43 results about "Vitamin injection" patented technology

The invention relates to the technical field of analytical chemistry, and particularly discloses an HPLC (High Performance Liquid Chromatography) detection method for related impurities in a vitamin B6 injection. The invention provides an HPLC detection method for related impurities in vitamin B6 injection. The HPLC detection method comprises the following steps: carrying out separation detection on a to-be-detected sample by adopting a chromatographic column taking octadecylsilane chemically bonded silica as a filler and a mobile phase gradient elution method; the mobile phase A is 0.04% sodium pentane sulfonate solution-methanol with the volume ratio of 95: 5, and the pH value of the 0.04% sodium pentane sulfonate solution is adjusted to 3.0 by adopting phosphoric acid; the mobile phase B is methanol. The HPLC detection method provided by the invention can detect 13 impurities in the vitamin B6 injection at the same time, the detection specificity is high, the sensitivity is high, the separation degree is good, and the quality of the vitamin B6 injection can be effectively controlled when the detection method is applied to production of the vitamin B6 injection.

The invention discloses a stable vitamin B6 composition and a preparation method thereof. The pH value of the vitamin B6 injection is controlled to be 2.5-2.8, and the impurity content in the product is remarkably reduced by controlling the heating and cooling rate in the terminal sterilization process, so that the product stability and the clinical use safety are improved.

The invention provides a vitamin D3 liquid composition, the vitamin D3 liquid composition comprises vitamin D3 and polyethylene glycol-15-hydroxystearate, the pH value of the vitamin D3 liquid composition is 7.1-7.6, and the vitamin D3 liquid composition does not contain ethanol, propylene glycol, polyethylene glycol, poloxamer or polyvinylpyrrolidone. The aqueous solution composition is stable and uniform, is more suitable for injection compared with an oil solution, and can be used for preventing and treating vitamin D deficiency.

The invention provides a vitamin B6 injection and a preparation method thereof. The vitamin B6 injection is prepared from the following raw materials in parts by weight: 10 to 15 parts of vitamin B6 nanocrystals, 0.5 to 0.8 part of water-soluble fullerene, 1 to 2 parts of tetrahydromethylpyrimidine carboxylic acid, 0.8 to 1 part of a polyglutamic acid-polyethylene glycol compound, 1 to 3 parts of a pH (Potential of Hydrogen) regulator and 100 to 200 parts of water for injection. The vitamin B6 injection provided by the invention has high stability, and the storage time is prolonged to 48 months from the traditional 12 months. Most importantly, a part of the vitamin B6 nanocrystals are loaded on the water-soluble fullerene, a part of the vitamin B6 nanocrystals are coated on the polyglutamic acid-polyethylene glycol compound, and the components are separately prepared and then mixed, so that the prepared vitamin B6 injection is difficult to decompose under illumination and resistant to high temperature, and after an accelerated experiment process, the clarity, pH, content and impurities of the vitamin B6 injection are stable; no obvious change exists, and the application prospect is wide.

The invention provides a vitamin B6 injection and a preparation method thereof, and particularly relates to the field of medicines. Comprising 10 g of vitamin B6, a proper amount of a pH regulator, a proper amount of nitrogen and the balance of water for injection, the volume is fixed to 100 ML, and the pH is 2.0-3.0. The method comprises the following steps: S1, adding 70% of injection water into a liquid preparation tank, controlling the water temperature to be less than 40 DEG C, and filling nitrogen into the liquid preparation tank and a pipeline; s2, weighing the vitamin B6 according to the prescription dosage, putting the vitamin B6 into a liquid preparation tank, and stirring for 30-60 minutes at the temperature of 10-40 DEG C to dissolve the vitamin B6; s3, adding a pH (Potential of Hydrogen) regulator with the concentration of 0.01 mol / L to 1 mol / L into the solution obtained in the S2; adjusting the pH (Potential of Hydrogen) to 2.0 to 2.8; s4, fixing the volume of the solution obtained in S3 to 100% of the total volume, and stirring for 15-30 minutes after fixing the volume; s5, sterilizing and filtering the stirred solution, and filling nitrogen; and S6, sterilizing the filled and sealed sample at 121 DEG C for 12 minutes to finally obtain the vitamin B6 injection product. Degradation of related substances of liquid medicine is reduced by controlling a liquid medicine production process, and the more stable vitamin B6 injection is obtained.

The invention discloses a vitamin B12 injection and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The preparation method of the injection comprises the following steps: (1) dissolving the raw material medicines: dissolving the vitamin B12 and the benzyl alcohol in the water for injection to obtain an injection A; (2) dissolving a stabilizer-synergist: firstly adding L-cysteine into the injection A, then adding liraglutide, and uniformly mixing to obtain an injection B; (3) pH value adjustment: adjusting the pH value of the injection B to 4.0-4.5 to obtain an injection C; (4) dissolution of an impurity reducing agent-osmotic pressure regulator: sequentially adding spleen aminopeptide and glucose into the injection C, and standing to obtain an injection D; (5) fixing the volume, filtering and sterilizing; and (6) filling. According to the vitamin B12 injection prepared by the method, the preparation time can be greatly shortened, and total impurities in a final finished product can be obviously reduced through reasonable dissolution sequence, selection of stirring materials and limitation of temperature and pH value.

This invention provides an injectable cefminox sodium preparation and its preparation method, belonging to the field of pharmaceutical preparation technology. The preparation, by weight, comprises: 1 part of refined cefminox sodium, 0.5 parts of sodium lactate Ringer's solution, 0.2 parts of vitamin B12 injection, 0.1-0.3 parts of a modified composite antioxidant, and 3 parts of physiological saline. The preparation method of the modified composite antioxidant is as follows: S1, add 1 part by weight of poloxamer to 20 parts by weight of distilled water and stir for 6-8 minutes to obtain a solution; S2, after passing 1 part by weight of natural vitamin C through a 100-mesh sieve, mix it into the solution obtained in S1, and sonicate for 10-15 minutes to obtain a vitamin C solution; S3, mix 0.5 parts by weight of vitamin D into the vitamin C solution obtained in S2, and sonicate for 15-20 minutes to obtain the modified composite antioxidant. The formulation of this invention exhibits excellent stability and stable content of cefminox sodium when exposed to environments of 35℃±2℃, 65%±5%RH and natural light, ensuring the safety and reliability of medication.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a vitamin B2 injection composition and a preparation method thereof. The invention provides a preparation method of a vitamin B2 injection composition, which comprises the following steps: mixing malic acid, citric acid and propylene glycol, heating to 80-90 DEG C, and continuously stirring until transparent liquid is formed; adding zein and riboflavin sodium phosphate into the transparent liquid under a dark condition, and carrying out heat preservation reaction at 25-30 DEG C for at least 30 seconds to obtain a stock solution; and mixing the stock solution, an auxiliary agent and water to prepare the vitamin B2 injection composition with the pH value of 4.5-6.5. The deep eutectic solvent is prepared from malic acid, citric acid and propylene glycol, the zein and the riboflavin sodium phosphate are uniformly mixed, and the prepared vitamin B2 injection composition has good light stability.

The application provides a kind of medicine composition for treating muscle and bone disease and its application, belong to medical technology field.The medicine composition includes the following weight parts components: compound angelica injection 5-10 parts, kadsura injection 5-10 parts, wild medlar injection 5-10 parts, methylcobalamin injection 5-10 parts;It can also be selectively added vitamin B1 injection, vitamin B12 injection, yellow Chinese wax injection or bone peptide injection.The composition of the application is administered by acupoint injection or intramuscular injection, utilizes the synergistic effect of multiple traditional Chinese medicine injection and western medicine injection, reaches the comprehensive treatment effect of promoting blood circulation to remove blood stasis, dispelling wind to stop pain, nerve nutrition.Clinical experiments show that the application has significant effect on lumbar disc herniation, cervical spondylosis, shoulder periarthritis, knee osteoarthritis, femoral head necrosis, osteoporosis and the like, and the total effective rate is more than 95%, with fast effect, low recurrence rate, and no hormone-related side effects, suitable for patients of all ages.

The invention relates to the technical field of veterinary medicines, in particular to a vitamin ADE injection for cattle and a preparation method thereof. Every 10 L of the vitamin ADE injection for the cattle is prepared from the following components: 500 to 600 g of vitamin A palmitate, 2 to 3 g of vitamin D3, 2800 to 3200 g of vitamin E acetate, 10 to 20 g of butylated hydroxytoluene, 1800 to 2200 g of absolute ethyl alcohol, 180 to 220 g of analgesic, 250 to 350 g of solubilizer, 150 to 250 g of stable synergist and the balance of isopropyl myristate. According to the invention, hydrogenated palm oil glyceride, ethylene oxide, succinic anhydride, ascorbyl palmitate and the like are used as raw materials, and the stable synergist with the following effects is prepared through related chemical reactions, and the prepared stable synergist integrates the functions of solubilization, oxidation resistance and stimulation reduction; as a raw material of the injection, the oxidation resistance and the stability of the injection are effectively improved; the injection prepared by the invention is clear and transparent, has excellent stability, can effectively relieve injection pain and tissue stimulation, and remarkably improves the safety, stability and clinical applicability of the injection.

To provide a preparation for vitamin C injection having high stability, free of sodium, and not inducing vascular pain.SOLUTION: A preparation for vitamin C injection comprising a freeze-dried powder of an aqueous solution containing 5 mass% or more and 22 mass% or less of L-arginine ascorbate neutral salt.SELECTED DRAWING: None

The utility model relates to a dilution tank for vitamin B12 injection production, which comprises a tank body, a sealing cover installed on the top of the tank body, a liquid inlet arranged on one side of the top of the tank body, a water inlet arranged on the other side of the top of the tank body, a liquid outlet arranged at the bottom of the tank body, a first filter element installed in the liquid inlet and extending into the tank body, a second filter element installed in the liquid outlet, an L-shaped liquid discharge pipe installed at the bottom of the liquid outlet, a corrugated flexible pipe arranged on the vertical section of the liquid discharge pipe, the second filter element arranged in the corrugated flexible pipe, a hanger connected with the liquid discharge pipe arranged at the bottom of the tank body, a safety valve and an ultrasonic liquid level sensor installed on the top of the sealing cover, a temperature sensor arranged on the inner wall of the tank body, a pressure sensor arranged on the bottom of the inner wall, a plurality of sampling valves arranged on one side of the tank body from top to bottom, and magnetic stirrers arranged on both sides of the bottom of the tank body and symmetrical to the liquid outlet. The utility model adds a filtering function, thereby improving the purity and production safety of the liquid medicine.

The present invention relates to the use of 25-hydroxy-vitamin D3 in animal breeding. More particularly, the invention relates to an injectable composition of 25-hydroxy- vitamin D3 and its use of 25-hydroxy-vitamin D3 raising plasma25-hydroxy-vitamin D3 levels of piglets in pig breeding.

The invention discloses a composite hyaluronic acid solution capable of dehydrating and decomposing fat, and relates to the technical field of biomedical materials. Adding the sodium hyaluronate into ultrapure water, and standing for 5-6 hours until the sodium hyaluronate is completely hydrated to prepare pure gel; placing the pure gel in a water bath kettle, gently stirring and heating, adding normal saline, homogenizing for 3 minutes, adding a composite vitamin B injection, uniformly stirring, gently stirring, and preparing a composite liquid; and sterilizing the composite liquid, and sub-packaging the sterilized composite liquid into sterile bottles to prepare the composite hyaluronic acid solution capable of dehydrating and decomposing fat. The face-lift mask is free of side effects, suitable for high-sensitivity people, good in face-lift effect and fast in face-lift recovery.

A vitamin shot having essential vitamins, minerals and a plant extract.

The invention discloses a vitamin C injection and a preparation method thereof. The preparation method of the vitamin C injection comprises the following steps: taking water for injection, which accounts for 65-80% of the total volume of the prepared solution, and introducing carbon dioxide until the water is saturated, so as to obtain a saturated solution of carbon dioxide; the preparation method comprises the following steps: adding sodium pyrosulfite, edetate disodium and cysteine hydrochloride into a saturated solution of carbon dioxide, and stirring to fully dissolve the sodium pyrosulfite, the edetate disodium and the cysteine hydrochloride to obtain a first liquid medicine; uniformly mixing vitamin C and sodium bicarbonate to obtain mixed powder, and adding the mixed powder into the first liquid medicine in batches to obtain second liquid medicine; adding activated carbon into the second liquid medicine, stirring and then filtering, replenishing the residual 20-35% of water for injection, and then finely filtering; and packaging and warehousing the finely filtered liquid medicine after encapsulation, sterilization, leak detection and light inspection. The vitamin C injection prepared by the invention is colorless and clear, the content of effective components is as high as 99.6%, and the impurity content is extremely low.

The invention discloses a vitamin C injection with low impurity content and a preparation method thereof, and belongs to the technical field of pharmaceutical preparation preparation. According to the vitamin C injection disclosed by the invention, D-calcium gluconate, L-cysteine and polyethylene glycol-6000 are adopted to prepare a stabilizer, and the three components have a synergistic effect, so that the stability of an injection system is remarkably improved, the oxidation chain reaction of vitamin C is effectively blocked, and the generation of impurities is reduced. In addition, a buffer system is optimized, compared with a traditional sodium bicarbonate buffer system, pH fluctuation caused by CO2 release is avoided, the content of active oxygen in the injection can be reduced through the ultra-pure deoxidation process, operation is conducted in the environment with the temperature smaller than or equal to 25 DEG C in the whole process, and light degradation is reduced by adopting an amber neutral glass ampoule. The long-acting stability of the injection is improved, and the impurity content is reduced.

The invention relates to the technical field of sterilization, in particular to a sterilization device for vitamin B6 injection production and a sterilization process thereof.The sterilization device comprises a sterilization box, rectangular holes are symmetrically formed in the inner walls of the two sides of the sterilization box, a conveying belt is arranged in the sterilization box, and the two ends of the conveying belt penetrate through the two rectangular holes correspondingly; the sterilization box is provided with a driving mechanism for driving the conveying belt to convey the ampoule bottles; box doors matched with the rectangular holes are symmetrically arranged on the two sides of the sterilization box, fourth hydraulic telescopic rods are fixedly connected to the two sides of the sterilization box respectively, and the telescopic ends of the fourth hydraulic telescopic rods are fixedly connected with the box doors; the high-temperature steam is directly blown to each ampoule bottle, so that the sterilization effect of the ampoule bottles and the injection is better, and the quality of the vitamin B6 injection packaged after sterilization is improved.

The present application relates to the technical field of pharmaceutical preparation, and discloses a fat-soluble vitamin injection and a preparation method thereof.In the present application, soybean oil, vitamin E and lecithin are mixed uniformly, and then other fat-soluble vitamins are added and mixed uniformly under the protection of inert gas; by controlling the dissolved oxygen in water for injection and the residual oxygen level in ampoule headspace, a method for preparing fat-soluble vitamin injection through one-time emulsification and conventional sterilization process is provided.The fat-soluble vitamin injection prepared by the above method has significantly improved stability, can be stored stably at 25 DEG C, and has practical significance and important social value.

The invention discloses an anti-inflammatory and analgesic medicament and a preparation process thereof, and relates to the technical field of medicaments. The defects in the prior art are overcome. The medicine for diminishing inflammation and relieving pain is prepared from the following components in parts by weight: 80 to 200g of gypsum, 80 to 200g of mirabilite, 80 to 200ml of water and 1 to 2ml of vitamin B12 injection. The preparation process of the anti-inflammatory and analgesic medicine comprises the following steps: taking the components according to the weight for later use; adding water into a boiler, boiling until boiling, sequentially adding mirabilite and gypsum powder, and slowly and uniformly stirring to obtain liquid medicine; and airing the liquid medicine to normal temperature, adding the vitamin B12 injection, and uniformly mixing with the liquid medicine. The traditional Chinese medicine preparation is safe, effective, free of toxic and side effects, free of stimulation, good in antibacterial, anti-inflammatory and repairing effects and easy to obtain raw materials, does not generate dependence after being used for a long time, has high popularization value, is short in use course of treatment and can keep negative after curing HPV for a long time, and relapse is not prone to occurring.

The invention discloses a method for simultaneously determining contents of various components in a vitamin injection (13), and belongs to the technical field of analysis and detection. The method provided by the invention comprises the following steps: adding a chelating agent into a vitamin injection (13), and then carrying out gradient dilution to a concentration to be detected by taking a mobile phase A or a mixed solution of the mobile phase A and a mobile phase B as a diluent, so as to obtain a test solution; a high performance liquid chromatography method is adopted for detection; wherein the mobile phase A is a phosphoric acid aqueous solution of 0.008-0.012 mol / L of sodium pentanesulfonate; and a mobile phase B is a phosphoric acid aqueous solution of 0.008-0.012 mol / L of sodium pentanesulfonate, namely acetonitrile. According to the method disclosed by the invention, the stability of the vitamin C and the separation degree of each component are remarkably improved, and the method is high in sensitivity, strong in specificity, good in reproducibility, high in accuracy, strong in universality and good in stability.

The present invention relates to the technical field of pharmaceutical analysis, and in particular to the use of an HPLC method to determine the 6 A method for determining degradation impurities in an injection. The method comprises the following steps: diluting a sample with a suitable solvent to a certain concentration, taking a certain volume, using high performance liquid chromatography, using mobile phase A and mobile phase B for gradient elution injection, using a C18 column, and detecting at a certain wavelength and column temperature. The present invention is simple to operate, has good method specificity and stability, can well separate various degradation impurities, and has been verified to have accurate and reliable detection results.

The invention discloses a method for determining an aluminum element in a vitamin injection by atomic absorption spectrometry, which is suitable for detecting the aluminum element in water-soluble vitamin and fat-soluble vitamin injections, and the technical scheme of the invention comprises a graphite tube treatment method capable of obviously prolonging the service life and a graphite furnace heating procedure matched with the graphite tube treatment method. The blank of the method for detecting the aluminum element in the vitamin injection in the prior art is filled, and the method has important significance in the aspect of improving the product quality.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a polyoxyethylene 35 castor oil and HS 15 solubilized multi-flower vitamin injection and a preparation method thereof, the polyoxyethylene 35 castor oil and HS 15 solubilized multi-flower vitamin injection comprises a plurality of vitamins, a solubilizer, a buffer agent and a pH value regulator, the plurality of vitamins comprise water-soluble vitamins and fat-soluble vitamins; the solubilizer is polyoxyethylene 35 castor oil and HS 15, the concentration range of the polyoxyethylene 35 castor oil is 0.025%-5% (g / ml), and the concentration range of the HS 15 is 0.025%-5% (g / ml). The problems that an existing solubilizer is insufficient in hemolytic property and stability, complex in production process and the like can be effectively solved, and meanwhile single-bottle packaging can be achieved.

The invention discloses an auxiliary metering device for preparing a multivitamin injection, and relates to the technical field of injection preparation. A device shell is arranged at the top of the workbench, a liquid conveying mechanism is arranged in the device shell, the left end of the liquid conveying mechanism is fixedly connected with a mixing bin, an air guide mechanism is arranged at the bottom of the device shell, the left end of the air guide mechanism is connected with the mixing bin, a mixing mechanism is arranged in the mixing bin, and scale marks are arranged at the front end of the mixing bin; a driving motor is arranged in the device shell, the driving motor is connected with the liquid conveying mechanism and the mixing mechanism, and the bottom of the driving motor is connected with the air guide mechanism. The driving motor drives the mixing mechanism and the liquid conveying mechanism to operate, so that the driving motor can drive the liquid conveying mechanism to operate while driving the mixing mechanism to operate, the liquid conveying mechanism records the conveying amount of each raw material, and then water lines reached by all the raw materials are recorded through the graduated scale; when the vitamin injection is proportioned, raw materials are metered through the infusion mechanism and the graduated scale.

The invention provides a method for detecting related substances of a vitamin K1 injection, and relates to the technical field of drug detection and analysis. According to the method, high performance liquid chromatography is adopted for determination, and the chromatographic conditions are as follows: an octadecyl silane bonded silica gel chromatographic column is adopted, a potassium chloride solution-absolute ethyl alcohol is taken as a mobile phase A, absolute ethyl alcohol is taken as a mobile phase B for gradient elution, the concentration of the mobile phase A is adjusted within the range of 15% v / v-40% v / v, the concentration of the mobile phase B is adjusted within the range of 60% v / v-85% v / v, and the elution time is 60-70 min. According to the detection method, the vitamin K1 can be effectively separated from the impurity B, the vitamin K1 epoxide and other impurities, the specificity of the method is high, the sensitivity is high, the reproducibility is good, and the drug quality of the vitamin K1 injection can be more effectively controlled by detecting related substances.

The invention discloses a composition and a preparation method of a vitamin C injection, the formula of the vitamin C injection comprises vitamin C, sodium bicarbonate, hydrochloric acid, thioglycerol and water for injection, and the dosage of the thioglycerol is 20mg / ml. The vitamin C injection disclosed by the invention is simple in composition, stable in quality, simple, convenient and efficient in preparation process, low in finished product impurity level and good in safety.

The invention provides a vitamin C injection as well as a preparation method and application thereof. The vitamin C injection comprises vitamin C, a composite antioxidant, a metal ion complexing agent, a pH regulator, activated carbon and a solvent, wherein the composite antioxidant is selected from one or more of sodium sulfite, sodium hydrogen sulfite, sodium pyrosulfite, sodium thiosulfate or L-cysteine. By the adoption of the vitamin C injection, the oxidation phenomenon of the vitamin C injection can be further reduced, the problem that the vitamin C injection is not uniform in color is solved, all the components in the vitamin C injection act synergistically, the stability of the vitamin C injection is improved, and the effect of the vitamin C injection is better.

The invention relates to the technical field of biological medicine, in particular to application of vitamin B1 in preparation of a medicine for inhibiting liver cancer. Researches find that the vitamin B1 can significantly inhibit proliferation of hepatoma carcinoma cells and induce death of hepatoma carcinoma cells within a certain dosage range, and presents time and dosage dependence. Furthermore, a liver cancer tumor-bearing animal model verifies that the injection administration of the vitamin B1 can obviously inhibit the increase of the tumor volume and the tumor weight, and the tumor growth tends to be stable under the condition of high dosage. Meanwhile, the vitamin B1 can obviously improve the microcirculation perfusion level of the tumor tissue and improve the blood perfusion amount and the blood cell perfusion speed along with the reduction of the number of tumor tissue capillaries. Animal experiment results show that no obvious toxic or side effect is observed in the administration process of the vitamin B1. The new application of the vitamin B1 in inhibiting the liver cancer is disclosed for the first time, and a new choice with high safety and good potential application value is provided for treatment of the liver cancer.

The invention discloses three impurities in B12 injection as well as a preparation method and application thereof. The structures of three impurities in the vitamin B12 injection are respectively shown as an impurity 1, an impurity 2 and an impurity 3. According to the specific embodiment of the invention, the contents of three impurities in the vitamin B12 injection can be gradually increased in the storage period of the vitamin B12 injection, so that the contents exceed the limit of the impurities in the vitamin B12 injection, and the quality of the vitamin B12 injection is possibly influenced. Therefore, the inventor researches and characterizes the impurities, so as to monitor the impurities in the vitamin B12 injection.