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239 results about "Brain Cell" patented technology

Brain Cell Repulsion is a mail art project begun by Ryosuke Cohen in June 1985. The project is a networked art project where individual artists contribute stamps, stickers, drawings or other images. These are sent through the mail to Cohen, who assembles and prints them as part of each cell. He prints 150 copies (30 x 42 cm) with a small silkscreen system called a Cyclostyle (now out of production). Each participant is mailed a Brain Cell print along with a documentation list of contributors worldwide.

AAV5 vector for transducing brain cells and lung cells

The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic acids to cells of the CNS such as cerebellar cells and ependymal cells. The invention also provides methods of delivering nucleic acids to cells of the lung such as alveolar cells using AAV5 vectors and particles.
Owner:US DEPT OF HEALTH & HUMAN SERVICES +1

Ultrasonic Cerebral Infarction Therapeutic Apparatus

An ultrasonic cerebral infarction therapeutic apparatus that does not produce side effects of destruction of brain cells, occurrence of intracerebral hemorrhage, destruction of nerve cells, etc. by avoiding formation of a standing wave by interference between an irradiated beam of an ultrasonic wave irradiated to the inside of the cranium and its reflected beam. An ultrasonic probe cap is constructed by arranging a plurality of laminated small transducers each made up of a PVDF film, a PZT ceramic, or the like in a mosaic-like pattern or in other form on the inside of the cap and one or more transducers are selected and activated according to a thrombus position. As a high frequency for actuating a transducer, a continuous sinusoidal wave, a burst wave, or a pulse wave shall be used so that no standing wave may be produced inside the cranium.
Owner:FURUHATA HIROSHI +4

Neural cell assay

InactiveUS20050031538A1Increase neurogenesisNeurogenesis is increasedCompounds screening/testingBiological testingNeurogenesisNeural cell
Methods and assay systems for analyzing effects of chemical and cellular agents on brain cell neurogenesis in vivo, comprising administering an agent to a test animal and determining responses of cells of brain marrow tissues, including irradiated brain marrow tissue depleted of neurogenic stems cells, and cells in brain marrow-derived neurospheres cultured in vitro.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

7 and 20 dehydro-silybin dialky ether and preparation method and medicine use thereof

InactiveCN101565419AStrong anti-lipid peroxidationProtects chelation abilityOrganic active ingredientsNervous disorderDiseaseSuperoxide
The invention relates to a 7 and 20 dehydro-silybin dialky ether and preparation method and medicine use thereof. The compounds are capable of obviously preventing the lipid superoxide induced by the free radical from being generated; effectively protecting the injury rat adrenal pheochromocytoma cells PC12 due to hydrogen dioxide, namely with oxidation resistance injury protection function on thePC12 cells which simulate the cranial nerves; preventing the brain cells and the cranial nerves from being oxidized and controlling the neurodegenerative diseases such as senile dementia. In addition, the compounds have strong chelation on the ferrous ion. The pharmacodynamics result shows that: the compounds are anticipated to prepare the medicine for controlling the neurodegenerative diseases.
Owner:DALI UNIV

Neuroprotective activity of activated protein c independent of its anticoagulant activity

InactiveUS20070142272A1Enhancing neuroprotectionPromote cell survivalCompound screeningNervous disorderNervous systemInhibitor of apoptosis
Activated protein C (APC), prodrug, and / or a variant thereof may be used as an inhibitor of apoptosis or cell death and / or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurode-generative disorders. Novel biological functions (e.g., neuroprotection) can be independent or separated from inhibition of clotting or inflammation, and other biological properties of APC (e.g., antithrombotic activity, ability to reduce NFκB-regulated gene expression). It can be used in the treatment of disease or other pathological conditions by at least inhibiting the p53-dependent and / or caspase-3-dependent pro-apoptotic signaling pathways in stressed or injured cells. Thus, APC, prodrugs, and variants thereof (e.g., APC protease domain mutants with reduced anti-coagulant activity) are prototypes of a class of agents for preventing apoptosis or cell death and / or promoting cell survival by direct action on brain cells. New protein C and / or APC variants with reduced anticoagulant activity may be selected thereby.
Owner:UNIVERSITY OF ROCHESTER +2

Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof

DNA encoding a recombinant antibody molecule end-specific for an amyloid-beta peptide, pharmaceutical compositions thereof, and a method for preventing or inhibiting progression of Alzheimer's Disease by introducing such a DNA molecule into brain cells to express the recombinant antibody molecule and prevent the accumulation of amyloid-beta peptides in the cerebrospinal fluid.
Owner:INTELLECT NEUROSCI

Construction method of mandarin fish brain cell system

The invention discloses a construction method of a mandarin fish brain cell system. Aiming at the characteristic of mandarin fish brain cells, the primary cell culture is carried out by separating the brain cells through a serum-contained collagenase digestion method, so that the mandarin fish brain cell system is constructed successfully. Thus, a great quantity of mandarin fish brain source cells can be provided; and the good growth status of sub-culture cells can be maintained. The construction method is strong in repeatability and brings convenience for researching fish virus infection paths and fish virus infection mechanisms, developing viral vaccines and the like.
Owner:PEARL RIVER FISHERY RES INST CHINESE ACAD OF FISHERY SCI

System and method for photodynamic cell therapy

The invention can be characterized as method for stimulating or inhibiting gene expression by photomodulating living cells using a source of narrowband multichromatic electromagnetic radiation. The cells may include, among others, nerve cells, skin cells, retinal cells, heart cells, stem cells, brain cells, cells found in human organs, cells found in hair follicles, and cells found in the human eye or retina. Photomodulation may be enhanced using topically or orally administered compositions. The source of narrowband multichromatic electromagnetic radiation may include at least one light emitting diode (LED) that can emit radiation having a wavelength of from about 300 nm to about 1600 nm.
Owner:GENTLEWAVES

Method of reducing brain cell damage or death

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia / ischemia condition or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with a transient cerebral hypoxic and / or ischemic condition, or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, in addition to the continuous intravenous infusion dose, a bolus dose of methamphetamine is administered to the subject as soon as possible after onset of the condition or occurrence of the TBI event.
Owner:UNIVERSITY OF MONTANA

Molecules for targeting compounds to various selected organs, tissues or tumor cells

The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat neuronal or neuromuscular disease, or a pathology of the brain, or a tumor of neuronal or neuroectodermal origin, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the brain cells or neuronal cells, or by the tumor cells of neuronal or neuroectodermal origin. The invention also provides a method of identifying and measuring neurite growth in neuronal cells.
Owner:BIOMARIN TECH BV

Synthetic Microfluidic Blood-Brain Barrier

An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
Owner:SYNVIVO INC

Brain to brain interface system applied to single brain

InactiveUS20170080256A1Unbalanced stateElectroencephalographyUltrasound therapyMedicineCerebrum
A brain to brain interface system has a brain activity detection device configured to detect activity state information of a brain, a brain stimulation device configured to stimulate an area of at least a part of the brain to activate or inactivate brain cells of the corresponding area, and a computer configured to control the brain activity detection device and the brain stimulation device, wherein brain activity state information of a subject's brain (“a target brain”) is obtained through the brain activity detection device, and an area of at least a part of the target brain is stimulated through the brain stimulation device based on the brain activity state information of the target brain to regulate a function of the target brain.
Owner:KOREA INST OF SCI & TECH

Composite moringa polypeptide and preparation method and application thereof

The invention discloses composite moringa polypeptide and a preparation method and application thereof, moringa polypeptide is extracted from a moringa raw material by enzymatic hydrolysis method, and then is added with salvia miltiorrhiza, ginseng, Chinese wolfberry extract and other traditional Chinese medicines for preparation of a compound preparation, the moringa polypeptide is further used in medicine, food and other fields for full application of the active ingredients in moringa. Micro-molecule polypeptides is obtained by low temperature enzymolysis of moringa protein under the effect of controlled protease by biological engineering technology method, the molecular weight of the micro-molecule polypeptides is 1-10 KD, the obtained composite moringa peptide raw material has the effects of oxidation resistance, protection of heart and brain cells against super oxygen free radical damage, prevention and treatment of cardiovascular and cerebrovascular diseases, relieving of fatigues, and regulation of body's metabolism balance, not only can be used in drugs, can be made into pharmaceutical preparations (tablets, capsules, granules, oral liquid and other dosage forms), and also can be used in health food, food and cosmetics.
Owner:ZHANJIANG TONGLING MEDICAL & BIOLOGICAL ENG CO LTD

Bone marrow transplantation for treatment of stroke

InactiveUS20090162327A1Reduces functional deficitRelieve symptomsBiocideNervous disorderDiseaseNeural cell
There is provided a treatment for patients suffering from neurodegenerative disease or neural injury including the steps of transplanting cultured bone marrow cells into the spinal cord or brain or injecting intravascularly bone marrow cells of a patient in need. Also provided is a method of activating the differentiation of neural cells in an injured brain including the steps of transplanting bone marrow cells adjacent to the injured brain cells and activating the endogenous central nervous system stem cells to differentiate into neurons. A method of treating injured brain or spinal cord cells is also provided including the steps of transplanting bone marrow cells near the injured brain cells and generating new neurons at the location of transplantation. A method of treating injured brain or spinal cord cells with a composite of MSCs and neurospheres.
Owner:HENRY FORD HEALTH SYST

Nitric oxide donors for inducing neurogenesis

There is provided a method of promoting neurogenesis by administering a therapeutic amount of a nitric oxide donor compound to a patient in need of neurogenesis promotion. Also provided is a compound for providing neurogenesis having an effective amount of a nitric oxide donor sufficient to promote neurogenesis. A nitric oxide compound for promoting neurogenesis is also provided. Further, a method of augmenting the production of brain cells and facilitating cellular structural and receptor changes by administering an effective amount of a nitric oxide donor compound to a site in need of augmentation is provided. There is provided a method of increasing both neurological and cognitive function by administering an effective amount of a nitric oxide donor compound to a patient.
Owner:HENRY FORD HEALTH SYST

Brain-strengthening and intelligence-benefiting nutritional composition and application thereof

The invention discloses a brain-strengthening and intelligence-benefiting nutritional composition. The brain-strengthening and intelligence-benefiting nutritional composition comprises the following raw materials in percentage by mass: 5-30% of phosphatidylserine, 1-10% of phospholipids, 1-10% of walnut peptides, 0.1-5% of DHA algae oil, 1-15% of L-theanine, 1-15% of sialic acid, 1-10% of a poriacocos extract, 1-10% of a dried orange peel extract, 1-10 % of a sharpleaf galangal fruit extract, 1-10% of a perilla fruit extract, and 1-10% of a saffron extract. The invention further provides a usage of the brain-strengthening and intelligence-benefiting nutritional composition. The brain-strengthening and intelligence-benefiting nutritional composition provided by the invention takes new-resource foods as main raw materials, and is prepared by performing matched blending with extracts of plants which have the functions of strengthening the brain and benefiting intelligence and are used asboth medicines and foods; and thus, the raw materials synergistically take an effect so as to increase brain cell viability of people with excessive brain-strain and / or the elderly, as well as improve the conditions of dizziness,headache and the like caused by overuse of the brain.
Owner:广东康侨药业有限公司

Synthetic microfluidic blood-brain barrier

An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
Owner:SYNVIVO INC

Molecules for targeting compounds to various selected organs, tissues or tumor cells

InactiveUS20100184947A1Improving in vivo uptakeNervous disorderIn-vivo radioactive preparationsDiseaseGerm layer
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat neuronal or neuromuscular disease, or a pathology of the brain, or a tumor of neuronal or neuroectodermal origin, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the brain cells or neuronal cells, or by the tumor cells of neuronal or neuroectodermal origin. The invention also provides a method of identifying and measuring neurite growth in neuronal cells.
Owner:BIOMARIN TECH BV

Brain nourishing, intelligence benefiting and healthy noodle capable of activating brain cell and production method thereof

The present invention relates to a noodle with the functions of brain tonic, mentality improving and health preserving, and a production process thereof, the raw material of the noodle is prepared by raw materials of 80 to 86 wt% of wheat flour, 10 wt% of black hen eggs, 2 wt% of strain and 10 to 18% of functional materials. The functional materials include qi-tonifying materials of yam, blood-enriching matter of tuber fleeceflower root, liver wind-extinguishing materials of gastrodia tuber, heart-nourishing and nerve-soothing matters of arborvitae seed, galangal fruit seed, tuckahoe and longan, resuscitation-inducing and fragrant matter of acorus calamus, diuresis and dampness-excreting matter of tuckahoe, interior-warming matter of common fennel fruit and astringing matter of oyster, with each functional matter taking account for 1 to 1.5%. The production process of the invention comprises the following steps of raw material inspection, drying, grinding, mixing, biological fluids preparing, bio-fermentation, debitterizing, mixing, noodle pressing, drying and packaging. The present invention combines the ancient anaerobic subterranean pot natural zymotechnics with modern aerobic zymotechnics, creatively invents a novel quantum biological multi-fermentation process which produces plentiful alkaline polysaccharide to activate brain cell.
Owner:王德荣

Use of stilbene glycoside in treating dementia

The present invention relates to stilbene glycosie compound and the use of its derivative and medicinal salt in preparing medicine for dementia, especially for Alzheimer disease and vascular dementia. Animal experiment proves that stilbene glycoside compound can resist brain cell damage caused by beta-amyloid protein and hydrogen peroxide, raise the memory capacity of mouse model with scopolaminedementia and A beta dementia and gerbille model with double-sided common carotid artery obstruction caused brain ischemia, inhibit the lipide peroxidation of brain tissue of mouse model with brain ischemia, strengthen the activity of its brain tissue SOD, and reduce the calcium ion density in its brain cells.
Owner:XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI

Construction method of bastard halibut brain cell system

The invention discloses a method for establishing a bastard halibut brain tissue-derived cell system. The method comprises brain tissue primary culture, subculture, cryopreservation, recovery and identification, wherein cell culture fluid adopted is obtained by adding fetal calf serum and human basic fibroblast growth factor to basal cell culture fluid. The established bastard halibut brain cell system is represented as an epithelioid-like astrocytic cell, which can support continuous passage to provide a great amount of bastard halibut brain cells and can be directly used for research of bastard halibut functional gene. The construction method disclosed by the invention not only is expected to serve as a platform for theoretical research of bastard halibut molecule cellular level but also can be used as an ideal material for research on fish hemadenology, reproductive biology and environmental internal-secretion interfering-substance toxicology.
Owner:INST OF OCEANOLOGY - CHINESE ACAD OF SCI

Manufacturing method of music file favorable for brain power enhancement

The invention relates to the technical field of brain power development, and discloses a manufacturing method of a music file favorable for brain power enhancement. The music file manufactured by themanufacturing method provided by the invention has the advantages that in the music listening process by a listener, low-frequency brain harmonic waves can enter the human ears and the brain in a sound wave form to further generate the resonance effect on the brain cells, so that the brain cells are always in an exercise and active state; the brain exercise function is improved; and the goals of enhancing the brain power, improving the attention, enhancing the long-period memory power and enhancing the sensing capability in a physical mode can be achieved. In addition, the manufacturing methodof the music file also has the advantages that the purposiveness is high, the efficiency is high, the realization is easy, and the like; and the practical popularization and application are convenient.
Owner:陈锐斐

Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract

The invention relates to a health care composite which consists of lecithin, grape pip extract and ginkgo leaf extract. The invention consists of the lecithin, the grape pip extract and the ginkgo leaf extract together; wherein, the lecithin accounts for 10 percent to 80 percent of the total weight, the grape pip extract accounts for 1-50 percent of the total weight and ginkgo leaf extract accounts for 1-50 percent of the total weight. The invention has the advantages that: the lecithin has the functions of nourishing the brain, improving intelligence, regulating blood lipid, eliminating fatigue, improving sleep, and so on; the grape pip extract has mighty antioxidation for the human body, can reduce erythrocyte aggregation and the permeability of capillary vessel; the ginkgo leaf extract can improve cerebrovascular circulation, protect brain cells from being damaged due to ischemia, dilate the coronary artery, prevent angina and myocardial infarction, eliminate harmful oxygen free radical, promote immunity and resist aging, and so on; the composite combined by three medicines brings convenience to consumers for oral administration and integrates three efficacies into a whole, thus enhancing the curative effect of the health care product.
Owner:JF PHARMALAND TECH DEV

Manufacturing method for salty dried peanut with cream

The invention discloses a manufacturing method for a salty dried peanut with cream. The salty dried peanut with cream comprises the following raw materials by weight: 50 to 60 parts of a peanut, 3 to 4 parts of salt, 2 to 3 parts of sodium saccharin, 1 to 2 parts of cream, 2 to 3 parts of rehmannia root, 1 to 2 parts of pumpkin, 0.8 to 1.2 parts of strawberry leaf, 1 to 1.5 parts of wolfberry fruit, 3 to 4 parts of dried orange peel, 0.8 to 1.2 parts of Kuding leaf, 3 to 4 parts of jujube, 1 to 2 parts of mulberry leaf and 70 to 80 parts of water. The salty dried peanut with cream produced in the invention contains rich nutrients, has delicate fragrance and agreeable taste and is good leisure food. The peanut has nourishing and tonifying effects, promotes growth of brain cells, improves memory functions and is beneficial for prolonging one's life span; the traditional Chinese medicinal materials consisting of rehmannia root, wolfberry fruit, dried orange peel and the like are cooperatively used, so the salty dried peanut with cream can be used for treating symptoms like malnutrition, disorder of the spleen and the stomach, cough and asthma due to excessive phlegm.
Owner:吴瑞凤

Sparse Deconvolution Spatial Light Microscopy in Two and Three Dimensions

Methods and a computer program product for applying deconvolution to spatial light interference microscopy for resolution enhancement with respect to the diffraction limit in two and three dimensions. By exploiting the sparsity properties of the phase images, which is prominent in many biological imaging applications, and modeling of the image formation via complex fields, the very fine structures can be recovered which were blurred by the optics. The resolution improvement leads to higher accuracy in monitoring dynamic activity over time. Experiments with primary brain cells, i.e. neurons and glial cells, reveal new subdiffraction structures and motions. This new information can be used for studying vesicle transport in neurons, which may shed light on dynamic cell functioning. Finally, the method may flexibly incorporate a wide range of image models for different applications and can be utilized for all imaging modalities acquiring complex field images.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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