1037results about How to "Inhibition of secretion" patented technology

A unique DHA product, 10, 17S-docosatriene (“Neuroprotectin D1” or “NPD1”), was found to provide surprisingly effective neuroprotection when administered right after an experimental stroke. Moreover, both nerve cells and retinal pigment epithelial (RPE) cells were found to synthesize 10,17S-docosatriene (NPD1) from DHA. NPD1 also potently counteracted H₂O₂/TNFα oxidative stress-mediated cell apoptotic damage. Under the same oxidative-stress conditions, NPD1 up-regulated the anti-apoptotic Bcl-2 proteins, Bcl-2 and Bcl-xL, and decreased expression of the pro-apoptotic proteins, Bad and Bax. Moreover, in RPE cells NPD1 inhibited oxidative stress-induced caspase-3 activation, IL-1β-stimulated human COX-2 promoter expression, and apoptosis due to N-retinylidene-N-retinylethanolamine (A2E). Overall, NPD1 protected both nerve and retinal pigment epithelial cells from cellular apoptosis and damage due to oxidative stress. NPD1 concentration in the brain of Alzheimer's patients was found to be significantly decreased from that of controls. In cultured human brain cells, NPD1 synthesis was up-regulated by neuroprotective soluble β amyloid, and NPD1 was found to inhibit secretion of toxic β amyloid peptides.

The invention comprises peptidyl analogs of ghrelin having greater stability which are active at the GHS receptor according to formulae depicted below:

(R²)-A¹-A²-A³-A⁴-A⁵-A⁶-A⁷-A⁸-A⁹-A¹⁰-A¹¹-A¹²-A¹³-A¹⁴-A¹⁵-A¹⁶-A¹⁷-A¹⁸-A¹⁹-A²⁰-A²¹-A²²-A²³-A²⁴-A²⁵-A²⁶-A²⁷-A²⁸-R¹

wherein the definitions of A¹ to A²⁸, R¹ and R² are provided for in the specification, with the exception that the N-terminal amino acid must be selected from the group consisting of Inp, 1-Apc and 4-Apc, the pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising an effective amount of said compound together with therapeutic and non-therapeutic uses thereof.

The present invention relates to biocompatible biogel compositions and methods of drug delivery. The biocompatible biogel is a physical polymer matrix formed via affinity interactions between its components. The components of the biocompatible biogel comprise a cationic component, an anionic component, and optionally a therapeutic agent.

A functional health-care beverage for elongating life of man and taking care of the health of man is prepared from the grains wine and 43 Chinese-medicinal materials including ginseng, pilose antler, genoderma, cordyceps, etc.

The invention provides conditioning powder suitable of being eaten by a diabetic patient. The conditioning powder comprises 6-12 parts of water-soluble dietary fiber extractive, 0.1-1 part of wheat germ extractive, 0.1-1.5 parts of soybean protein isolate, 1-3 parts of secalin, 0.5-2 part of vegetable fat powder, 0.2-1.5 parts of Chinese yam extractive, 0.2-1 part of sealwort extractive, 0.2-1 part of mulberry leaf extractive, 0.2-1 part of polygonatum odoratum extractive, 0.1-1 part of medlar extractive, 0.1-0.3 part of flaxseed gum, 0.5-2 parts of L-arabinose, 0.09-0.3 part of yeast and 0.001-0.006 part of zinc gluconate. The conditioning powder is low in carbohydrate content, has abundant nutrients, is particularly suitable for serving as food of the diabetic patent, has the remarkable hypoglycemic effect and the conditioning function, has the prevention and treatment functions on various diabetic complications, and particularly has the good conditioning effect on a diabetes type nephropathy patient. The nutrients of the conditioning powder are easy to digest and absorb. The conditioning powder is convenient to eat and good in taste.

The invention develops a simplified method for the in-vitro isolation and expansion of umbilical mesenchymal stem cells (MSCs) and confirms that the MSCs obtained by the method have the effects of immunoregulation and inflammation inhibition in the treatment of rheumatoid arthritis.

Disclosed is an expression vector system for variants of coagulation factor VIII (FVIII) and von Willebrand factor (vWF). In detail, mutant vWF the size of which is significantly reduced by deleting exons but which has remarkably increased FVIII stabilizing and activating efficiency, and an expression vector system useful for the treatment of hemophilia which is capable of expressing the same along with FVIII are disclosed. Use of the mutant vWF with a reduced size enables effective expression of FVIII in a viral vector and significantly enhanced FVIII activity. Further, the viral vector may be effectively used to treat hemophilia through gene therapy.

The present invention is related to novel oral compositions comprising an irreversible gastric H⁺/K⁺-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor, pentagastrin (PG) or a PG analogue as an activator of parietal cells in the gastric lumen. In a preferred embodiment, the composition further comprises at least one agent that preserves the availability of PG in the gastric fluids, thus enabling PG to act locally in the stomach. Unexpectedly, the compositions of the present invention exhibit anti-acid activity locally in the stomach that is meal-independent, exhibit fast onset and prolonged inhibition of acid secretion.

The invention discloses an L-arabinose functional biscuit and a manufacturing method thereof, and belongs to the technical field of health-care foods. The technical key points are that: L-arabinose is added into the raw materials of the biscuit; the formula and the proportion of the raw materials are adjusted; the using amount of the common sugar raw material is reduced; and the raw materials consist of weak flour, phospholipid, milk powder, egg, refined salt, vegetable oil, baking soda, taurine, L-arabinose and granulated sugar. The process comprises the following steps of: (1) preparing the raw materials; (2) proofing; (3) shaping; (4) baking; (5) spraying oil; (6) drying and cooling; (7) inspecting the finished product so as to obtain the finished product. The biscuit suppresses the absorption of the human body to the cane sugar, suppresses insulin secretion and obesity, protects the blood sugar level from rise and prevents occurrence of hyperglycemia by adding the L-arabinose in the raw materials, and solves the problems that people with obesity, hyperglycemia, insulin disorder, diabetes and the like cannot eat biscuit; and because the phospholipid, the taurine and the like are added into the raw materials, the product has high nutritive value and good mouthfeel and is suitable for all the people to eat.

The present invention provides a thienopyrimidine compound, represented by the formula

• • [wherein, R¹ is C_1-4 alkyl, R² is (1) phenyl optionally having a substituent such as amino, mono C_1-4 alkylamino and di C_1-4 alkylamino, or (2) a heterocyclic group optionally having a substituent such as amino, mono C_1-4 alkylamino and di C_1-4 alkylamino and the like, R³ is a hydrogen atom or C_1-4 alkyl, R⁴ is C_1-4 alkyl optionally having a substituent such as C_1-4 alkoxy-carbonyl, carboxyl, mono C_1-4 alkylamino and N—C_1-4 alkyl-N—C_7-10 aralkylamino and the like] or a salt thereof, which has antagonistic action for gonadotropin-releasing hormone.

Methods and compounds for increasing or decreasing mucus secretion in subjects, and particularly mucus secretion in the airways, are described. Methods of screening compounds for the ability to increase or decrease mucus secretion are also described.

A pharmaceutical composition for preventing or treating chronic inflammatory airway diseases comprising alpha-enolase protein as an active ingredient is provided. The present invention also provides a diagnostic composition and a diagnostic kit for diagnosing chronic inflammatory airway diseases comprising alpha-enolase protein. The present invention further provides a composition for screening a therapeutic agent for chronic inflammatory airway diseases, comprising one or more of alpha-enolase protein or autoantibodies to alpha-enolase obtained from patients with chronic inflammatory airway diseases, and a method for screening a therapeutic agent for chronic inflammatory airway diseases using this composition. The present invention still further provides methods for diagnosing, preventing or treating chronic inflammatory airway diseases using alpha-enolase protein.

Relating to the fields of biotechnologies and gene therapy, the invention provides application of a gene modified mesenchymal stem cell in pulmonary fibrosis treatment. The gene modified mesenchymal stem cells are obtained through: in-vitro isolated culture and amplification of a mesenchymal stem cell (MSC) deriving from bone marrow and an umbilical cord, and recombinant adenovirus Ad-HGF mediated in-vitro modification of the MSC by a hepatocyte growth factor (HGF). By transplanting the gene modified MSC to a C57 mouse to intervene in radiation induced lung injury and fibrosis, exudation of a plurality proteins including albumin, IgM and the like from an alveolar space can be reduced, local inflammatory responses of the lung can be alleviated, and expression of TNF-alpha, soluble ICAM-1 and multiple factors is inhibited, expression of the profibrotic factor TGF-beta, the collagen gene col1 alpha 1 and col 3 alpha 1 can be inhibited, and pulmonary tissue collagen fiber deposition is reduced. The expression results of endogenous HGF and its receptor cmet show that endogenous HGF expression can be induced and endogenous MSC can home to injured parts. Therefore, the employment of HGF modified MSC in treatment of lung injury and fibrosis brought by various pathogenic causes is of great significance.

A kitchen mask includes a cover body provided for covering a mouth/nose position of a user's face, a strap disposed separately on both sides of the cover body and installed at the user's ears, and a nose portion disposed on the cover body and corresponding to the user's nose, and matched with the user's nasal profile, such that when the kitchen mask is worn, the nose portion is protruded out from the cover body, and at least one air hole disposed at the nose portion and corresponding to a position of the user's nostril, and having a thin ventilating filter material disposed at the air hole of the nose portion.

The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

Compounds represented by the general formula. [I]:

wherein R¹ and R² are each hydrogen, halogen, an optionally substituted linear hydrocarbon group, or hydroxyl which may be substituted with an optionally substituted liner hydrocarbon group, or R¹ and R² together with the carbon atoms adjacent thereto may form an optionally substituted cyclic hydrocarbon or a dihydrofuran ring which may have an oxo group; ring A is a benzene ring which may be further substituted; ring B is an aromatic ring which may be substituted; X is a bond or a spacer whose main chain has 1 to 6 atoms; Y is carboxyl which may be esterified, carbamoyl which may be substituted, cyano, or an optionally substituted heterocyclic group bearing a hydrogen atom capable of being deprotonated, or salts thereof, which are useful as lipid-rich plaque regressing agents and/or ACAT inhibitors.

The present invention relates to a pharmaceutical composition having dopaminergic activity and other related pharmaceutical activities comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s), optionally along with excipients(s); a process of preparing a pharmaceutical composition comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s), optionally along with excipients(s), wherein the process comprising steps of: (a) extracting a clear solution containing trigonelline and 4-hydroxyisoleucine from plant source; and (b) optionally precipitating derivative(s) of trigonelline and 4-hydroxyisoleucine from the clear solution and obtaining said composition; and an in-vitro method to increase levels of dopamine or to inhibit prolactin by allowing composition comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s) to bind to cell receptors.

The invention discloses a skin caring composition having a function of removing acne, a preparation and a preparation method of the skin caring composition. The skin caring composition consists of the following functional components in parts by weight: 0.01-2 parts of zinc carbonate hydroxide, 0.01-0.1 part of borax, 0.001-0.01 part of amber powder, 0.001-0.05 part of pearl powder, 0.5-2 parts of salicylic acid, 0.1-1 part of borneol, 0.1-1 part of salvia miltiorrhiza extract, 0.075-0.75 part of syzygium aromaticum extract, 0.065-0.65 part of scutellaria baicalensis extract, 0.05-0.5 part of liquorice extract, 0.12-1.2 parts of potassium azelaoyl diglycinate, 0.05-0.5 part of radix sophorae flavescentis extract, 0.01-0.1 part of vitamin B6, 0.01-0.5 part of houttuynia cordata extract and 0.5-5 parts of mint oil. The skin caring composition is scientific and strict in formula, definite in effect and free from toxic and side effect, and has obvious functions of reducing skin roughness and removing acne; and the skin caring composition can guarantee a good skin status.