215results about How to "Promote secretion" patented technology

The invention discloses lactobacillus reuteri CCFM1288 for relieving depressive mood and application of the lactobacillus reuteri CCFM1288, and belongs to the technical field of microorganisms. The lactobacillus reuteri CCFM1288 has the tryptophan metabolism capability, and can survive for 7 days in the intestinal tract; after the lactobacillus reuteri CCFM1288 intervenes a depressive mouse, anxiety-like and depression-like behaviors of the mouse can be obviously relieved, flora alpha-diversity is improved, intestinal symbiotic bacteria are promoted to secrete indole substances, intestinal homeostasis is maintained, hypothalamic-pituitary-adrenal axis hyperfunction is relieved, dopamine and serotonin neurotransmitter nervous system functions are improved, and the effect of preventing and treating depression is achieved. The neurotransmitter release is promoted, and the anti-depression effect is achieved. In clinical tests, intervention of Lactobacillus reuteri CCFM1288 can significantly improve the depressive symptom of MDD patients, and a new safe alleviation approach is provided for depression treatment.

The invention belongs to the technical field of sewage treatment, and discloses an anaerobic ammonia oxidation enhanced denitrification device and method based on an electron mediator type biological carrier and iron oxide. The anaerobic ammonia oxidation enhanced denitrification device comprises a reactor main body, a heat preservation circulating water device, a stirring device, a water inlet pipeline and a water outlet pipeline, anaerobic ammonium oxidation bacteria are contained in the reactor main body, a certain proportion of electron mediator type biological carriers are filled in the reactor, and a proper amount of iron oxide is added; wherein the added high-valence iron oxide can be used as an extracellular electron acceptor of anaerobic ammonium oxidation bacteria, the electron mediator type carrier can be used as a redox mediator, and nitrogen removal of the anaerobic ammonium oxidation system is promoted by strengthening the extracellular electron transfer process of the anaerobic ammonium oxidation bacteria.

The invention belongs to the field of preparation of sedation maintaining agents, and particularly relates to a sedation maintaining agent administrated through oral mucosa and a preparation method of the sedation maintaining agent. Bamboo leaf polysaccharide and pigskin collagen peptide are heated and mixed with chlorogenic acid and butyl acetate under the catalytic action of lanthanum nitrate, and the obtained moisturizing adhesive has biocompatibility, can be stably adhered to oral mucosa and can promote salivary secretion of children; nanoparticles obtained through freeze spray drying are uniformly dispersed in a copolymer solution containing sodium salicylate and polyacrylate, and the obtained nervous system regulator can balance excitability of sympathetic nerves and parasympathetic nerves of children; the emotion relieving composition contains modified felwort powder obtained through esterification reaction, the modified felwort powder is mixed with a moisturizing adhesive and a nervous system regulator, and the prepared sedation maintaining medicament administrated through the oral mucosa protects oral health of children in the oral operation anesthesia process, is free of irritation, improves anxiety emotion and does not affect postoperative awakening.

The invention belongs to the technical field of biological medicines, and particularly relates to a postbiotic hydrogel for relieving alcoholic gastric ulcer as well as a preparation method and application thereof. The metagen hydrogel for relieving the alcoholic gastric ulcer, provided by the invention, is mainly prepared from metagen of rhamnobacter and modified lactoferrin; the lactobacillus rhamnosus is lactobacillus rhamnosus JM023. Tests prove that when the postbiotic hydrogel is applied to an alcoholic gastric ulcer rat model, the occurrence of gastric ulcer can be inhibited by inhibiting oxidative stress and inflammatory response and improving protection factor secretion; and the alcoholic gastric ulcer is relieved by regulating and controlling the expression of oxidation, inflammation, cell apoptosis and tissue repair related metabolic pathways and regulating gastrointestinal flora. The metagen hydrogel disclosed by the invention has the effect of effectively relieving gastric ulcer symptoms caused by alcohol, and is suitable for being developed and applied as a medicine or a health-care product for relieving alcoholic gastric ulcer.

The invention discloses application of a metal boride nano material in preparation of an immunosuppressant, and belongs to the technical field of biological medicine. Specifically, through a series of researches, it is found that the metal boride nano material catalyzes an organic substrate containing a-CH-OH group in cells, and meanwhile, NAD (P) < + > is converted to generate NAD (P) H, GSH rising is promoted, and cell reductive stress is initiated. The immune cells are further induced to differentiate to an immunosuppressive phenotype, secretion of immunosuppressive factors is promoted, secretion of immune activating factors is inhibited at the same time, and finally the immunosuppressive effect is achieved. The catalytic action of the substance can provide a lasting and stable immunosuppression effect, and the feasibility of the substance in initiation of reduction stress and immunosuppression is proved through in-vivo and in-vitro experiments. The invention provides a new immunosuppression strategy, which is expected to make up the defects of the traditional immunosuppressor, and provides a new choice for related treatment of clinical organ transplantation, autoimmune diseases, inflammatory diseases and the like.

The invention provides a culture method for improving immunity of fishes. The culture method comprises the following steps: S1, selection of culture points; S2, specification and layout of net cages; S3, selection and throwing of fish fries; according to the fry disinfection method disclosed by the invention, the fry are soaked and disinfected by using a compound disinfectant prepared from povidone iodine, polysorbate, citric acid and vitamin C in a specific proportion, so that pathogenic microorganisms on the surfaces and gill parts of fish bodies are effectively killed. According to the breeding management, the immunity of the fish body is comprehensively enhanced by feeding the fish with an immune conditioner composed of campesterol palmitate, immunomodulatory peptide, beta-glucan and astaxanthin in a specific proportion. According to the bottom mud management, the content of harmful substances is reduced by putting a bottom mud modifier composed of sodium molybdate, nitrifying bacteria, photosynthetic bacteria, tetrandrine and sodium alginate in a specific proportion, growth of pathogenic bacteria is inhibited, nutrient substance circulation is promoted, the water quality environment is optimized, and healthy growth of fry is promoted.

The invention belongs to the technical field of regenerated medical dressings, particularly relates to a plant polysaccharide hydrogel medical dressing for promoting tissue damage repair and application thereof, and provides the following scheme that a medical and mechanical combined product comprises a regenerated medical dressing and a low-temperature sterile storage box for storing the regenerated medical dressing, the regenerated medical dressing comprises a hydrogel main body, open pores formed in the hydrogel main body, sustained-release vesicles arranged in the open pores, and stem cells and a cell culture medium which are filled in the sustained-release vesicles. The stem cell hydrogel can rapidly break blood, rapidly stop bleeding by being attached to a wound surface and promote wound closing, stem cells are inoculated to the upper surface of the hydrogel formed by dendrobium polysaccharides, aloe, lily, coptis chinensis and honeysuckle, safe application of the stem cells is achieved, active factors secreted by the stem cells are slowly released to the skin wound surface, and the wound healing effect is achieved. Through contact stimulation between cells, various cytokines can be secreted better, and the skin repair efficiency is improved.

The invention provides an AI and VR nursing method and device integrating multiple senses, a medium and a program product, and relates to the field of intelligent medical treatment. The method comprises the steps that a first instruction for entering a virtual scene is received, and a subject enters the virtual scene to generate a virtual subject; the virtual scene comprises a foretaste area; receiving a second instruction that the virtual subject moves to the foretaste area in the virtual scene and moving the virtual subject to the foretaste area; receiving an instruction for a fake feeding object placed in the foretaste area, wherein the fake feeding object appears in the hand of the virtual subject; the category of the fake feeding object is recognized, and according to whether the distance between the fake feeding object and the mouth of the virtual subject in the virtual scene exceeds a threshold value or not or whether a feeding instruction is received or not, the smell spraying device receives a smell simulation instruction of the fake feeding object and starts the device to generate corresponding smell. A voice control module of the false feeding device is developed through AI, and a sniffing intention recognition algorithm is developed, so that accurate analysis and conversion of signals are realized, and the equipment intelligence is improved.

The invention discloses application of N-acetyl serotonin in preparation of a medicine for treating type 2 diabetes mellitus, and belongs to the field of biological medicine. In-vivo and in-vitro experiments prove that the N-acetyl serotonin can promote secretion of GLP-1, has the effects of obviously reducing blood sugar, being good in sugar tolerance and insulin tolerance, and is obviously improved aiming at high fasting blood glucose, high postprandial blood glucose, poor glucose tolerance and reduced insulin tolerance; the GLP-1 secretion insufficiency is obviously improved. The invention is of great significance in maintaining blood sugar stability and improving glucose and insulin tolerance of diabetic patients, and provides a new solution for treatment of type 2 diabetes mellitus.

The invention discloses bifidobacterium breve BBr26 capable of inhibiting hyaluronidase activity and relieving allergy as well as an application, a product and a method of the bifidobacterium breve BBr26, and belongs to the technical field of microorganisms. The invention provides a Bifidobacterium breve (Bifidobacterium breve) strain BBr26 with anti-allergy and / or immunoregulation capability, and the preservation number of the Bifidobacterium breve strain BBr26 is CGMCC (China General Microbiological Culture Collection Center) NO.32424. The invention also provides a preparation method of the Bifidobacterium breve strain The invention also provides an application of the strain bifidobacterium breve BBr26 in preparation of products for relieving atopic dermatitis, and / or food for enhancing immune function, and / or bacteriostatic agents, and a product and a method based on the strain BBr26. The strain disclosed by the invention has broad-spectrum bacteriostasis, can relieve allergy and atopic dermatitis, and can effectively play a role in immunoregulation.

The continuous flow sludge rapid granulation system based on particle size separation comprises a micro-aerobic tank, an aerobic tank, a precipitation device and a particle size separation device, the micro-aerobic tank is communicated with the aerobic tank, the precipitation device and the particle size separation device are both installed on the upper portion of the aerobic tank, the bottoms of the precipitation device and the particle size separation device are both communicated with the aerobic tank, the micro-aerobic tank is communicated with the precipitation device, and the particle size separation device is communicated with the precipitation device. And the precipitation device is communicated with the particle size separation device. Wherein the particle size separation device realizes screening and enrichment of granular sludge, and a continuous flow aerobic granular sludge system with a high granulation ratio is rapidly formed; the precipitation device can accelerate the formation of the granular sludge, and long-term stable operation of the granular sludge is ensured by coexistence of the precipitation device and the granular sludge; the outer-layer aerobic and inner-layer anoxic / anaerobic microenvironment can be used for synchronously removing phosphorus by nitrification and denitrification. The continuous flow aerobic granular sludge which operates stably for a long time and has good carbon, nitrogen and phosphorus removal performance can be rapidly cultured, in addition, investment is small, compatibility is easy, the occupied area and operation energy consumption are saved, and the method has good application prospects.

The present invention proposes a Chinese medicine composition for treating allergic rhinitis, and a preparation method and application thereof, which belong to the field of pharmaceutical technology. Ag-graphene oxide is adsorbed on in vitro proliferated γδT cells, a Chinese medicine fermentation product obtained by fermentation and extraction of Xanthium sibiricum, Astragalus, Poria, Magnolia officinalis, and Mentha is prepared, berberine and quercetin are prepared into eutectic powder, the three are mixed and added into water, probiotics, carboxymethyl chitosan, poloxamer 407 and poloxamer 188 are added, and mixed evenly to prepare a Chinese medicine composition for treating allergic rhinitis, which has a good effect of improving allergic rhinitis, adopts a method of combining traditional Chinese and Western medicine, reduces inflammatory response, enhances the immune function of patients, improves the clinical symptoms of patients with allergic rhinitis, reduces the long-term recurrence rate, reduces the use of drugs, improves the quality of life, and reduces the risk of developing asthma, and has broad application prospects.

The invention provides application of baicalin in preparation of a medicine for treating streptococcus agalactiae induced mastitis, and relates to the technical field of medicine. A mouse is selected as an animal model to research the intervention effect and mechanism of the baicalin on the streptococcus agalactiae induced mouse mastitis inflammatory response, and it is clear that the baicalin can play a role in protecting the mouse mammary gland by regulating and controlling an NLRP3 inflammatory small body pathway; a reference basis is provided for treating the cow mastitis caused by streptococcus agalactiae infection by applying the baicalin.

The invention discloses a hydrogel microneedle patch and a preparation method and application thereof.The hydrogel microneedle patch is characterized in that a gel main body is obtained by mixing PEG600 and PEG1000 according to the mass ratio of 3: 4, erythromycin, vaccarin and 7-demethylated corticin are loaded, a temperature response type gel microneedle is prepared, DG is in a solid needle shape at the room temperature, and the temperature response type gel microneedle patch is a hydrogel microneedle patch. Under the action of external force, the medicine can penetrate through a biological membrane secreted by bacteria and then is quickly melted into liquid by virtue of body temperature, and loaded medicine is released; in the invention, the wound healing is promoted through the synergistic effect between the hydrogel and the medicine. The hydrogel microneedle patch prepared by the invention can remarkably promote rapid healing of a staphylococcus aureus infected wound surface and can remarkably promote rapid healing of a back wound surface of a diabetic rat.

The invention belongs to the field of biological tissue and organ 3D printing, and discloses a biomimetic valve type organ obtained through 3D biological printing and corresponding 3D printing ink, and the 3D printing ink for forming the biomimetic valve type organ is biological ink obtained by dispersing a photocurable biological material in a phosphate buffer solution, then adding a photoinitiator solution, uniformly mixing, discharging bubbles, and then adding cell spheres to obtain the photoinitiator. The cell ball is a valve interstitial cell ball with a micron-scale diameter, which is obtained by culturing valve interstitial cells by using an agarose mold in the presence of a cell culture medium; and the agarose mold is provided with micron-scale holes. According to the method, the loading mode of the valvular interstitial cells is improved, the cell balls serve as the minimum printing unit, damage to the cells in the 3D printing period is avoided, the interaction between the cells is enhanced, the cells are stimulated to secrete the extracellular matrix, and extracellular matrix remodeling is completed.

The invention provides a stem cell extract composition for promoting hair growth and a preparation method thereof, and belongs to the technical field of cosmetics. Fetal calf serum, dexamethasone, penicillin, streptomycin, interleukin-2 and magnetic composite particles are added into a DMEM culture medium to prepare the culture medium, the culture medium is used for in-vitro culture of stem cells, during culture, a stem cell solution is prepared by combining a low-frequency magnetic field with low-energy laser culture, exosomes are extracted from an extracting solution, the exosomes and the stem cells are mixed and embedded to prepare embedded microspheres, and the embedded microspheres are used for in-vitro culture of the stem cells. The stem cell extract composition for promoting hair growth is prepared by uniformly mixing the stem cell extract with extracts extracted from fresh ginger, ginseng and polygonum multiflorum, the storage stability of stem cells and exosomes is obviously improved, hair growth is promoted, hair follicle development is promoted, mouse hair is induced and maintained in a growth period, and the stem cell extract composition is free of hormone addition, safe and non-irritant, and has a good application prospect. Wide application prospects are realized.

The invention discloses a sleep-aiding and growth-promoting traditional Chinese medicine composition which is mainly prepared from the following traditional Chinese medicine raw materials by weight: 10-30 g of astragalus membranaceus, 5-15 g of roasted rhizoma atractylodis macrocephalae, 2-8 g of pericarpium citri reticulatae, 10-20 g of codonopsis pilosula, 5-15 g of rhizoma cimicifugae, 2-8 g of radix bupleuri, 2-8 g of angelica sinensis, 10-30 g of radix rehmanniae, 5-15 g of honey-fried licorice root, 10-20 g of Chinese yam, 5-15 g of cortex moutan, 5-15 g of rhizoma alismatis, 5-15 g of dogwood, 1-5 g of cinnamon, 5-15 g of poria cocos and 2-8 g of myristica fragrans. The traditional Chinese medicine is prepared from 5-15 g of radix aucklandiae, 1-5 g of rhizoma coptidis, 2-8 g of fructus amomi, 5-15 g of fructus crataegi, 5- Correspondingly, the invention further discloses a preparation method and application of the traditional Chinese medicine composition for helping sleep and growth. The traditional Chinese medicine composition has outstanding curative effects on poor sleep quality, slow growth, short body, easy cold constitution and adenoid hypertrophy at the same time, and has the effect of treating multiple diseases by one medicine.

The invention provides a Dendrobium officinale Kimura amp (MIG) leaf extract, a preparation method of the Dendrobium officinale Kimura amp (MIG) leaf extract, and application of the Dendrobium officinale Kimura amp (MIG) leaf extract in the fields of cosmetics and medicines. Belongs to the technical field of cosmetics and medicines. The dendrobium officinale leaf extract WYH169, the dendrobium officinale leaf extract WYH2202, the dendrobium officinale leaf extract WYH205 and the dendrobium officinale leaf extract WYH328 have the effect of promoting collagen secretion in human dermis fibroblasts (human dermis fibroblasts, HDFa), and can be used for preparing anti-aging drugs or skin care products, so that the dendrobium officinale leaf extract WYH169, the dendrobium officinale leaf extract WYH2202, the dendrobium officinale leaf extract WYH205 and the dendrobium officinale leaf extract WYH328 can be used for preparing anti-aging drugs or skin care products.

The preparation method comprises the following steps: selecting PLGA (poly (lactic-co-glycolic acid)) with biocompatibility and biodegradability as a carrier material, loading an immunopotentiator alpha-tocopherol on PLGA nano-particles, and preparing the nano-particle immunologic adjuvant by using a nano-precipitation method, so as to obtain the nano-particle immunologic adjuvant with an immune synergistic effect. By controlling the polymer concentration and the drug concentration in the preparation process, the average particle size of the drug-loaded nano-particles is 90-120nm, the monodispersion coefficient is less than 0.2, the particle size of the product is uniform and stable, the encapsulation efficiency reaches 80% or more, the content of alpha-tocopherol in the nano-particles is 1-30%, and the drug-loaded nano-particles have a sustained-release effect of one month or more. The PLGA nanoparticles loaded with alpha-tocopherol can promote proliferation of mouse macrophages and enhance secretion of cell inflammatory cytokines and expression of surface costimulatory molecules, have a synergistic enhancement effect of the PLGA nanoparticles and alpha-tocopherol, and can be used as an effective immunologic adjuvant.

The invention provides a skin care composition containing stem cell extract as well as a preparation method and application of the skin care composition, and belongs to the technical field of cosmetics. The method comprises the following steps: mixing and culturing the extracted urine-derived stem cells and pilose antler stem cells in a DMEM culture medium added with epidermal growth factors, cholera toxin, penicillin, streptomycin, transferrin, IL-2 and IL-15, then separating a culture solution to obtain mixed exosomes, mixed stem cells and extracellular matrixes, preparing the mixed stem cells into stem cell lipidosome, and preparing the stem cell lipidosome. Embedding the stem cell extract and the mixed exosome into titanium dioxide / silicon dioxide microspheres, adding into an extracellular matrix, and uniformly dispersing to obtain the skin care composition containing the stem cell extract. The skin care composition containing the stem cell extract prepared by the invention can obviously prolong the preservation period of stem cells and exosomes and improve the repair and improvement of the stem cells and the exosomes on skin, and the prepared composition has better effects of resisting aging, whitening, promoting skin elasticity, resisting wrinkles and the like, and has a wide application prospect.

The invention discloses a display device with an active red light function and application thereof, and belongs to the technical field of display. Comprising a backlight unit; the backlight unit comprises a light guide plate and a light source; the light source comprises a red light source and a blue light source; the light source is located on the lower side of the diffusion plate or located on at least one side of the periphery of the light guide plate. A quantum dot yellow film, a first prism film, a second prism film, a DBEF brightness enhancement film, a diffusion film and a liquid crystal panel are sequentially arranged on the upper side of the diffusion plate or the light guide plate from bottom to top in a stacked mode. When the display device is applied, the white light mode is used for conventional use, the quantum dot yellow film is used for converting blue LED backlight, high-purity green light and eye protection red light with the long wavelength of 650 nm are emitted, the blue light content in the display device can be remarkably reduced, the display color gamut can be improved, and the eye use comfort degree can be improved. In the red light mode, the display device is used for emitting high-intensity long-wavelength 650nm eye protection red light, so that the beneficial effects of preventing and controlling myopia and protecting eye health are achieved.

The invention discloses a whitening composition suitable for sensitive skin and capable of improving skin resistance and self-healing power and application of the whitening composition, and belongs to the technical field of cosmetics. The whitening composition provided by the invention is prepared from the following components in parts by mass: 0.1 to 3 parts of mulberry root extract, 0.1 to 3 parts of golden camellia extract, 0.01 to 1 part of wood apple extract, 0.1 to 3 parts of herba andrographitis extract and 0.01 to 1 part of epigallocatechin gallate. According to the whitening composition disclosed by the invention, the components in a proper mass ratio are selected for compounding, and the obtained whitening composition can effectively promote generation and secretion of human beta defensin in a skin barrier, so that the tight connection function of the skin barrier is effectively improved, the resistance of the skin is improved, and the metabolism of the skin can be effectively promoted; the self-healing power of the skin is activated; the skin is mildly whitened.

The invention relates to the technical field of health-care products, in particular to a health-care product rich in momordica charantia polypeptide and capable of regulating blood sugar metabolism and promoting insulin secretion, momordica charantia polypeptide can stimulate pancreatic beta cells to secrete insulin, and insulin is the only hormone capable of reducing blood sugar in a human body. The balsam pear polypeptide component in the balsam pear extract is specially used for reducing the blood sugar level and improving related health problems, the application of the balsam pear polypeptide in the health care product can effectively regulate the blood sugar metabolism of a human body and promote the secretion of insulin, and the balsam pear polypeptide stimulates pancreas islet beta cells to promote the secretion of insulin. In addition, the balsam pear polypeptide can improve the insulin resistance, increase the number of insulin receptors or enhance the activity of the insulin receptors, so that the body cells are more sensitive to the insulin, the uptake and utilization of glucose are promoted, and the abnormal increase of the blood glucose level is avoided.

The invention belongs to the technical field of agricultural microorganisms, and particularly relates to an aspergillus niger composition and application thereof. According to the composition disclosed by the invention, the aspergillus niger and the fertilizer synergist are combined for application, a synergistic effect is achieved, and the aspergillus niger also has high-concentration lead tolerance and lead repairing capability. The composition disclosed by the invention not only has phosphorus dissolving and straw degrading functions, but also can effectively improve the soil fertility and reduce the effectiveness of heavy metal lead. The composition disclosed by the invention plays an important role in promoting reutilization of phosphorus-containing solid wastes, promoting decomposition of straws, reducing emission of industrial and agricultural wastes, reducing the bioavailability of lead, maintaining the safety of an ecological environment and the like.

The invention provides a pedicel and inflorescence extract of Gastrodia elata Blume, a preparation method of the pedicel and inflorescence extract of Gastrodia elata Blume, and application of the pedicel and inflorescence extract of Gastrodia elata Blume in the fields of cosmetics and medicines. Belongs to the technical field of cosmetics and medicines. The gastrodia elata pedicel and inflorescence extracts ZTM-2, ZTM-4, ZTM-5, ZTM-6, ZTM-7 and ZTM-8 have the effect of promoting collagen secretion, and the ZTM-5 and the ZTM-6 have the activity of promoting collagen secretion in human dermis fibroblasts (human dermis fibroblasts, HDFa) at the extremely low concentration (1 mu g / mL), and have the activity of promoting collagen secretion in human dermis fibroblasts (human dermis fibroblasts, human dermis fibroblasts) at the extremely low concentration (1 mu g / mL) at the extremely low concentration (1 mu g / mL) at the extremely low concentration (1 mu g / mL) at the extremely low concentration (1 mu g / mL) at the extremely low concentration (1 mu g / mL). Under the concentration, the compound has no cytotoxicity and can be used for preparing anti-aging drugs or skin care products.

The invention provides ancient plum syrup as well as a preparation method and application thereof, and belongs to the technical field of foods. The ancient plum syrup comprises the following raw materials in parts by weight: 14-25 parts of smoked smoked plum, 8-10 parts of roselle, 8-10 parts of mulberry, 3-6 parts of sweet osmanthus, 8-10 parts of pericarpium citri reticulatae, 8-15 parts of hawthorn, 3-6 parts of liquorice, 10-15 parts of red dates, 1-5 parts of mint and 100-120 parts of brown rock candy. The ancient plum syrup is prepared from genuine traditional Chinese medicinal materials, and is higher in purity, more accurate in formula and good in taste; the beverage has the effects of relieving summer-heat, resisting fatigue, appetizing, helping produce saliva and slake thirst, nourishing and protecting liver, warming lung to dissipate beverage and the like.

The invention provides scalp oil-controlling and soothing essence added with agilawood extract and a preparation process of the scalp oil-controlling and soothing essence. The scalp oil-controlling and soothing essence comprises the following components in percentage by weight: 3 to 9 percent of agilawood extract, 1 to 3 percent of chlorella extract, 0.3 to 0.8 percent of scalp conditioner, 0.1 to 0.6 percent of scalp soothing factor, 0.01 to 0.4 percent of hydrolyzed procyanidine, 1 to 3 percent of mulberry stem extract, 0.5 to 1.8 percent of PEG-40 hydrogenated castor oil, 0.4 to 0.9 percent of sodium laureth sulfate, 0.1 to 0.6 percent of xanthan gum, 1 to 3 percent of olive fruit oil, 0.8 to 1 percent of sodium benzoate, 0.2 to 0.6 percent of phenoxyethanol and 0.5 to 1 percent of jojoba oil. According to the present invention, the preparation process is simple, and the prepared essence is beneficial to improvement of skin irritation and other states, can improve the scalp grease secretion condition, can adjust the scalp micro-ecological balance, can maintain the scalp fresh and cool, can effectively strengthen the hair root, inhibit the hair loss, adjust the metabolism, and promote the growth of new hair, and further has characteristics of no side effect, no side effect, and no side effect. After long-term use, the hair can be nourished, and the hair is smoother and fluffy.

The invention relates to the technical field of livestock feed, in particular to a nutrient solution containing chlorella as well as a preparation method, application and a use method of the nutrient solution. The nutrient solution comprises a chlorella product, a nutrition additive and a rumen fermentation regulator, and the ratio of the chlorella product to the nutrition additive to the rumen fermentation regulator is 100 mL: (5-10) g: (20-35) g. The chlorella product is prepared from chlorella enzymatic hydrolysate and lactobacillus plantarum fermentation liquor. The nutrition additive comprises vitamins and trace elements; the rumen fermentation regulator comprises sodium bicarbonate and chitosan. The invention also provides an application of the nutrient solution in barn-feeding beef cattle breeding and a preparation and use method of the nutrient solution. The prepared nutrient solution containing chlorella not only can improve the immunity of barn-feeding beef cattle, but also can reduce fat deposition of the beef cattle and improve the beef quality.

The invention discloses an amniotic mesenchymal stem cell exosome and a preparation method and application thereof.The preparation method comprises the following steps that amniotic mesenchymal stem cells are inoculated into a complete culture medium to be cultured, and after the cells adhere to the wall, epidermal growth factors and polypeptide are added into the complete culture medium to continue to be cultured; replacing the complete culture medium, continuously culturing until the cell fusion degree is not lower than 85%, replacing the complete culture medium again, culturing, and collecting supernate; and extracting the exosome in the supernate by adopting an ultracentrifugation method to obtain the amniotic mesenchymal stem cell exosome. According to the preparation method of the amniotic mesenchymal stem cell exosome, the epidermal growth factor and the polypeptide are added into the culture medium, so that secretion of the cell exosome can be stimulated, meanwhile, carrying substances of the exosome are improved, the functions of promoting cell proliferation, migration and the like of the exosome are improved, and then healing of skin injury can be better promoted; the wound healing time is obviously shortened, and the pain of a patient is relieved.

The invention mainly relates to composite hydrogel of a targeted cartilage end plate as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of biological medicines. The composite hydrogel of the targeting cartilage end plate comprises a cartilage targeting peptide modified drug-loaded exosome, calcium carbonate, chitosan and water, and the cartilage targeting peptide modified drug-loaded exosome comprises an exosome, a cartilage targeting peptide and salvianolic acid A. The composite hydrogel of the targeting cartilage end plate is prepared by the following steps: encapsulating salvianolic acid A by exosome derived from human mesenchymal stem cells, modifying by cartilage targeting peptide to obtain drug-loaded exosome modified by the cartilage targeting peptide, and mixing the drug-loaded exosome with calcium carbonate, chitosan and water. The compound can be used for accurately targeting cartilage endplate cells (CEPCs), remarkably relieving the inflammation of the CEPCs, changing the secretion phenotype of the CEPCs, delaying the senescence of nucleus pulposus cells (NPCs), relieving the inflammation of the NPCs and effectively treating intervertebral disc diseases.