2 results about "CEFMINOX SODIUM" patented technology

This invention provides an injectable cefminox sodium preparation and its preparation method, belonging to the field of pharmaceutical preparation technology. The preparation, by weight, comprises: 1 part of refined cefminox sodium, 0.5 parts of sodium lactate Ringer's solution, 0.2 parts of vitamin B12 injection, 0.1-0.3 parts of a modified composite antioxidant, and 3 parts of physiological saline. The preparation method of the modified composite antioxidant is as follows: S1, add 1 part by weight of poloxamer to 20 parts by weight of distilled water and stir for 6-8 minutes to obtain a solution; S2, after passing 1 part by weight of natural vitamin C through a 100-mesh sieve, mix it into the solution obtained in S1, and sonicate for 10-15 minutes to obtain a vitamin C solution; S3, mix 0.5 parts by weight of vitamin D into the vitamin C solution obtained in S2, and sonicate for 15-20 minutes to obtain the modified composite antioxidant. The formulation of this invention exhibits excellent stability and stable content of cefminox sodium when exposed to environments of 35℃±2℃, 65%±5%RH and natural light, ensuring the safety and reliability of medication.

The invention relates to the technical field of drug detection, and discloses a method for detecting beta-lactam compound residues in a terbinafine hydrochloride bulk drug, which effectively corrects the matrix effect of terbinafine hydrochloride on a target object by adopting a matrix target method. According to the present invention, with the combination of the optimized pretreatment steps (the ratio of the diluent to the phosphate buffer), the chromatographic conditions and the mass spectrum parameters, the simultaneous quantitative detection of the eight beta-lactam compounds (cefoxitin sodium TBXD, cefotaxime sodium TBSW, cefminox sodium TBMN, cefmetazole acid TBMZ, meropenem MEP, imipenem IMP, ertapenem sodium ERP and biapenem BIP) is achieved, the quantification limit is as low as 0.008 ppm, and the detection sensitivity is high; the detection sensitivity and accuracy are remarkably improved, and the technical problem that the trace beta-lactam cross contamination in the terbinafine hydrochloride raw material medicine cannot be reliably monitored in the prior art is solved.