70 results about "Decenoic Acid" patented technology

The invention provides methods for treating a surface, the method including steps of applying a surface treatment composition to a surface, wherein the surface treatment composition includes a substantially phenol-free cleansing agent and an antimicrobial agent, the antimicrobial agent comprising 9-decenoic acid, a salt of 9-decenoic acid, an ester of 9-decenoic acid, or a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to control microbial growth. Also described are methods for treating a surface that include the step of applying a surface treatment composition having a pH in the range of 4.1 to 8.5 to a surface, wherein the surface treatment composition includes a cleansing agent and an antimicrobial agent, the antimicrobial agent comprising 9-decenoic acid, a salt of 9-decenoic acid, an ester of 9-decenoic acid, or a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to control microbial growth. Also described are surface treatment compositions including the antimicrobial agents.

The preparation process of water soluble royal jelly includes the following steps: defreezing royal jelly at room temperature; homogenizing via adding water in 1.5-3 times and stirring; enzymolyzing with proteinase at 40-45deg.c while stirring for 2-4 hr and ultrafiltering membrane or vacuum concentration at normal temperature to the amount of 1-1.5 times of royal jelly material; freeze drying; and vacuum packing. The water soluble royal jelly product has water content not more than 3 wt% and 10-HAD content not less than 4.0 wt%. The preparation process is simple and reliable, and the water soluble royal jelly product has wide dissolving temperature range, high stability, water dissolving retention rate as high as 90 % and other features.

The invention relates to a plateau royal jelly berry buccal tablet and a preparation method thereof. The product is prepared by extracting 10-hydroxy-2-decenoic acid, 5-hydroxytryptamine and procyanidine from royal jelly, seabuckthorn fruit, nitraria sibirica pall and lycium ruthenicum murr, granulating, drying, arranging granules and tabletting. The invention aims at providing a plateau royal jelly berry buccal tablet which is rich in 10-hydroxy-2-decenoic acid, 5-hydroxytryptamine and procyanidine; the buccal tablet has functions of promoting sleeping, relieving the occurrence of depression, resisting oxidation and delaying aging, and the buccal tablet is broad in market prospect.

The invention discloses an application of E-10-hydroxy-2-decenoic acid in preparation of medicines or healthcare products for hepatic disease, and relates to the technical field of applications of hydroxy-containing unsaturated compounds in which carboxyl is connected to a non-ring carbon. The hepatic disease relates to fatty liver, hepatitis or liver cirrhosis. The E-10-hydroxy-2-decenoic acid has definite treatment or aided treatment functions for the hepatic disease, can be used for preparation of the medicines or healthcare products which are used for treatment or aided treatment of the hepatic disease, and has advantages of low cost, good effects, low using amount, and no side or toxic effects.

The present invention relates to a method of inhibiting degradation of skin or mucous membranes by inhibiting action of collagenases comprising applying to the skin or mucous membranes a composition comprising at least one of 10-hydroxy-2-decenoic acid derivative. The invention also relates to a process for treating signs of aging.

The invention provides an L plantarum living bacterium preparation and an application thereof, and belongs to the technical field of biology. The L plantarum living bacterium preparation comprises freeze-dried L plantarum powder and freeze-dried L plantarum microcapsules, wherein a freeze-drying protective agent used in the preparation process comprises 1-3wt% of glycerol and 0.05-0.15 wt% of 10-hydroxyl-2-decenoic acid, and the mass ratio of the 10-hydroxy-2-decenoic acid to the glycerol is 1: (15-20). The L plantarum viable bacterium preparation provided by the invention has the advantages of high biological activity, capability of enhancing the body immune function and capability of efficiently and durably adjusting intestinal flora balance.

The invention discloses a process for extracting 10-hydroxyl -2-decenoic acid (10-HAD) from royal jelly by using a macroporous adsorption resin method. The process comprises the following steps of: dissolving royal jelly in 95-percent ethanol, and performing ultrasonic extraction; adding deionized water to dilute the extracting solution, and adsorbing the 10-HAD from the extracting solution by using macroporous adsorption resin X-5; putting the resin subjected to adsorption into a chromatography column, performing desorption by using 75 to 95 percent ethanol, and collecting desorption solution containing the 10-HAD; and performing evaporation concentration and freeze drying on eluant to obtain the 10-HAD of which the purity is greater than or equal to 92.5 percent.

The invention relates to a mutant enzyme CYP153A M228L and an application of the mutant enzyme CYP153A M228L in synthesis of 10-hydroxy-2-decenoic acid. The mutant enzyme CYP153A M228L is characterized in that amino acid at the 228th site of CYP153A enzyme is mutated into L from M; a method for biologically synthesizing 10-hydroxy-2-decenoic acid through a two-step method by taking decanoic acid as a raw material mainly comprises the following steps: constructing an optimized recombinant plasmid pCDFDuet-1-MaMACS-PpFadE, an optimized recombinant plasmid pET21b-CYP153A M228L-CPRBM3, and an optimized recombinant plasmid pET28a-SUMO-ctYdiI; constructing escherichia coli recombinant bacteria to prepare resting cells, further culturing the resting cells to prepare the 10-hydroxy-2-decenoic acid. The conversion rate of the 10-hydroxy-2-decenoic acid is remarkably improved according to the technical scheme.

An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1):

(In the formula, Y is —O—, —NR— or —S—, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury.

The invention relates to the technical field of medicines, and discloses a cyclopeptide antitumor active compound, and particularly relates to a cyclopeptide active molecule with a structure shown in a formula (I), the cyclopeptide active molecule with the structure shown in the formula (I) and pharmaceutically acceptable salt or ester thereof: GFKX1LLKX2X3AKX4LVKX5VLF.NH2(I), wherein X1 represents aspartic acid or (2R)-2-amino-2-methyl-6-heptenoic acid; X2 represents glycine or (2R)-2-amino-2-methyl-6-heptenoic acid; X3 represents alanine or (2R)-2-amino-2-methyl-9-decenoic acid; X4 represents alanine or (2R)-2-amino-2-methyl-6-heptenoic acid; X5 represents threonine or (2R)-2-amino-2-methyl-6-heptenoic acid; and paired (2R)-2-amino-2-methyl-6-heptenoic acid or (2R)-2-amino-2-methyl-9-decenoic acid in a fragment is cyclized through an olefin metathesis reaction. The cyclopeptide antitumor active compound and a preparation method and application thereof aim to enhance the cell permeability and improve the enzyme stability and antitumor activity.

The invention relates to the technical field of medicine, and discloses a cyclic peptide anti-tumor activity compound, in particular to a cyclic peptide active molecule with a structure shown by a formula (I). According to the cyclic peptide active molecule with the structure of the formula (I) and pharmaceutically acceptable salt or ester thereof: GX1FAX2X3KKX4ASVX5KX6L (I), X1 represents leucineor (2R)-2-amino-2-methyl-6-heptenoic acid or (2R)-2-amino-2- methyl-9-decenoic acid; X2 represents valine or (2R)-2-amino-2-methyl-6-heptenoic acid; X3 represents isoleucine or (2R)-2-amino-2-methyl-6-heptenoic acid; X4 represents valine or (2R)-2-amino-2-methyl-6-heptenoic acid; X5 represents isoleucine or (2R)-2-amino-2-methyl-6-heptenoic acid; X6 represents glycine or (2R)-2-amino-2-methyl-6-heptenoic acid; and coupled (2R)-2-amino-2-methyl6-heptenoic acids or (2R)-2-amino-2-methyl-9-decenoic acids in a fragment are cyclized through olefin metathesis. The cyclic peptide anti-tumor activitycompound and a preparation method therefor and application of the cyclic peptide anti-tumor activity compound aim to enhance the cell permeability of the cyclic peptide anti-tumor activity compound,and to improve enzyme stability and anti-tumor activity.

The invention belongs to the technical field of food detection, in particular relates to a quick and accurate method for detecting whether pure natural royal jelly and freeze-dried powder are mixed with artificial decenoic acid, and aims to develop a quick and accurate method for qualitative and quantitative detection of the artificial decenoic acid in the royal jelly and the freeze-dried powder in allusion to the foul means of mixing of the artificial decenoic acid in the royal jelly and the freeze-dried powder for seeking high profits in the market in the prior art. The invention discloses the quick determination method of the artificial decenoic acid in the royal jelly and the freeze-dried powder so as to achieve the purpose, and the quick determination method comprises three steps of pretreatment, liquid chromatographic separation and mass spectrometric detection. According to the HPLC-MS detection method, ion peaks with the mass to charge ratio of 225 m/z (parent ion), 163 m/z (daughter ion) and 181 m/z (daughter ion) are taken as feature detection peaks.

This invention relates to a method for preparing optically active 2-amino-9-decenoic acid. The method comprises: attacking chiral 6-oxy-piperidine-2-carboxylate with Grignard reagent of crotyl bromide to obtain chiral 2-amino-6-oxy-9-decadienoate, reducing to convert carbonyl into methylene and obtain chiral or racemized 2-amino-9-decadienoate, and hydrolyzing to obtain optically active 2-amino-9-decenoic acid. The method overcomes the problems of long synthesis route, low yield and expensive chiral catalyst or resolution reagent faced by the present method. The method in this invention has such advantages as simple route, reasonable process, low cost, and high yield, and is suitable for mass production.

The present invention provides a preparation method and application of a functional material for adsorption of 10-hydroxy-2-decenoic acid. The functional material is synthesized by using 10-hydroxy-2-decenoic acid as a template molecule, 4-vinyl pyridine as a functional monomer, N,N'-methylene bisacrylamide as a crosslinking agent and methanol as a pore forming agent through a sol-gel technology and molecular imprinting technology, and the adsorption capacity of the functional material reaches 22.97mg / g. The synthesis process of the invention is simple, low in cost, and easy to control the reaction conditions; and the prepared specific adsorption material for 10-hydroxy-2-decenoic acid can be used in combination of solid phase extraction enrichment and high performance liquid chromatography, and is applicable to detection of royal jelly and 10-hydroxy-2-decenoic acid in royal jelly products.

The invention relates to a compound with cinnamon fragrance as well as a preparation method and application thereof. The compound has the following structural formula, wherein the structural formula can be named as 2-decenoic acid-2-(4-methoxy)-phenyl-2-butyl ester. The provided compound has the advantages of obvious cinnamon aroma, rich aroma, lasting aroma and good stability, and enriches the sources of cinnamon aroma. When the essence is prepared in different periods, the compound has consistent cinnamon aroma, so that the required aroma can be accurately mastered.