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An olefin metathesis process involving contacting an unsaturated fatty acid ester or unsaturated fatty acid, such as methyloleate or oleic acid, with a lower olefin, preferably ethylene, in the presence of a metathesis catalyst so as to prepare a first product olefin, preferably, a reduced chain α-olefin, such as methyl-9-decenoate or 9-decenoic acid, respectively. The metathesis catalyst contains ruthenium or osmium and a chelating ligand, preferably, a chelating ligand containing a carbene moiety and a second donor moiety of a Group 15 or 16 element Optionally, the catalyst can be supported on a catalyst support, such as, a cross-linked polymeric resin.

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Described herein are processes for the preparation of compounds of formula (I): and pharmaceutically acceptable salts, solvates, and hydrates thereof.

O.sup.6 -hetarylalkyl- or naphthylalkylguanine derivatives of the formula ##STR1## wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR', wherein X is O or S, R" and R"' are alkyl, or substituted derivatives thereof, R' is H, or alkyl or hydroxyalkyl R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocylic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hereto atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) naphthyl or a substituted derivative thereof and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity. A process for preparation of the compounds is described. The compounds have utility in combination with alkylating agents in the chemotherapeutic treatment of tumour cells.

The present invention provides a thienopyrimidine compound, represented by the formula

• • [wherein, R¹ is C_1-4 alkyl, R² is (1) phenyl optionally having a substituent such as amino, mono C_1-4 alkylamino and di C_1-4 alkylamino, or (2) a heterocyclic group optionally having a substituent such as amino, mono C_1-4 alkylamino and di C_1-4 alkylamino and the like, R³ is a hydrogen atom or C_1-4 alkyl, R⁴ is C_1-4 alkyl optionally having a substituent such as C_1-4 alkoxy-carbonyl, carboxyl, mono C_1-4 alkylamino and N—C_1-4 alkyl-N—C_7-10 aralkylamino and the like] or a salt thereof, which has antagonistic action for gonadotropin-releasing hormone.

A pyrrolo[3,2-d]pyrimidine derivative represented by the formula (I) or a pharamaceutically acceptable salt of the derivative. The derivative or salt is useful as a GSK-3 inhibitor.

The invention discloses a diesel vehicle exhaust purification SCR (Selective Catalytic Reduction) catalyst. The catalyst comprises a cordierite honeycomb ceramic carrier and a coating which is loaded on the cordierite honeycomb ceramic carrier; the coating comprises the following raw materials: titanium dioxide/silicon dioxide composite oxide powder, ammonium tungstate and ammonium metavanadate according to a mass ratio of 100:(12-18):(3-6). A preparation method of the catalyst comprises the steps of mixing the ammonium tungstate with the titanium dioxide/silicon dioxide composite oxide powder firstly to prepare TiO2-SiO2/WO3 pccowder, then mixing the ammonium metavanadate with TiO2-SiO2/WO3 to prepare slurry to be coated, and then coating the cordierite honeycomb ceramic carrier with the slurry to be coated by using an impregnation method. The catalyst is wide in activity temperature window, high in high-temperature activity and water/heat resistant stability, and good in reproducibility.

An electric catalyst used for proton exchange membrane fuel cells, active component is Pt or PtRu, auxiliary component is titanium oxide; the atom ratio of platinum and titanium is 0.01-99, the atom ratio of platinum and ruthenium is 0.01-99, the particle size of the active component is 1-20nm. The active component can be impregnated in the titanium oxide modified porous conductive material, gained support-type electric catalyst, which contained activity group sharing percentage for the quality of 1-99%, the atom ratio of platinum and titanium is 0.01-99. Active components can be added as a percentage of 0-99% of the auxiliary components, become a multi-component catalysts; adding auxiliary components was transition metal or a transition metal oxides or several. Preparation methods can be used colloidal law or impregnation - Reduction Act. The invention of the electric catalyst can be used in proton exchange membrane fuel cells.

The invention discloses a catalyst for preparing light aromatic hydrocarbon by synthetic gas one-step process, and a preparation method and an application thereof. The catalyst comprises a Fischer-Tropsch synthesis catalyst and an aromatization catalyst, wherein the Fischer-Tropsch synthesis catalyst includes an oxide of Fe and an oxide of Mn, and a composite metal oxide can fully improve the high-temperature Fischer-Tropsch synthesis activity; the aromatization catalyst is a modified molecular sieve with HZSM-5 as a carrier and with Mo and Ni double metals as active components, and the aromatization performance can be significantly improved. Through the combination of the two catalysts, series coupling of a Fischer-Tropsch synthesis reaction and an aromatization reaction is achieved, a one-way conversion rate of CO is increased obviously, and at the same time, a technology route for preparing light aromatic hydrocarbon-benzene, toluene and xylene (BTX) by synthetic gas one-step process is exploited. Experiments verify that the conversion rate of CO reaches up to 98% or more, the selectivity of hydrocarbonyl of aromatic hydrocarbon reaches 73% or more, and the selectivity of hydrocarbyl of BTX reaches 53%. The catalyst for preparing aromatic hydrocarbon by the synthetic gas one-step process has the advantages of relatively good catalytic activity, good stability and simple preparation, and has relatively good industrial application prospects.

The invention belongs to the food processing field, in particular relates to a method for preparing an acidic drink from the main raw material of burdock by means of the fermentation of a few compound bacteria including lactobacillus rhamnose, lactobacillus acidophilus, lactobacillus plantarum and bifidobacteria. A method for preparing an immunity-enhancing burdock lactic acid bacteria drink is a fermentation process of lactic acid bacteria by taking burdock juice, brown sugar, stabilizer and water as raw materials and the compound bacteria of the lactobacillus rhamnose, the lactobacillus acidophilus, the lactobacillus plantarum and the bifidobacteria as strains. The method disclosed by the invention has the advantages that the drink which is prepared according to the method for preparing the burdock lactic acid bacteria drink from the raw material of the burdock juice by means of the fermentation of the compound bacteria contains the active ingredient of burdock and accordingly, is favorable for the health of a human body and capable of enhancing the immunity of the human body; the product obtained from the process for preparing the burdock lactic acid bacteria drink is stable in performances, pure and smooth in taste and abundant in nutrients.

The invention relates to a nickel iron bimetallic methanation catalyst and preparation and application thereof; according to the ratio of 0.7-1ml of a soluble salt solution to 1g of an alumina carrier, the prepared soluble salt solution is immersed on the carrier; according to the ratio of 0.7-1ml of a soluble nickel salt solution to 1g of an additive-containing carrier, the soluble nickel salt solution is immersed on the carrier to obtain a nickel containing carrier; according to the ratio of 0.7-1ml of a soluble iron salt solution to 1g of the nickel containing carrier, the soluble iron salt solution is immersed on the nickel containing carrier for drying and roasting to obtain the catalyst; nickel oxide is 2.5-10wt%; iron oxide is 2.5-10wt%; an additive is 0.01-5wt%; the additive is at least one substance from lanthanum, cerium, barium and magnesium; the catalyst greatly improves low temperature methanation activity of the catalyst, decreases the cost of the catalyst, improves methane selectivity of the catalyst, and increases the stability of the catalyst.

The invention discloses a method for catalytic oxidation of cyclohexane by using a supported-type Au/C3N4@SBA-15 nano-catalyst, and belongs to the technical field of chemical engineering. The catalyst is prepared by the following steps: loading dicyandiamide on SBA-15 by an impregnation method, and roasting at certain temperature to prepare a C3N4@SBA-15 carrier; conducting effective loading of gold by an anion exchange method; and filtering, washing, drying and roasting. The method for catalytic oxidation of cyclohexane is as below: placing the prepared catalyst in a reactor, adding a certain amount of cyclohexane, heating the reactor to a certain temperature, introducing oxygen, rising to a certain pressure and maintaining for a period of time; and finally collecting the products and conducting gas chromatographic analysis. The cyclohexane oxidation reaction using the catalyst has selectivity on products cyclohexanol and cyclohexanone of above 90% and conversion rate of more than 13%, which are significantly better than those of an Au / SBA-15 catalyst.

The invention relates to medical facilities, aiming at providing a hybrid artificial liver support system equipped with a nano fibre sheet stacked reactor. The system comprises a plasma separating part, a nonbiological liver circulating part and a biological liver circulating part which comprises a thermostatic gas bath incubator; an extracorporeal circulating pool, a plasma pump and dissolved oxygen which are connected sequeitically and form a circulating system; a temperature testing bottle; and the nano fibre sheet stacked reactor. The system is easily to be amplified so as to improve the defect that cells block a semipermeable membrane easily, the efficiency of material exchange is high and both oxygenation and immunity obstruction function are provided. The reactor has strong function, can be used for biological or hybrid artificial liver, and also used for the cultivation and inducing differentiation of stem cells. The reactor of the system has oxygenation function, thereby saving an oxygenator needing to be equipped independently in normal systems.

The invention discloses a lignin-degrading enzyme regulator and an application thereof. The lignin-degrading enzyme regulator is added by two steps in an aerobic composting process. The lignin-degrading enzyme regulator comprises a manganese peroxidase and lignin peroxidase regulator and a laccase regulator, wherein the manganese peroxidase and lignin peroxidase regulator comprises mixed liquid A of Tween 80, hydrogen peroxide and trace stimulation elements; the laccase regulator comprises mixed liquid B of Tween 80, 1,2-dimethoxybenzene and trace stimulation elements. The lignin-degrading enzyme regulator can be used for regulating secretion of lignin-degrading enzyme in fungi and has the advantages of good promotion effect, simple, economic and practical technology and the like.

An exhaust gas purifying catalyst formed by having a first rhodium-containing catalyst layer, a second zeolite-containing catalyst layer, and a third palladium-containing catalyst layer superposed sequentially on a carrier, and a process for purifying the exhaust gas from an internal combustion engine by using the catalyst. A catalyst possessing durability and excelling in the ability to adsorb hydrocarbon, the ability to purify, and the three-way performance is provided.

The present invention relates to a metal nanoplate, a method for manufacturing same, and a conductive ink composition and a conductive film comprising metal nanoplate. The metal nanoplate does not require application of a high temperature and high pressure and thus can be easily manufactured at a low temperature and at normal pressure, and a conductive film or a conductive pattern, among others, having excellent conductivity can be formed even when the conductive ink composition comprising the metal nanoplate is printed on a substrate and then heat-treated or dried at a low temperature. As a result, the metal nanoplate and the conductive ink composition comprising same can be very appropriately applied to various semiconductor elements, display devices, or when forming a conductive pattern or a conductive film for a solar cell in an environment requiring low-temperature firing.

A crossbreed method for different geographical species parti-colour abalone, which relates to a genetic improved method for parti-colour abalone, especially relates to a crossbreed method using different geographical species parti-colour abalone which comprises, putting the abalone in 16-18Deg C. sea water and elevating temperature to make the parent abalone accelerate. The bait comprises gracilaria 100, Ulva lactuca 30-60, pinnatifida 20-50, spirulina 1-15. Injecting 5-hydroxytryptamine to the head or abdominal feet of the parti-colour abalone, and making the lay eggs and discharge spermium synchronous with a different geographical parti-colour abalone. Making artificial insemination and getting filial generation. and guaranteeing the survival rate during the line haul, making a two species parent parti-colour abalones mature in a same time by using reasonable bait breeding; Using ejecting 5-hydroxytryptamine to make the gamete discharge in a same time and overcome the physiological difference of gamete discharging and sexual maturity because of geographic isolation of different geographical species, and making the gonadal mature and gamete discharge at the same time.

A high-temperature solution process for polymerizing ethylene is disclosed. The polymerization is performed in the presence of a preassembled bimetallic Ziegler-Natta catalyst and an aluminum compound. Molecular modeling calculations predict that the bimetallic Ziegler-Natta catalyst will have good activity and improved stability versus traditional Ziegler-Natta catalysts. This makes the catalyst especially suitable for solution polymerization processes, which require a thermally robust catalyst.

The invention relates to cell culture and transplantation, in particular to a serum-free medium which is suitable for microencapsulated CHO cells, wherein, DMEM/F12 is taken as a basic medium; the characteristics of growth and metabolism of the microencapsulated cells are focused; and a certain proportion of insulin, soybean lecithin, Tween 80, Tropolone, FAC, sodium selenite, beta-mercaptoethanol and amino acid are added. The serum-free medium can promote vigorous growth of the microencapsulated CHO cells, and the cell density, the product expression and the activity all reach or are superior to the cell culture level of a serum medium, thereby the serum-free medium can replace the serum medium to be used for culture and transplantation of the microencapsulated CHO cells, greatly reduce the culture cost, and improve the biological safety of the microencapsulated animal cells.

The invention belongs to the technical field of microbes, and particularly relates to a method for preparing a low temperature-resistant garbage treatment composite microbial agent. The method comprises the following steps: strain collection, strain separation, strain enrichment, strain acclimation, primary strain screening, low temperature acclimation, and preparation of the composite microbial agent. The composite microbial agent prepared by the method of the invention is better than commercial common microbial agents in microbial agent growth, the removal rate of ammonia nitrogen and COD inlandfill leachate and the enzyme production activity of the cellulose at a low temperature of 10 DEG C; and outdoor simulated reactor test results show that the temperature of the center of the garbage rises fast, the concentrations of ammonia nitrogen and COD in the landfill leachate are low, and the sedimentation rate of the garbage after a reaction is high. The composite microbial agent is suitable for solid garbage treatment in northwest regions, and has a good application prospect.

The present invention relates to a composition for preventing or treating a nerve gas-induced disease comprising a phenyl carbamate compound and a method for preventing or treating a nerve gas-induced disease therewith. The present invention ensures the enhancement of neuroprotection, such that it is promising for preventing or treating various diseases caused by exposure to nerve gas.

The invention discloses a sterilization composition, and belongs to the field of agricultural bactericides. An active component of the sterilization composition comprises bacillus subtilis and polyoxin. The sterilization composition comprises 10 to 85 wt% of the active component. The active component comprises 10 to 70 wt% of bacillus subtilis. The invention also discloses a use of the sterilization composition in prevention and treatment of grey mould fruit rot of strawberry, cucumber fusarium wilt and rice sheath blight. Compared with a sterilization preparation prepared only from polyoxin or bacillus subtilis as an active component, the sterilization composition provided by the invention has better effects and activity of prevention and treatment of grey mould fruit rot of strawberry, cucumber fusarium wilt and rice sheath blight. Because of different mechanisms of effects produced by bacillus subtilis and polyoxin in the active component, polyoxin resistance is relieved and a sterilization composition service life is prolonged.

The invention discloses a platinum catalyst. In the platinum catalyst, organic ligands are a compound containing vinyl and an organic compound containing nitrogen. A platinum complex formed through coordination of the two organic ligands and chloroplatinic acid not only breaks through traditional imprisonment that only a platinum catalyst containing a low content of platinum can be synthesized, and synthesizes the platinum catalyst with a high content of platinum, but also forms the platinum catalyst which has excellent catalytic activity and excellent storage stability. When the platinum catalyst is used for catalyzing and synthesizing silicone rubber, the obtained silicon rubber has excellent vulcanization activity and an excellent mechanical property. In addition, the prepared platinum catalyst can be diluted to various suitable concentrations according to the need so as to be used for silica gel products of various forms, and thus being easy to weigh and accurate in dosage.

The invention provides a kit and method for rapidly detecting the endocrine disrupting activity of a chemical substance based on magnetic microspheres. The kit comprises a microsphere-GST/6*HIS-NR LBDprotein polymer solution, an SRC-BAP protein solution, a BSA Solution, a reaction solution, a washing solution, a color developing solution and a coloring stop solution. According to the invention, the activated microsphere-protein polymer solution, the SRC-BAP protein solution, the BSA solution and a to-be-detected substance are mixed and incubation is performed; after cleaning, the color developing solution is added and color development is carried out and then is stopped; and a light absorption value is measured by a common optical microplate reader; the light absorption value is processedby software and EC50 or IC50 is calculated, so that the receptor activity of a chemical substance is quickly determined. With the provided detecting method, the experimental period can be shortened,the purity and activity of the receptor can be enhanced, and the detection sensitivity can be improved, so that an objective of detecting and screening the endocrine disrupting receptor activity in the chemical product sensitively, efficiently, and rapidly is achieved.

The present invention relates to β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives (I) and a method for preparing same and the use in the aspects of preventing and treating plant viruses, fungicides and insecticides. For the meaning of each group in formula (I) see the description. The β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives of the present invention show a particularly ourstanding anti-plant virus activity, and also have fungicidal and insecticidal activities.

The invention provides a carbon-based bimetal Fe-Mn monatomic electrocatalyst, a preparation and application thereof. The electrocatalyst takes Fe and Mn bimetals as active components, wherein the Feand Mn bimetals are respectively dispersed on the surface of a carbon matrix in a monatomic form, and the microstructure of the catalyst is an oxygen-bridged FeN4-O-MnN4 structure. The method comprises the following steps: carrying out surface functionalization on carbon black with a large specific surface area by utilizing concentrated acid, so that certain oxygen-containing functional groups areattached to the surface of the carbon black, and the carbon black is dispersed in an organic solvent; then introducing acetate precursors of two metals, and adding a ligand to carry out spontaneous complexing reaction; adding a certain amount of MgO nano-particles, so that agglomeration of metal in the high-temperature process can be effectively inhibited; and further performing acid treatment toremove MgO so as to obtain the atom-dispersed bimetallic electrocatalyst. The electrocatalyst provided by the invention can improve the metal atom utilization rate of the material and realize high-efficiency oxygen reduction.

The invention belongs to the technical field of biological gene engineering, and particularly relates to a long-acting canine interferon alpha fusion protein as well as a preparation method and an application thereof. The preparation method comprises the following steps: carrying out codon optimization on canine interferon alpha and CSA truncated peptide, synthesizing the canine interferon alpha and CSA truncated peptide on a plasmid vector, carrying out double enzyme digestion, cloning to obtain a target fragment, carrying out Linker connection to obtain a recombinant plasmid vector protein,carrying out enzyme digestion linearization on recombinant plasmids, and introducing the recombinant plasmids into expression host bacteria to obtain recombinant yeast; and carrying out induced expression, deglycosylation and chromatographic purification to obtain a target protein, namely the canine interferon-alpha fusion protein. The fusion protein is established by adopting an efficient pichiapastoris methanol induced secretory expression system, and meanwhile, CSA truncated peptide and Linker with high stability and long-acting canine interferon alpha with high activity are selected, so that the fusion protein can be used for preparing antiviral drugs.

The present invention relates to aloe vera sprout concentrate or extract having cell growth promotion, antioxidant, and anti-allergy effects, and to a skin cell growth promoting, antioxidant, and anti-allergy pharmaceutical composition and functional health food or cosmetics containing the aloe vera sprout concentrate or extract as an active ingredient.

The invention belongs to the technical field of new energy, and relates to an electrocatalyst for cathodes of fuel cells and metal-air cells, in particular to a core-shell platinum-based alloy electrocatalyst with high oxygen reduction performance and a preparation method of the core-shell platinum-based alloy electrocatalyst. The preparation method comprises the following steps: 1) adding a platinum compound and a transition metal compound into oleylamine, introducing oxygen-containing gas into the reaction system, and conducting heating in an oxidizing atmosphere to carry out a first-stage reaction, then switching the oxidizing atmosphere into an inert atmosphere, continuously conducting heating to carry out a second-stage reaction, conducting cooling after the reaction is finished, andconducting washing to obtain a product; and 2) carrying out electrochemical dealloying treatment on the product to obtain the core-shell platinum-based alloy electrocatalyst, wherein in the step 1), the first-stage reaction time and the second-stage reaction time are not zero at the same time. According to the preparation method, a segmented copolymer represented by PVP and the like is not added as a protective agent, and the Pt-based alloy electrocatalyst is prepared simply by switching atmosphere regulation.

The invention discloses three kinds of acidic high-temperature-resistant recombinant cellulase and application thereof. Amino acid sequences of the three kinds of recombinant cellulase are shown in SEQIDNO:1-3 respectively. The three kinds of recombinant cellulase have the highest enzyme activity of 1.54 U/mg to CMC-Na and the highest vitality of 0.167 U/mg to Avicel under the conditions that thepH value is 4.0-5.0 and the temperature is 60-80 DEG C. The vitality of the three kinds of recombinant cellulase basically remains unchanged under the conditions that the temperature is 75 DEG C and the pH value is 4.0-4.5 after heat preservation is carried out for 2 hours. The three kinds of recombinant cellulase can directly degrade the CMC-Na, crystalline cellulose, filter paper and other natural lignocellulose such as rice straw and wheat straw, and the highest vitality of the three kinds of recombinant cellulase to the rice straw reaches 0.106 U/mg. Compared with the prior art, the threekinds of recombinant cellulose have greater superiority, can effectively degrade the natural lignocellulose, and have potential industrial application value.