Use of stilbene glycoside in treating dementia

Abstract

The present invention relates to stilbene glycosie compound and the use of its derivative and medicinal salt in preparing medicine for dementia, especially for Alzheimer disease and vascular dementia. Animal experiment proves that stilbene glycoside compound can resist brain cell damage caused by beta-amyloid protein and hydrogen peroxide, raise the memory capacity of mouse model with scopolaminedementia and A beta dementia and gerbille model with double-sided common carotid artery obstruction caused brain ischemia, inhibit the lipide peroxidation of brain tissue of mouse model with brain ischemia, strengthen the activity of its brain tissue SOD, and reduce the calcium ion density in its brain cells.

Description

technical field

[0001] The present invention relates to the use of stilbene glycoside compound, its derivatives and pharmaceutically acceptable salts, specifically the use in the preparation of medicines for treating dementia. Background technique

[0002] Dementia (dementia) is an acquired and persistent intellectual disability syndrome caused by brain dysfunction. Intellectual impairment includes varying degrees of memory, language, visual space function, abnormal personality and cognitive decline. Dementia mainly includes Alzheimer's disease, Vascular dementia, etc. The pathological changes of Alzheimer's disease include the formation of senile plaques (mainly composed of Aβ (β-amyloid protein), the loss of cholinergic neurons, and the deposition of Aβ in vascular endothelial cells. Vascular dementia is caused by cerebrovascular disease, mainly ischemia. The pathological changes are multiple lacunar lesions or large infarcts and atherosclerotic lesions (see Neurology, F...