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Method for extracting 10-hydroxy-2-decenoic acid from royal jelly freeze-dried powder

A technology of royal jelly freeze-dried powder and decenoic acid, which is applied in the separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problems of large amount of solvent and long time consumption, and achieve the effect of shortening the total process time

Inactive Publication Date: 2018-01-30
刘峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The amount of solvent consumed by the macroporous resin separation method is too large, and the extraction process usually takes more than 10 hours, which takes a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of dispersion: disperse royal jelly freeze-dried powder in water according to the ratio of material to liquid 1:8 (w / v), and stir for 2 hours at 100 rpm to obtain dispersion.

[0042] (2) Adjust the pH value of the dispersion prepared in step (1) to 2. Centrifuge the dispersion liquid with adjusted pH value under the condition of 3000 rpm for 10 minutes, take the precipitate, and discard the supernatant.

[0043] (3) Add the precipitate obtained in step (2) into 5 times the volume of ethyl acetate, and extract with stirring at 100 rpm for 10 minutes at room temperature. The extract obtained by the stirring extraction was centrifuged at 3000 rpm for 10 minutes, and the supernatant was taken.

[0044] (4) The supernatant obtained in step (3) was distilled under reduced pressure at -0.08MPa and 55°C to obtain a product containing 10-hydroxy-2-decenoic acid as a light yellow oil.

[0045] After testing, the content of 10-hydroxy-2-decenoic acid in the prod...

Embodiment 2

[0047] (1) Preparation of dispersion: disperse royal jelly freeze-dried powder in water according to the material-to-liquid ratio of 1:9 (w / v), and stir at 150 rpm for 1 hour to obtain a dispersion.

[0048] (2) Adjust the pH value of the dispersion prepared in step (1) to 2. Centrifuge the dispersion liquid with adjusted pH value under the condition of 5000 rpm for 10 minutes, take the precipitate, and discard the supernatant.

[0049] (3) Add the precipitate obtained in step (2) into 7.5 times the volume of ethyl acetate, and extract with stirring at 150 rpm for 10 minutes at room temperature. The extract obtained by the stirring extraction was centrifuged at 4000 rpm for 10 minutes, and the supernatant was taken.

[0050] (4) The supernatant obtained in step (3) was distilled under reduced pressure at -0.08MPa and 55°C to obtain a product containing 10-hydroxy-2-decenoic acid as a light yellow oil.

[0051] After testing, the content of 10-hydroxy-2-decenoic acid in the p...

Embodiment 3

[0053] (1) Preparation of dispersion: disperse royal jelly freeze-dried powder in water according to the material-to-liquid ratio of 1:10 (w / v), and stir at 200 rpm for 1 hour to obtain a dispersion.

[0054] (2) Adjust the pH value of the dispersion prepared in step (1) to 2. Centrifuge the dispersion liquid with adjusted pH value under the condition of 7000 rpm for 10 minutes, take the precipitate, and discard the supernatant.

[0055] (3) Add the precipitate obtained in step (2) into 10 times the volume of ethyl acetate, and extract with stirring at 200 rpm for 10 minutes at room temperature. The extract obtained by the stirring extraction was centrifuged at 7000 rpm for 10 minutes, and the supernatant was taken.

[0056] (4) The supernatant obtained in step (3) was distilled under reduced pressure at -0.08MPa and 55°C to obtain a product containing 10-hydroxy-2-decenoic acid as a light yellow oil.

[0057] After testing, the content of 10-hydroxy-2-decenoic acid in the p...

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PUM

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Abstract

The embodiment of the invention provides a method for extracting 10-hydroxy-2-decenoic acid from royal jelly freeze-dried powder. The method comprises the following steps: (1) dispersing the royal jelly freeze-dried powder into water and stirring to obtain a dispersion solution; (2) regulating the pH (Potential of Hydrogen) value of the dispersion solution to 2 to 3; centrifuging and taking sediment; (3) adding the sediment into ethyl acetate and stirring; centrifuging and taking supernatant; (4) decompressing and distilling the supernatant to obtain a product containing the 10-hydroxy-2-decenoic acid. The extraction method provided by the invention has a simple technology and short time consumption; the content of the 10-hydroxy-2-decenoic acid in the obtained product is high and the product can meet application to development of medicines and health-care foods.

Description

technical field [0001] The invention relates to the field of extraction methods of 10-hydroxy-2-decenoic acid, in particular to a method for extracting 10-hydroxy-2-decenoic acid from freeze-dried royal jelly powder. Background technique [0002] 10-Hydroxy-2-decenoic acid (10-HDA for short) is an important fatty acid in royal jelly, which has antibacterial, anti-inflammatory, anti-cancer, immune regulation, anti-diabetic and anti-ulcer properties , skin care, promote brain cell differentiation, lower blood pressure, lower blood fat and other functions. 10-HDA can not only be used directly as a medicine, but also can be used as an additive for food and cosmetics, as well as for the synthesis of spices and pharmaceutical intermediates. The market demand is huge. [0003] At present, the extraction methods of 10-HDA mainly include the traditional extraction method using ethanol, ether or ethyl acetate as solvent, solution precipitation crystallization method, precipitation cr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C59/42
Inventor 刘峰张欣李明
Owner 刘峰
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