterilization, and the like, and the preparation of the second ampoule comprises steps of medicinal liquid preparation, pH adjustment, active carbon adsorption, decarburization, filtration, filling, fusing sealing, sterilization and the like. According to the invention, the solubilizer, the antioxidant, and the preparation process of the composite vitamin injection pharmaceutical composition containing 13 vitamins are improved, and the composite vitamin injection pharmaceutical composition has the advantages of few using kinds of auxiliary materials, good stability, high clarity, high security, simple preparation method, and easy realization of industrialization.

The invention provides compound vitamin submicron emulsion lyophilized powder for injection; the oil phase of the prepared submicron emulsion is soybean oil for injection only; the emulsifying agent is soybean phospholipids for injection, which are safely degraded and have no toxic or side effects, so the emulsifying agent has great safety advantage. The compound vitamin submicron emulsion lyophilized powder comprises compound vitamin, emulsifying agent, oil, sodium oleate, sodium bicarbonate, sodium thiosulfate pentahydrate, cryoprotectant and injection water; each 100 ml of lyophilized powder comprises 0.01 mg-2.0 g of compound vitamin, 0.5-3.0 g of oil, 0.5-4.0 g of emulsifying agent, 0.05-0.3 g of sodium oleate, 2-10 g of sodium bicarbonate, 0.1-0.5 g of sodium thiosulfate pentahydrate, cryoprotectant and injection water. According to the invention, a plurality of vitamins with different dissolubility are held in a preparation, so that compound vitamin injection, which can carry medicine successfully, is safe to take and has no toxic, is prepared.

The invention relates to the technical field of cryopreservation solutions, in particular to a cryopreservation solution for long-term preservation of human umbilical cord mesenchymal stem cells. The cryopreservation solution for long-term preservation of the human umbilical cord mesenchymal stem cells at least comprises the following preparation raw materials: dimethyl sulfoxide, human serum albumin, a compound electrolyte injection, a sodium chloride injection, a trehalose solution, dextran and a vitamin C injection. The cryopreservation liquid has small toxic and side effects on the human umbilical cord mesenchymal stem cells, can be directly used clinically, obviously improves the safety and biocompatibility of human umbilical cord mesenchymal stem cell retransfusion to human bodies, can improve the motility, proliferation and differentiation capabilities of the human umbilical cord mesenchymal stem cells on the premise of reducing the use amount of DMSO (dimethylsulfoxide), and can be directly retransfused after resuscitation, centrifugal washing is not needed, and damage to cells is reduced.

The invention provides composite fat-soluable vitamin injection which is composed of the following raw materials: 0.5-1g of vitamin A palmitate, 0.001-0.005g of vitamin D2, 5-10g of vitamin E, 1.0+/-0.1g of vitamin K1, 50-80g of Solutol Hs 15 and proper amount of fat-soluable antioxygen. The fat-soluable vitamin injection can be totally placed under the normal-temperature and normal environment, can be always kept to be clear within the shelf life of the injection, and has no particles or phenomena of turbidity, layering and other unstable states.

The invention discloses a composite amino acid vitamin injection and the application thereof. Every 1000ml of the composite amino acid vitamin injection comprises 5-40g of L-leucine, 2-30g of L-isoleucine, 2-30g of L-valine, 5-90g of L-alanyl-L-glutamine, 1-5g of L-threonin 1-10g of L-lysine, 1-12g of L-methionine, 1-10g of L-phenylalanine, 0.5-8g of L-tryptophan, 2-30g of L-arginine, 1-10g of L-histidine, 1-100mg of vitamin B6, 0-50mg of vitamin B1 and 0-100mu g of vitamin B12. Aiming at variation of stress, immunity, metabolism and the like of a human body in a perioperative anesthesia period, the composite amino acid vitamin injection achieves the purposes of inhibiting catabolism, promoting anabolism, generating heat and keeping warm, improving body substance energy metabolism and immunity functions and accelerating heal through creative formulae on the basis of enhanced recovery after surgery.

The present invention discloses one kind of vitamin injection as female animal aphrodisiac and its preparation process. The vitamin injection has main components including vitamin A, vitamin D and vitamin E, and supplementary materials, including antioxidant, bacteriostat and oil for injection. It is suitable for cow, mare, sow, ewe and other female animal in the duration period, and has the functions of promoting growth, raising reproductive capacity, regulating immunity, etc.

The invention discloses a vitamin K1 injection and a preparation method thereof. The vitamin K1 injection is prepared from an active ingredient vitamin K1, additives and injection water. The preparation method comprises the following steps: adding anhydrous sodium acetate into 80% of formula amount of injection water to obtain a solution A; sequentially weighing and adding formula amount of vitamin K1, HS15 and propylene glycol into a clean and anhydrous container, and uniformly emulsifying to obtain a solution B; slowly adding the solution A into the solution B, adding sodium pyrosulfite, uniformly stirring, and then, adjusting the pH to 5.8-6.2 through glacial acetic acid; supplementing the injection water to the total formula amount, filtering, filling nitrogen, filling and sealing, and carrying out rotary sterilizing at 121 DEG C for 12 minutes to obtain the vitamin K1 injection, or preparing the vitamin K1 injection through an aseptic preparation method. Compared with the commercially available vitamin K1 injection, the vitamin K injection has the advantages that brand new formula and process are adopted, so that the prepared product not only meets the pharmacopoeia criterion of the vitamin K1 injection, and the safety of clinical use of the vitamin K1 injection is greatly improved as well.

The invention relates to an improved intravenously dripped multi-vitamin injection. The injection can be mixed with high-calorie parenteral nutrients to be dissolved and adjusted to have isotonicity and isostension and then can be administrated through peripheral intravenous drip, wherein the intravenously dripping time is 6 to 12 hours; and dripping is performed at constant speed and for one time per day.

The invention belongs to the field of pharmacology and pharmaceutics and relates to a fat-soluble vitamin injection concentrated solution (II), a preparation method and an application thereof. According to the invention, the defect that a traditional fat emulsion preparation technology is complex and has poor stability is overcome. The preparation technology provided by the invention is simple; the general physical stirring process is only needed; and no homogenization technology is required. A product prepared in the invention can be sterilized through a 0.22-micron microfiltration membrane; in clinical use, the product can be spontaneously emulsified after diluted by the use of an aqueous solution such as normal saline or a glucose solution, etc. and slightly oscillated; and under optimized conditions, average particle size is about 0.2 micron, and injection fat emulsion characteristics are fully embodied. The product has good fluidity, will not be retained on the wall, is single-phase, transparent and clear in appearance, can undergo clarification detection, will not cause preparation stratification after multigelation and is used in providing adults who need to receive intravenous nutrition with a daily dose of fat-soluble vitamin.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a 12-vitamin freeze-dried preparation for injection, and a preparation method thereof. The freeze-dried preparation uses 12 water-soluble and fat-soluble vitamins as active components, wherein the active components are dissolved by using a suitable dissolution assisting method, a metal ion complexing agent is added, the pH value is adjusted to 7.1-7.6, and the obtained material and a pharmaceutically acceptable excipient are subjected to freeze drying to obtain the freeze-dried preparation for sterile injection. The invention further provides a preparation method of the freeze-dried preparation. According to the present invention, the sterile multi-vitamin freeze-dried preparation for injection has the clarified drug liquid and does not produce the precipitated drug particles after re-dissolving, and has advantages of oxidation resistance, good long-term stability, no use of toxic organic solvents and high medication safety.

The invention relates to an analysis and detection method of multivitamin injection impurities, belongs to the field of medicine analysis, and mainly relates to a detection method of oxalic acid, 3-aminopropanol, retinol, alpha-tocopherol, menadione and vitamin K1 cis-isomer impurities in a multivitamin injection.

The present invention provides a vitamin C injection and a preparation method thereof. The preparation method uses nitrogen gas, dissolves drugs in a multiple-time manner and adds a specific antioxidant to prevent a neutralization reaction, reduce generation of impurities and improve stability and safety of the drugs.

The invention discloses vitamin K1 injection and preparation method thereof. The vitamin K1 injection is prepared from vitamin K1 which is an active ingredient, auxiliary materials and water for injection. The preparation method comprises the following steps of taking the water for injection accounting for 80% of a formula ratio and adding anhydrous sodium acetate to obtain a solution A; sequentially weighing the vitamin K1 of the formula ratio and HS15 of the formula ratio, feeding the vitamin K1 and the HS15 in a clean container without water and emulsifying evenly to obtain a solution V; slowly adding the solution A in the solution B, then adding sodium pyrosulfite, evenly stirring, and regulating pH with a glacial acetic acid to be 5.8-6.2; and replenishing the water for injection until the water for injection fills up the total formula ratio, filtering, carrying out rotary sterilization for 12 minutes at the temperature of 121 DEG C or sterile preparation after nitrogen filling encapsulation to obtain the vitamin K1 injection. Compared with the existing vitamin K1 injection, the product prepared by the preparation method conforms to a vitamin K1 injection pharmacopoeia criterion, and clarity of the product is greatly improved.

The invention discloses a method for simultaneously measuring contents of three fat-soluble vitamins in multiple vitamin injections, and relates to the field of analytic chemistry. The method in the invention comprises the steps of: taking octadecylsilane chemically bonded silica as the stationary phase, and filling in the chromatographic column of a liquid chromatograph; preparing methanol-acetonitrile-ethyl acetate as the mobile phase; precisely weighing proper vitamin A, vitamin D3 and vitamin E contrasts, and diluting by adding isopropyl alcohol to obtain contrast solution; precisely weighing multiple vitamin injections to be measured, and diluting by using isopropyl alcohol to prepare test solution; respectively taking contrast solution and test solution, injecting into the liquid chromatograph to perform isocratic elution, and recording the chromatogram; and calculating the concentration of the test solution in terms of peak area according to the external standard method. By means of the method in the invention, the problems that gradient elution and the mobile phase are complex and sample processing is fussy and time-saving due to the fact that three different detection wavelengths are adopted in the prior art are solved.

The invention discloses mesenchymal stem cell injection for treating cerebral ischemic stroke and a preparation method. The injection is prepared from activated mesenchymal stem cells with the quantity of 5*10<5> to 2*10<6>/mL, human serum albumin with the mass/volume ratio of 1 percent to 5 percent, mannitol injection with the mass/volume ratio of 1 percent to 8 percent, compound vitamin injection with the mass/volume ratio of 1 percent to 5 percent, 50 percent glucose injection with the mass/volume ratio of 1 percent to 5 percent and the balance of normal saline. The mesenchymal stem cell injection for treating the cerebral ischemic stroke, disclosed by the invention, releases pro-inflammatory factors including TNF (Tumor Necrosis Factor)-alpha, IL (Interleukin)-1, IL-6 and the like in an inflammatory damage process after cerebral ischemia; the mesenchymal stem cell injection is injected to treat the cerebral ischemic stroke.

The invention relates to the field of medicines, and relates to a vitamin K1 injection and a preparation method thereof. In particular, the invention relates to a micelle solution and a preparation method thereof, and also relates to an injection containing the micelle solution and a preparation method thereof.

The invention belongs to the field of pharmacology and pharmaceutics and relates to a fat-soluble vitamin injection concentrated solution (I), a preparation method and an application thereof. According to the invention, the defect that a traditional fat emulsion preparation technology is complex and has poor stability is overcome. The preparation technology provided by the invention is simple; the general physical stirring process is only needed; and no homogenization technology is required. A product prepared in the invention can be sterilized through a 0.22-micron microfiltration membrane; in clinical use, the product can be spontaneously emulsified after diluted by the use of an aqueous solution such as normal saline or a glucose solution, etc. and slightly oscillated; and under optimized conditions, average particle size is about 0.2 micron, and injection fat emulsion characteristics are fully embodied. The product has good fluidity, will not be retained on the wall, is single-phase, transparent and clear in appearance, can undergo clarification detection, will not cause preparation stratification after multigelation and is used in providing children who need to receive intravenous nutrition with a daily dose of fat-soluble vitamin.

The invention provides a vitamin C composition which comprises amino acids and vitamin C. The composition has no use limitation for patients with diseases avoiding sodium salts, and no gas is generated during the germ-free dissolution of the vitamin C powder injection, thus it can be applied safely into clinical uses.

A composite vitamin injection for veterinary use and a preparing method thereof are disclosed. The injection comprises vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin B1, riboflavin sodium phosphate, vitamin B6, nicotinamide, dexpanthenol, vitamin B12, Tween-80, disodium ethylenediamintetraacetate, ethylparaben, butylparaben, and the like. By utilizing the Tween-80 and other auxiliary agents, lipid-soluble vitamins are dissolved into water to prepare the composite vitamin injection comprising the lipid-soluble vitamins and water-soluble vitamins. The injection has significant curative effects on malnourished livestock. Properties of a product of the injection are stable. In addition, the injection is a composite injection, is convenient to use, and achieves treating effects of a plurality of medicines through one time of administration.

The invention discloses an osteoporosis treatment instrument, and belongs to the technical field of medical instruments. The osteoporosis treatment instrument comprises an osteoporosis treatment instrument main body, and is characterized in that a multifunctional dosage controller and a protective cover are arranged on the upper side of the osteoporosis treatment instrument main body, the multifunctional dosage controller is provided with a vitamin medicine lead-in pipe, the vitamin medicine lead-in pipe is provided with a vitamin medicine storage tank, a hormone lead-in pipe is arranged on the upper side of the vitamin medicine lead-in pipe and provided with a hormone storage tank, and a vitamin injection pipe is arranged on the right side of the multifunctional dosage controller. The osteoporosis treatment instrument is complete in function, is convenient to use, saves time and labor when used for treating an osteoporosis patient, is safe, practical, efficient, rapid and thorough in cleaning, and relieves work difficulty of medical staff.

The invention discloses a compound vitamin injection medicine composition and a preparation method, and belongs to the field of medicine manufacturing. According to the compound vitamin injection medicine composition, the active ingredients per dosage unit comprise 110 mg of vitamin B, 5 mg of riboflavin in riboflavin sodium phosphate and 200 mg of vitamin C. The compound vitamin injection medicine composition and the preparation method have the advantages that the PH is stable, the PH value is small in change, the content of main drugs is stable, related matter is less, the process is simplified, the liquid dosing time is shortened, and the operation difficulty is lowered.