22 results about "Decenoic Acid" patented technology

The invention relates to a genetically engineered bacterium with high capric acid tolerance as well as a construction method and application of the genetically engineered bacterium. The genetically engineered bacterium takes escherichia coli as a starting strain, an aaS gene is knocked out, and meanwhile, a mla Z gene and a mla Y gene are overexpressed; wherein the Gene ID (Identity) of the nucleotide sequence of the aaS gene is 947315; the Gene ID (Identity) of the nucleotide sequence of the mla Z gene is 882402; and the Gene ID (Identity) of the nucleotide sequence of the mla Y gene is 882401. The aaS gene in the escherichia coli is knocked out, and the mla Z and mla Y genes are overexpressed at the same time, so that the membrane lipid strength of the escherichia coli engineering bacteria is effectively enhanced, and the genetically engineered bacteria show better robustness and higher tolerance in the fermentation process of a high-concentration substrate capric acid. When the capric acid is fed to the maximum concentration of 3.0 g / L, the yield of the trans-2-decenoic acid can reach 1.47 g / L, the conversion rate is 49.13%, and the yield is remarkably improved.

The present application relates to the technical field of chemical essence and flavor, and particularly relates to a decenoic acid ester compound, a preparation method and application thereof, and comprises the following steps: (1) preparing 2-(4-methyl-benzylidene) heptanal: under the condition of an inorganic alkaline reagent, p-methylbenzaldehyde and n-heptanal are subjected to aldol condensation reaction to synthesize 2-(4-methyl-benzylidene) heptanal; (2) preparing 2-(4-methyl-benzylidene) heptyl alcohol: under the condition of a reducing agent, 2-(4-methyl-benzylidene) heptanal is reduced to 2-(4-methyl-benzylidene) heptyl alcohol; (3) preparing 5-decenoic acid 2-(4-methyl-benzylidene) heptyl alcohol ester: under the catalysis of an acid, 5-decenoic acid and 2-(4-methyl-benzylidene) heptyl alcohol are subjected to esterification to synthesize 5-decenoic acid 2-(4-methyl-benzylidene) heptyl alcohol ester. The compound in the present application has jasmine aroma and milk aroma, has elegant aroma, has long-lasting aroma, and has important use in the field of daily chemical flavoring.

The invention discloses a method for synthesizing jasmine lactone through photocatalytic reaction, and belongs to the field of fine chemicals. The synthesis method comprises the following steps: taking (E)-1, 6-octadiene-3-ketone-2 and iodoacetic acid as raw materials, carrying out photocatalytic reaction to obtain (E)-5-oxo-8-decenoic acid, then reacting with sodium borohydride to obtain (E)-5-hydroxy-8-decenoic acid, and carrying out esterification reaction on a crude product under the catalysis of acid without separation to obtain jasmonlactone. The method for obtaining the jasmine lactone has the advantages of easiness in synthesis of raw materials, mild reaction conditions, low cost and few steps, shows the superiority and simplicity of the synthesis method, and provides a simple way for preparation of the compounds.

To provide a novel penetration enhancer of royal jelly into skin.SOLUTION: A penetration enhancer into skin of 10-hydroxydecanoic acid and / or 10-hydroxy-2-decenoic acid contained in royal jelly, comprising, as an active ingredient, an (ammonium acryloyldimethyltaurate / methacrylic acid beheneth-25) crosspolymer.SELECTED DRAWING: Figure 1

The purpose of the present invention is to provide a composition for activating hair follicle stem cells, said composition containing, as an active ingredient, a naturally-derived, safe-approved component capable of activating hair follicle stem cells. The purpose is achieved by a composition for activating hair follicle stem cells, which comprises: at least one first active ingredient selected from the group consisting of 10-hydroxy-2-decenoic acid, derivatives thereof, and salts thereof; and at least one second active ingredient selected from the group consisting of 2-decenoic acid, derivatives thereof, and salts thereof.

The invention relates to a cytochrome P450 enzyme mutant capable of improving substrate tolerance and catalytic efficiency and application of the cytochrome P450 enzyme mutant, and belongs to the technical field of gene engineering and enzyme engineering. On the basis of cytochrome P450 enzyme CYPLY, the 243 site or the 592 site is selected for single-site or multi-site mutation, and the catalytic efficiency of the obtained CYPLY mutant is improved by 37-590%. Compared with cytochrome P450 enzyme CYPLY, the cytochrome P450 enzyme CYPLY has the advantages that the cytochrome P450 enzyme CYPLY has the advantages that the cytochrome P450 enzyme CYPLY has the optimal substrate tolerance characteristic, the conversion rate of 30.1% is still kept under the high substrate concentration of 1.0 g / L and is increased by about 6 times compared with 5.1% of the cytochrome P450 enzyme, the use of the cytochrome P450 enzyme is greatly promoted, and the cytochrome P450 enzyme CYPLY has important significance on the biosynthesis of 10-hydroxy-2-decenoic acid.

The present application relates to a kind of containing fatty acyl-coa dehydrogenase engineering bacteria and its application method, belong to microbial fermentation technical field.The engineering bacteria containing fatty acyl-coa dehydrogenase gene in the present application include fatty acyl-coa dehydrogenase gene and fatty acyl-coa thioesterase gene, the fatty acyl-coa dehydrogenase gene is derived from Candida tropicalis or Yarrowia lipolytica, its nucleotide sequence is SEQ ID NO.1 or SEQ ID NO.2;The nucleotide sequence of the fatty acyl-coa thioesterase gene is SEQ ID NO.3.Fatty acyl-coa dehydrogenase from Candida tropicalis and Yarrowia lipolytica, combined with existing fatty acyl-coa thioesterase, jointly convert 10-hydroxy decanoic acid, significantly improve the conversion rate of 10-hydroxy-2-decenoic acid, so that the industrialization production of 10-hydroxy-2-decenoic acid becomes possible.

The invention discloses a urea-based nutritional feed and application thereof in ruminants, and belongs to the technical field of enzyme engineering feed processing. According to the feed, components such as corn, urea, a urease inhibitor, carglutamic acid, potassium magnesium sulfate, bentonite and 10-hydroxy-2-decenoic acid are scientifically proportioned, so that the safe utilization efficiency of ruminants on urea is improved. The urease inhibitor controls the urea decomposition speed and reduces the risk of ammonia poisoning; carboglutamic acid further improves the utilization rate and safety of urea by accelerating blood ammonia conversion. The nutritional feed can partially or completely replace soybean meal, so that the feed cost is reduced, and meanwhile, the environmental pollution is reduced. Experiments show that the feed significantly improves the growth performance and feed conversion efficiency of ruminants, and has good economic benefits and environmental protection benefits.

This invention belongs to the field of cosmetic technology, specifically relating to a composition containing 10-hydroxy-2-decenoic acid and its application. The composition is obtained by compounding probiotic-fermented brown algae, pterostilbene, and 10-hydroxy-2-decenoic acid in a certain proportion. Experiments have shown that the components of the above composition can produce a synergistic effect, significantly inhibiting the production of inflammatory factors, resisting inflammatory aging, and inhibiting lipid peroxidation. Furthermore, this invention unexpectedly discovered that compounding probiotic-fermented brown algae, 10-hydroxy-2-decenoic acid, and pterostilbene can significantly improve the light and heat stability of pterostilbene, thus possessing good practical application value.

The invention provides a composition, a preparation method, application and a medicine or health food prepared from the composition. The composition is prepared from the following components in parts by weight: 5-20 parts of docosahexaenoic acid, 5-15 parts of eicosapentaenoic acid, 0.5-10 parts of 10-hydroxy-alpha-decenoic acid, 10-30 parts of taurine and 1-20 parts of squalene. According to the present invention, the composition having the immunity regulating effect is provided, and the composition can improve the immune function and can inhibit the growth of bordetella pertussis so as to provide the pertussis prevention and / or treatment effect. The composition disclosed by the invention can be used for preparing medicines for improving the immune function and preventing and / or treating pertussis; meanwhile, the raw materials in the composition are all food additive components meeting the national safety standard, and the composition can be used for preparing health-care food.

The invention provides a method of microbial control in water comprising adding to the water one or more bromine-based biocide(s) and cis-2-decenoic acid or a salt thereof. Compositions in the form of liquid concentrates comprising bromine-based biocides and cis-2-decenoic acid or a salt thereof are also described.

The present application relates to a kind of genetically engineered bacteria and its application in preparation 10-hydroxy-2-decenoic acid, belong to biological fermentation technical field.The genetically engineered bacteria of the present application includes fatty acyl-coa oxidase gene, fatty acyl-coa thioesterase gene and CYP153AM228L-CPR BM3 Fusion enzyme gene, the fatty acyl-coa oxidase gene is derived from Candida tropicalis, its nucleotide sequence is SEQ ID NO.3.The key enzyme of biosynthesis 10-hydroxy-2-decenoic acid is supplemented, integrated in the present application, fatty acid hydroxylase, fatty acyl-coa oxidase, fatty acyl-coa thioesterase is jointly transferred into host bacteria, so that each enzyme system in engineering bacteria synergistic effect, to achieve the purpose of decanoic acid as raw material one-step synthesis 10-hydroxy-2-decenoic acid.

To provide a novel penetration enhancer for royal jelly into the skin.SOLUTION: The present invention provides a cosmetic composition comprising 10-hydroxydecanoic acid and / or 10-hydroxy-2-decenoic acid, for promoting penetration of 10-hydroxydecanoic acid and / or 10-hydroxy-2-decenoic acid into the skin, the cosmetic composition including carrageenan as an active ingredient.SELECTED DRAWING: None

The invention relates to an application of 10-hydroxy-2-decenoic acid in preparation of a medicine for treating psoriasis. The invention discloses an application of 10-hydroxy-2-decenoic acid or a salt thereof in preparation of a medicine for treating psoriasis and atopic dermatitis co-disease caused by psoriasis. The invention discloses a 10-hydroxy-2-decenoic acid ointment for treating psoriasis and atopic dermatitis co-diseases caused by the psoriasis, and a preparation method of the 10-hydroxy-2-decenoic acid ointment. The invention discloses a 10-hydroxy-2-decenoic acid zinc-containing ointment which is used for treating psoriasis and atopic dermatitis codiseases caused by the psoriasis. The invention discloses a 10-hydroxy-2-decenoic acid gel for treating psoriasis and AD (Alzheimer's disease) codiseases caused by the psoriasis. The 10-hydroxy-2-decenoic acid or zinc salt ointment and the 10-hydroxy-2-decenoic acid gel are beneficial to being coated on the surface of the skin, play a role in treating the psoriasis and the AD co-disease caused by the psoriasis, and can be used for remarkably improving the psoriasis and the AD co-disease caused by the psoriasis.

The invention relates to a saccharomyces cerevisiae engineering bacterium for preparing 10-hydroxy-2-decenoic acid with high efficiency and low cost as well as a construction method and application of the saccharomyces cerevisiae engineering bacterium. According to the saccharomyces cerevisiae engineering bacteria, a 10-HDA synthetic gene and a cofactor supply gene are localized and expressed in mitochondria of saccharomyces cerevisiae; the 10-HDA synthetic gene comprises an acyl-coenzyme A oxidase gene ACO, an acyl-coenzyme A thioesterase gene FatB1 and a cytochrome P450 enzyme gene CYP153A33 (M228L)-CPRBM3, and the acyl-coenzyme A thioesterase gene FatB1 and the cytochrome P450 enzyme gene CYP153A33 (M228L)- And the auxiliary synthetic gene comprises an NADH kinase gene POS5 and an auxiliary protein gene Sil1. By constructing a 10-HDA synthesis route in mitochondria, the mitochondrial region compartmentalized expression strategy is found to have obvious advantages, so that the yield of 10-HDA is increased to 40.50 mg / L. Ethyl caprate is adopted as a fed-batch fermentation substrate and is slowly hydrolyzed into capric acid after entering cells, so that the growth inhibition of the capric acid on the saccharomyces cerevisiae is relieved, the yield of 10-HDA is increased, when the addition amount of the ethyl caprate reaches 1g / L, the yield of 10-HDA reaches 298.6 mg / L, and an effective method is provided for optimizing a fermentation process.

The invention discloses an application of 10-hydroxy-2-decenoic acid (10-HDA) or a salt thereof in medicine preparation, and an application of the compound in treatment or prevention of cardiovascular diseases, especially acute myocardial infarction. According to the application, generation of inflammatory factors and active oxygen is inhibited by regulating and controlling a TLR4 / MyD88 / NF-kappa B signal channel, the anti-inflammatory and anti-oxidative stress effects are achieved, and therefore cardiac dysfunction and heart diseases caused by myocardial infarction are relieved.

Provided herein are methods of making compositions comprising mixtures of lactones. Also provided herein are mixtures of lactones produced by the methods provided herein. An example lactone composition can include a 5-hydroxy-2-decenoic acid-δ-lactone, a 3,5-dihydroxydecanoic acid-δ-lactone, and sulfur, nitrogen, phosphorus, potassium, magnesium, calcium, sodium, iron, aluminum, silicon, organic chloride, 3,5-dihydroxydecanoic acid, a carbohydrate, free fatty acids, or a combination thereof.

The invention provides a method for increasing the content of 10-hydroxy-2-decenoic acid (10-HDA) in royal jelly, the content of 10-HDA in royal jelly can be increased by adding a stearic acid and reduced coenzyme II tetrasodium (NADPH) composition in a certain proportion into pollen feed for continuous feeding, and the method has the characteristics of simplicity and convenience in operation, short period, good effect and the like, and is suitable for large-scale production. And a new thought can be provided for high-quality royal jelly production.

A method comprising reacting crude cis-2-alkenoic acid with an amine base and isolating the resultant ammonium salt of cis-2- alkenoic acid in a solid form, from an organic solvent or a mixture of organic solvents, is provided by the invention. The method can be used to purify crude cis-2-decenoic acid. The crystalline cyclohexylammonium salt of cis-2-decenoic acid forms another aspect of the invention.

A polypeptide for promoting collagen synthesis, a preparation method therefor, a formulation and use thereof. The polypeptide is a nonapeptide having 10-hydroxy-2-decenoic acid coupled at the terminus, and is prepared by means of a solid-phase peptide synthesis method. The polypeptide can increase the content of cellular collagen, has a weak effect on capsaicin receptors and mediated calcium influx, and causes relatively low pain stimulation.

The application relates to a food-derived antioxidant tablet and a preparation method thereof. The food-derived antioxidant tablet comprises 10-hydroxy-alpha-decenoic acid, curcumin, ferulic acid and vitamin C. The food-derived antioxidant tablet contains not only a direct scavenger of oxygen free radicals but also a promoter of an antioxidant pathway, and the synergistic effect of 10-hydroxy-alpha-decenoic acid, curcumin, ferulic acid and vitamin C can improve the antioxidant capacity of organisms.

The present invention addresses the problem of providing a technique for masking bitterness in a plant-derived-protein-containing food. The present invention provides, inter allia, a composition for masking bitterness in a plant-derived-protein-containing food, the composition containing component (a): at least one component selected from the group consisting of cysteine or salts thereof, lauric acid, nootkatone, 5-hydroxy-2-decenoic acid lactone, guanylic acid or salts thereof, advantame, acesulfame potassium, vitamin B6, and 3-(methylthio)propyl isothiocyanate.