239 results about "Brain Cell" patented technology

The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic acids to cells of the CNS such as cerebellar cells and ependymal cells. The invention also provides methods of delivering nucleic acids to cells of the lung such as alveolar cells using AAV5 vectors and particles.

An ultrasonic cerebral infarction therapeutic apparatus that does not produce side effects of destruction of brain cells, occurrence of intracerebral hemorrhage, destruction of nerve cells, etc. by avoiding formation of a standing wave by interference between an irradiated beam of an ultrasonic wave irradiated to the inside of the cranium and its reflected beam. An ultrasonic probe cap is constructed by arranging a plurality of laminated small transducers each made up of a PVDF film, a PZT ceramic, or the like in a mosaic-like pattern or in other form on the inside of the cap and one or more transducers are selected and activated according to a thrombus position. As a high frequency for actuating a transducer, a continuous sinusoidal wave, a burst wave, or a pulse wave shall be used so that no standing wave may be produced inside the cranium.

Methods and assay systems for analyzing effects of chemical and cellular agents on brain cell neurogenesis in vivo, comprising administering an agent to a test animal and determining responses of cells of brain marrow tissues, including irradiated brain marrow tissue depleted of neurogenic stems cells, and cells in brain marrow-derived neurospheres cultured in vitro.

The invention relates to a 7 and 20 dehydro-silybin dialky ether and preparation method and medicine use thereof. The compounds are capable of obviously preventing the lipid superoxide induced by the free radical from being generated; effectively protecting the injury rat adrenal pheochromocytoma cells PC12 due to hydrogen dioxide, namely with oxidation resistance injury protection function on thePC12 cells which simulate the cranial nerves; preventing the brain cells and the cranial nerves from being oxidized and controlling the neurodegenerative diseases such as senile dementia. In addition, the compounds have strong chelation on the ferrous ion. The pharmacodynamics result shows that: the compounds are anticipated to prepare the medicine for controlling the neurodegenerative diseases.

Activated protein C (APC), prodrug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurode-generative disorders. Novel biological functions (e.g., neuroprotection) can be independent or separated from inhibition of clotting or inflammation, and other biological properties of APC (e.g., antithrombotic activity, ability to reduce NFκB-regulated gene expression). It can be used in the treatment of disease or other pathological conditions by at least inhibiting the p53-dependent and/or caspase-3-dependent pro-apoptotic signaling pathways in stressed or injured cells. Thus, APC, prodrugs, and variants thereof (e.g., APC protease domain mutants with reduced anti-coagulant activity) are prototypes of a class of agents for preventing apoptosis or cell death and/or promoting cell survival by direct action on brain cells. New protein C and/or APC variants with reduced anticoagulant activity may be selected thereby.

The invention features methods for increasing or maintaining the number of functional cells of a predetermined type, for example, insulin producing cells of the pancreas, blood cells, spleen cells, brain cells, heart cells, vascular tissue cells, cells of the bile duct, or skin cells, in a mammal (e.g., a human patient) that has injured or damaged cells of the predetermined type.

The invention discloses a construction method of a mandarin fish brain cell system. Aiming at the characteristic of mandarin fish brain cells, the primary cell culture is carried out by separating the brain cells through a serum-contained collagenase digestion method, so that the mandarin fish brain cell system is constructed successfully. Thus, a great quantity of mandarin fish brain source cells can be provided; and the good growth status of sub-culture cells can be maintained. The construction method is strong in repeatability and brings convenience for researching fish virus infection paths and fish virus infection mechanisms, developing viral vaccines and the like.

The invention can be characterized as method for stimulating or inhibiting gene expression by photomodulating living cells using a source of narrowband multichromatic electromagnetic radiation. The cells may include, among others, nerve cells, skin cells, retinal cells, heart cells, stem cells, brain cells, cells found in human organs, cells found in hair follicles, and cells found in the human eye or retina. Photomodulation may be enhanced using topically or orally administered compositions. The source of narrowband multichromatic electromagnetic radiation may include at least one light emitting diode (LED) that can emit radiation having a wavelength of from about 300 nm to about 1600 nm.

This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia/ischemia condition or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with a transient cerebral hypoxic and/or ischemic condition, or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, in addition to the continuous intravenous infusion dose, a bolus dose of methamphetamine is administered to the subject as soon as possible after onset of the condition or occurrence of the TBI event.

The invention discloses composite moringa polypeptide and a preparation method and application thereof, moringa polypeptide is extracted from a moringa raw material by enzymatic hydrolysis method, and then is added with salvia miltiorrhiza, ginseng, Chinese wolfberry extract and other traditional Chinese medicines for preparation of a compound preparation, the moringa polypeptide is further used in medicine, food and other fields for full application of the active ingredients in moringa. Micro-molecule polypeptides is obtained by low temperature enzymolysis of moringa protein under the effect of controlled protease by biological engineering technology method, the molecular weight of the micro-molecule polypeptides is 1-10 KD, the obtained composite moringa peptide raw material has the effects of oxidation resistance, protection of heart and brain cells against super oxygen free radical damage, prevention and treatment of cardiovascular and cerebrovascular diseases, relieving of fatigues, and regulation of body's metabolism balance, not only can be used in drugs, can be made into pharmaceutical preparations (tablets, capsules, granules, oral liquid and other dosage forms), and also can be used in health food, food and cosmetics.

There is provided a treatment for patients suffering from neurodegenerative disease or neural injury including the steps of transplanting cultured bone marrow cells into the spinal cord or brain or injecting intravascularly bone marrow cells of a patient in need. Also provided is a method of activating the differentiation of neural cells in an injured brain including the steps of transplanting bone marrow cells adjacent to the injured brain cells and activating the endogenous central nervous system stem cells to differentiate into neurons. A method of treating injured brain or spinal cord cells is also provided including the steps of transplanting bone marrow cells near the injured brain cells and generating new neurons at the location of transplantation. A method of treating injured brain or spinal cord cells with a composite of MSCs and neurospheres.

The invention discloses a brain-strengthening and intelligence-benefiting nutritional composition. The brain-strengthening and intelligence-benefiting nutritional composition comprises the following raw materials in percentage by mass: 5-30% of phosphatidylserine, 1-10% of phospholipids, 1-10% of walnut peptides, 0.1-5% of DHA algae oil, 1-15% of L-theanine, 1-15% of sialic acid, 1-10% of a poriacocos extract, 1-10% of a dried orange peel extract, 1-10 % of a sharpleaf galangal fruit extract, 1-10% of a perilla fruit extract, and 1-10% of a saffron extract. The invention further provides a usage of the brain-strengthening and intelligence-benefiting nutritional composition. The brain-strengthening and intelligence-benefiting nutritional composition provided by the invention takes new-resource foods as main raw materials, and is prepared by performing matched blending with extracts of plants which have the functions of strengthening the brain and benefiting intelligence and are used asboth medicines and foods; and thus, the raw materials synergistically take an effect so as to increase brain cell viability of people with excessive brain-strain and/or the elderly, as well as improve the conditions of dizziness,headache and the like caused by overuse of the brain.

The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat neuronal or neuromuscular disease, or a pathology of the brain, or a tumor of neuronal or neuroectodermal origin, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the brain cells or neuronal cells, or by the tumor cells of neuronal or neuroectodermal origin. The invention also provides a method of identifying and measuring neurite growth in neuronal cells.

The present invention relates to a noodle with the functions of brain tonic, mentality improving and health preserving, and a production process thereof, the raw material of the noodle is prepared by raw materials of 80 to 86 wt% of wheat flour, 10 wt% of black hen eggs, 2 wt% of strain and 10 to 18% of functional materials. The functional materials include qi-tonifying materials of yam, blood-enriching matter of tuber fleeceflower root, liver wind-extinguishing materials of gastrodia tuber, heart-nourishing and nerve-soothing matters of arborvitae seed, galangal fruit seed, tuckahoe and longan, resuscitation-inducing and fragrant matter of acorus calamus, diuresis and dampness-excreting matter of tuckahoe, interior-warming matter of common fennel fruit and astringing matter of oyster, with each functional matter taking account for 1 to 1.5%. The production process of the invention comprises the following steps of raw material inspection, drying, grinding, mixing, biological fluids preparing, bio-fermentation, debitterizing, mixing, noodle pressing, drying and packaging. The present invention combines the ancient anaerobic subterranean pot natural zymotechnics with modern aerobic zymotechnics, creatively invents a novel quantum biological multi-fermentation process which produces plentiful alkaline polysaccharide to activate brain cell.

The invention discloses a manufacturing method for a salty dried peanut with cream. The salty dried peanut with cream comprises the following raw materials by weight: 50 to 60 parts of a peanut, 3 to 4 parts of salt, 2 to 3 parts of sodium saccharin, 1 to 2 parts of cream, 2 to 3 parts of rehmannia root, 1 to 2 parts of pumpkin, 0.8 to 1.2 parts of strawberry leaf, 1 to 1.5 parts of wolfberry fruit, 3 to 4 parts of dried orange peel, 0.8 to 1.2 parts of Kuding leaf, 3 to 4 parts of jujube, 1 to 2 parts of mulberry leaf and 70 to 80 parts of water. The salty dried peanut with cream produced in the invention contains rich nutrients, has delicate fragrance and agreeable taste and is good leisure food. The peanut has nourishing and tonifying effects, promotes growth of brain cells, improves memory functions and is beneficial for prolonging one's life span; the traditional Chinese medicinal materials consisting of rehmannia root, wolfberry fruit, dried orange peel and the like are cooperatively used, so the salty dried peanut with cream can be used for treating symptoms like malnutrition, disorder of the spleen and the stomach, cough and asthma due to excessive phlegm.

A pillow with better neck support structure in accordance with the present invention comprises: a head support portion connected to a correction support portion, the head support portion is softer than the correction support portion. The user's head can be well positioned when laid on the head support portion which is softer than the correction support portion, and the correction support portion which is relatively harder can support the user's head in such a manner that the scapula of the user is supported on the second support section of the correction support portion, while the user's neck is suspended with respect to the traction section, so that the cervical spine, under its gravity, can be returned to a pressure-free and most ergonomic position, thus improving blood circulation in the brain cells.

Methods and a computer program product for applying deconvolution to spatial light interference microscopy for resolution enhancement with respect to the diffraction limit in two and three dimensions. By exploiting the sparsity properties of the phase images, which is prominent in many biological imaging applications, and modeling of the image formation via complex fields, the very fine structures can be recovered which were blurred by the optics. The resolution improvement leads to higher accuracy in monitoring dynamic activity over time. Experiments with primary brain cells, i.e. neurons and glial cells, reveal new subdiffraction structures and motions. This new information can be used for studying vesicle transport in neurons, which may shed light on dynamic cell functioning. Finally, the method may flexibly incorporate a wide range of image models for different applications and can be utilized for all imaging modalities acquiring complex field images.