5 results about "CEFMINOX SODIUM" patented technology

This invention provides an injectable cefminox sodium preparation and its preparation method, belonging to the field of pharmaceutical preparation technology. The preparation, by weight, comprises: 1 part of refined cefminox sodium, 0.5 parts of sodium lactate Ringer's solution, 0.2 parts of vitamin B12 injection, 0.1-0.3 parts of a modified composite antioxidant, and 3 parts of physiological saline. The preparation method of the modified composite antioxidant is as follows: S1, add 1 part by weight of poloxamer to 20 parts by weight of distilled water and stir for 6-8 minutes to obtain a solution; S2, after passing 1 part by weight of natural vitamin C through a 100-mesh sieve, mix it into the solution obtained in S1, and sonicate for 10-15 minutes to obtain a vitamin C solution; S3, mix 0.5 parts by weight of vitamin D into the vitamin C solution obtained in S2, and sonicate for 15-20 minutes to obtain the modified composite antioxidant. The formulation of this invention exhibits excellent stability and stable content of cefminox sodium when exposed to environments of 35℃±2℃, 65%±5%RH and natural light, ensuring the safety and reliability of medication.

The invention relates to the technical field of drug detection, and discloses a method for detecting beta-lactam compound residues in a terbinafine hydrochloride bulk drug, which effectively corrects the matrix effect of terbinafine hydrochloride on a target object by adopting a matrix target method. According to the present invention, with the combination of the optimized pretreatment steps (the ratio of the diluent to the phosphate buffer), the chromatographic conditions and the mass spectrum parameters, the simultaneous quantitative detection of the eight beta-lactam compounds (cefoxitin sodium TBXD, cefotaxime sodium TBSW, cefminox sodium TBMN, cefmetazole acid TBMZ, meropenem MEP, imipenem IMP, ertapenem sodium ERP and biapenem BIP) is achieved, the quantification limit is as low as 0.008 ppm, and the detection sensitivity is high; the detection sensitivity and accuracy are remarkably improved, and the technical problem that the trace beta-lactam cross contamination in the terbinafine hydrochloride raw material medicine cannot be reliably monitored in the prior art is solved.

The invention provides a method for preparing cefminox sodium through continuous flow, and belongs to the technical field of pharmaceutical chemistry synthesis. The method comprises the following steps: respectively introducing a 7-ACA solution and an MMT solution into a continuous flow microreactor for substitution reaction; introducing chloroacetyl chloride, and carrying out acylation reaction; then introducing a D-cysteine solution, carrying out condensation reaction to obtain an intermediate 2 reaction solution, and acidifying and crystallizing to obtain an intermediate 2; dissolving the intermediate 2 in an organic solvent, respectively introducing the intermediate 2 solution, tert-butyl hypochlorite and a sodium methoxide solution into a continuous flow microreactor, and carrying out a methoxylation reaction; and then introducing glacial acetic acid for quenching, cooling, hydrolyzing and crystallizing to obtain the product. The method has the advantages of high conversion rate, high yield and high purity. # imgabs0 #

The invention provides a pharmaceutical preparation of a cefminox sodium compound and a preparation method thereof, belonging to the technical field of drug synthesis. The preparation method comprises the following steps: using 7-MAC as a raw material, sequentially performing an acylation reaction and a decarboxylation protecting group reaction to obtain 7β-bromoacetamide-7α-methoxy-3-(1-methyl-1H-5-tetrazolyl)thiomethyl-3-cephem-4-carboxylic acid; mixing 460g of 7β-bromoacetamide-7α-methoxy-3-(1-methyl-1H-5-tetrazolyl)thiomethyl-3-cephem-4-carboxylic acid, 235g of D-cysteine ​​hydrochloride and 1.5L of water, performing ultrasonic oscillation, adding 4-10g of anthocyanin and 4-8g of polyvinyl alcohol, wherein the frequency of the ultrasonic oscillation decreases gradually within 80KHZ-45KHZ and the duration is 2h, to obtain a reaction solution; and purifying the reaction solution through a Diaion HP-20 column, concentrating the reaction solution under reduced pressure to dryness, cooling the reaction solution, and precipitating a solid to obtain the cefminox sodium compound. The cefminox sodium crystals prepared by the present invention have strong adaptability to the storage environment, the crystal particle size distribution will not easily change in a short period of time, the crystal particle size distribution has good stability, and the quality is stable and guaranteed.

The present invention provides a continuous flow method for preparing cefminox sodium, belonging to the technical field of pharmaceutical chemical synthesis. The method comprises the following steps: introducing a 7-ACA solution and an MMT solution into a continuous flow microreactor for a substitution reaction; then introducing chloroacetyl chloride for an acylation reaction; then introducing a D-cysteine ​​solution for a condensation reaction to obtain an intermediate 2 reaction solution, which is then acidified and crystallized to obtain intermediate 2; dissolving intermediate 2 in an organic solvent, and introducing the intermediate 2 solution, tert-butyl hypochlorite, and a sodium methoxide solution into a continuous flow microreactor for a methoxylation reaction; then introducing glacial acetic acid for quenching, cooling, hydrolysis, and crystallization to obtain the product. The method of the present invention has high conversion rate, high yield, and high purity. #imgabs0#